J D Raffetto
Raffetto J. Inflammation in chronic venous ulcers. Phlebology. 2013;28 Suppl 1:61-7 pubmed publisher
Raffetto J, Bernardo J, Menzoian J. Aortobifemoral graft infection with Mycobacterium tuberculosis: treatment with abscess drainage, debridement, and long-term administration of antibiotic agents. J Vasc Surg. 2004;40:826-9 pubmed
..A review of the literature contains only 1 other report of tuberculosis graft infection and treatment. We discuss a rare form of aortic graft infection from M tuberculosis and its treatment. ..
Raffetto J, Khalil R. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology. 2008;23:85-98 pubmed publisher
..Thus, vein wall dilation appears to precede valve dysfunction, and the MMP activation and superimposed inflammation and fibrosis would then lead to chronic and progressive venous insufficiency and varicose vein formation. ..
Raffetto J. Dermal pathology, cellular biology, and inflammation in chronic venous disease. Thromb Res. 2009;123 Suppl 4:S66-71 pubmed publisher
..Ultimately, the persistent inflammatory-proteinase activity leads to advanced chronic venous insufficiency (CVI) and ulcer formation. ..
Raffetto J. Pathophysiology of Chronic Venous Disease and Venous Ulcers. Surg Clin North Am. 2018;98:337-347 pubmed publisher
..Understanding the pathophysiology of chronic venous disease and venous leg ulcers identifies cellular pathways, biomarkers, metabolic signatures, and cellular cross-talk for targeted therapy. ..
Raffetto J, Eberhardt R. Benefit of anticoagulation for the treatment of lower extremity superficial venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2015;3:236-41 pubmed publisher
Raffetto J, Eberhardt R, Dean S, Ligi D, Mannello F. Pharmacologic treatment to improve venous leg ulcer healing. J Vasc Surg Venous Lymphat Disord. 2016;4:371-4 pubmed publisher
..This evidence-based review assesses randomized clinical trials and meta-analyses with the objective of determining the effectiveness of venotonics to promote VLU healing. ..
Raffetto J. Pathophysiology of wound healing and alterations in venous leg ulcers-review. Phlebology. 2016;31:56-62 pubmed publisher
..With further understanding of inflammatory pathways and potential mechanisms, certain biomarkers could be revealed and studied as both involvement in the pathophysiology of VLU but also as therapeutic targets for VLU healing. ..