Research Topics
| David J WatersSummaryAffiliation: Purdue University Country: USA Publications
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Detail Information
Publications
Aging research 2011: exploring the pet dog paradigmDavid J Waters
Center for Exceptional Longevity Studies, Gerald P Murphy Cancer Foundation, 3000 Kent Avenue, Suite E2 100, West Lafayette, IN 47906, USA
ILAR J 52:97-105. 2011..Yet the pet dog paradigm in aging research is nascent; tapping into the potential of this model will add to the existing strengths of conventional model systems...
Prostatic response to supranutritional selenium supplementation: comparison of the target tissue potency of selenomethionine vs. selenium-yeast on markers of prostatic homeostasisDavid J Waters
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907, USA
Nutrients 4:1650-63. 2012....- Noninvasive prediction of prostatic DNA damage by oxidative stress challenge of peripheral blood lymphocytesDavid J Waters
Gerald P Murphy Cancer Foundation, 3000 Kent Avenue, Suite E2 100, West Lafayette, IN 47906, USA
Cancer Epidemiol Biomarkers Prev 16:1906-10. 2007..These findings lend support to the concept that oxidative stress contributes to genotoxic damage, and that oxidative stress challenge may stratify men for prostate cancer risk... 
Probing the perils of dichotomous binning: how categorizing female dogs as spayed or intact can misinform our assumptions about the lifelong health consequences of ovariohysterectomyD J Waters
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, USA
Theriogenology 76:1496-500. 2011....- The art of casting nets: fishing for the prize of personalized cancer preventionDavid J Waters
The Center on Aging and the Life Course, Purdue University, and Gerald P Murphy Cancer Foundation West Lafayette, IN 47906, USA
Nutr Cancer 60:1-6. 2008..Every fisherman knows that where he casts his net determines his catch. Now, we ask: When it comes to solving the cancer problem, where should we be casting our nets?.. - Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogsDavid J Waters
Center for Exceptional Longevity Studies, Gerald P Murphy Cancer Foundation, 3000 Kent Avenue, West Lafayette, IN 47906, USA
Aging Cell 8:752-5. 2009..This work introduces a conceptual framework for designing additional studies in pet dogs to define the ovary-sensitive biological processes that promote healthy human longevity... - Prostate cancer risk and DNA damage: translational significance of selenium supplementation in a canine modelDavid J Waters
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907, USA
Carcinogenesis 26:1256-62. 2005.... - Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostateDavid J Waters
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907, USA
J Natl Cancer Inst 95:237-41. 2003..7 (interquartile range = 0.2-2.8) for the control dogs ( P =.04, Mann-Whitney U test). These data suggest that dietary selenium supplementation decreases DNA damage and increases epithelial cell apoptosis within the aging canine prostate... - Defining the Optimal Selenium Dose for Prostate Cancer Risk Reduction: Insights from the U-Shaped Relationship between Selenium Status, DNA Damage, and ApoptosisEmily C Chiang
Gerald P Murphy Cancer Foundation, West Lafayette, IN Interdepartmental Nutrition Program and The Center on Aging and the Life Course, Purdue University, West Lafayette, IN
Dose Response 8:285-300. 2009..8 ppm in toenails can achieve cancer risk reduction through daily supplementation... - Exceptional longevity in pet dogs is accompanied by cancer resistance and delayed onset of major diseasesDawn M Cooley
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, USA
J Gerontol A Biol Sci Med Sci 58:B1078-84. 2003..0001). The reduction in cancer mortality in oldest-old pet dogs mimics that seen in human centenarians and provides strong rationale for using this animal model to study comparative mechanisms of cancer resistance in the extreme aged... - Influence of host factors on survival in dogs with malignant mammary gland tumorsJeffrey C Philibert
Department of Veterinary Clinical Sciences, Purdue University School of Veterinary Medicine, West Lafayette, IN, USA
J Vet Intern Med 17:102-6. 2003..Further study of other prognostic factors is needed to determine which tumors are adequately addressed with local therapy only and which dogs may require adjuvant treatment with chemotherapy... - Cancer clues from pet dogsDavid J Waters
Purdue University, USA
Sci Am 295:94-101. 2006 - Making sense of sex and supplements: differences in the anticarcinogenic effects of selenium in men and womenDavid J Waters
Gerald P Murphy Cancer Foundation, 1291 Cumberland Ave, West Lafayette, IN 47906, USA
Mutat Res 551:91-107. 2004..Ultimately, achieving the ambitious goal of cancer prevention may require sex- and gender-specific approaches... - Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinomaMary Jo Turk
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
Cancer Lett 213:165-72. 2004..These results demonstrate that, in addition to their cancer cell-targeting properties, folate-liposomes may be useful for targeting drugs to tumor-associated macrophages in vivo... - Reevaluation of predictive factors for complete recovery in dogs with nonambulatory tetraparesis secondary to cervical disk herniationRobert B Hillman
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907 2026, USA
J Am Anim Hosp Assoc 45:155-63. 2009..Reliable preoperative predictors of complete recovery are needed to advance current diagnostic and treatment protocols to improve overall prognosis... - Cyclooxygenase inhibitors in urinary bladder cancer: in vitro and in vivo effectsSulma I Mohammed
Department of Veterinary Clinical Sciences, Purdue University, 625 Harrison Street, West Lafayette, IN 47907-2026, USA
Mol Cancer Ther 5:329-36. 2006..Athymic mice bearing TCC xenografts provide a useful in vivo system for COX inhibitor studies. Results of this study provide justification for further evaluation of COX inhibitors as antitumor agents against TCC... - Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized ratsLeecole L Legette
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
J Nutr 139:1908-13. 2009..Dietary equol had no stimulatory effect on mammary gland epithelium. We conclude that in OVX rats, a dietary equol dose that had modest effect on bone also exerts mild uterotropic effects... - Endogenous gonadal hormone exposure and bone sarcoma riskDawn M Cooley
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Cancer Epidemiol Biomarkers Prev 11:1434-40. 2002.... - Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticalsCarla J Mathias
Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
Nucl Med Biol 30:725-31. 2003..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers... - Nuclear imaging of Met-expressing human and canine cancer xenografts with radiolabeled monoclonal antibodies (MetSeek)Rick V Hay
Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
Clin Cancer Res 11:7064s-7069s. 2005..In this study, we compared two antibodies, Met5 and Met3, for nuclear imaging of human and canine Met-expressing tumor xenografts in nude mice... - RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survivalNariyoshi Shinomiya
Laboratory of Molecular Oncology, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
Cancer Res 64:7962-70. 2004..Thus, Met small-interfering RNA adenoviruses are reliable tools for studying Met function and raise the possibility of their application for cancer therapy... - Group consensus reports from the Consensus Conference on Focal Treatment of Prostatic Carcinoma, Celebration, Florida, February 24, 2006David G Bostwick
Bostwick Laboratories, Richmond, Virginia 23060, USA
Urology 70:42-4. 2007 - Human prostate cancer risk factorsDavid G Bostwick
Bostwick Laboratories, Richmond, Virginia 23294, USA
Cancer 101:2371-490. 2004..An understanding of the risk factors for prostate cancer has practical importance for public health research and policy, genetic and nutritional education and chemoprevention, and prevention strategies... - Preoperative prediction of multifocal prostate cancer and application of focal therapy: review 2007Isabelle Meiers
Bostwick Laboratories, Glen Allen, Virginia 23060, USA
Urology 70:3-8. 2007..This article reviews the importance of multifocal prostate cancer and the application of focal treatment...