Peter D Reaven

Summary

Country: USA

Publications

  1. ncbi Actos Now for the prevention of diabetes (ACT NOW) study
    Ralph A DeFronzo
    Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX, USA
    BMC Endocr Disord 9:17. 2009
  2. ncbi Intensive glucose-lowering therapy reduces cardiovascular disease events in veterans affairs diabetes trial participants with lower calcified coronary atherosclerosis
    Peter D Reaven
    Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
    Diabetes 58:2642-8. 2009
  3. ncbi Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the Veterans Affairs Diabetes Trial (VADT)
    Peter D Reaven
    Carl T Hayden VA Medical Center, Phoenix, Arizona 85012 1892, USA
    Diabetes Care 31:952-7. 2008
  4. ncbi Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    Eric A Schwartz
    Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road 111E, Phoenix, AZ 85012 1892, USA
    Atherosclerosis 212:217-22. 2010
  5. ncbi The duration of diabetes affects the response to intensive glucose control in type 2 subjects: the VA Diabetes Trial
    William C Duckworth
    Phoenix VA Health Care Center, Phoenix, AZ 85012, USA
    J Diabetes Complications 25:355-61. 2011
  6. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
  7. ncbi Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation
    Eric A Schwartz
    Phoenix VA Health Care System, 650 E Indian School Rd, Phoenix, AZ 85012 1892, USA
    Arterioscler Thromb Vasc Biol 30:802-8. 2010
  8. ncbi Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes
    Juraj Koska
    Department of Endocrinology, Phoenix VA Health Care System, Phoenix, Arizona, USA
    Diabetes Care 33:1028-30. 2010
  9. ncbi Pioglitazone inhibits the expression of inflammatory cytokines from both monocytes and lymphocytes in patients with impaired glucose tolerance
    Wei Yang Zhang
    Department of Medicine, Section of Endocrinology, Phoenix Veteran s Affairs Health Care System, 650 E Indian School Road, Phoenix, AZ 85012 1892, USA
    Arterioscler Thromb Vasc Biol 28:2312-8. 2008
  10. ncbi Fetuin-A does not explain ethnic disparity in cardiometabolic risk factors and subclinical atherosclerosis between Hispanics and non-Hispanic whites
    Iyad Syoufi
    Department of Endocrinology, Phoenix VA Health Care System, Phoenix, Arizona 85012 1892, USA
    Metab Syndr Relat Disord 9:77-9. 2011

Detail Information

Publications40

  1. ncbi Actos Now for the prevention of diabetes (ACT NOW) study
    Ralph A DeFronzo
    Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX, USA
    BMC Endocr Disord 9:17. 2009
    ..TRIAL REGISTRATION: clinical trials.gov identifier: NCT00220961...
  2. ncbi Intensive glucose-lowering therapy reduces cardiovascular disease events in veterans affairs diabetes trial participants with lower calcified coronary atherosclerosis
    Peter D Reaven
    Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
    Diabetes 58:2642-8. 2009
    ..This study investigated the hypothesis that baseline calcified coronary atherosclerosis may determine cardiovascular disease events in response to intensive glycemic control within the Veterans Affairs Diabetes Trial (VADT)...
  3. ncbi Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the Veterans Affairs Diabetes Trial (VADT)
    Peter D Reaven
    Carl T Hayden VA Medical Center, Phoenix, Arizona 85012 1892, USA
    Diabetes Care 31:952-7. 2008
    ..We determined the relationship between retinopathy and coronary atherosclerosis as measured by computed tomography-detectable coronary artery calcium (CAC)...
  4. ncbi Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    Eric A Schwartz
    Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road 111E, Phoenix, AZ 85012 1892, USA
    Atherosclerosis 212:217-22. 2010
    ..Therefore, the effect of a single injection of exenatide on postprandial lipids, remnant lipoproteins, and apolipoproteins was studied...
  5. ncbi The duration of diabetes affects the response to intensive glucose control in type 2 subjects: the VA Diabetes Trial
    William C Duckworth
    Phoenix VA Health Care Center, Phoenix, AZ 85012, USA
    J Diabetes Complications 25:355-61. 2011
    ..No significant benefit was found. This report examines predictors of the effect of intensive therapy on the primary outcome in this population...
  6. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
    ..The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain...
  7. ncbi Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation
    Eric A Schwartz
    Phoenix VA Health Care System, 650 E Indian School Rd, Phoenix, AZ 85012 1892, USA
    Arterioscler Thromb Vasc Biol 30:802-8. 2010
    ..The present study tests the novel hypothesis that metabolism of SFA cooperatively amplifies Toll-like receptor-4-mediated inflammation...
  8. ncbi Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes
    Juraj Koska
    Department of Endocrinology, Phoenix VA Health Care System, Phoenix, Arizona, USA
    Diabetes Care 33:1028-30. 2010
    ..Because exenatide reduces postprandial glucose and lipid excursions, we hypothesized that it may also improve postprandial endothelial function...
  9. ncbi Pioglitazone inhibits the expression of inflammatory cytokines from both monocytes and lymphocytes in patients with impaired glucose tolerance
    Wei Yang Zhang
    Department of Medicine, Section of Endocrinology, Phoenix Veteran s Affairs Health Care System, 650 E Indian School Road, Phoenix, AZ 85012 1892, USA
    Arterioscler Thromb Vasc Biol 28:2312-8. 2008
    ..The current study determines whether pioglitazone (PIO) therapy reduces both monocyte and lymphocyte inflammatory activity and their ability to induce inflammation in other tissues...
  10. ncbi Fetuin-A does not explain ethnic disparity in cardiometabolic risk factors and subclinical atherosclerosis between Hispanics and non-Hispanic whites
    Iyad Syoufi
    Department of Endocrinology, Phoenix VA Health Care System, Phoenix, Arizona 85012 1892, USA
    Metab Syndr Relat Disord 9:77-9. 2011
    ..The present study evaluated whether serum fetuin-A explains the ethnic disparity in the subclinical atherosclerosis and risk for diabetes between healthy Hispanic and non-Hispanic white (NHW) subjects...
  11. ncbi Pioglitazone reduces inflammatory responses of human adipocytes to factors secreted by monocytes/macrophages
    Paska A Permana
    Phoenix Veterans Affairs Health Care System, Phoenix, AZ 85012 1892, USA
    Am J Physiol Endocrinol Metab 296:E1076-84. 2009
    ..These beneficial effects of Pio may attenuate proinflammatory responses resulting from monocyte/macrophage infiltration into adipose tissue and suppress tissue inflammation resulting from the interaction between both cell types...
  12. ncbi Pioglitazone slows progression of atherosclerosis in prediabetes independent of changes in cardiovascular risk factors
    Aramesh Saremi
    Phoenix Veterans Affair VA Health Care System, Phoenix, AZ, USA
    Arterioscler Thromb Vasc Biol 33:393-9. 2013
    ....
  13. ncbi Rates and determinants of coronary and abdominal aortic artery calcium progression in the Veterans Affairs Diabetes Trial (VADT)
    Aramesh Saremi
    Phoenix VA Health Care System, Phoenix, Arizona, USA
    Diabetes Care 33:2642-7. 2010
    ..To determine the predictors of progression of calcified atherosclerosis and the effect of intensive glycemic control on this process in patients with type 2 diabetes...
  14. ncbi Lipolysis of triglyceride-rich lipoproteins, vascular inflammation, and atherosclerosis
    Eric A Schwartz
    Division of Research, Phoenix VA Health Care System, 650 E Indian School Rd, Phoenix, AZ 85012, USA
    Biochim Biophys Acta 1821:858-66. 2012
    ..This article is part of a Special Issue entitled Triglyceride Metabolism and Disease...
  15. ncbi Preliminary report: hepatic fat and inflammation in type 2 diabetes mellitus
    Aramesh Saremi
    Phoenix VA Health Care System, Phoenix, AZ 85012 1892, USA
    Metabolism 59:430-2. 2010
    ..These data support the concept that accumulation of hepatic fat is related to enhanced inflammation in type 2 diabetes mellitus independent of general measures of obesity and standard cardiovascular risk factors...
  16. ncbi Reduced coronary artery and abdominal aortic calcification in Hispanics with type 2 diabetes
    Peter D Reaven
    Division of Endocrinology and Metabolism, Carl T Hayden Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA
    Diabetes Care 27:1115-20. 2004
    ..To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic white (NHW) individuals with type 2 diabetes...
  17. ncbi Does aggressive glycemic control benefit macrovascular and microvascular disease in type 2 diabetes? Insights from ACCORD, ADVANCE, and VADT
    Toni Terry
    Division of Endocrinology, Phoenix VA Health Care System, 650 East Indian School Road, Phoenix, AZ 85012, USA
    Curr Cardiol Rep 14:79-88. 2012
    ..Glycated hemoglobin goals should account for these factors and be individualized for each patient...
  18. ncbi Intensive glycemic control and cardiovascular disease: are there patients who may benefit?
    Nalurporn Chokrungvaranon
    Phoenix VA Health Care System, Phoenix, AZ 85012, USA
    Postgrad Med 123:114-23. 2011
    ....
  19. ncbi Molecular and signaling mechanisms of atherosclerosis in insulin resistance
    Eric A Schwartz
    Division of Research, Carl T. Hayden VA Medical Center, 650 East Indian School Road, Phoenix, AZ 85012, USA
    Endocrinol Metab Clin North Am 35:525-49, viii. 2006
    ..We review several key cell-signalling pathways, describe how they are activated in they insulin-resistant state and the damage they induce, and discusses possible therapeutic approaches to limit vascular damage...
  20. ncbi Postprandial hyperlipidemia, endothelial dysfunction and cardiovascular risk: focus on incretins
    Sameer Ansar
    Department of Endocrinology, Phoenix Veteran Affairs Healthcare System, 650 E Indian School Rd, CS111E, Phoenix, AZ 85012, USA
    Cardiovasc Diabetol 10:61. 2011
    ....
  21. ncbi Comparison of frequency of coronary artery calcium in healthy Hispanic versus non-Hispanic white men by electron beam computed tomography
    Peter D Reaven
    Division of Endocrinology and Metabolism, Department of Medicine, Carl T Hayden Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA
    Am J Cardiol 92:1198-200. 2003
    ..These results demonstrate that healthy Hispanic men have reduced CAC compared with age-matched NHW men and this occurs despite evidence for a worse cardiovascular risk profile...
  22. ncbi Cardiovascular risk factors associated with insulin resistance in children persist into late adolescence
    Peter D Reaven
    Division of Endocrinology and Metabolism, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona, USA
    Diabetes Care 28:148-50. 2005
  23. ncbi Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation
    Phyllis S Laine
    Department of Medicine, Division of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Biochem Biophys Res Commun 358:150-5. 2007
    ..These events in turn may lead to an increasing feed-forward loop of chronic inflammation...
  24. ncbi Improvements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexes
    Fahim Abbasi
    Division of Endocrinology and Metabolism, Deptartment of Medicine, Carl T. Hayden Veterans Affairs Medical Center, 650 East Indian School Road, Phoenix, AZ 85012, USA
    Am J Physiol Regul Integr Comp Physiol 290:R139-44. 2006
    ....
  25. ncbi Progression of vascular calcification is increased with statin use in the Veterans Affairs Diabetes Trial (VADT)
    Aramesh Saremi
    Phoenix VA Health Care System, Phoenix, AZ, USA
    Diabetes Care 35:2390-2. 2012
    ..To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM)...
  26. ncbi Heart protection study: LDL lowering therapy and cardiovascular outcomes in patients with low cholesterol levels or diabetes
    Mrinalini Kulkarni
    Department of Medicine (CS/111E, Carl T. Hayden VAMC, 650 E. Indian School Road, Phoenix, AZ 85012-1892, USA
    Curr Diab Rep 2:269-73. 2002
  27. ncbi Macrophage-secreted factors induce adipocyte inflammation and insulin resistance
    Paska A Permana
    Research Service, Carl T Hayden Veterans Affairs Medical Center, Phoenix, AZ 85012 1892, USA
    Biochem Biophys Res Commun 341:507-14. 2006
    ..These effects of macrophage-secreted factors on adipocytes may contribute significantly to the systemic inflammation and insulin resistance associated with obesity...
  28. ncbi Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol
    John M Hayden
    Division of Endocrinology and Metabolism, Department of Medicine (CS/111E, Carl T. Hayden Veterans Affairs Medical Center, 650 E. Indian School Road, Phoenix, AZ 85012-1892, USA
    J Lipid Res 43:26-35. 2002
    ..These studies also suggest that 7-KC induces monocyte differentiation through a sterol-mediated regulatory pathway that remains to be characterized...
  29. ncbi Quantification of 8-iso-prostaglandin-F(2alpha) and 2,3-dinor-8-iso-prostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry
    Yuanling Liang
    Kronos Science Laboratory, Phoenix, AZ, USA
    Free Radic Biol Med 34:409-18. 2003
    ..003 for 2,3-dinor-8-iso-PGF(2alpha), respectively). The excellent accuracy, reproducibility, and high throughput of this method should permit it to be used in large clinical studies and standard clinical laboratories...
  30. ncbi Peroxisome proliferator-activated receptor-alpha and atherosclerosis: from basic mechanisms to clinical implications
    Zarmen Israelian-Konaraki
    Department of Endocrinology and Metabolism, Carl T. Hayden VA Medical Center, Phoenix, Arizona, USA
    Cardiol Rev 13:240-6. 2005
    ....
  31. ncbi Peroxisome proliferator-activated receptor-alpha and atherosclerosis: from basic mechanisms to clinical implications
    Zarmen Israelian-Konaraki
    Department of Endocrinology and Metabolism, Carl T. Hayden VA Medical Center, Phoenix, Ariz. 85012, USA
    Cardiology 103:1-9. 2005
    ....
  32. ncbi Urinary excretion of three nucleic acid oxidation adducts and isoprostane F(2)alpha measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    Free Radic Biol Med 35:1301-9. 2003
    ..Whether characteristic patterns of excretion of these indicators forecast differential disease risk should be explored in future research...
  33. ncbi Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes
    Neelima V Chu
    Department of Endocrinology and Metabolism, VA San Diego Healthcare System/University of California, San Diego, California 92161, USA
    Diabetes Care 25:542-9. 2002
    ..These data suggest that medications that more effectively address this underlying metabolic defect may be more beneficial in reducing cardiovascular risk in type 2 diabetes...
  34. ncbi Discrimination between obesity and insulin resistance in the relationship with adiponectin
    Fahim Abbasi
    Divisions of Cardiovascular Medicine and Endocrinology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Diabetes 53:585-90. 2004
    ..These results suggest that adiponectin concentrations are more closely related to differences in insulin-mediated glucose disposal than obesity...
  35. ncbi Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women
    Fahim Abbasi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Metabolism 53:280-3. 2004
    ..Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations...
  36. ncbi Exercise training is not associated with improved levels of C-reactive protein or adiponectin
    Taylor J Marcell
    School of Human Performance and Recreation, University of Southern Mississippi, Hattiesburg 39406 001, USA
    Metabolism 54:533-41. 2005
    ..Moreover, improvements in insulin sensitivity resulting from exercise or modest weight loss did not appear to be related to changes in these markers...
  37. ncbi The relationship between plasma adiponectin concentration and insulin resistance is altered in smokers
    Fahim Abbasi
    Department of Medicien, Stanford University School of Medicine, CA 94305, USA
    J Clin Endocrinol Metab 91:5002-7. 2006
    ..These findings suggest that low levels of adiponectin in smokers may be independent of both insulin resistance and a generalized inflammatory response...
  38. ncbi Managing lipid disorders: further evaluation of the VA-HIT
    Zoltan Vajo
    Curr Diab Rep 3:245-7. 2003
  39. ncbi Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study
    Peter W F Wilson
    Medical University of South Carolina, 96 Jonathan Lucas St, Suite 815, P O Box 250609, Charleston, SC 29425, USA
    Atherosclerosis 189:364-8. 2006
    ..The relation between measures of oxidation of lipid particles and cardiovascular disease has not been extensively investigated prospectively on a population basis...
  40. ncbi Ethnic differences in the relationship between adiponectin and insulin sensitivity in South Asian and Caucasian women
    Marlene Martin
    Stanford University School of Medicine, Stanford, California, USA
    Diabetes Care 31:798-801. 2008
    ..To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance...