S C Bodine

Summary

Affiliation: Regeneron Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    S C Bodine
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Cell Biol 3:1014-9. 2001
  2. ncbi request reprint Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
    C Rommel
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591-6707, USA
    Nat Cell Biol 3:1009-13. 2001
  3. ncbi request reprint Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
  4. ncbi request reprint Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats
    J R Tonra
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA
    Exp Neurol 172:220-7. 2001

Collaborators

  • J C Lawrence
  • J R Tonra
  • C Rommel
  • R M Lindsay
  • K D Cliffer
  • L Nunez
  • P S DiStefano
  • T N Stitt
  • G D Yancopoulos
  • R Rossman
  • D J Glass
  • B A Clarke
  • S R Carson

Detail Information

Publications4

  1. ncbi request reprint Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    S C Bodine
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Cell Biol 3:1014-9. 2001
    ....
  2. ncbi request reprint Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
    C Rommel
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591-6707, USA
    Nat Cell Biol 3:1009-13. 2001
    ..In contrast, in addition to demonstrating that calcineurin does not mediate IGF-1-induced hypertrophy, we show that IGF-1 unexpectedly acts via Akt to antagonize calcineurin signalling during myotube hypertrophy...
  3. ncbi request reprint Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    ..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy...
  4. ncbi request reprint Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats
    J R Tonra
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA
    Exp Neurol 172:220-7. 2001
    ..The recovery of the H wave in STZ-treated rats distinguishes this deficit mechanistically from other STZ-induced electrophysiological changes and may model a similar recovery of the H wave reported in diabetic patients...