Research Topics
Species | Murray RaskindSummaryCountry: USA Publications
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Publications
Diagnosis and treatment of depression comorbid with neurologic disordersMurray A Raskind
Mental Health Service, VA Puget Sound Health Care System Mental Illness Research, University of Washington, Seattle, Washington 98108, USA
Am J Med 121:S28-37. 2008..Investigating the neuroanatomical and neurochemical correlates of depression comorbid with neurologic conditions also may clarify depression etiology and treatment in the general population...
The challenge of a PTSD brain bankMurray A Raskind
Department of Psychiatry and Behavioral Sciences, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Psychiatry 67:404-6. 2004- The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trialMurray A Raskind
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA
Arch Neurol 61:252-6. 2004..Alzheimer disease (AD) causes progressive cognitive and functional decline over years. Although cholinesterase inhibitors have demonstrated efficacy in studies lasting 3 to 6 months, little is known about long-term therapy... - Update on Alzheimer drugs (galantamine)Murray A Raskind
Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Alzheimer Disease Research Center, University of Washington, Seattle, WA 98108, USA
Neurologist 9:235-40. 2003..Deficient cholinergic function contributes to the cognitive and behavioral signs and symptoms of Alzheimer disease (AD). A successful treatment approach in AD has been the enhancement of cholinergic function by cholinesterase inhibitors... - Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled studyMurray A Raskind
Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
Am J Psychiatry 160:371-3. 2003..Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans... - Prazosin reduces nightmares in combat veterans with posttraumatic stress disorderMurray A Raskind
Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
J Clin Psychiatry 63:565-8. 2002..Preclinical and clinical observations suggest that the centrally active alpha1-adrenergic antagonist prazosin might alleviate trauma content nightmares and other symptoms in combat veterans with chronic posttraumatic stress disorder (PTSD)... - A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorderMurray A Raskind
Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
Biol Psychiatry 61:928-34. 2007..The current parallel group trial in a larger sample of veterans evaluated prazosin effects on trauma nightmares, sleep quality, global clinical status, dream characteristics, and comorbid depression... - Preliminary findings concerning the use of prazosin for the treatment of posttraumatic nightmares in a refugee populationLorin Boynton
University of Washington, Seattle, USA
J Psychiatr Pract 15:454-9. 2009.... - Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosinCharles E Thompson
VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
J Trauma Stress 21:417-20. 2008..6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma-related nightmares and NNDA in PTSD... - Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorderElaine R Peskind
Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
J Geriatr Psychiatry Neurol 16:165-71. 2003..Prazosin was well tolerated. These open-label results are consistent with demonstrated therapeutic efficacy of prazosin for PTSD nightmares and sleep disturbance in a recent placebo-controlled trial in Vietnam veterans... 
Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggressionLucy Y Wang
VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
Am J Geriatr Psychiatry 17:744-51. 2009..This pilot study examined the efficacy and tolerability of prazosin for behavioral symptoms in patients with agitation/aggression in AD...- Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjectsGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 4:e5424. 2009..01). CONCLUSIONS/SIGNIFICANCE: Reduced CSF BDNF was associated with age-related cognitive decline, suggesting a potential mechanism that may contribute in part to cognitive decline in older individuals... - Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findingsEric C Petrie
Mail Code S 182 GRECC, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 66:632-7. 2009.... - Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case reportRichard A Rosin
Department of Veterans Affairs, Puget Sound Health Care System Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98108, USA
Int Psychogeriatr 17:313-8. 2005..Here we describe the apparently sustained elimination of previously treatment-resistant agitation and aggression with goserelin treatment in a 78-year-old male nursing-home resident with Alzheimer's disease... - Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled studyFletcher B Taylor
Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Biol Psychiatry 63:629-32. 2008..We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD... - Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in IraqJess Calohan
Madigan Army Medical Center and VA Northwest Network Mental Illness, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
J Trauma Stress 23:645-8. 2010..0 (SD = 0.7) to 2.9 (SD = 3.0, p < .001) and those of disturbed sleep from 6.7 (SD = 0.9) to 3.7 (SD = 2.4, p < .001). Prazosin appears effective and well tolerated in the desert warfare environment... - A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependenceTracy L Simpson
Center of Excellence in Substance Abuse Treatment and Education, University of Washington, Seattle, WA 98108, USA
Alcohol Clin Exp Res 33:255-63. 2009..Theory and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. We therefore tested the alpha-1 adrenergic receptor antagonist, prazosin, as a pharmacotherapy for AD... - Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled studyElaine R Peskind
Department of Veterans Affairs Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, WA, USA
Alzheimer Dis Assoc Disord 19:23-8. 2005..We evaluated the efficacy of the beta-adrenergic antagonist propranolol for treatment-resistant disruptive behaviors and overall behavioral status in nursing home residents with probable or possible AD... - 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary studyLaura D Baker
Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle/Tacoma, WA, USA
Am J Geriatr Psychiatry 11:239-44. 2003..This finding suggests that the hormone may serve as an Abeta-lowering agent for HRT-naïve AD women, which may, in turn, have ultimate ramifications for the progression of AD pathology... - Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognitionElaine R Peskind
VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
Arch Neurol 63:936-9. 2006..Normal aging and the presence of the apolipoprotein E (APOE*4) allele are the most important known risk factors for Alzheimer disease... - Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodiesPatricia Szot
Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
J Neurosci 26:467-78. 2006.... - Truncation of tau at E391 promotes early pathologic changes in transgenic micePamela J McMillan
Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Neuropathol Exp Neurol 70:1006-19. 2011..In addition, these mice exhibit atypical neuritic tau immunoreactivity, including abnormal neuritic processes and dystrophic neurites. These results suggest that changes in tau proteolysis can initiate tauopathy... - The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) ratsDennis D Rasmussen
VISN 20 Mental Illness Research Education and Clinical Center, Mental Health Service, Department of Veterans Affairs Medical Center and University of Washington, Seattle, Washington, USA
Alcohol Clin Exp Res 33:264-72. 2009..Accordingly, we tested the hypothesis that blockade of alpha(1)-adrenergic receptors will suppress alcohol drinking in rats selectively bred for alcohol preference (P line)... - Safety and acceptability of the research lumbar punctureElaine R Peskind
VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center MIRECC, University of Washington School of Medicine, Seattle, WA 98108, USA
Alzheimer Dis Assoc Disord 19:220-5. 2005.... - Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based studyJames B Leverenz
Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
Arch Neurol 59:1099-106. 2002..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community... - Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in ratsMurray A Raskind
VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
Neuropsychopharmacology 32:284-8. 2007.... - Increased galanin receptor occupancy in Alzheimer's diseasePamela J McMillan
Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Neurobiol Aging 25:1309-14. 2004..The regional differences in GALR density and receptor occupancy between normal and AD subjects may play a role in the cognitive disturbances associated with the disease... - Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotypeJames B Leverenz
Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
Arch Neurol 63:370-6. 2006..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood... - Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampusPamela J McMillan
Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington, USA
J Neurochem 91:843-51. 2004.... - Salivary cortisol and memory function in human agingGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Neurobiol Aging 27:1705-14. 2006..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition... - Beneficial effects of prazosin for visual hallucinations associated with chronic cocaine abuseAndre M Tapp
J Clin Psychiatry 67:1819-20. 2006 - Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorderFletcher B Taylor
Rainier Associates, Tacoma, Washington 98467, USA
Biol Psychiatry 59:577-81. 2006..This study addressed whether daytime prazosin compared to placebo would alleviate psychological distress provoked experimentally by a trauma-related word list included in the emotional Stroop (E-Stroop) paradigm... - High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trialPaul S Aisen
Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
JAMA 300:1774-83. 2008..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline... - The alpha1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorderFletcher Taylor
Rainier Associates, Tacoma, WA 98467, USA
J Clin Psychopharmacol 22:82-5. 2002..The drug was reasonably tolerated, and there were no drug discontinuations. These preliminary findings provide a rationale for blind placebo-controlled efficacy trials of the alpha 1 antagonist prazosin for PTSD... - Antipsychotic polypharmacy: do benefits justify the risks?Andre M Tapp
Ann Pharmacother 39:1759-60. 2005 - alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanolBrendan M Walker
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Alcohol 42:91-7. 2008..None of the doses tested reliably affected concurrent water self-administration. These results suggest the involvement of the noradrenergic system in the excessive alcohol drinking seen during acute withdrawal in ethanol-dependent rats...
Research Grants
- Psychopathology of Alzheimer's: APOE and the HPA AxisMurray Raskind; Fiscal Year: 2005..Specific Aim 3. To determine the effect of CSF cortisol concentrations on cognitive decline and on incidence of mild cognitive impairment and probable AD among nondemented older persons with the APOE-E4 allele followed longitudinally. ..
- Prazosin for Noncombat Trauma PTSDMurray Raskind; Fiscal Year: 2007..Number of study days completed and adverse events also will be compared between groups. ..
- PSYCHOPATHOLOGY OF ALZHEIMER'S--PSYCHONEUROENDOCRINOLOGYMurray Raskind; Fiscal Year: 1993..These studies will provide data relevant to the psychoneuroendocrine physiology of Alzheimer's disease and human aging and potentially suggest directions for therapeutic interventions...
- PSYCHOPATHOLOGY OF ALZHEIMER'S--PSYCHONEUROENDOCRINOLOGYMurray Raskind; Fiscal Year: 1999....
- PSYCHOPATHOLOGY OF ALZHEIMER'S-PSYCHONEUROENDOCRINOLOGYMurray Raskind; Fiscal Year: 1991..These studies should increase knowledge of AD pathophysiology and suggest clinically useful diagnostic and therapeutic approaches to this disorder...