Research Topics
Genomes and GenesSpecies | David J GlassSummaryAffiliation: Regeneron Pharmaceuticals Country: USA Publications
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Detail Information
Publications
Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteinsHui Hua Li
Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
J Clin Invest 117:3211-23. 2007....
Signalling pathways that mediate skeletal muscle hypertrophy and atrophyDavid J Glass
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
Nat Cell Biol 5:87-90. 2003....- Molecular mechanisms modulating muscle massDavid J Glass
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
Trends Mol Med 9:344-50. 2003..The pathways modulating hypertrophy and atrophy will be further discussed, to highlight potential targets for clinical intervention... - Skeletal muscle hypertrophy and atrophy signaling pathwaysDavid J Glass
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
Int J Biochem Cell Biol 37:1974-84. 2005..This review will focus on the recent progress in the understanding of molecular signalling, which governs skeletal muscle atrophy and hypertrophy, and the known instances of cross-regulation between the two systems... - Conditional activation of MET in differentiated skeletal muscle induces atrophyTiziana Crepaldi
Center for Experimental Research and Medical Studies, University of Turin, 10126 Turin, Italy
J Biol Chem 282:6812-22. 2007.... - Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathwayEsther Latres
Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591 6707, USA
J Biol Chem 280:2737-44. 2005..Thus both the Akt/FOXO and the Akt/mTOR pathways are required for the transcriptional changes induced by IGF-1... - The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factorsTrevor N Stitt
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Mol Cell 14:395-403. 2004.... - Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasisHaruka Okamoto
Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA
Diabetes 56:1350-6. 2007.... - Conditional activation of akt in adult skeletal muscle induces rapid hypertrophyKa Man V Lai
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
Mol Cell Biol 24:9295-304. 2004..These findings suggest that pharmacologic approaches directed toward activating Akt will be useful in inducing skeletal muscle hypertrophy and that an increase in lean muscle mass is sufficient to decrease fat storage... - Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesityMark W Sleeman
Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
Nat Med 11:199-205. 2005..These results suggest that inhibition of SHIP2 would be useful in the effort to ameliorate diet-induced obesity, but call into question a dominant role of SHIP2 in modulating glucose homeostasis... - The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscleBrian A Clarke
Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
Cell Metab 6:376-85. 2007..These data identify the mechanism by which MYH is depleted under atrophy conditions and demonstrate that inhibition of a single E3 ligase, MuRF1, is sufficient to maintain this important sarcomeric protein... - IKKbeta/NF-kappaB activation causes severe muscle wasting in miceDongsheng Cai
Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Cell 119:285-98. 2004.... - Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivoMonte S Willis
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
Circ Res 100:456-9. 2007..These studies describe for the first time distinct and nonoverlapping functional characteristics of MuRF1 and MuRF2 in response to cardiac stress in vivo... - Two tales concerning skeletal muscleDavid J Glass
Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
J Clin Invest 117:2388-91. 2007..Here it is shown that nNOS is similarly perturbed in a setting of skeletal muscle atrophy. Both of these studies suggest new avenues for the treatment of skeletal muscle disease... - Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3Jens Fielitz
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
J Clin Invest 117:2486-95. 2007..These findings identify MuRF1 and MuRF3 as key E3 ubiquitin ligases for the UPS-dependent turnover of sarcomeric proteins and reveal a potential basis for myosin storage myopathies... - A signaling role for dystrophin: inhibiting skeletal muscle atrophy pathwaysDavid J Glass
Novartis Institutes for BioMedical Research, 400 Technology Square, Cambridge, Massachusetts 02139, USA
Cancer Cell 8:351-2. 2005..These data reposition dystrophin as a signaling protein and connect an important cellular complex required for the structural integrity of muscle to the pathways that modulate muscle size...