David J Glass

Summary

Affiliation: Regeneron Pharmaceuticals
Country: USA

Publications

  1. pmc Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
    Hui Hua Li
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Clin Invest 117:3211-23. 2007
  2. ncbi request reprint Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
    David J Glass
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
    Nat Cell Biol 5:87-90. 2003
  3. ncbi request reprint Molecular mechanisms modulating muscle mass
    David J Glass
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
    Trends Mol Med 9:344-50. 2003
  4. ncbi request reprint Skeletal muscle hypertrophy and atrophy signaling pathways
    David J Glass
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
    Int J Biochem Cell Biol 37:1974-84. 2005
  5. ncbi request reprint Conditional activation of MET in differentiated skeletal muscle induces atrophy
    Tiziana Crepaldi
    Center for Experimental Research and Medical Studies, University of Turin, 10126 Turin, Italy
    J Biol Chem 282:6812-22. 2007
  6. ncbi request reprint Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway
    Esther Latres
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591 6707, USA
    J Biol Chem 280:2737-44. 2005
  7. ncbi request reprint The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    Trevor N Stitt
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Mol Cell 14:395-403. 2004
  8. ncbi request reprint Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis
    Haruka Okamoto
    Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA
    Diabetes 56:1350-6. 2007
  9. pmc Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy
    Ka Man V Lai
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
    Mol Cell Biol 24:9295-304. 2004
  10. ncbi request reprint Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
    Mark W Sleeman
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Med 11:199-205. 2005

Collaborators

  • C Patterson
  • Hui Hua Li
  • Yi Wei
  • Jongsoon Lee
  • Rhonda Bassel-Duby
  • Steven Shoelson
  • Per Olof J Hasselgren
  • E N Olson
  • Trevor N Stitt
  • George D Yancopoulos
  • Esther Latres
  • Monte S Willis
  • Brian A Clarke
  • Mark W Sleeman
  • Ka Man V Lai
  • William O Kline
  • Jens Fielitz
  • Tiziana Crepaldi
  • Haruka Okamoto
  • Jennifer Griffiths
  • Doreen Drujan
  • Michael Gonzalez
  • Dongsheng Cai
  • Luge Li
  • Da Zhi Wang
  • Christian Leo
  • Roberto Chiarle
  • James A Richardson
  • Claudio Scuoppo
  • Chiara Prunotto
  • Jeffrey A Spencer
  • Sergey V Rakhilin
  • Riccardo Taulli
  • Francesca Bersani
  • Richard A Corpina
  • Karen Thabet
  • Paolo E Forni
  • Carola Ponzetto
  • John M Shelton
  • Mi Sung Kim
  • Leon O Murphy
  • Rong Liu
  • Paolo Accornero
  • Shuaib Latif
  • Christopher Ike
  • David Valenzeula
  • Elena Burova
  • Andrew Murphy
  • Lori C Gowen
  • Katherine E Wortley
  • Francis J Martin
  • Ami R Amini
  • Stanley J Wiegand
  • Jennifer Kintner
  • Karen Garcia
  • Hsin Chieh Lin
  • Ashley A Amini
  • Walter R Frontera
  • Elizabeth Zlotchenko
  • J Daniel Frantz
  • Frank Panaro
  • Yekatarina Timofeyva
  • Hart G W Lidov
  • Byung Chul Oh
  • Aris N Economides
  • Peter A Melendez
  • Nicholas E Tawa
  • William T Poueymirou
  • Erqian Na

Detail Information

Publications16

  1. pmc Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
    Hui Hua Li
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Clin Invest 117:3211-23. 2007
    ....
  2. ncbi request reprint Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
    David J Glass
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
    Nat Cell Biol 5:87-90. 2003
    ....
  3. ncbi request reprint Molecular mechanisms modulating muscle mass
    David J Glass
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
    Trends Mol Med 9:344-50. 2003
    ..The pathways modulating hypertrophy and atrophy will be further discussed, to highlight potential targets for clinical intervention...
  4. ncbi request reprint Skeletal muscle hypertrophy and atrophy signaling pathways
    David J Glass
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
    Int J Biochem Cell Biol 37:1974-84. 2005
    ..This review will focus on the recent progress in the understanding of molecular signalling, which governs skeletal muscle atrophy and hypertrophy, and the known instances of cross-regulation between the two systems...
  5. ncbi request reprint Conditional activation of MET in differentiated skeletal muscle induces atrophy
    Tiziana Crepaldi
    Center for Experimental Research and Medical Studies, University of Turin, 10126 Turin, Italy
    J Biol Chem 282:6812-22. 2007
    ....
  6. ncbi request reprint Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway
    Esther Latres
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591 6707, USA
    J Biol Chem 280:2737-44. 2005
    ..Thus both the Akt/FOXO and the Akt/mTOR pathways are required for the transcriptional changes induced by IGF-1...
  7. ncbi request reprint The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    Trevor N Stitt
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Mol Cell 14:395-403. 2004
    ....
  8. ncbi request reprint Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis
    Haruka Okamoto
    Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA
    Diabetes 56:1350-6. 2007
    ....
  9. pmc Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy
    Ka Man V Lai
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
    Mol Cell Biol 24:9295-304. 2004
    ..These findings suggest that pharmacologic approaches directed toward activating Akt will be useful in inducing skeletal muscle hypertrophy and that an increase in lean muscle mass is sufficient to decrease fat storage...
  10. ncbi request reprint Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
    Mark W Sleeman
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Med 11:199-205. 2005
    ..These results suggest that inhibition of SHIP2 would be useful in the effort to ameliorate diet-induced obesity, but call into question a dominant role of SHIP2 in modulating glucose homeostasis...
  11. ncbi request reprint The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle
    Brian A Clarke
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Cell Metab 6:376-85. 2007
    ..These data identify the mechanism by which MYH is depleted under atrophy conditions and demonstrate that inhibition of a single E3 ligase, MuRF1, is sufficient to maintain this important sarcomeric protein...
  12. ncbi request reprint IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
    Dongsheng Cai
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Cell 119:285-98. 2004
    ....
  13. ncbi request reprint Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Circ Res 100:456-9. 2007
    ..These studies describe for the first time distinct and nonoverlapping functional characteristics of MuRF1 and MuRF2 in response to cardiac stress in vivo...
  14. pmc Two tales concerning skeletal muscle
    David J Glass
    Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    J Clin Invest 117:2388-91. 2007
    ..Here it is shown that nNOS is similarly perturbed in a setting of skeletal muscle atrophy. Both of these studies suggest new avenues for the treatment of skeletal muscle disease...
  15. pmc Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3
    Jens Fielitz
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Clin Invest 117:2486-95. 2007
    ..These findings identify MuRF1 and MuRF3 as key E3 ubiquitin ligases for the UPS-dependent turnover of sarcomeric proteins and reveal a potential basis for myosin storage myopathies...
  16. ncbi request reprint A signaling role for dystrophin: inhibiting skeletal muscle atrophy pathways
    David J Glass
    Novartis Institutes for BioMedical Research, 400 Technology Square, Cambridge, Massachusetts 02139, USA
    Cancer Cell 8:351-2. 2005
    ..These data reposition dystrophin as a signaling protein and connect an important cellular complex required for the structural integrity of muscle to the pathways that modulate muscle size...