Christopher Daly

Summary

Affiliation: Regeneron Pharmaceuticals
Country: USA

Publications

  1. ncbi Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA
    Genes Dev 18:1060-71. 2004
  2. ncbi Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA
    Cancer Res 73:108-18. 2013
  3. ncbi Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 103:15491-6. 2006
  4. ncbi Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis
    Zhe Li
    Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 106:22399-404. 2009
  5. ncbi Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor
    Keith D Anderson
    VelociGene Division, Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 108:2807-12. 2011
  6. ncbi Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    Irene Noguera-Troise
    Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA
    Nature 444:1032-7. 2006
  7. ncbi Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis
    Melissa G Dominguez
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 104:3243-8. 2007
  8. ncbi The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway
    Gavin Thurston
    Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA
    Cold Spring Harb Perspect Med 2:a006550. 2012
  9. ncbi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA
    Genes Dev 18:1060-71. 2004
    ....
  2. ncbi Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA
    Cancer Res 73:108-18. 2013
    ..Thus, blockade of Ang2 might enhance the clinical benefits currently provided by anti-VEGF agents. ...
  3. ncbi Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 103:15491-6. 2006
    ..Our data suggests a model in which Ang-2 expression is induced in stressed endothelial cells, where it acts as an autocrine Tie2 agonist and protective factor...
  4. ncbi Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis
    Zhe Li
    Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 106:22399-404. 2009
    ..Endothelial differentiation in the ES teratoma model allows gene-targeting methods to be used in the study of tumor angiogenesis...
  5. ncbi Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor
    Keith D Anderson
    VelociGene Division, Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 108:2807-12. 2011
    ..These results represent a unique function attributed to a long N-terminal group B-type G protein-coupled receptor in a mammalian system...
  6. ncbi Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    Irene Noguera-Troise
    Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA
    Nature 444:1032-7. 2006
    ....
  7. ncbi Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis
    Melissa G Dominguez
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 104:3243-8. 2007
    ..VE-PTP is also expressed in the vasculature of growing tumors, suggesting that VE-PTP may be a new potential target for angiogenic therapies...
  8. ncbi The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway
    Gavin Thurston
    Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA
    Cold Spring Harb Perspect Med 2:a006550. 2012
    ..The application of these reagents in preclinical models of inflammation and cancer has begun to elucidate the role of Ang2 in vascular remodeling and disease pathogenesis and has led to emerging clinical tests of Ang2 inhibitors...
  9. ncbi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
    ..These results offer a molecular basis for the link between AJs and TJs and explain why VE-cadherin inhibition may cause a marked increase in permeability...