J D Raffetto
- Matrix metalloproteinases in venous tissue remodeling and varicose vein formationJoseph D Raffetto
Department of Surgery, VA Boston Healthcare System, West Roxbury, MA 02132, USA
Curr Vasc Pharmacol 6:158-72. 2008..Inhibition of MMPs may represent a novel therapeutic intervention to limit the progression of varicose veins to CVI and leg ulceration...
- bFGF-induced alterations in cellular markers of senescence in growth-rescued fibroblasts from chronic venous ulcer and venous reflux patientsCraig Seidman
Section of Vascular Surgery, Department of Surgery, Boston University Medical Center, Boston, MA 02118 2393, USA
Ann Vasc Surg 17:239-44. 2003..This represents the possibility that by stimulating growth, bFGF may drive cells toward senescence. This suggests clinical implication for the use of bFGF and other growth factors in general...
- Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formationJoseph D Raffetto
VA Boston Healthcare System, West Roxbury, MA, USA
J Vasc Surg 45:373-80. 2007..The purpose of this study was to determine whether MMP-induced inhibition of venous contraction involves an endothelium-dependent and/or -independent pathway...
- Benefit of anticoagulation for the treatment of lower extremity superficial venous thrombosisJoseph D Raffetto
Division of Vascular Surgery, VA Boston Healthcare System, Boston, Mass Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Mass Harvard Medical School, Boston, Mass Electronic address
J Vasc Surg Venous Lymphat Disord 3:236-41. 2015....
- Pathophysiology of wound healing and alterations in venous leg ulcers-reviewJoseph D Raffetto
Boston VA Health Care System, Vascular Surgery, Boston, MA, USA Brigham and Women s Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Phlebology 31:56-62. 2016..With further understanding of inflammatory pathways and potential mechanisms, certain biomarkers could be revealed and studied as both involvement in the pathophysiology of VLU but also as therapeutic targets for VLU healing. ..
- Pathophysiology of chronic venous diseaseJ D Raffetto
Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA, USA
Int Angiol 33:212-21. 2014..Work focusing on metabolic changes, miRNA regulation, inflammatory modulation and the glycocalyx will further our knowledge in the pathophysiology of CVD, and provide answers critical to treatment and prevention. ..
- Inflammation in chronic venous ulcersJ D Raffetto
VA Boston Healthcare System, 1400 VFW Parkway, Surgery 112, West Roxbury, MA 02135, USA
Phlebology 28:61-7. 2013....
- Venous ulcer: what is new?Joseph D Raffetto
Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
Plast Reconstr Surg 127:279S-288S. 2011....
- Dermal pathology, cellular biology, and inflammation in chronic venous diseaseJoseph D Raffetto
Vascular Surgery Division VA Boston Healthcare System, West Roxbury, MA, USA
Thromb Res 123:S66-71. 2009..Ultimately, the persistent inflammatory-proteinase activity leads to advanced chronic venous insufficiency (CVI) and ulcer formation...
- Mitogen-activated protein kinase p38 pathway in venous ulcer fibroblastsJoseph D Raffetto
Boston University School of Medicine, MA, USA
Vasc Endovascular Surg 42:367-74. 2008..Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb...
- Mechanisms of varicose vein formation: valve dysfunction and wall dilationJ D Raffetto
Division of Vascular Surgery, VA Boston Healthcare System, Surgery 112, 1400 VFW Parkway, West Roxbury, MA 02132, USA
Phlebology 23:85-98. 2008..Thus, vein wall dilation appears to precede valve dysfunction, and the MMP activation and superimposed inflammation and fibrosis would then lead to chronic and progressive venous insufficiency and varicose vein formation...
- Aortobifemoral graft infection with Mycobacterium tuberculosis: treatment with abscess drainage, debridement, and long-term administration of antibiotic agentsJoseph D Raffetto
Department of Surgery, Boston Univerity Medical Center, MA, USA
J Vasc Surg 40:826-9. 2004..A review of the literature contains only 1 other report of tuberculosis graft infection and treatment. We discuss a rare form of aortic graft infection from M tuberculosis and its treatment...
- Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblastsJoseph D Raffetto
Boston University School of Medicine, Boston VA Healthcare System, MA 02132, USA
Vasc Endovascular Surg 40:59-66. 2006..Venous ulcer wound fluid directly inhibits the MAPK ERK pathway, suggesting that the venous ulcer wound environment has negative trophic factors that effect fibroblasts proliferation and ulcer healing...
- Proliferative capacity of venous ulcer wound fibroblasts in the presence of platelet-derived growth factorRicardo Vasquez
Department of Surgery, Section of Vascular Surgery, Boston University Medical Center, Boston, MA 02118, USA
Vasc Endovascular Surg 38:355-60. 2004..In venous ulcers, decreased basal levels of fibroblast PDGF-alpha and -beta receptors may explain reduced proliferation. Further clinical studies are needed to elucidate the role growth factors may play in venous ulcers...
- Comparison of costs of staged versus simultaneous lower extremity arterial hybrid proceduresJames L Ebaugh
Boston VA Healthcare System, Surgical Service 112, 1400 VFW Pkwy, West Roxbury, MA 02132, USA
Am J Surg 196:634-40. 2008..Hybrid procedures combine endovascular and open surgical techniques. We examined utilization rates and ways of performing them more efficiently...
- Chronic venous insufficiencyRobert T Eberhardt
Cardiovascular Medicine, Boston Medical Center, Boston, Mass 02118, USA
Circulation 111:2398-409. 2005
- Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular diseaseJoseph D Raffetto
Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, United States
Biochem Pharmacol 75:346-59. 2008....
- Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veinsJoseph D Raffetto
VA Boston Healthcare System, West Roxbury, Mass, USA
J Vasc Surg 48:447-56. 2008..The purpose of this study was to test the hypothesis that prolonged increases in venous wall tension cause overexpression of MMPs and decreased contractility, which in turn promote venous dilation...
- Chronic traumatic pseudoaneurysm of polytetrafluoroethylene axillofemoral bypass graft in a quadriplegic patientRebecca M Grochow
Boston University School of Medicine, Boston, MA, USA
Ann Vasc Surg 22:688-91. 2008..To our knowledge this represents the first case of a chronic nonanastomotic pseudoaneurysm of a PTFE axillofemoral bypass graft secondary to abrasion and pressure that was repaired via an endovascular approach...
- Noninfectious saccular abdominal aortic aneurysm--a report of two casesMichael E Minor
Boston Medical Center, Boston, MA, USA
Vasc Endovascular Surg 37:353-8. 2003..The authors describe 2 cases of symptomatic, penetrating atherosclerotic ulcers of the abdominal aorta causing saccular, noninfectious abdominal aortic aneurysms...
- Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgeryAlex L Huang
Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 27:2113-9. 2007..The predictive value of reactive hyperemia for cardiovascular events in patients with atherosclerosis and the relative importance of reactive hyperemia compared with other measures of vascular function have not been previously studied...
- Acute thrombosis of abdominal aortic aneurysms--report of two cases and review of the literatureAhmed S Suliman
Boston University School of Medicine, The Department of Surgery, Boston Medical Center, Boston, MA, USA
Vasc Endovascular Surg 37:71-5. 2003..Although this complication is rare, its high mortality rate makes it an important disease to understand, recognize, diagnose, and treat for a successful outcome...
- Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veinsJoseph D Raffetto
Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Vasc Surg 51:972-81. 2010..We hypothesized that the sex differences in venous function reflect reduced constriction and enhanced venous dilation in women due to direct venous relaxation effects of estrogen on specific estrogen receptors (ER)...
- Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veinsJoseph D Raffetto
Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Vasc Surg 51:962-71. 2010....
- MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptidesJoseph D Raffetto
Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Surg Res 159:755-64. 2010..We tested whether MMP-2 induced venous relaxation involves inhibition of the Ca(2+) mobilization mechanisms of VSM contraction due to generation of Arg-Gly-Asp (RGD)-containing peptides...
- Factors that predict site of outflow target artery anastomosis in infrainguinal revascularizationJoseph D Raffetto
Department of Surgery, Section of Vascular Surgery D506, Boston University Medical Center, One Boston Medical Center Place, Boston, MA 02118 2393, USA
J Vasc Surg 35:1093-9. 2002..This study examines the risk factors and indication for infrainguinal revascularization with respect to the type of bypass performed...
- Venous ulcer fibroblasts respond to basic fibroblast growth factor at the cell cycle protein levelCraig Seidman
Eugene Surgical Associates Peacehealth, Eugene, OR, USA
Ann Vasc Surg 20:376-80. 2006..The role of bFGF may be useful in the clinical treatment of venous ulcer pathology...