Murray A Raskind

Summary

Country: USA

Publications

  1. doi request reprint Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq
    Jess Calohan
    Madigan Army Medical Center and VA Northwest Network Mental Illness, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    J Trauma Stress 23:645-8. 2010
  2. pmc Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
  3. ncbi request reprint A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Murray A Raskind
    Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 61:928-34. 2007
  4. ncbi request reprint Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Arch Neurol 63:936-9. 2006
  5. pmc Cerebrospinal fluid norepinephrine and cognition in subjects across the adult age span
    Lucy Y Wang
    Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 34:2287-92. 2013
  6. pmc Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease
    Pamela J McMillan
    Northwest Network for Mental Illness, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    Brain Res 1373:240-52. 2011
  7. pmc Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    Lucy Y Wang
    VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
    Am J Geriatr Psychiatry 17:744-51. 2009
  8. ncbi request reprint Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neurosci 26:467-78. 2006
  9. pmc Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings
    Eric C Petrie
    Mail Code S 182 GRECC, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 66:632-7. 2009
  10. doi request reprint Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin
    Charles E Thompson
    VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
    J Trauma Stress 21:417-20. 2008

Detail Information

Publications32

  1. doi request reprint Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq
    Jess Calohan
    Madigan Army Medical Center and VA Northwest Network Mental Illness, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    J Trauma Stress 23:645-8. 2010
    ..0 (SD = 0.7) to 2.9 (SD = 3.0, p < .001) and those of disturbed sleep from 6.7 (SD = 0.9) to 3.7 (SD = 2.4, p < .001). Prazosin appears effective and well tolerated in the desert warfare environment...
  2. pmc Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
    ..We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline...
  3. ncbi request reprint A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Murray A Raskind
    Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 61:928-34. 2007
    ..The current parallel group trial in a larger sample of veterans evaluated prazosin effects on trauma nightmares, sleep quality, global clinical status, dream characteristics, and comorbid depression...
  4. ncbi request reprint Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Arch Neurol 63:936-9. 2006
    ..Normal aging and the presence of the apolipoprotein E (APOE*4) allele are the most important known risk factors for Alzheimer disease...
  5. pmc Cerebrospinal fluid norepinephrine and cognition in subjects across the adult age span
    Lucy Y Wang
    Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 34:2287-92. 2013
    ..0, SE 2.2, p = 0.024; Stroop Word-Color Interference task: regression coefficient 6.1, SE 2.0, p = 0.003). Findings are consistent with the earlier literature relating excess noradrenergic activity with cognitive impairment. ..
  6. pmc Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease
    Pamela J McMillan
    Northwest Network for Mental Illness, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    Brain Res 1373:240-52. 2011
    ..These data suggest that there is a differential response of the noradrenergic nervous system in PD compared to AD in response to the loss of LC neurons...
  7. pmc Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    Lucy Y Wang
    VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
    Am J Geriatr Psychiatry 17:744-51. 2009
    ..This pilot study examined the efficacy and tolerability of prazosin for behavioral symptoms in patients with agitation/aggression in AD...
  8. ncbi request reprint Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neurosci 26:467-78. 2006
    ....
  9. pmc Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings
    Eric C Petrie
    Mail Code S 182 GRECC, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 66:632-7. 2009
    ....
  10. doi request reprint Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin
    Charles E Thompson
    VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
    J Trauma Stress 21:417-20. 2008
    ..6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma-related nightmares and NNDA in PTSD...
  11. pmc Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study
    Fletcher B Taylor
    Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Biol Psychiatry 63:629-32. 2008
    ..We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD...
  12. pmc Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms
    Elaine R Peskind
    Northwest Network Mental Illness, Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Neuroimage 54:S76-82. 2011
    ..Given the potential public health implications of these findings, further investigation of brain function in these Veterans appears warranted...
  13. ncbi request reprint Salivary cortisol and memory function in human aging
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neurobiol Aging 27:1705-14. 2006
    ..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition...
  14. pmc Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
    James B Leverenz
    Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
    Arch Neurol 63:370-6. 2006
    ..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood...
  15. ncbi request reprint Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 16:165-71. 2003
    ..Prazosin was well tolerated. These open-label results are consistent with demonstrated therapeutic efficacy of prazosin for PTSD nightmares and sleep disturbance in a recent placebo-controlled trial in Vietnam veterans...
  16. ncbi request reprint Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report
    Richard A Rosin
    Department of Veterans Affairs, Puget Sound Health Care System Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98108, USA
    Int Psychogeriatr 17:313-8. 2005
    ..Here we describe the apparently sustained elimination of previously treatment-resistant agitation and aggression with goserelin treatment in a 78-year-old male nursing-home resident with Alzheimer's disease...
  17. pmc The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder
    Valerie G Olson
    Mental Illness Research, Education, and Clinical Center, Department of Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    Biol Psychiatry 70:441-8. 2011
    ..The neural circuits involved in susceptibility or resiliency to PTSD remain unclear, but clinical evidence implicates changes in the noradrenergic system...
  18. ncbi request reprint Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, WA, USA
    Alzheimer Dis Assoc Disord 19:23-8. 2005
    ..We evaluated the efficacy of the beta-adrenergic antagonist propranolol for treatment-resistant disruptive behaviors and overall behavioral status in nursing home residents with probable or possible AD...
  19. ncbi request reprint Update on Alzheimer drugs (galantamine)
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Alzheimer Disease Research Center, University of Washington, Seattle, WA 98108, USA
    Neurologist 9:235-40. 2003
    ..Deficient cholinergic function contributes to the cognitive and behavioral signs and symptoms of Alzheimer disease (AD). A successful treatment approach in AD has been the enhancement of cholinergic function by cholinesterase inhibitors...
  20. ncbi request reprint Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder
    Murray A Raskind
    Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    J Clin Psychiatry 63:565-8. 2002
    ..Preclinical and clinical observations suggest that the centrally active alpha1-adrenergic antagonist prazosin might alleviate trauma content nightmares and other symptoms in combat veterans with chronic posttraumatic stress disorder (PTSD)...
  21. pmc Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during "abstinence"
    Dennis D Rasmussen
    VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center, University of Washington, Seattle, WA 98108, USA
    Alcohol 38:173-7. 2006
    ..These results suggest that daily ethanol consumption can induce persistent increases in sympathoadrenal activation during subsequent "abstinence," which are relatively refractory to further stimulation...
  22. ncbi request reprint Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus
    Pamela J McMillan
    Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington, USA
    J Neurochem 91:843-51. 2004
    ....
  23. ncbi request reprint Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression
    Patricia Szot
    Northwest Network Mental Illness Research, Education and Clinical Center S 116, VA Puget Sound Health Care System, S 116 MIRECC, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 139:367-71. 2005
    ..These results confirm a difference in hippocampal alpha1-AR localization between rat and humans and further describe a difference in the localization of the alpha1A- and alpha1D-AR mRNA subtype between rats and humans...
  24. pmc The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats
    Dennis D Rasmussen
    VISN 20 Mental Illness Research Education and Clinical Center, Mental Health Service, Department of Veterans Affairs Medical Center and University of Washington, Seattle, Washington, USA
    Alcohol Clin Exp Res 33:264-72. 2009
    ..Accordingly, we tested the hypothesis that blockade of alpha(1)-adrenergic receptors will suppress alcohol drinking in rats selectively bred for alcohol preference (P line)...
  25. ncbi request reprint Safety and acceptability of the research lumbar puncture
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center MIRECC, University of Washington School of Medicine, Seattle, WA 98108, USA
    Alzheimer Dis Assoc Disord 19:220-5. 2005
    ....
  26. ncbi request reprint Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats
    Murray A Raskind
    VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
    Neuropsychopharmacology 32:284-8. 2007
    ....
  27. ncbi request reprint The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial
    Murray A Raskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA
    Arch Neurol 61:252-6. 2004
    ..Alzheimer disease (AD) causes progressive cognitive and functional decline over years. Although cholinesterase inhibitors have demonstrated efficacy in studies lasting 3 to 6 months, little is known about long-term therapy...
  28. ncbi request reprint Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
    Am J Psychiatry 160:371-3. 2003
    ..Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans...
  29. doi request reprint Diagnosis and treatment of depression comorbid with neurologic disorders
    Murray A Raskind
    Mental Health Service, VA Puget Sound Health Care System Mental Illness Research, University of Washington, Seattle, Washington 98108, USA
    Am J Med 121:S28-37. 2008
    ..Investigating the neuroanatomical and neurochemical correlates of depression comorbid with neurologic conditions also may clarify depression etiology and treatment in the general population...
  30. ncbi request reprint The challenge of a PTSD brain bank
    Murray A Raskind
    Department of Psychiatry and Behavioral Sciences, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Psychiatry 67:404-6. 2004
  31. ncbi request reprint Increased galanin receptor occupancy in Alzheimer's disease
    Pamela J McMillan
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurobiol Aging 25:1309-14. 2004
    ..The regional differences in GALR density and receptor occupancy between normal and AD subjects may play a role in the cognitive disturbances associated with the disease...
  32. ncbi request reprint Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study
    James B Leverenz
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1099-106. 2002
    ..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community...