Yury Verlinsky

Summary

Affiliation: Reproductive Genetics Institute
Country: USA

Publications

  1. ncbi Preimplantation diagnosis for Fanconi anemia combined with HLA matching
    Y Verlinsky
    Reproductive Genetics Institute, Chicago, IL, USA
    JAMA 285:3130-3. 2001
  2. ncbi Preimplantation HLA testing
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, Ill 60657, USA
    JAMA 291:2079-85. 2004
  3. ncbi Preimplantation genetic diagnosis with HLA matching
    Svetlana Rechitsky
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 9:210-21. 2004
  4. ncbi Multiple micromanipulations for preimplantation genetic diagnosis do not affect embryo development to the blastocyst stage
    Jeanine Cieslak-Janzen
    IVF and Preimplantation Genetics Diagnosis Program, Reproductive Genetics Institute, Chicago, Illinois, USA
    Fertil Steril 85:1826-9. 2006
  5. ncbi Three-dimensional partial zona dissection for preimplantation genetic diagnosis and assisted hatching
    J Cieslak
    Reproductive Genetics Institute, Illinois Masonic Medical Center, Chicago 60657, USA
    Fertil Steril 71:308-13. 1999
  6. ncbi Preimplantation diagnosis for neurofibromatosis
    Yury Verlinsky
    Reproductive Genetics Institute and IVF Illinois, Chicago, USA
    Reprod Biomed Online 4:218-22. 2002
  7. ncbi Designing babies: what the future holds
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 10:24-6. 2005
  8. ncbi Polar body-based preimplantation diagnosis for X-linked disorders
    Y Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 4:38-42. 2002
  9. ncbi Preimplantation genetic diagnosis for cancer predisposition
    Svetlana Rechitsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, Illinois, USA
    Reprod Biomed Online 5:148-55. 2002
  10. ncbi Morula-derived human embryonic stem cells
    Nick Strelchenko
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 9:623-9. 2004

Collaborators

Detail Information

Publications54

  1. ncbi Preimplantation diagnosis for Fanconi anemia combined with HLA matching
    Y Verlinsky
    Reproductive Genetics Institute, Chicago, IL, USA
    JAMA 285:3130-3. 2001
    ..This is a novel and useful way to preselect a potential donor for an affected sibling requiring stem cell transplantation...
  2. ncbi Preimplantation HLA testing
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, Ill 60657, USA
    JAMA 291:2079-85. 2004
    ....
  3. ncbi Preimplantation genetic diagnosis with HLA matching
    Svetlana Rechitsky
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 9:210-21. 2004
    ....
  4. ncbi Multiple micromanipulations for preimplantation genetic diagnosis do not affect embryo development to the blastocyst stage
    Jeanine Cieslak-Janzen
    IVF and Preimplantation Genetics Diagnosis Program, Reproductive Genetics Institute, Chicago, Illinois, USA
    Fertil Steril 85:1826-9. 2006
    ....
  5. ncbi Three-dimensional partial zona dissection for preimplantation genetic diagnosis and assisted hatching
    J Cieslak
    Reproductive Genetics Institute, Illinois Masonic Medical Center, Chicago 60657, USA
    Fertil Steril 71:308-13. 1999
    ..To develop a new approach to partial zona dissection of oocytes and embryos for facilitating preimplantation genetic sampling and assisted hatching...
  6. ncbi Preimplantation diagnosis for neurofibromatosis
    Yury Verlinsky
    Reproductive Genetics Institute and IVF Illinois, Chicago, USA
    Reprod Biomed Online 4:218-22. 2002
    ..This suggests that PGD is a useful approach for avoiding the birth of children with inherited cancer predisposition, determined by NF1 and NF2 gene mutations...
  7. ncbi Designing babies: what the future holds
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 10:24-6. 2005
    ..This form of treatment has alleviated the inherited disease in many recipients. The outlook and ethics of this approach to the alleviation of human disorders are discussed...
  8. ncbi Polar body-based preimplantation diagnosis for X-linked disorders
    Y Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 4:38-42. 2002
    ..Presented results demonstrate the clinical usefulness of the specific polar body testing for X-linked disorders as an alternative to PGD by gender determination...
  9. ncbi Preimplantation genetic diagnosis for cancer predisposition
    Svetlana Rechitsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, Illinois, USA
    Reprod Biomed Online 5:148-55. 2002
    ....
  10. ncbi Morula-derived human embryonic stem cells
    Nick Strelchenko
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 9:623-9. 2004
    ..Similar to ES cell originating from blastocyst, the morula-derived ES cells were shown to spontaneously differentiate in vitro into a variety of cell types, including the neuron-like and contracting primitive cardiocyte-like cells...
  11. ncbi Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, IL, USA
    JAMA 287:1018-21. 2002
    ....
  12. ncbi Reliability of preimplantation diagnosis for single gene disorders
    S Rechitsky
    Reproductive Genetics Institute, 2825 North Halsted, Chicago, IL 60657, USA
    Mol Cell Endocrinol 183:S65-8. 2001
    ..Of 75 (8.5%) detected ADO, only seven (under 1%) were missed in the actual PGD, demonstrating high reliability of PGD (98%) based on multiplex single cell PCR...
  13. ncbi Chromosomal abnormalities in the first and second polar body
    Y Verlinsky
    Mol Cell Endocrinol 183:S47-9. 2001
    ..Polar body testing of oocytes provides an approach for pre-selection of aneuploidy free embryos, improving pregnancy rate in IVF patents of advanced maternal age...
  14. ncbi Preimplantation testing for phenylketonuria
    Y Verlinsky
    Reproductive Genetics Institute, Chicago, Illinois, USA
    Fertil Steril 76:346-9. 2001
    ..To use preimplantation genetic diagnosis to achieve a phenylketonuria-free pregnancy in a couple at 50% risk for producing an affected child...
  15. ncbi Preimplantation diagnosis for aneuploidies using fluorescence in situ hybridization or comparative genomic hybridization
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, Illinois 60657, USA
    Fertil Steril 80:869-70; discussion 875. 2003
  16. ncbi Preimplantation genetics: Improving access to stem cell therapy
    Anver Kuliev
    Reproductive Genetics Institute, 2825 N Halsted St, Chicago, IL 60657, USA
    Ann N Y Acad Sci 1054:223-7. 2005
    ..Successful therapy with HLA-matched stem cells, obtained from these PGD children, has been achieved already for Diamond-Blackfan anemia hypohidrotic ectodermal dysplasia with immune deficiency and thalassemia...
  17. ncbi Preimplantation HLA typing with aneuploidy testing
    Svetlana Rechitsky
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 12:89-100. 2006
    ....
  18. ncbi Preimplantation diagnosis for sonic hedgehog mutation causing familial holoprosencephaly
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, IL, USA
    N Engl J Med 348:1449-54. 2003
  19. ncbi Impact of meiotic and mitotic non-disjunction on generation of human embryonic stem cell lines
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, IL 60657, USA
    Reprod Biomed Online 18:120-6. 2009
    ....
  20. ncbi Preimplantation diagnosis for immunodeficiencies
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 14:214-23. 2007
    ..HLA-identical stem cells from some of these children have been used for transplantation therapy, resulting in the restoration of normal function in siblings with HIGM and HED-ID...
  21. ncbi Pre-embryonic diagnosis for Sandhoff disease
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 12:328-33. 2006
    ..The transfer of two of these embryos resulted in birth of an unaffected child, demonstrating feasibility of pre-embryonic diagnosis to avoid embryo discard...
  22. ncbi Over a decade of experience with preimplantation genetic diagnosis
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted, Chicago, IL 60657, USA
    Fertil Steril 82:302-3. 2004
    ..e., microarray analysis), and more refined patient selection may be required before shifting from preselection of embryos based solely on morphological parameters to transfer of only aneuploidy-free embryos...
  23. ncbi Correlation between preimplantation genetic diagnosis for chromosomal aneuploidies and the efficiency of establishing human ES cell lines
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, IL 60657, USA
    Stem Cell Res 2:78-82. 2009
    ..Furthermore, the success rates for generating aneuploid cell lines originating from fertilized oocytes carrying a prezygotic nondisjunction error seem to mirror the miscarriage rates during pregnancy of embryos carrying such errors...
  24. ncbi Impact of preimplantation genetic diagnosis for chromosomal disorders on reproductive outcome
    Anver Kuliev
    Reproductive Genetics Institute, 2825 N Halsted, Chicago, IL 60657, USA
    Reprod Biomed Online 16:9-10. 2008
    ....
  25. ncbi Obtaining metaphase spreads from single blastomeres for PGD of chromosomal rearrangements
    Artem Shkumatov
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 14:498-503. 2007
    ..The method is simple for obtaining metaphases from single blastomeres, and may be implemented in clinical practice of PGD for structural rearrangements...
  26. ncbi Is there any predictive value of first polar body morphology for embryo genotype or developmental potential?
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted, Chicago, IL 60657, USA
    Reprod Biomed Online 7:336-41. 2003
    ..This suggests that PB1 morphology may not be a reliable predictor of genotype or the developmental potential of the corresponding oocytes or embryos...
  27. ncbi Preimplantation HLA typing and stem cell transplantation: report of International Meeting, Cyprus, 27-8 March, 2004
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 9:205-9. 2004
    ..The applied method resulted in the accurate pre-selection and transfer of HLA-matched embryos, yielding 25 clinical pregnancies and the birth of 14 HLA-matched children to the siblings who required stem cell transplantation...
  28. ncbi Conversion and non-conversion approach to preimplantation diagnosis for chromosomal rearrangements in 475 cycles
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 21:93-9. 2010
    ..The spontaneous abortion rate in these cycles was as low as 17%, which confirms an almost five-fold reduction of spontaneous abortion rate following PGD for chromosomal rearrangements...
  29. ncbi Preimplantation genetic diagnosis for the Kell genotype
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, Illinois, USA
    Fertil Steril 80:1047-51. 2003
    ..CONCLUSION(S): PGD of the K1 genotype resulted in the birth of healthy twins confirmed to be free of the K1 allele. PGD in couples with a heterozygous K1/K2 male partner provides an option for avoiding HDN in sensitized mothers...
  30. ncbi The role of preimplantation genetic diagnosis in women of advanced reproductive age
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, Illinois, USA
    Curr Opin Obstet Gynecol 15:233-8. 2003
    ..More than half of in-vitro fertilization patients are of advanced reproductive age and at risk for producing offspring with age-related aneuploidies, which contribute significantly to spontaneous abortions and implantation failure...
  31. ncbi Current features of preimplantation genetic diagnosis
    Anver Kuliev
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 5:294-9. 2002
    ....
  32. ncbi Cytoplasmic cell fusion: Stembrid technology for reprogramming pluripotentiality
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 N Halsted St, Chicago, IL 60657, USA
    Stem Cell Rev 2:297-9. 2006
    ..The resulting constructs was demonstrated to have the "stemness" of hESC and the genotype of the donor somatic cells. So this "Stembrid technology," may be used for the construction of patient-specific hESC...
  33. ncbi Duplication of the sperm genome by human androgenetic embryo production: towards testing the paternal genome prior to fertilization
    Valeriy Kuznyetsov
    Reproductive Genetic Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 14:504-14. 2007
    ..9 and 33.3% in MII enucleation). Fluorescence in-situ hybridization (FISH) analysis of 30 2- to 5-cell androgenic embryos for two to seven chromosomes revealed the correct chromosome distribution in 76.7% of haploid human androgenotes...
  34. ncbi Nuclear transfer for full karyotyping and preimplantation diagnosis for translocations
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 5:300-5. 2002
    ....
  35. ncbi Preimplantation genetic diagnosis for polycystic kidney disease
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, Illinois 60657, USA
    Fertil Steril 82:926-9. 2004
    ..Preimplantation genetic diagnosis based on linked marker analysis provides an alternative for avoiding the pregnancy and birth of children with PKD, even in at-risk couples without exact PKD1 or PKD2 carrier information...
  36. ncbi Reprogramming of human somatic cells by embryonic stem cell cytoplast
    Nick Strelchenko
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Reprod Biomed Online 12:107-11. 2006
    ....
  37. ncbi Chromosomal abnormalities in a series of 6,733 human oocytes in preimplantation diagnosis for age-related aneuploidies
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, IL 60657, USA
    Reprod Biomed Online 6:54-9. 2003
    ..35 embryos per transfer), resulting in 241 (21.9%) clinical pregnancies and 176 healthy children born, suggesting a positive clinical outcome following aneuploidy testing of oocytes in a group of IVF patients of average age 38.5 years...
  38. ncbi Place of preimplantation diagnosis in genetic practice
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, Illinois 60657, USA
    Am J Med Genet A 134:105-10. 2005
    ..This makes of practical relevance to inform couples at-risk about availability of PGD option, so they make their own choice in avoiding the birth of affected offspring and having healthy children of their own...
  39. ncbi Preimplantation diagnosis: a realistic option for assisted reproduction and genetic practice
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, Illinois 60657, USA
    Curr Opin Obstet Gynecol 17:179-83. 2005
    ..This review will describe the current progress of PGD for Mendelian and chromosomal disorders and its impact on reproductive medicine...
  40. ncbi Embryonic stem cells from morula
    Nick Strelchenko
    Reproductive Genetics Institute, Chicago, Illinois, USA
    Methods Enzymol 418:93-108. 2006
    ..Technical approaches of freezing morula-derived hESC are discussed...
  41. ncbi Current status of preimplantation diagnosis for single gene disorders
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL, USA
    Reprod Biomed Online 7:145-50. 2003
    ..This extends the practical value of PGD, with its utility being no longer limited to prevention of single gene disorders, by expanding it to treatment of siblings requiring stem cell transplantation...
  42. ncbi Preimplantation FISH diagnosis of aneuploidies
    Yury Verlinsky
    Reproductive Genetics Institute, Chicago, IL, USA
    Methods Mol Biol 204:259-73. 2002
  43. ncbi Preimplantation diagnosis for diseases with genetic predisposition and nondisease testing
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL USA
    Expert Rev Mol Diagn 2:509-13. 2002
    ....
  44. ncbi Preimplantation genetic diagnosis: technological advances to improve accuracy and range of applications
    Anver Kuliev
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL, USA
    Reprod Biomed Online 16:532-8. 2008
    ..This paper describes the present status of PGD for genetic and chromosomal disorders, its accuracy and range, and how PGD is an integral part of IVF and genetic practices...
  45. ncbi Oocyte-like structures arising from cells of follicular fluid are not captured in aspirates
    Nicolas H Zech
    Reproductive Genetics Institute, 2825 N Halsted, Chicago, IL 60657, USA
    Reprod Biomed Online 18:443-8. 2009
    ..Investigations could not confirm the development of oocyte-like cells from cells of FF aspirates...
  46. ncbi Preimplantation genetic diagnosis in assisted reproduction
    Anver Kuliev
    Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
    Expert Rev Mol Diagn 5:499-505. 2005
    ....
  47. ncbi Over a decade of experience with preimplantation genetic diagnosis: a multicenter report
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted, Chicago, IL 60657, USA
    Fertil Steril 82:292-4. 2004
    ....
  48. ncbi Thirteen years' experience of preimplantation diagnosis: report of the Fifth International Symposium on Preimplantation Genetics
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, IL, USA
    Reprod Biomed Online 8:229-35. 2004
    ..Current developments and application of nuclear transfer and sperm duplication techniques, and microarray technology, may also contribute to the improvement of PGD and help in the development of PGD for genetic expression disorders...
  49. ncbi Fusion as the etiology of chimerism in monochorionic dizygotic twins
    Norman A Ginsberg
    Illinois Masonic Hospital and Northwestern Memorial Hospital, Chicago, IL 60062, USA
    Fetal Diagn Ther 20:20-2. 2005
    ..Monochorionicity was confirmed by a combination of ultrasound, histological evaluation and DNA technology. Etiologic hypotheses are offered to explain this rare circumstance...
  50. ncbi Meiotic and mitotic nondisjunction: lessons from preimplantation genetic diagnosis
    Anver Kuliev
    Reproductive Genetics Institute, Chicago, IL 60657, USA
    Hum Reprod Update 10:401-7. 2004
    ....
  51. ncbi Genetic testing of embryos: a critical need for data
    Susannah Baruch
    Genetics and Public Policy Centre, Berman Bioethics Institute, Johns Hopkins University, Washington DC 20036, USA
    Reprod Biomed Online 11:667-70. 2005
    ..To address the gaps in knowledge, a working group of the leading experts in the development and practice of PGD and IVF has begun to design a database to collect information about PGD as practised in the United States...
  52. ncbi Discussion (day 1 session 2): Designer babies
    Ruth Chadwick
    Reprod Biomed Online 10:40-2. 2005
  53. ncbi Preimplantation diagnosis for homeobox gene HLXB9 mutation causing Currarino syndrome
    Yury Verlinsky
    Am J Med Genet A 134:103-4. 2005
  54. ncbi Substandard application of preimplantation genetic screening may interfere with its clinical success
    Santiago Munne
    Reprogenetics, Livingston, New Jersey 07039, USA
    Fertil Steril 88:781-4. 2007
    ..At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial...