Wei Zheng

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. pmc Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases
    Wei Zheng
    School of Health Sciences, Purdue University, West Lafayette, Indiana, USA
    Pharmacol Ther 133:177-88. 2012
  2. pmc Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure
    Mamta Behl
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Cerebrospinal Fluid Res 6:11. 2009
  3. pmc Biomarkers of manganese intoxication
    Wei Zheng
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Neurotoxicology 32:1-8. 2011
  4. pmc Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats
    Wei Zheng
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Neurotoxicology 30:240-8. 2009
  5. pmc Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1
    Mamta Behl
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1169, West Lafayette, IN 47907, USA
    Toxicol Appl Pharmacol 240:245-54. 2009
  6. pmc Use of Z310 cells as an in vitro blood-cerebrospinal fluid barrier model: tight junction proteins and transport properties
    Lewis Zhichang Shi
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907 2051, United States
    Toxicol In Vitro 22:190-9. 2008
  7. doi request reprint Manganese exposure among smelting workers: relationship between blood manganese-iron ratio and early onset neurobehavioral alterations
    Dallas M Cowan
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
    Neurotoxicology 30:1214-22. 2009
  8. doi request reprint Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model
    Andrew D Monnot
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL1169, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 237:327-33. 2012
  9. doi request reprint Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure
    Xueqian Wang
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 233:1561-71. 2008
  10. pmc Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity
    Gang Zheng
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Toxicol Appl Pharmacol 260:285-93. 2012

Collaborators

Detail Information

Publications39

  1. pmc Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases
    Wei Zheng
    School of Health Sciences, Purdue University, West Lafayette, Indiana, USA
    Pharmacol Ther 133:177-88. 2012
    ....
  2. pmc Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure
    Mamta Behl
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Cerebrospinal Fluid Res 6:11. 2009
    ..Since metalloendopeptidase insulin-degrading enzyme (IDE), has been implicated in the metabolism of Abeta, we sought to investigate whether accumulation of Abeta following Pb exposure was due to the effect of Pb on IDE...
  3. pmc Biomarkers of manganese intoxication
    Wei Zheng
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Neurotoxicology 32:1-8. 2011
    ..Considering the large accumulation of Mn in bone, developing an X-ray fluorescence spectroscopy or neutron-based spectroscopy method may create yet another novel non-invasive tool for assessing Mn exposure and toxicity...
  4. pmc Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats
    Wei Zheng
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Neurotoxicology 30:240-8. 2009
    ..These data suggest that PAS likely acts as a chelating agent to mobilize and remove tissue Mn. A high-dose and prolonged PAS treatment appears necessary for its therapeutic effectiveness...
  5. pmc Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1
    Mamta Behl
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1169, West Lafayette, IN 47907, USA
    Toxicol Appl Pharmacol 240:245-54. 2009
    ....
  6. pmc Use of Z310 cells as an in vitro blood-cerebrospinal fluid barrier model: tight junction proteins and transport properties
    Lewis Zhichang Shi
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907 2051, United States
    Toxicol In Vitro 22:190-9. 2008
    ..Taken together, these data indicate that the Z310 BCB model expresses major tight junction proteins and forms a tight barrier in vitro. The model also exhibits the ability to transport substances of various categories across the barrier...
  7. doi request reprint Manganese exposure among smelting workers: relationship between blood manganese-iron ratio and early onset neurobehavioral alterations
    Dallas M Cowan
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
    Neurotoxicology 30:1214-22. 2009
    ..Combining their usefulness in Mn-exposure assessment, we recommend that the blood Mn-Fe ratio may serve as a reasonable biomarker not only for assessment of Mn exposure but also for health risk assessment...
  8. doi request reprint Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model
    Andrew D Monnot
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL1169, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 237:327-33. 2012
    ....
  9. doi request reprint Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure
    Xueqian Wang
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 233:1561-71. 2008
    ..Enhanced TfR-mediated influx of Fe from the blood and ferroportin-mediated expelling Fe toward the CSF may compromise DMT1-mediated efflux, leading to an increased Fe concentration in the CSF as seen in Mn-exposed animals...
  10. pmc Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity
    Gang Zheng
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Toxicol Appl Pharmacol 260:285-93. 2012
    ..These data indicate that CTR1, but not DMT1, plays an essential role in transporting Cu by the BCB in the choroid plexus. Mn-induced cellular overload of Cu at the BCB is due, primarily, to Mn-induced over-expression of CTR1...
  11. ncbi request reprint Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure
    G Jane Li
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
    Neurotoxicology 27:737-44. 2006
    ..The disrupted Fe transport by brain barriers may underlie the distorted Fe homeostasis in the CSF...
  12. pmc Macromolecules involved in production and metabolism of beta-amyloid at the brain barriers
    Janelle S Crossgrove
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
    Brain Res 1138:187-95. 2007
    ..Disruption of this homeostasis due to aging, injury or toxicant exposure may contribute to accumulation of beta-amyloid peptides in the brain fluids, leading to AD...
  13. pmc The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats
    Terry L Davidson
    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
    Physiol Behav 107:26-33. 2012
    ....
  14. pmc Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron
    Xueqian Wang
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Toxicol Appl Pharmacol 230:167-74. 2008
    ..The intracellular trafficking of metal transporters in the choroid plexus following Mn exposure may partially contribute to Mn-induced disruption in Fe homeostasis in the cerebrospinal fluid (CSF) following Mn exposure...
  15. pmc X-ray fluorescence imaging of the hippocampal formation after manganese exposure
    Gregory Robison
    Purdue University, Department of Physics, 525 Northwestern Avenue, West Lafayette, IN 47907, USA
    Metallomics 5:1554-65. 2013
    ..A consistent Mn-Zn correlation both at the tissue (40 μm × 40 μm) and cellular (0.3 μm × 0.3 μm) levels suggests that a Zn transport/storage mechanism in the HPCf is likely associated with Mn accumulation. ..
  16. pmc Regulation of brain copper homeostasis by the brain barrier systems: effects of Fe-overload and Fe-deficiency
    Andrew D Monnot
    School of Health Sciences, Purdue University, West Lafayette, IN, USA
    Toxicol Appl Pharmacol 256:249-57. 2011
    ..FeD has a more profound effect on brain Cu levels than FeO. FeD increases Cu transport at the brain barriers and prompts Cu overload in the CNS. The BCB plays a key role in removing the excess Cu from the CSF...
  17. ncbi request reprint Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitro
    Lewis Zhichang Shi
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907, USA
    Hum Exp Toxicol 26:159-67. 2007
    ..The immature barrier appears to be more vulnerable to Pb toxicity than the mature, well-developed, brain barrier, the fact possibly contributing to Pb-induced neurotoxicity among young children...
  18. pmc Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C
    Mamta Behl
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Neurotoxicology 31:524-32. 2010
    ..These studies suggest that Pb exposure disrupts Abeta homeostasis at the CP, owing partly to a Pb-induced relocalization of LRP1 via PKC-delta...
  19. pmc Copper transport to the brain by the blood-brain barrier and blood-CSF barrier
    Byung Sun Choi
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, USA
    Brain Res 1248:14-21. 2009
    ....
  20. doi request reprint Culture of choroid plexus epithelial cells and in vitro model of blood-CSF barrier
    Andrew D Monnot
    School of Health Sciences, Purdue University, West Lafayette, IN, USA
    Methods Mol Biol 945:13-29. 2013
    ..These choroidal epithelia cultures with the Transwell system will perceivably assist blood-CSF barrier research...
  21. ncbi request reprint Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro
    Xueqian Wang
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907, USA
    Brain Res 1097:1-10. 2006
    ..The facilitated transport of Fe by DMT1 at the blood-CSF barrier may partly contribute to Mn-induced neurodegenerative Parkinsonism...
  22. doi request reprint Thalamic GABA Predicts Fine Motor Performance in Manganese-Exposed Smelter Workers
    Zaiyang Long
    School of Health Sciences, Purdue University, West Lafayette, Indiana, United States of America Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 9:e88220. 2014
    ..Thus in Mn-exposed subjects, increased thalamic GABA levels may serve as a biomarker for subtle deficits in motor control and may become valuable for early diagnosis of Mn poisoning. ..
  23. pmc Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone
    Yulia Pushkar
    Department of Physics, Purdue University, 525 Northwestern Ave, West Lafayette, IN, 47907, USA
    Aging Cell 12:823-32. 2013
    ..We demonstrate that the Cu distribution and age-related concentration changes in the brain are highly cell specific. ..
  24. ncbi request reprint The choroid plexus removes beta-amyloid from brain cerebrospinal fluid
    Janelle S Crossgrove
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 230:771-6. 2005
    ..Overall, these results suggest the choroid plexus selectively cleanses Abeta from the CSF by an undetermined mechanism(s), potentially reducing Abeta from normal brains and the brains of Alzheimer's disease patients...
  25. doi request reprint The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat
    Scott E Kanoski
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 19104 6241, USA
    J Alzheimers Dis 21:207-19. 2010
    ..These results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity...
  26. pmc In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese
    Ulrike Dydak
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Environ Health Perspect 119:219-24. 2011
    ..Exposure to excessive levels of manganese (Mn) is known to induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection of Mn neurotoxicity is desirable...
  27. pmc X-ray fluorescence imaging: a new tool for studying manganese neurotoxicity
    Gregory Robison
    Department of Physics, Purdue University, West Lafayette, IN, USA
    PLoS ONE 7:e48899. 2012
    ..The obtained data is the first demonstration of Mn accumulation in the substantia nigra pars compacta, and thus, can represent a link between Mn exposure and its potential effects for development of Parkinson's disease...
  28. doi request reprint Manganese exposure among smelting workers: blood manganese-iron ratio as a novel tool for manganese exposure assessment
    Dallas M Cowan
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Biomarkers 14:3-16. 2009
    ..77, p < 0.01) and plasma (pMIR) (r = 0.70, p < 0.01). The results suggest that the MIR may serve as a useful biomarker to distinguish Mn-exposed workers from the unexposed, control population...
  29. doi request reprint 1α, 25-Dihydroxyvitamin D regulates hypoxia-inducible factor-1α in untransformed and Harvey-ras transfected breast epithelial cells
    Yan Jiang
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47906, USA
    Cancer Lett 298:159-66. 2010
    ..These results support that 1,25(OH)(2)D regulates HIF-1α protein level via transcriptional regulation in MCF10A cells in contrast to through proteosomal degradation with the presence of H-ras oncogene in MCF10A cells...
  30. ncbi request reprint Brain barrier systems: a new frontier in metal neurotoxicological research
    Wei Zheng
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Toxicol Appl Pharmacol 192:1-11. 2003
    ..They represent both clear challenges and fruitful research domains not only in neurotoxicology, but also in neurophysiology and pharmacology...
  31. ncbi request reprint Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study
    Lewis Zhichang Shi
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907 2051, USA
    Brain Res 1057:37-48. 2005
    ..The Z310 cell-based in vitro model appears to be suitable for transepithelial transport study of drugs and toxicants...
  32. pmc Brain regional pharmacokinetics of p-aminosalicylic acid and its N-acetylated metabolite: effectiveness in chelating brain manganese
    Lan Hong
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Drug Metab Dispos 39:1904-9. 2011
    ..Furthermore, PAS and AcPAS seem to be effective in reducing manganese levels in brain...
  33. doi request reprint Upregulation of zinc transporter 2 in the blood-CSF barrier following lead exposure
    Xue Fu
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 239:202-12. 2014
    ....
  34. doi request reprint 1,25-dihydroxyvitamin D regulation of glucose metabolism in Harvey-ras transformed MCF10A human breast epithelial cells
    Wei Zheng
    Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN 47906, United States Electronic address
    J Steroid Biochem Mol Biol 138:81-9. 2013
    ..The results suggest a novel mechanism involving the regulation of glucose metabolism by which 1,25(OH)2D may prevent breast cancer progression. ..
  35. doi request reprint Visualizing systemic clearance and cellular level biodistribution of gold nanorods by intrinsic two-photon luminescence
    Ling Tong
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Langmuir 25:12454-9. 2009
    ..With spectral detection to distinguish GNR TPL from tissue autofluorescence, we also mapped the cellular distribution of GNRs in the explanted organs, and found most GNRs resided in the macrophages in liver and spleen...
  36. ncbi request reprint Manganese toxicity upon overexposure
    Janelle Crossgrove
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    NMR Biomed 17:544-53. 2004
    ..In conclusion, repeated administration of Mn, or compounds that readily release Mn, may increase the risk of Mn-induced toxicity...
  37. ncbi request reprint Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro
    G Jane Li
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907, USA
    Toxicol Appl Pharmacol 205:188-200. 2005
    ..The disrupted protein-TfR mRNA interaction in the choroidal epithelial cells may explain the toxicity of manganese at the blood-CSF barrier...
  38. ncbi request reprint Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development
    Qiang Wang
    Department of Occupational and Environmental Health, Faculty of Military Preventive Medicine, Fourth Military Medical University, 17 Changlexi Street, Xi an, 710032, China
    Toxicol Appl Pharmacol 219:33-41. 2007
    ..The increased BBB permeability may facilitate the accumulation of Pb. Fe supplement appears to protect the integrity of the BBB against Pb insults, a beneficial effect that may have significant clinical implications...
  39. ncbi request reprint The blood-CSF barrier in culture. Development of a primary culture and transepithelial transport model from choroidal epithelial cells
    Wei Zheng
    Division of Environmental Health Sciences, School of Public Health, Columbia University, New York, NY, USA
    Methods Mol Biol 188:99-114. 2002

Research Grants17

  1. Choroid Plexus as a Target in Metal-Induced Neurotoxicity
    Wei Zheng; Fiscal Year: 2009
    ....
  2. Choroid Plexus as a Target in Metal-Induced Neurotoxicity
    Wei Zheng; Fiscal Year: 2007
    ....
  3. Creation of an In Vitro Brain Barrier Transport System
    Wei Zheng; Fiscal Year: 2006
    ....
  4. Choroid Plexus a Target in Metal-Induced Neurotoxicity
    Wei Zheng; Fiscal Year: 2005
    ..In addition, we will study the effect of Mn on the RNA binding capability of a newly discovered IRP which regulates the synthesis of an [Fe-S] subunit of Complex-I. ..
  5. Workshop on Choroid Plexus in Brain Health and Disease.
    Wei Zheng; Fiscal Year: 2003
    ..abstract_text> ..
  6. CHOROID PLEXUS AS A TARGET IN LEAD INDUCED NEUROTOXICITY
    Wei Zheng; Fiscal Year: 2000
    ..We believe that this study will likely create a highly fruitful avenue of research in environmental neurotoxicology. ..
  7. Choroid Plexus as a Target in Metal-Induced Neurotoxicity
    Wei Zheng; Fiscal Year: 2010
    ..This project will uncover how Cu is transferred in and out of the brain and how exposure to environmental toxicant manganese (Mn) interferes with the Cu balance in brain, which in turn causes the degenerative manganese parkinsonism. ..