D Vashishth

Summary

Affiliation: Rensselaer Polytechnic Institute
Country: USA

Publications

  1. ncbi request reprint Influence of nonenzymatic glycation on biomechanical properties of cortical bone
    D Vashishth
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180
    Bone 28:195-201. 2001
  2. ncbi request reprint Susceptibility of aging human bone to mixed-mode fracture increases bone fragility
    W T George
    Department of Biomedical Engineering, Room 7046, Jonnson Engineering Center, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12182, USA
    Bone 38:105-11. 2006
  3. ncbi request reprint Age-dependent fatigue behaviour of human cortical bone
    T Diab
    Department of Biomedical Engineering, Jonsson Engineering Center, Room 7046, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY, 12180, USA
    Eur J Morphol 42:53-9. 2005
  4. ncbi request reprint Contribution, development and morphology of microcracking in cortical bone during crack propagation
    D Vashishth
    Department of Biomedical Engineering, Jonnson Engineering Center, Rensselaer Polytechnic Institute, Troy, NY 12180 3590, USA
    J Biomech 33:1169-74. 2000
  5. ncbi request reprint Damage mechanisms and failure modes of cortical bone under components of physiological loading
    W T George
    Department of Biomedical Engineering, Jonsson Engineering Center, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    J Orthop Res 23:1047-53. 2005
  6. doi request reprint Differences in non-enzymatic glycation and collagen cross-links between human cortical and cancellous bone
    L Karim
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, CBIS room 3137, 110 Eighth Street, Troy, NY 12180, USA
    Osteoporos Int 24:2441-7. 2013
  7. doi request reprint Non-enzymatic glycation alters microdamage formation in human cancellous bone
    S Y Tang
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Bone 46:148-54. 2010
  8. ncbi request reprint Effects of non-enzymatic glycation on cancellous bone fragility
    S Y Tang
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Bone 40:1144-51. 2007
  9. ncbi request reprint Fatigue of cortical bone under combined axial-torsional loading
    D Vashishth
    Department of Biomedical Engineering, Jonsson Engineering Center, Rensselaer Polytechnic Institute, Troy, NY 12180 3590, USA
    J Orthop Res 19:414-20. 2001
  10. pmc Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate
    S Y Tang
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Osteoporos Int 20:887-94. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Influence of nonenzymatic glycation on biomechanical properties of cortical bone
    D Vashishth
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180
    Bone 28:195-201. 2001
    ....
  2. ncbi request reprint Susceptibility of aging human bone to mixed-mode fracture increases bone fragility
    W T George
    Department of Biomedical Engineering, Room 7046, Jonnson Engineering Center, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12182, USA
    Bone 38:105-11. 2006
    ....
  3. ncbi request reprint Age-dependent fatigue behaviour of human cortical bone
    T Diab
    Department of Biomedical Engineering, Jonsson Engineering Center, Room 7046, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY, 12180, USA
    Eur J Morphol 42:53-9. 2005
    ..Thus, the propensity of aging human bone to form more linear microcracks than diffuse damage may be a significant contributor to bone quality, and age related fragility in bone...
  4. ncbi request reprint Contribution, development and morphology of microcracking in cortical bone during crack propagation
    D Vashishth
    Department of Biomedical Engineering, Jonnson Engineering Center, Rensselaer Polytechnic Institute, Troy, NY 12180 3590, USA
    J Biomech 33:1169-74. 2000
    ..Analyses of fracture surfaces indicated that, consistent with its higher toughness, bovine bone displays a rougher surface than human bone but they both have the same basic fractured element, i.e. a mineralised collagen fibril...
  5. ncbi request reprint Damage mechanisms and failure modes of cortical bone under components of physiological loading
    W T George
    Department of Biomedical Engineering, Jonsson Engineering Center, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    J Orthop Res 23:1047-53. 2005
    ..Thus, fatigue behavior of bone was found to be uniquely related to the individual mechanical components of physiological loading and the latter determined the specific damage mechanisms associated with fatigue fracture...
  6. doi request reprint Differences in non-enzymatic glycation and collagen cross-links between human cortical and cancellous bone
    L Karim
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, CBIS room 3137, 110 Eighth Street, Troy, NY 12180, USA
    Osteoporos Int 24:2441-7. 2013
    ..Results illustrate the importance of measuring pentosidine and AGEs separately in cancellous and cortical bone...
  7. doi request reprint Non-enzymatic glycation alters microdamage formation in human cancellous bone
    S Y Tang
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Bone 46:148-54. 2010
    ..The formation of AGEs increases crosslinking in the organic matrix of bone but it is unknown how elevated levels of AGEs affect the mechanisms of fracture resistance such as microdamage formation...
  8. ncbi request reprint Effects of non-enzymatic glycation on cancellous bone fragility
    S Y Tang
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Bone 40:1144-51. 2007
    ..95, p<0.008). This study shows that cancellous bone is susceptible to NEG that increases its propensity to fracture. Moreover, despite tissue turnover, cancellous bone may be susceptible to an age-related accumulation of AGEs...
  9. ncbi request reprint Fatigue of cortical bone under combined axial-torsional loading
    D Vashishth
    Department of Biomedical Engineering, Jonsson Engineering Center, Rensselaer Polytechnic Institute, Troy, NY 12180 3590, USA
    J Orthop Res 19:414-20. 2001
    ..Based on these results, it is suggested that torsional loading plays a significant role in determining the fatigue life of cortical bone...
  10. pmc Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate
    S Y Tang
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Osteoporos Int 20:887-94. 2009
    ..The increased accumulation of AGEs in these tissues may help explain altered bone matrix quality due to the administration of BPs in animal models..
  11. ncbi request reprint Effects of damage morphology on cortical bone fragility
    T Diab
    Department of Biomedical Engineering, Jonsson Engineering Center, Room 7046, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
    Bone 37:96-102. 2005
    ..05). Thus, cortical bone compartmentalizes the damage morphologies in different regions and the sequence of damage production in different phases of cyclic loading to dissipate energy and resist a catastrophic fracture...
  12. pmc The relative contributions of non-enzymatic glycation and cortical porosity on the fracture toughness of aging bone
    Tang S Y
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA
    J Biomech 44:330-6. 2011
    ..The outcome of this study suggests that it may be important to include the age-related changes in the material level properties by using finite element analysis towards the prediction of fracture risk...
  13. ncbi request reprint Determination of bone volume by osteocyte population
    D Vashishth
    Department of Biomedical Engineering, Rensellaer Polytechnic University, Troy, New York, USA
    Anat Rec 267:292-5. 2002
    ....
  14. ncbi request reprint Influence of phase angle between axial and torsional loadings on fatigue fractures of bone
    W T George
    Department of Biomedical Engineering, Jonsson Engineering Center, Room 7046, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180 3590, USA
    J Biomech 38:819-25. 2005
    ..Change in phase angle, seen in vivo during a number of physiological activities including walking, running and sprinting, will therefore affect fatigue behavior and contribute to pathogenesis of fatigue fractures...
  15. ncbi request reprint Collagen glycation and its role in fracture properties of bone
    D Vashishth
    Department of Biomedical Engineering, Center of Biotechnology and Interdisciplinary Studies, Rensselear Polytechnic Institute, Troy, NY 12180, USA
    J Musculoskelet Neuronal Interact 5:316. 2005
  16. pmc A non-invasive in vitro technique for the three-dimensional quantification of microdamage in trabecular bone
    S Y Tang
    Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Bone 40:1259-64. 2007
    ..This non-invasive in vitro technique for the detection of microdamage using microCT may serve as a valuable complement to existing morphometric analyses of bone...
  17. ncbi request reprint Experimental validation of a microcracking-based toughening mechanism for cortical bone
    D Vashishth
    Jonsson Engineering Center, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Room 7046, 110 8th Street, Troy, NY 12180, USA
    J Biomech 36:121-4. 2003
    ..These results support the microcrack-based toughening mechanism in cortical bone. Bone toughness is, therefore, determined by its ability to form microcracks during fracture...