Jian Kang Zhu


Affiliation: Purdue University
Country: USA


  1. Xiao L, Yang G, Zhang L, Yang X, Zhao S, Ji Z, et al. The resurrection genome of Boea hygrometrica: A blueprint for survival of dehydration. Proc Natl Acad Sci U S A. 2015;112:5833-7 pubmed publisher
    ..The lack of desiccation tolerance-specific genome organizational features suggests the resurrection phenotype evolved mainly by an alteration in the control of dehydration response genes. ..
  2. Lang Z, Wang Y, Tang K, Tang D, Datsenka T, Cheng J, et al. Critical roles of DNA demethylation in the activation of ripening-induced genes and inhibition of ripening-repressed genes in tomato fruit. Proc Natl Acad Sci U S A. 2017;114:E4511-E4519 pubmed publisher
    ..Our results show that SlDML2 is critical for tomato fruit ripening and suggest that active DNA demethylation is required for both the activation of ripening-induced genes and the inhibition of ripening-repressed genes. ..
  3. Chen I, Xue L, Hsu C, Paez J, Pan L, Andaluz H, et al. Phosphoproteins in extracellular vesicles as candidate markers for breast cancer. Proc Natl Acad Sci U S A. 2017;114:3175-3180 pubmed publisher
    ..This study demonstrates that the development of phosphoproteins in plasma EV as disease biomarkers is highly feasible and may transform cancer screening and monitoring. ..
  4. Feng Z, Zhang Z, Hua K, Gao X, Mao Y, Botella J, et al. A Highly Efficient Cell Division-Specific CRISPR/Cas9 System Generates Homozygous Mutants for Multiple Genes in Arabidopsis. Int J Mol Sci. 2018;19: pubmed publisher
    ..Our results demonstrate the advantage of using cell division promoters for CRISPR/Cas9 gene editing applications in Arabidopsis, especially in multiplex applications. ..
  5. Zhao Y, Zhang Z, Gao J, Wang P, Hu T, Wang Z, et al. Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA-Independent SnRK2 Activity. Cell Rep. 2018;23:3340-3351.e5 pubmed publisher
    ..Our results demonstrate an important role of basal ABA signaling in growth, senescence, and abscission and reveal that PYLs antagonize ABA-independent activation of SnRK2s by osmotic stress. ..
  6. Lei M, Zhang H, Julian R, Tang K, Xie S, Zhu J. Regulatory link between DNA methylation and active demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 2015;112:3553-7 pubmed publisher
    ..Therefore, the ROS1 promoter functions like a thermostat (i.e., methylstat) to sense DNA methylation levels and regulates DNA methylation by controlling ROS1 expression. ..
  7. Zhao C, Lang Z, Zhu J. Cold responsive gene transcription becomes more complex. Trends Plant Sci. 2015;20:466-8 pubmed publisher
    ..Recent work by Park et al. showed that CBF regulon genes and other cold-responsive genes are regulated by a complex network that involves many early cold-induced transcription factors. ..
  8. Wang P, Zhu J. Assessing Kinase Activity in Plants with In-Gel Kinase Assays. Methods Mol Biol. 2016;1363:189-97 pubmed publisher
    ..Here, we describe in detail an in-gel kinase assay to measure the activity of some protein kinases in plants. ..
  9. Mao Y, Botella J, Zhu J. Heritability of targeted gene modifications induced by plant-optimized CRISPR systems. Cell Mol Life Sci. 2017;74:1075-1093 pubmed publisher

More Information


  1. Zhu J. Abiotic Stress Signaling and Responses in Plants. Cell. 2016;167:313-324 pubmed publisher
    ..Understanding stress signaling and responses will increase our ability to improve stress resistance in crops to achieve agricultural sustainability and food security for a growing world population. ..
  2. Zhang Z, Mao Y, Ha S, Liu W, Botella J, Zhu J. A multiplex CRISPR/Cas9 platform for fast and efficient editing of multiple genes in Arabidopsis. Plant Cell Rep. 2016;35:1519-33 pubmed publisher
    ..We anticipate that the application of this multiplex CRISPR/Cas9 system will strongly facilitate functional analysis of genes pathways and families. ..
  3. Zhang H, Zhang J, Yan J, Gou F, Mao Y, Tang G, et al. Short tandem target mimic rice lines uncover functions of miRNAs in regulating important agronomic traits. Proc Natl Acad Sci U S A. 2017;114:5277-5282 pubmed publisher
    ..Our collection of STTM lines thus represents a valuable resource for functional analysis of rice miRNAs, as well as for agronomic improvement that can be readily transferred to other important food crops. ..
  4. Zhao Y, Chan Z, Gao J, Xing L, Cao M, Yu C, et al. ABA receptor PYL9 promotes drought resistance and leaf senescence. Proc Natl Acad Sci U S A. 2016;113:1949-54 pubmed publisher
    ..Our results uncover the molecular mechanism of ABA-induced leaf senescence and suggest an important role of PYL9 and leaf senescence in promoting resistance to extreme drought stress. ..
  5. Srivastava A, Lu Y, Zinta G, Lang Z, Zhu J. UTR-Dependent Control of Gene Expression in Plants. Trends Plant Sci. 2018;23:248-259 pubmed publisher
    ..We demonstrate functional specificity in genes with variable UTR length and propose future research directions. ..
  6. Zhan X, Yang L, Wang D, Zhu J, Lang Z. De novo assembly and analysis of the transcriptome of Ocimum americanum var. pilosum under cold stress. BMC Genomics. 2016;17:209 pubmed publisher
    ..Although most of the CBF pathway genes have orthologs in O. americanum var. pilosum, none of the identified cold responsive (COR) gene orthologs was induced by cold, which is consistent with the lack of cold tolerance in this plant. ..
  7. Zhang H, Tang K, Qian W, Duan C, Wang B, Zhang H, et al. An Rrp6-like protein positively regulates noncoding RNA levels and DNA methylation in Arabidopsis. Mol Cell. 2014;54:418-30 pubmed publisher
    ..Our results suggest that AtRRP6L1 functions in epigenetic regulation by helping with the retention of noncoding RNAs in normal cells. ..
  8. Lang Z, Lei M, Wang X, Tang K, Miki D, Zhang H, et al. The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. Mol Cell. 2015;57:971-83 pubmed publisher
    ..Thus, MBD7 tethers the IDM proteins to methylated DNA, which enables the function of DNA demethylases that in turn limit DNA methylation and prevent transcriptional gene silencing. ..
  9. Wang P, Du Y, Hou Y, Zhao Y, Hsu C, Yuan F, et al. Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. Proc Natl Acad Sci U S A. 2015;112:613-8 pubmed publisher
    ..6 is present in several yeast and human protein kinases and can be S-nitrosylated, suggesting that the S-nitrosylation may be an evolutionarily conserved mechanism for protein kinase regulation. ..
  10. Duan C, Zhang H, Tang K, Zhu X, Qian W, Hou Y, et al. Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. EMBO J. 2015;34:581-92 pubmed publisher
    ..Our results suggest that AGO4 and AGO6 mainly act sequentially in mediating small RNA-directed DNA methylation. ..
  11. Qian W, Miki D, Lei M, Zhu X, Zhang H, Liu Y, et al. Regulation of active DNA demethylation by an ?-crystallin domain protein in Arabidopsis. Mol Cell. 2014;55:361-71 pubmed publisher
    ..IDM2 is required for the full activity of H3K18 acetylation but not H3K23 acetylation of IDM1 in planta. Our results suggest that IDM2 functions in active DNA demethylation and in antisilencing by regulating IDM1. ..