Bruce A Watkins

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. ncbi request reprint Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USA
    Prostaglandins Leukot Essent Fatty Acids 68:387-98. 2003
  2. ncbi request reprint Dietary PUFA and flavonoids as deterrents for environmental pollutants
    Bruce A Watkins
    Department of Food Science, Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA
    J Nutr Biochem 18:196-205. 2007
  3. doi request reprint Serum phospholipid fraction of polyunsaturated fatty acids is the preferred indicator for nutrition and health status in hemodialysis patients
    Bruce A Watkins
    Department of Nutrition, University of California, Davis, CA Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN Center on Aging, University of Connecticut Health Center, Farmington, CT Electronic address
    J Nutr Biochem 38:18-24. 2016
  4. doi request reprint Circulating levels of endocannabinoids and oxylipins altered by dietary lipids in older women are likely associated with previously identified gene targets
    Bruce A Watkins
    Department of Nutrition, University of California, Davis, Davis, CA, United States Center on Aging, University of Connecticut Health Center, Farmington, CT, United States Electronic address
    Biochim Biophys Acta 1861:1693-1704. 2016
  5. doi request reprint The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health
    Bruce A Watkins
    Lipid Chemistry and Molecular Biology Laboratory, School of Agriculture, West Lafayette, IN 47907, USA
    J Nutr Biochem 21:1141-52. 2010
  6. ncbi request reprint Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 17:282-9. 2006
  7. ncbi request reprint Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomized rats
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 16:479-88. 2005
  8. ncbi request reprint A test of Ockham's razor: implications of conjugated linoleic acid in bone biology
    Bruce A Watkins
    Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    Am J Clin Nutr 79:1175S-1185S. 2004
  9. ncbi request reprint Conjugated linoleic acids alter the fatty acid composition and physical properties of egg yolk and albumen
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, Indiana 47907 2009, USA
    J Agric Food Chem 51:6870-6. 2003
  10. doi request reprint Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats
    Yong Li
    Lipid Chemistry and Molecular Biology Laboratory, 745 Agriculture Mall Drive, Purdue University, West Lafayette, IN 47907, USA
    Br J Nutr 104:674-85. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USA
    Prostaglandins Leukot Essent Fatty Acids 68:387-98. 2003
    ..Other studies indicate that the dietary source of PUFA may affect protein expression of Cbfa1 and nodule formation in fetal rat calvarial cells...
  2. ncbi request reprint Dietary PUFA and flavonoids as deterrents for environmental pollutants
    Bruce A Watkins
    Department of Food Science, Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA
    J Nutr Biochem 18:196-205. 2007
    ....
  3. doi request reprint Serum phospholipid fraction of polyunsaturated fatty acids is the preferred indicator for nutrition and health status in hemodialysis patients
    Bruce A Watkins
    Department of Nutrition, University of California, Davis, CA Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN Center on Aging, University of Connecticut Health Center, Farmington, CT Electronic address
    J Nutr Biochem 38:18-24. 2016
    ....
  4. doi request reprint Circulating levels of endocannabinoids and oxylipins altered by dietary lipids in older women are likely associated with previously identified gene targets
    Bruce A Watkins
    Department of Nutrition, University of California, Davis, Davis, CA, United States Center on Aging, University of Connecticut Health Center, Farmington, CT, United States Electronic address
    Biochim Biophys Acta 1861:1693-1704. 2016
    ..This study shows phenotypic responses (in levels) to n-3 PUFA supplementation in PMW and increases of n-3 acyl-ethanolamide and n-3-derived OL of clinical considerations in aging...
  5. doi request reprint The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health
    Bruce A Watkins
    Lipid Chemistry and Molecular Biology Laboratory, School of Agriculture, West Lafayette, IN 47907, USA
    J Nutr Biochem 21:1141-52. 2010
    ..Third, we discuss the potential implications of how dietary PUFA impact this system to minimize muscle atrophy and osteopenia and support healthy muscle development and bone modeling...
  6. ncbi request reprint Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 17:282-9. 2006
    ....
  7. ncbi request reprint Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomized rats
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 16:479-88. 2005
    ..The concentration of serum pyridinoline cross-links was significantly lower in the N3+IF group. These findings indicate a complementary action of soy IFs and n-3 PUFAs for attenuating bone mineral reduction in OVX rats...
  8. ncbi request reprint A test of Ockham's razor: implications of conjugated linoleic acid in bone biology
    Bruce A Watkins
    Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    Am J Clin Nutr 79:1175S-1185S. 2004
    ..Thus, the purpose of this review is to advance the science of CLA and to identify areas of research in which these nutrients affect bone metabolism and skeletal health...
  9. ncbi request reprint Conjugated linoleic acids alter the fatty acid composition and physical properties of egg yolk and albumen
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, Indiana 47907 2009, USA
    J Agric Food Chem 51:6870-6. 2003
    ....
  10. doi request reprint Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats
    Yong Li
    Lipid Chemistry and Molecular Biology Laboratory, 745 Agriculture Mall Drive, Purdue University, West Lafayette, IN 47907, USA
    Br J Nutr 104:674-85. 2010
    ....
  11. pmc Inverse relationship between long-chain n-3 fatty acids and risk of sudden cardiac death in patients starting hemodialysis
    Allon N Friedman
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 83:1130-5. 2013
    ..Thus, long-chain n-3 fatty acids are strongly and independently associated with a lower risk of sudden cardiac death in hemodialysis patients throughout the first year of hemodialysis...
  12. ncbi request reprint Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells
    Eva Horia
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA
    Carcinogenesis 28:809-15. 2007
    ....
  13. doi request reprint Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle
    Heather L Hutchins-Wiese
    Center on Aging, University of Connecticut Health Center, Farmington, CT 06030 6147, USA
    J Nutr Biochem 23:986-93. 2012
    ..The higher mRNA levels for EC with HS and dietary n-3 PUFA suggest that muscle disuse and diet induce changes in the EC system to sensitize muscle in response to metabolic and physiological consequences of atrophy...
  14. doi request reprint Fat to treat fat: emerging relationship between dietary PUFA, endocannabinoids, and obesity
    Jeffrey Kim
    Lipid Chemistry and Molecular Biology Laboratory, Center on Aging, University of Connecticut, Storrs, CT 06269 4004, USA
    Prostaglandins Other Lipid Mediat 104:32-41. 2013
    ..Future research in this endeavor must be hypothesis driven utilizing appropriate models for investigations on dietary PUFA, endocannabinoids and obesity. ..
  15. ncbi request reprint Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients--a pilot study
    Akber Saifullah
    Division of Nephrology, Indiana University School of Medicine, Indianapolis IN, USA
    Nephrol Dial Transplant 22:3561-7. 2007
    ....
  16. ncbi request reprint Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis
    Allon N Friedman
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Kidney Dis 47:1064-71. 2006
    ..There is reason to believe that hemodialysis patients are at risk for inadequate omega-3 intake and, consequently, low blood levels...
  17. pmc Feasibility study of erythrocyte long-chain omega-3 polyunsaturated fatty acid content and mortality risk in hemodialysis patients
    Allon N Friedman
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Ren Nutr 18:509-12. 2008
    ..We tested the hypothesis that erythrocyte n-3 PUFA levels, as measured by the omega-3 index (O3I), are inversely related to mortality in hemodialysis patients...
  18. pmc Low blood levels of long-chain n-3 polyunsaturated fatty acids in US hemodialysis patients: clinical implications
    Allon N Friedman
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, USA
    Am J Nephrol 36:451-8. 2012
    ..We therefore investigated, in the first study of its kind, the blood content and distribution of these fatty acids in a large representative population of US hemodialysis patients...
  19. ncbi request reprint Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women
    Megan L Diaz
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
    J Nutr Biochem 19:61-8. 2008
    ..The use of a combined CP and CLA supplement for 3 months does not affect diet- and exercise-induced changes in weight and body composition or improve indexes of metabolic and cardiovascular health in young overweight women...
  20. doi request reprint Dietary source of stearidonic acid promotes higher muscle DHA concentrations than linolenic acid in hybrid striped bass
    Anant S Bharadwaj
    Department of Forestry and Natural Resources, Purdue University, 715 West State Street, West Lafayette, IN 47907 2061, USA
    Lipids 45:21-7. 2010
    ..Muscle 22:6n-3 concentrations were significantly higher in fish fed SDA compared to fish fed ALA. Based on these data, it appears that feeding SDA can increase long chain n-3 fatty acid concentrations in fish muscle...
  21. doi request reprint Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells
    Heather L Hutchins
    Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA
    J Nutr Biochem 22:195-200. 2011
    ..In conclusion, EPA lowered mRNA levels for proteins of the EC system and mRNA for AEA synthesis/degradation is reported in osteoblasts...
  22. ncbi request reprint Impact of dietary n-3 FA deficiency on rat bone tissue FA composition
    Yong Li
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, Indiana 47907, USA
    Lipids 38:683-6. 2003
    ..This study showed that bone is sensitive to changes in dietary n-3 FA and that DHA is more effective than LNA in maintaining DHA levels in these tissues...
  23. ncbi request reprint Repletion with (n-3) fatty acids reverses bone structural deficits in (n-3)-deficient rats
    Susan Reinwald
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA
    J Nutr 134:388-94. 2004
    ..This study showed that repletion with dietary (n-3) fatty acids restored the ratio of (n-6)/(n-3) PUFA in bone compartments and reversed compromised bone modeling in (n-3)-deficient rats...
  24. ncbi request reprint Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures
    Eva Horia
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 16:184-92. 2005
    ....
  25. pmc Association between plasma endocannabinoids and appetite in hemodialysis patients: A pilot study
    Allon N Friedman
    Indiana University School of Medicine, Indianapolis, IN, 46202 Electronic address
    Nutr Res 36:658-62. 2016
    ..74, P≤.001), and its questions associated with appetite (ρ=-0.69, P≤.01) and satiety (ρ=-0.81, P≤.001). These findings support a link between circulating EC and appetite in hemodialysis patients. ..
  26. pmc Acute rise of omega-3 polyunsaturated fatty acids during hemodialysis treatment
    Allon N Friedman
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Ren Nutr 18:301-3. 2008
    ..We performed this study to measure the effect of a single-standard hemodialysis treatment on plasma and erythrocyte omega-3 PUFA levels in chronic hemodialysis patients...
  27. doi request reprint Endocannabinoid signaling and energy metabolism: a target for dietary intervention
    Jeffrey Kim
    Lipid Chemistry and Molecular Biology Laboratory, Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USA
    Nutrition 27:624-32. 2011
    ....
  28. ncbi request reprint Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells
    Ana Cecilia Muñoz-Espada
    Lipid Chemistry and Molecular Biology Laboratory, Center for Enhancing Foods to Protect Health, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 17:589-96. 2006
    ..1 and 1 microM) and cyanidin (1 microM). The reduction of COX-2 mRNA by kaempferol and cyanidin may be mediated through the actions of NFkappaB and PPARgamma as nuclear factors that bind to the COX-2 gene promoter...
  29. doi request reprint High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study
    Heather L Hutchins-Wiese
    a Eastern Michigan University, Dietetics and Human Nutrition, Ypsilanti, Michigan, USA, and Center on Aging, University of Connecticut, Farmington, Connecticut, USA
    Nutr Cancer 66:68-76. 2014
    ....
  30. ncbi request reprint Oxidized lipid depresses canine growth, immune function, and bone formation
    John J Turek
    Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, W Lafayette, IN 47907, USA
    J Nutr Biochem 14:24-31. 2003
    ..The rapid growth and weight gain of the dog during the first 6 months of life may also provide a better model for assessing the risks of dietary oxidized lipid in children and adolescents than previously used rodent models...
  31. pmc Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts
    Jeffrey Kim
    Center on Aging, University of Connecticut Health Center Farmington, CT, USA
    Front Physiol 5:100. 2014
    ..These findings indicate a compensatory effect of DHA and DHEA compared to AA-derived ligands on the ECS and associated ECS gene expression and higher glucose uptake in myoblasts. ..
  32. doi request reprint Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity
    Jeffrey Kim
    Lipid Chemistry and Molecular Biology Laboratory, Farmington, CT, USA
    J Nutr Biochem 25:815-23. 2014
    ..These findings suggest that COX activity and protein levels are influenced by the ECS, specifically by the ligand AEA for CB1 and by inverse agonism of CB2. ..
  33. ncbi request reprint Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
    Br J Nutr 95:462-8. 2006
    ..These findings indicate a protective action of LC n-3 PUFA on ageing-induced bone loss in gonad-intact middle-aged male rats through a modulation of local factors and systemic calcitrophic hormones...
  34. ncbi request reprint Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acids
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Lipids 39:161-6. 2004
    ..The fact that CLA alone or in combination with other PUFA modulated PGE2 and NO production in human OC cultures suggests that these 18:2 isomers may have the potential to influence OA pathogenesis...
  35. ncbi request reprint Ectopic expression of IGF-I and Shh by skeletal muscle inhibits disuse-mediated skeletal muscle atrophy and bone osteopenia in vivo
    Mohammed Borhan Alzghoul
    Basic Veterinary Sciences, School of Veterinary Medicine, Irbid Jordan
    FASEB J 18:221-3. 2004
    ..These results support the theory that skeletal muscle can regulate bone maintenance and could offer potentially novel and efficient therapeutic options for attenuating muscle and bone atrophy during aging, illness and spaceflight...
  36. ncbi request reprint Origins and evolution of the Western diet: health implications for the 21st century
    Loren Cordain
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
    Am J Clin Nutr 81:341-54. 2005
    ..The evolutionary collision of our ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization...