Anne Marie Api

Summary

Affiliation: Research Institute for Fragrance Materials
Country: USA

Publications

  1. ncbi Genotoxicity tests with 6-acetyl-1,1,2,4,4,7-hexamethyltetraline and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyr an
    A M Api
    Research Institute for Fragrance Materials, Hackensack, NJ 07601, USA
    Mutat Res 446:67-81. 1999
  2. ncbi Evaluation of the dermal subchronic toxicity of diphenyl ether in the rat
    A M Api
    Research Institute for Fragrance Materials, Inc, 2 University Plaza Drive, Suite 406, Hackensack, NJ 07601 6209, USA
    Food Chem Toxicol 41:259-64. 2003
  3. ncbi Sensitization methodology and primary prevention of the research institute for fragrance materials
    Anne Marie Api
    Research Institute for Fragrance Materials Inc, Hackensack, NJ, USA
    Dermatology 205:84-7. 2002
  4. ncbi Lack of effect of coumarin on the formation of micronuclei in an in vivo mouse micronucleus assay
    A M Api
    Research Institute for Fragrance Materials Inc, Two University Plaza, Suite 406, Hackensack, NJ 07601, USA
    Food Chem Toxicol 39:837-41. 2001
  5. ncbi Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients
    A M Api
    Research Institute for Fragrance Materials Inc, Two University Plaza, Suite 406, Hackensack, NJ 07601, USA
    Food Chem Toxicol 39:97-108. 2001
  6. ncbi An in vivo mouse micronucleus assay on musk ketone
    A M Api
    Research Institute for Fragrance Materials, 2 University Plaza Drive, Suite 406, Hackensack, NJ, USA
    Mutat Res 464:263-7. 2000
  7. ncbi Evaluation of the oral subchronic toxicity of HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2 -benzopyran) in the rat
    A M Api
    Research Institute for Fragrance Materials Inc, Hackensack, NJ 07601 6209, USA
    Toxicol Lett 111:143-9. 1999
  8. ncbi Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl) ethanone (OTNE) in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 28:213-8. 2009
  9. doi Uterotrophic assay of percutaneous lavender oil in immature female rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 32:123-9. 2013
  10. doi Oral and dermal developmental toxicity studies of phenylethyl alcohol in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 32:32-8. 2013

Collaborators

Detail Information

Publications39

  1. ncbi Genotoxicity tests with 6-acetyl-1,1,2,4,4,7-hexamethyltetraline and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyr an
    A M Api
    Research Institute for Fragrance Materials, Hackensack, NJ 07601, USA
    Mutat Res 446:67-81. 1999
    ..These considerations, along with other negative published data, lead to the conclusion that both AHTN and HHCB do not have significant potential to act as genotoxic carcinogens...
  2. ncbi Evaluation of the dermal subchronic toxicity of diphenyl ether in the rat
    A M Api
    Research Institute for Fragrance Materials, Inc, 2 University Plaza Drive, Suite 406, Hackensack, NJ 07601 6209, USA
    Food Chem Toxicol 41:259-64. 2003
    ..Owing to mitigating factors, the systemic findings were judged to lack biological significance and the no-observed-adverse-effect level (NOAEL) was determined to be 1000 mg/kg body weight/day...
  3. ncbi Sensitization methodology and primary prevention of the research institute for fragrance materials
    Anne Marie Api
    Research Institute for Fragrance Materials Inc, Hackensack, NJ, USA
    Dermatology 205:84-7. 2002
    ..In subjects where sensitization was induced by predictive testing, no serious recurring adverse dermatological conditions developed...
  4. ncbi Lack of effect of coumarin on the formation of micronuclei in an in vivo mouse micronucleus assay
    A M Api
    Research Institute for Fragrance Materials Inc, Two University Plaza, Suite 406, Hackensack, NJ 07601, USA
    Food Chem Toxicol 39:837-41. 2001
    ..There was no evidence of coumarin or mitomycin C treatment related cytotoxicity to bone marrow cells. The results of this study demonstrate that coumarin is negative in the mouse in vivo micronucleus assay...
  5. ncbi Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients
    A M Api
    Research Institute for Fragrance Materials Inc, Two University Plaza, Suite 406, Hackensack, NJ 07601, USA
    Food Chem Toxicol 39:97-108. 2001
    ..75 mg/kg/day oral exposure) indicates no significant toxic liability for the use of DEP in fragrances and cosmetic products...
  6. ncbi An in vivo mouse micronucleus assay on musk ketone
    A M Api
    Research Institute for Fragrance Materials, 2 University Plaza Drive, Suite 406, Hackensack, NJ, USA
    Mutat Res 464:263-7. 2000
    ..Based on the total weight of evidence available, it was concluded that musk ketone does not have significant potential to act as a genotoxic carcinogen...
  7. ncbi Evaluation of the oral subchronic toxicity of HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2 -benzopyran) in the rat
    A M Api
    Research Institute for Fragrance Materials Inc, Hackensack, NJ 07601 6209, USA
    Toxicol Lett 111:143-9. 1999
    ..This examination did not reveal any evidence of hormonal effects...
  8. ncbi Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl) ethanone (OTNE) in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 28:213-8. 2009
    ..086 mg/kg/d...
  9. doi Uterotrophic assay of percutaneous lavender oil in immature female rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 32:123-9. 2013
    ..Based on these data, lavender oil, at dosages of 20 or 100 mg/kg, was not active in the rat uterotrophic assay and gave no evidence of estrogenic activity...
  10. doi Oral and dermal developmental toxicity studies of phenylethyl alcohol in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 32:32-8. 2013
    ..02 mg/kg/d, resulting in a margin of safety >2600, when marked differences in dermal absorption between rats and humans are considered. Under normal fragrance use conditions, PEA is not a developmental toxicity hazard for humans...
  11. ncbi In vitro penetration and subchronic toxicity of alpha-methyl-1,3-benzodioxole-5-propionaldehyde
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 45:702-7. 2007
    ..During the 4-week recovery period of the 90-day study, the animals had largely recovered from MMDHCA induced dermal irritation and the associated microscopic findings...
  12. doi Evaluation of the developmental toxicity of dihydromyrcenol in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 28:80-7. 2009
    ..02 mg/kg/d...
  13. ncbi Evaluation of the developmental toxicity of alpha-iso-methylionone in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 26:271-6. 2007
    ..It is concluded that alpha-iso-methylionone is not a developmental toxicant in rats at maternal doses of up to 30 mg/kg/day...
  14. doi Ninety-day toxicity study of alpha-iso-methylionone in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 31:595-601. 2012
    ..The no-observed-effect level was 5 mg/kg/d for males and 30 mg/kg/d for females. Based on histopathological changes in the kidney in males, the no-observed-adverse-effect level was 30 mg/kg/d...
  15. doi The pharmacokinetics of phenylethyl alcohol (PEA): safety evaluation comparisons in rats, rabbits, and humans
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 32:39-47. 2013
    ....
  16. doi Implementation of the dermal sensitization Quantitative Risk Assessment (QRA) for fragrance ingredients
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Regul Toxicol Pharmacol 52:53-61. 2008
    ..One of the first four IFRA Standards based on the QRA was on the fragrance material citral. The basis for the acceptable exposure limits are presented in this paper...
  17. ncbi Evaluation of the developmental toxicity of methyl dihydrojasmonate (MDJ) in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 27:295-300. 2008
    ..It is concluded that MDJ is not a developmental toxicant in rats under the conditions of this study...
  18. doi Evaluation of the developmental toxicity of linalool in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey, USA
    Int J Toxicol 27:183-8. 2008
    ..It is concluded that linalool is not a developmental toxicant in rats at maternal doses of up to 1000 mg/kg/day...
  19. doi Citral: identifying a threshold for induction of dermal sensitization
    Jon Lalko
    Human Health, Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Regul Toxicol Pharmacol 52:62-73. 2008
    ..This subsequent assessment will form the basis of a risk management approach; specifically a new IFRA (International Fragrance Association) standard on the use of citral in consumer products...
  20. ncbi Evaluation of the developmental toxicity of acetyl cedrene
    Aurelia Lapczynski
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 25:423-8. 2006
    ..Based on these data, maternal and developmental no-observable-adverse-effect levels (NOAELs) of 50 and 100 mg/kg/day, respectively, were established for AC...
  21. doi Evaluation of the developmental toxicity of 4-tert-butylcyclohexyl acetate in Sprague-Dawley rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 31:477-82. 2012
    ..Maternal and developmental no observable adverse effect levels (NOAELs) were 160 mg/kg per d. It was concluded that 4-tBCHA is not a developmental toxicant in rats...
  22. doi The Research Institute for Fragrance Materials' human repeated insult patch test protocol
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Regul Toxicol Pharmacol 52:35-8. 2008
    ..This study is designed to confirm the No-Observed-Effect-Level for induction of dermal sensitization in a normal human population...
  23. doi Disposition and excretion of 14C-AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) and 14c-hhcb (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran) after intravenous administration to Sprague-Dawley rats and dom
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, New Jersey 07677 USA
    Int J Toxicol 32:288-95. 2013
    ..Components found in the urine of the 2 species were qualitatively similar but quantitatively different. Both AHTN and HHCB were completely metabolized and excreted. No unchanged parent compound was detected in rat or pig urine. ..
  24. doi The fate of dermally applied [14C]d-limonene in rats and humans
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 32:130-5. 2013
    ....
  25. doi Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, USA
    Regul Toxicol Pharmacol 52:3-23. 2008
    ....
  26. ncbi Evaluation of the oral subchronic toxicity of AHTN (7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) in the rat
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 42:791-801. 2004
    ..Further work on the mechanism of production of the abnormal color is in progress. Based on these results, the 90-day conservative no-observed-effect level (NOAEL) is 1.5 mg/kg body weight/day...
  27. ncbi Skin contact transfer of three fragrance residues from candles to human hands
    Anne Marie Api
    Research Institute for Fragrance Materials Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Regul Toxicol Pharmacol 48:279-83. 2007
    ..The total mean residues of cinnamic aldehyde and eugenol transferred per grasp from the candles to the hands were 0.255 microg/cm(2) and 0.279 microg/cm(2), respectively...
  28. ncbi The effects of vehicles on the human dermal irritation potentials of allyl esters
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 25:183-93. 2006
    ..33%, 0.26%, 0.25%, respectively. These data showed a trend for lower concentration thresholds to induce irritation when higher levels of ethanol were used in the vehicle...
  29. ncbi Evaluation of the developmental toxicity of alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde in rats
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 25:127-32. 2006
    ..It is concluded that MMDHCA is not a developmental toxicant in rats under the conditions of this study and dosing regimen...
  30. ncbi Evaluation of the dermal subchronic toxicity of phenoxyethyl isobutyrate in the rat
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 42:307-11. 2004
    ..The local skin irritation and systemic toxicity no-observed-effect-levels (NOELs) for PEIB in this study were determined to be >1000 mg/kgBW/day...
  31. doi The selective peptide reactivity of chemical respiratory allergens under competitive and non-competitive conditions
    Jon F Lalko
    Research Institute for Fragrance Materials Inc, Woodcliff Lake, NJ 07677, USA
    J Immunotoxicol 10:292-301. 2013
    ..Discrete patterns of reactivity were observed showing various levels of competitive selectivity between the two allergen classes. ..
  32. doi A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test
    Cecilia Svedman
    Department of Occupational and Environmental Dermatology, Skane University Hospital, Lund University, 205 02 Malmo, Sweden
    Contact Dermatitis 66:137-9. 2012
    ..Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers...
  33. ncbi Only Peru Balsam extracts or distillates are used in perfumery
    Anne Marie Api
    Contact Dermatitis 54:179. 2006
  34. ncbi Chromogenic derivatives of AHTN (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) react with amino acids and protein in vitro. Spectral characteristics of the colour products
    Sandra Pipino
    Department of Anatomy, Pharmacology and Forensic Medicine, Medical Pharmacology Section, Via Pietro Giuria 13, 10125 Torino, Italy
    Food Chem Toxicol 42:785-90. 2004
    ..The data suggest that the AHTN-derived chromogenic material is metabolite-related rather than representative of a toxic process, although further work is necessary to confirm this hypothesis...
  35. ncbi Considerations for testing irritancy, allergy, and photoreactivity in fragrance safety evaluations
    Jon M Hanifin
    Department of Dermatology, Oregon Health Sciences University, Portland, OR, USA
    Am J Contact Dermat 14:100-3. 2003
    ..This paper gives an overview of the RIFM testing and research program, how priorities are established, and how RIFM's safety evaluation process works...
  36. ncbi Comparative metabolism of geranyl nitrile and citronellyl nitrile in mouse, rat, and human hepatocytes
    Raymond A Kemper
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
    Drug Metab Dispos 34:1019-29. 2006
    ..No evidence for either phase I or phase II metabolism of the conjugated nitrile moiety was obtained. Thus, the presumed metabolic basis for differences in genotoxicity remains elusive...
  37. ncbi Dermal absorption and disposition of musk ambrette, musk ketone and musk xylene in human subjects
    David R Hawkins
    Huntingdon Life Sciences Ltd, Alconbury, Huntingdon, Cambridgeshire PE17 5HS, UK
    Toxicol Lett 131:147-51. 2002
    ..The aglycones were chromatographically different, but of similar polarity, to the major rat metabolites excreted in bile also as glucuronides...
  38. ncbi Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant
    Linda Loretz
    Cosmetic, Toiletry, and Fragrance Association, 1101 17th Street NW, Suite 300, Washington, DC 20036, USA
    Food Chem Toxicol 44:2008-18. 2006
    ..67, 1.49 (aerosol) and 1.51 (pump), 1.24, 1.11, 1.37, and 1.3, respectively. This study provides current exposure information for commonly used products which will be useful for risk assessment purposes...
  39. ncbi B220 analysis with the local lymph node assay: proposal for a more flexible prediction model
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    J Appl Toxicol 27:506-10. 2007
    ..As a result a new prediction model is proposed in which reliance on the use of absolute thresholds is reduced, and in which small changes in control values can be better accommodated...