Affiliation: Quest Diagnostics
- Additional HIV-1 mutation patterns associated with reduced phenotypic susceptibility to etravirine in clinical samplesRon M Kagan
Department of Infectious Diseases, Quest Diagnostics Nichols Institute, San Juan Capistrano, California 92675, USA
AIDS 23:1602-5. 2009..Although the effect of K103S is unclear, additional position 138 substitutions seem important for etravirine susceptibility...
- HIV type 1 genotypic resistance in a clinical database correlates with antiretroviral utilizationRon Kagan
Department of Infectious Diseases, Quest Diagnostics Nichols Institute, San Juan Capistrano, California 92690, USA
AIDS Res Hum Retroviruses 20:1-9. 2004..Continued monitoring of ARV resistance prevalence, patterns, and utilization trends in clinical databases provides insight into the evolving relationship between clinical practice and ARV resistance...
- Structural analysis of an HIV-1 protease I47A mutant resistant to the protease inhibitor lopinavirRon M Kagan
Department of Infectious Diseases, Quest Diagnostics Inc, San Juan Capistrano, CA 92675, USA
Protein Sci 14:1870-8. 2005..The emergence of mutations at PR residue 47 strongly correlates with increasing prescriptions of LPV (Spearman correlation r(s) = 0.96, P < .0001)...
- Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap regionMilan Kozísek
Gilead Sciences and IOCB Research Center, Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, v v i, Flemingovo 2, 166 10 Praha 6, Czech Republic
J Virol 82:5869-78. 2008..Amino acid insertions in the vicinity of the binding cleft therefore represent a novel mechanism of HIV resistance development...
- Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptaseMarleen C D G Huigen
Department of Medical Microbiology, University Medical Center Utrecht, The Netherlands
Retrovirology 5:20. 2008..To unravel the role of two of these newly identified changes, E40F and K43E, we investigated their effect on viral drug susceptibility and replicative capacity...
- The probable source of both the primary multidrug-resistant (MDR) HIV-1 strain found in a patient with rapid progression to AIDS and a second recombinant MDR strain found in a chronically HIV-1-infected patientGary Blick
Circle Medical LLC, Norwalk, CT 06851, USA
J Infect Dis 195:1250-9. 2007..The probable source of this HIV-1 (hereafter referred to as "CT01") and the development of a recombinant MDR HIV-1 in the source's partner (hereafter referred to as "CT02") are described...
- New two-amino acid insertion near codon 70 of the HIV type 1 protease geneMark A Winters
Division of Infectious Diseases, Stanford University Medical Center, Stanford, California 94305, USA
AIDS Res Hum Retroviruses 21:311-3. 2005..Susceptibility of this strain to protease inhibitors was similar to that of non-insert-containing strains with comparable resistance mutations and one or more other major PI mutations...
- Rare one and two amino acid inserts adjacent to codon 103 of the HIV-1 reverse transcriptase (RT) affect susceptibility to non-nucleoside RT inhibitorsMark A Winters
Center for AIDS Research, Stanford University, Stanford, CA, USA
Antivir Ther 10:363-6. 2005..These results suggest that inserts in the NNRTI-binding pocket contribute to NNRTI resistance, but are tolerated only under specific genetic conditions...
- Increasing prevalence of HIV-1 reverse transcriptase mutation K65R correlates with tenofovir utilizationRon M Kagan
Antivir Ther 9:827-8. 2004
- Structure-based phenotyping predicts HIV-1 protease inhibitor resistanceMark D Shenderovich
Cengent Therapeutics Inc, 10929 Technology Place, San Diego, CA 92127, USA
Protein Sci 12:1706-18. 2003..666) with PhenoSense and Antivirogram phenotypes, respectively. The structural phenotyping predicted drug resistance of clinical HIV-1 PR variants with an accuracy approaching that of frequently used cell-based phenotypic assays...