Murray Raskind

Summary

Country: USA

Publications

  1. doi request reprint Diagnosis and treatment of depression comorbid with neurologic disorders
    Murray A Raskind
    Mental Health Service, VA Puget Sound Health Care System Mental Illness Research, University of Washington, Seattle, Washington 98108, USA
    Am J Med 121:S28-37. 2008
  2. ncbi request reprint The challenge of a PTSD brain bank
    Murray A Raskind
    Department of Psychiatry and Behavioral Sciences, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Psychiatry 67:404-6. 2004
  3. ncbi request reprint The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial
    Murray A Raskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA
    Arch Neurol 61:252-6. 2004
  4. ncbi request reprint Update on Alzheimer drugs (galantamine)
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Alzheimer Disease Research Center, University of Washington, Seattle, WA 98108, USA
    Neurologist 9:235-40. 2003
  5. ncbi request reprint Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
    Am J Psychiatry 160:371-3. 2003
  6. ncbi request reprint Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder
    Murray A Raskind
    Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    J Clin Psychiatry 63:565-8. 2002
  7. ncbi request reprint A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Murray A Raskind
    Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 61:928-34. 2007
  8. doi request reprint Preliminary findings concerning the use of prazosin for the treatment of posttraumatic nightmares in a refugee population
    Lorin Boynton
    University of Washington, Seattle, USA
    J Psychiatr Pract 15:454-9. 2009
  9. doi request reprint Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin
    Charles E Thompson
    VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
    J Trauma Stress 21:417-20. 2008
  10. ncbi request reprint Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 16:165-71. 2003

Research Grants

Detail Information

Publications36

  1. doi request reprint Diagnosis and treatment of depression comorbid with neurologic disorders
    Murray A Raskind
    Mental Health Service, VA Puget Sound Health Care System Mental Illness Research, University of Washington, Seattle, Washington 98108, USA
    Am J Med 121:S28-37. 2008
    ..Investigating the neuroanatomical and neurochemical correlates of depression comorbid with neurologic conditions also may clarify depression etiology and treatment in the general population...
  2. ncbi request reprint The challenge of a PTSD brain bank
    Murray A Raskind
    Department of Psychiatry and Behavioral Sciences, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Psychiatry 67:404-6. 2004
  3. ncbi request reprint The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial
    Murray A Raskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA
    Arch Neurol 61:252-6. 2004
    ..Alzheimer disease (AD) causes progressive cognitive and functional decline over years. Although cholinesterase inhibitors have demonstrated efficacy in studies lasting 3 to 6 months, little is known about long-term therapy...
  4. ncbi request reprint Update on Alzheimer drugs (galantamine)
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Alzheimer Disease Research Center, University of Washington, Seattle, WA 98108, USA
    Neurologist 9:235-40. 2003
    ..Deficient cholinergic function contributes to the cognitive and behavioral signs and symptoms of Alzheimer disease (AD). A successful treatment approach in AD has been the enhancement of cholinergic function by cholinesterase inhibitors...
  5. ncbi request reprint Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
    Am J Psychiatry 160:371-3. 2003
    ..Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans...
  6. ncbi request reprint Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder
    Murray A Raskind
    Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    J Clin Psychiatry 63:565-8. 2002
    ..Preclinical and clinical observations suggest that the centrally active alpha1-adrenergic antagonist prazosin might alleviate trauma content nightmares and other symptoms in combat veterans with chronic posttraumatic stress disorder (PTSD)...
  7. ncbi request reprint A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Murray A Raskind
    Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 61:928-34. 2007
    ..The current parallel group trial in a larger sample of veterans evaluated prazosin effects on trauma nightmares, sleep quality, global clinical status, dream characteristics, and comorbid depression...
  8. doi request reprint Preliminary findings concerning the use of prazosin for the treatment of posttraumatic nightmares in a refugee population
    Lorin Boynton
    University of Washington, Seattle, USA
    J Psychiatr Pract 15:454-9. 2009
    ....
  9. doi request reprint Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin
    Charles E Thompson
    VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
    J Trauma Stress 21:417-20. 2008
    ..6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma-related nightmares and NNDA in PTSD...
  10. ncbi request reprint Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 16:165-71. 2003
    ..Prazosin was well tolerated. These open-label results are consistent with demonstrated therapeutic efficacy of prazosin for PTSD nightmares and sleep disturbance in a recent placebo-controlled trial in Vietnam veterans...
  11. pmc Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    Lucy Y Wang
    VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
    Am J Geriatr Psychiatry 17:744-51. 2009
    ..This pilot study examined the efficacy and tolerability of prazosin for behavioral symptoms in patients with agitation/aggression in AD...
  12. pmc Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
    ..We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline...
  13. pmc Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings
    Eric C Petrie
    Mail Code S 182 GRECC, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 66:632-7. 2009
    ....
  14. ncbi request reprint Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report
    Richard A Rosin
    Department of Veterans Affairs, Puget Sound Health Care System Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98108, USA
    Int Psychogeriatr 17:313-8. 2005
    ..Here we describe the apparently sustained elimination of previously treatment-resistant agitation and aggression with goserelin treatment in a 78-year-old male nursing-home resident with Alzheimer's disease...
  15. pmc Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study
    Fletcher B Taylor
    Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Biol Psychiatry 63:629-32. 2008
    ..We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD...
  16. doi request reprint Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq
    Jess Calohan
    Madigan Army Medical Center and VA Northwest Network Mental Illness, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    J Trauma Stress 23:645-8. 2010
    ..0 (SD = 0.7) to 2.9 (SD = 3.0, p < .001) and those of disturbed sleep from 6.7 (SD = 0.9) to 3.7 (SD = 2.4, p < .001). Prazosin appears effective and well tolerated in the desert warfare environment...
  17. doi request reprint A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence
    Tracy L Simpson
    Center of Excellence in Substance Abuse Treatment and Education, University of Washington, Seattle, WA 98108, USA
    Alcohol Clin Exp Res 33:255-63. 2009
    ..Theory and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. We therefore tested the alpha-1 adrenergic receptor antagonist, prazosin, as a pharmacotherapy for AD...
  18. ncbi request reprint Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, WA, USA
    Alzheimer Dis Assoc Disord 19:23-8. 2005
    ..We evaluated the efficacy of the beta-adrenergic antagonist propranolol for treatment-resistant disruptive behaviors and overall behavioral status in nursing home residents with probable or possible AD...
  19. ncbi request reprint 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle Tacoma, WA, USA
    Am J Geriatr Psychiatry 11:239-44. 2003
    ..The authors evaluated the effects of estrogen administration on plasma concentration of one by-product of APP processing, Abeta40, for postmenopausal women with AD...
  20. ncbi request reprint Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Arch Neurol 63:936-9. 2006
    ..Normal aging and the presence of the apolipoprotein E (APOE*4) allele are the most important known risk factors for Alzheimer disease...
  21. ncbi request reprint Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neurosci 26:467-78. 2006
    ....
  22. pmc Truncation of tau at E391 promotes early pathologic changes in transgenic mice
    Pamela J McMillan
    Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neuropathol Exp Neurol 70:1006-19. 2011
    ..In addition, these mice exhibit atypical neuritic tau immunoreactivity, including abnormal neuritic processes and dystrophic neurites. These results suggest that changes in tau proteolysis can initiate tauopathy...
  23. pmc The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats
    Dennis D Rasmussen
    VISN 20 Mental Illness Research Education and Clinical Center, Mental Health Service, Department of Veterans Affairs Medical Center and University of Washington, Seattle, Washington, USA
    Alcohol Clin Exp Res 33:264-72. 2009
    ..Accordingly, we tested the hypothesis that blockade of alpha(1)-adrenergic receptors will suppress alcohol drinking in rats selectively bred for alcohol preference (P line)...
  24. ncbi request reprint Safety and acceptability of the research lumbar puncture
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center MIRECC, University of Washington School of Medicine, Seattle, WA 98108, USA
    Alzheimer Dis Assoc Disord 19:220-5. 2005
    ....
  25. ncbi request reprint Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study
    James B Leverenz
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1099-106. 2002
    ..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community...
  26. ncbi request reprint Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats
    Murray A Raskind
    VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
    Neuropsychopharmacology 32:284-8. 2007
    ....
  27. ncbi request reprint Increased galanin receptor occupancy in Alzheimer's disease
    Pamela J McMillan
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurobiol Aging 25:1309-14. 2004
    ..The regional differences in GALR density and receptor occupancy between normal and AD subjects may play a role in the cognitive disturbances associated with the disease...
  28. pmc Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
    James B Leverenz
    Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
    Arch Neurol 63:370-6. 2006
    ..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood...
  29. ncbi request reprint Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus
    Pamela J McMillan
    Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington, USA
    J Neurochem 91:843-51. 2004
    ....
  30. ncbi request reprint Salivary cortisol and memory function in human aging
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neurobiol Aging 27:1705-14. 2006
    ..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition...
  31. ncbi request reprint Beneficial effects of prazosin for visual hallucinations associated with chronic cocaine abuse
    Andre M Tapp
    J Clin Psychiatry 67:1819-20. 2006
  32. ncbi request reprint Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder
    Fletcher B Taylor
    Rainier Associates, Tacoma, Washington 98467, USA
    Biol Psychiatry 59:577-81. 2006
    ..This study addressed whether daytime prazosin compared to placebo would alleviate psychological distress provoked experimentally by a trauma-related word list included in the emotional Stroop (E-Stroop) paradigm...
  33. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  34. ncbi request reprint The alpha1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorder
    Fletcher Taylor
    Rainier Associates, Tacoma, WA 98467, USA
    J Clin Psychopharmacol 22:82-5. 2002
    ..The drug was reasonably tolerated, and there were no drug discontinuations. These preliminary findings provide a rationale for blind placebo-controlled efficacy trials of the alpha 1 antagonist prazosin for PTSD...
  35. ncbi request reprint Antipsychotic polypharmacy: do benefits justify the risks?
    Andre M Tapp
    Ann Pharmacother 39:1759-60. 2005
  36. pmc alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol 42:91-7. 2008
    ..None of the doses tested reliably affected concurrent water self-administration. These results suggest the involvement of the noradrenergic system in the excessive alcohol drinking seen during acute withdrawal in ethanol-dependent rats...

Research Grants20

  1. Psychopathology of Alzheimer's: APOE and the HPA Axis
    Murray Raskind; Fiscal Year: 2005
    ..Specific Aim 3. To determine the effect of CSF cortisol concentrations on cognitive decline and on incidence of mild cognitive impairment and probable AD among nondemented older persons with the APOE-E4 allele followed longitudinally. ..
  2. Prazosin for Noncombat Trauma PTSD
    Murray Raskind; Fiscal Year: 2007
    ..Number of study days completed and adverse events also will be compared between groups. ..
  3. PSYCHOPATHOLOGY OF ALZHEIMER'S--PSYCHONEUROENDOCRINOLOGY
    Murray Raskind; Fiscal Year: 1993
    ..These studies will provide data relevant to the psychoneuroendocrine physiology of Alzheimer's disease and human aging and potentially suggest directions for therapeutic interventions...
  4. PSYCHOPATHOLOGY OF ALZHEIMER'S--PSYCHONEUROENDOCRINOLOGY
    Murray Raskind; Fiscal Year: 1999
    ....
  5. PSYCHOPATHOLOGY OF ALZHEIMER'S-PSYCHONEUROENDOCRINOLOGY
    Murray Raskind; Fiscal Year: 1991
    ..These studies should increase knowledge of AD pathophysiology and suggest clinically useful diagnostic and therapeutic approaches to this disorder...