Garth T Whiteside

Summary

Affiliation: Purdue Pharma
Country: USA

Publications

  1. ncbi request reprint A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833
    Garth T Whiteside
    Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Eur J Pharmacol 528:65-72. 2005
  2. pmc Pharmacological characterisation of a rat model of incisional pain
    Garth T Whiteside
    Neuropharmacology, Purdue Pharma LP, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Br J Pharmacol 141:85-91. 2004
  3. ncbi request reprint DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid agonist with antihyperalgesic activity: II. In vivo pharmacological characterization in the
    Garth T Whiteside
    Departments of Molecular Pharmacology and Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 310:793-9. 2004
  4. ncbi request reprint The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid)
    Garth T Whiteside
    Purdue Pharma Discovery Research, Cranbury, New Jersey, USA
    J Pharmacol Exp Ther 314:1234-40. 2005
  5. ncbi request reprint Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
    Kenneth J Valenzano
    Department of Pharmacology, Purdue Pharma Discovery Research, Cranbury, NJ 08512, USA
    Neuropharmacology 48:658-72. 2005
  6. ncbi request reprint Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states
    Victor I Ilyin
    Discovery Research, Purdue Pharma LP, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 318:1083-93. 2006
  7. ncbi request reprint Neuropathy-induced osteopenia in rats is not due to a reduction in weight born on the affected limb
    Garth T Whiteside
    Department of Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Bone 38:387-93. 2006
  8. ncbi request reprint An industry perspective on the role and utility of animal models of pain in drug discovery
    Garth T Whiteside
    Discovery Research, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, United States
    Neurosci Lett 557:65-72. 2013
  9. ncbi request reprint A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats
    Gang Wu
    Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Eur J Pharmacol 504:45-53. 2004
  10. doi request reprint Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
    Pranab K Chanda
    Neuroscience Research Unit, Pfizer Global Research, Princeton, New Jersey, USA
    Mol Pharmacol 78:996-1003. 2010

Collaborators

Detail Information

Publications11

  1. ncbi request reprint A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833
    Garth T Whiteside
    Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Eur J Pharmacol 528:65-72. 2005
    ..Furthermore, these data suggest that the mechanism of action for GW405833 does not depend on the release of endogenous opioids...
  2. pmc Pharmacological characterisation of a rat model of incisional pain
    Garth T Whiteside
    Neuropharmacology, Purdue Pharma LP, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Br J Pharmacol 141:85-91. 2004
    ....
  3. ncbi request reprint DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid agonist with antihyperalgesic activity: II. In vivo pharmacological characterization in the
    Garth T Whiteside
    Departments of Molecular Pharmacology and Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 310:793-9. 2004
    ..This is the first report of a peripherally restricted, small-molecule mu opioid agonist that is nonsedating, antihyperalgesic, and effective against inflammatory and postsurgical pain when administered systemically...
  4. ncbi request reprint The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid)
    Garth T Whiteside
    Purdue Pharma Discovery Research, Cranbury, New Jersey, USA
    J Pharmacol Exp Ther 314:1234-40. 2005
    ..Furthermore, our data demonstrate that activation of mu receptors in the brain inhibits carrageenan-induced edema and suggest that the antiedematous effect of morphine is due to action at central receptors alone...
  5. ncbi request reprint Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
    Kenneth J Valenzano
    Department of Pharmacology, Purdue Pharma Discovery Research, Cranbury, NJ 08512, USA
    Neuropharmacology 48:658-72. 2005
    ....
  6. ncbi request reprint Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states
    Victor I Ilyin
    Discovery Research, Purdue Pharma LP, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 318:1083-93. 2006
    ..Optimizing the biophysical parameters of broad-spectrum voltage-gated Na(+) channel blockers may lead to improved pain therapeutics...
  7. ncbi request reprint Neuropathy-induced osteopenia in rats is not due to a reduction in weight born on the affected limb
    Garth T Whiteside
    Department of Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Bone 38:387-93. 2006
    ..Furthermore, chronic bisphosphonate treatment inhibits neuropathy-induced osteopenia without affecting behavioral measurements of neuropathic pain. This indicates that osteopenia is not directly related to neuropathic pain behaviors...
  8. ncbi request reprint An industry perspective on the role and utility of animal models of pain in drug discovery
    Garth T Whiteside
    Discovery Research, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, United States
    Neurosci Lett 557:65-72. 2013
    ....
  9. ncbi request reprint A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats
    Gang Wu
    Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Eur J Pharmacol 504:45-53. 2004
    ..Its efficacy demonstrates the importance of peripheral P2X3/P2X(2/3) receptors in mediating ATP-associated mechanical hyperalgesia following inflammation, confirming previous suggestions of a significant role for P2X(2/3)...
  10. doi request reprint Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
    Pranab K Chanda
    Neuroscience Research Unit, Pfizer Global Research, Princeton, New Jersey, USA
    Mol Pharmacol 78:996-1003. 2010
    ..These findings provide the first genetic in vivo evidence that MAGL is the major regulator of 2-AG levels and signaling and reveal a pivotal role for 2-AG in modulating CB1 receptor sensitization and endocannabinoid tone...
  11. ncbi request reprint Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain
    Nicole R Sullivan
    Neuroscience Discovery Research, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 322:1294-304. 2007
    ..The data presented herein suggest that muscarinic agonists, such as WAY-132983, may have a broad therapeutic efficacy for the treatment of pain...