J D Raffetto

Summary

Country: USA

Publications

  1. ncbi request reprint Matrix metalloproteinases in venous tissue remodeling and varicose vein formation
    Joseph D Raffetto
    Department of Surgery, VA Boston Healthcare System, West Roxbury, MA 02132, USA
    Curr Vasc Pharmacol 6:158-72. 2008
  2. ncbi request reprint bFGF-induced alterations in cellular markers of senescence in growth-rescued fibroblasts from chronic venous ulcer and venous reflux patients
    Craig Seidman
    Section of Vascular Surgery, Department of Surgery, Boston University Medical Center, Boston, MA 02118 2393, USA
    Ann Vasc Surg 17:239-44. 2003
  3. pmc Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation
    Joseph D Raffetto
    VA Boston Healthcare System, West Roxbury, MA, USA
    J Vasc Surg 45:373-80. 2007
  4. ncbi request reprint Pathophysiology of chronic venous disease
    J D Raffetto
    Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA, USA
    Int Angiol 33:212-21. 2014
  5. doi request reprint Inflammation in chronic venous ulcers
    J D Raffetto
    VA Boston Healthcare System, 1400 VFW Parkway, Surgery 112, West Roxbury, MA 02135, USA
    Phlebology 28:61-7. 2013
  6. doi request reprint Mitogen-activated protein kinase p38 pathway in venous ulcer fibroblasts
    Joseph D Raffetto
    Boston University School of Medicine, MA, USA
    Vasc Endovascular Surg 42:367-74. 2008
  7. doi request reprint Dermal pathology, cellular biology, and inflammation in chronic venous disease
    Joseph D Raffetto
    Vascular Surgery Division VA Boston Healthcare System, West Roxbury, MA, USA
    Thromb Res 123:S66-71. 2009
  8. ncbi request reprint Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts
    Joseph D Raffetto
    Boston University School of Medicine, Boston VA Healthcare System, MA 02132, USA
    Vasc Endovascular Surg 40:59-66. 2006
  9. ncbi request reprint Aortobifemoral graft infection with Mycobacterium tuberculosis: treatment with abscess drainage, debridement, and long-term administration of antibiotic agents
    Joseph D Raffetto
    Department of Surgery, Boston Univerity Medical Center, MA, USA
    J Vasc Surg 40:826-9. 2004
  10. doi request reprint Venous ulcer: what is new?
    Joseph D Raffetto
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Plast Reconstr Surg 127:279S-288S. 2011

Collaborators

  • Robert T Eberhardt
  • Joseph Vita
  • C D Owens
  • James L Ebaugh
  • William Marston
  • Gary W Gibbons
  • Michael Conte
  • James O Menzoian
  • Craig Seidman
  • Rebecca M Grochow
  • Alex L Huang
  • Ricardo Vasquez
  • Michael E Minor
  • Ahmed S Suliman
  • David W Schopfer
  • Alex Shpilman
  • Annemarie E Silver
  • Jonathan Woodson
  • John F Keaney
  • Mandeep Dhadly
  • Elena Shvenke
  • Michael T Watkins
  • Eiman Jahangir
  • Palma M Shaw
  • Noyan Gokce
  • Megan A Titas
  • Kristen C Overman
  • Christopher Gram
  • David G Goodwin
  • Brian J Marien
  • Craig S Seidman
  • Chris Kroon
  • Brian Marien
  • Ching Ching Seah

Detail Information

Publications25

  1. ncbi request reprint Matrix metalloproteinases in venous tissue remodeling and varicose vein formation
    Joseph D Raffetto
    Department of Surgery, VA Boston Healthcare System, West Roxbury, MA 02132, USA
    Curr Vasc Pharmacol 6:158-72. 2008
    ..Inhibition of MMPs may represent a novel therapeutic intervention to limit the progression of varicose veins to CVI and leg ulceration...
  2. ncbi request reprint bFGF-induced alterations in cellular markers of senescence in growth-rescued fibroblasts from chronic venous ulcer and venous reflux patients
    Craig Seidman
    Section of Vascular Surgery, Department of Surgery, Boston University Medical Center, Boston, MA 02118 2393, USA
    Ann Vasc Surg 17:239-44. 2003
    ..This represents the possibility that by stimulating growth, bFGF may drive cells toward senescence. This suggests clinical implication for the use of bFGF and other growth factors in general...
  3. pmc Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation
    Joseph D Raffetto
    VA Boston Healthcare System, West Roxbury, MA, USA
    J Vasc Surg 45:373-80. 2007
    ..The purpose of this study was to determine whether MMP-induced inhibition of venous contraction involves an endothelium-dependent and/or -independent pathway...
  4. ncbi request reprint Pathophysiology of chronic venous disease
    J D Raffetto
    Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA, USA
    Int Angiol 33:212-21. 2014
    ..Work focusing on metabolic changes, miRNA regulation, inflammatory modulation and the glycocalyx will further our knowledge in the pathophysiology of CVD, and provide answers critical to treatment and prevention. ..
  5. doi request reprint Inflammation in chronic venous ulcers
    J D Raffetto
    VA Boston Healthcare System, 1400 VFW Parkway, Surgery 112, West Roxbury, MA 02135, USA
    Phlebology 28:61-7. 2013
    ....
  6. doi request reprint Mitogen-activated protein kinase p38 pathway in venous ulcer fibroblasts
    Joseph D Raffetto
    Boston University School of Medicine, MA, USA
    Vasc Endovascular Surg 42:367-74. 2008
    ..Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb...
  7. doi request reprint Dermal pathology, cellular biology, and inflammation in chronic venous disease
    Joseph D Raffetto
    Vascular Surgery Division VA Boston Healthcare System, West Roxbury, MA, USA
    Thromb Res 123:S66-71. 2009
    ..Ultimately, the persistent inflammatory-proteinase activity leads to advanced chronic venous insufficiency (CVI) and ulcer formation...
  8. ncbi request reprint Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts
    Joseph D Raffetto
    Boston University School of Medicine, Boston VA Healthcare System, MA 02132, USA
    Vasc Endovascular Surg 40:59-66. 2006
    ..Venous ulcer wound fluid directly inhibits the MAPK ERK pathway, suggesting that the venous ulcer wound environment has negative trophic factors that effect fibroblasts proliferation and ulcer healing...
  9. ncbi request reprint Aortobifemoral graft infection with Mycobacterium tuberculosis: treatment with abscess drainage, debridement, and long-term administration of antibiotic agents
    Joseph D Raffetto
    Department of Surgery, Boston Univerity Medical Center, MA, USA
    J Vasc Surg 40:826-9. 2004
    ..A review of the literature contains only 1 other report of tuberculosis graft infection and treatment. We discuss a rare form of aortic graft infection from M tuberculosis and its treatment...
  10. doi request reprint Venous ulcer: what is new?
    Joseph D Raffetto
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Plast Reconstr Surg 127:279S-288S. 2011
    ....
  11. doi request reprint Mechanisms of varicose vein formation: valve dysfunction and wall dilation
    J D Raffetto
    Division of Vascular Surgery, VA Boston Healthcare System, Surgery 112, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Phlebology 23:85-98. 2008
    ..Thus, vein wall dilation appears to precede valve dysfunction, and the MMP activation and superimposed inflammation and fibrosis would then lead to chronic and progressive venous insufficiency and varicose vein formation...
  12. ncbi request reprint Proliferative capacity of venous ulcer wound fibroblasts in the presence of platelet-derived growth factor
    Ricardo Vasquez
    Department of Surgery, Section of Vascular Surgery, Boston University Medical Center, Boston, MA 02118, USA
    Vasc Endovascular Surg 38:355-60. 2004
    ..In venous ulcers, decreased basal levels of fibroblast PDGF-alpha and -beta receptors may explain reduced proliferation. Further clinical studies are needed to elucidate the role growth factors may play in venous ulcers...
  13. doi request reprint Comparison of costs of staged versus simultaneous lower extremity arterial hybrid procedures
    James L Ebaugh
    Boston VA Healthcare System, Surgical Service 112, 1400 VFW Pkwy, West Roxbury, MA 02132, USA
    Am J Surg 196:634-40. 2008
    ..Hybrid procedures combine endovascular and open surgical techniques. We examined utilization rates and ways of performing them more efficiently...
  14. ncbi request reprint Chronic venous insufficiency
    Robert T Eberhardt
    Cardiovascular Medicine, Boston Medical Center, Boston, Mass 02118, USA
    Circulation 111:2398-409. 2005
  15. pmc Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins
    Joseph D Raffetto
    VA Boston Healthcare System, West Roxbury, Mass, USA
    J Vasc Surg 48:447-56. 2008
    ..The purpose of this study was to test the hypothesis that prolonged increases in venous wall tension cause overexpression of MMPs and decreased contractility, which in turn promote venous dilation...
  16. doi request reprint Chronic traumatic pseudoaneurysm of polytetrafluoroethylene axillofemoral bypass graft in a quadriplegic patient
    Rebecca M Grochow
    Boston University School of Medicine, Boston, MA, USA
    Ann Vasc Surg 22:688-91. 2008
    ..To our knowledge this represents the first case of a chronic nonanastomotic pseudoaneurysm of a PTFE axillofemoral bypass graft secondary to abrasion and pressure that was repaired via an endovascular approach...
  17. pmc Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery
    Alex L Huang
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2113-9. 2007
    ..The predictive value of reactive hyperemia for cardiovascular events in patients with atherosclerosis and the relative importance of reactive hyperemia compared with other measures of vascular function have not been previously studied...
  18. pmc Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease
    Joseph D Raffetto
    Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, United States
    Biochem Pharmacol 75:346-59. 2008
    ....
  19. ncbi request reprint Noninfectious saccular abdominal aortic aneurysm--a report of two cases
    Michael E Minor
    Boston Medical Center, Boston, MA, USA
    Vasc Endovascular Surg 37:353-8. 2003
    ..The authors describe 2 cases of symptomatic, penetrating atherosclerotic ulcers of the abdominal aorta causing saccular, noninfectious abdominal aortic aneurysms...
  20. ncbi request reprint Acute thrombosis of abdominal aortic aneurysms--report of two cases and review of the literature
    Ahmed S Suliman
    Boston University School of Medicine, The Department of Surgery, Boston Medical Center, Boston, MA, USA
    Vasc Endovascular Surg 37:71-5. 2003
    ..Although this complication is rare, its high mortality rate makes it an important disease to understand, recognize, diagnose, and treat for a successful outcome...
  21. pmc Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins
    Joseph D Raffetto
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Vasc Surg 51:972-81. 2010
    ..We hypothesized that the sex differences in venous function reflect reduced constriction and enhanced venous dilation in women due to direct venous relaxation effects of estrogen on specific estrogen receptors (ER)...
  22. pmc Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins
    Joseph D Raffetto
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Vasc Surg 51:962-71. 2010
    ....
  23. pmc MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides
    Joseph D Raffetto
    Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Surg Res 159:755-64. 2010
    ..We tested whether MMP-2 induced venous relaxation involves inhibition of the Ca(2+) mobilization mechanisms of VSM contraction due to generation of Arg-Gly-Asp (RGD)-containing peptides...
  24. ncbi request reprint Factors that predict site of outflow target artery anastomosis in infrainguinal revascularization
    Joseph D Raffetto
    Department of Surgery, Section of Vascular Surgery D506, Boston University Medical Center, One Boston Medical Center Place, Boston, MA 02118 2393, USA
    J Vasc Surg 35:1093-9. 2002
    ..This study examines the risk factors and indication for infrainguinal revascularization with respect to the type of bypass performed...
  25. ncbi request reprint Venous ulcer fibroblasts respond to basic fibroblast growth factor at the cell cycle protein level
    Craig Seidman
    Eugene Surgical Associates Peacehealth, Eugene, OR, USA
    Ann Vasc Surg 20:376-80. 2006
    ..The role of bFGF may be useful in the clinical treatment of venous ulcer pathology...