Lynne S Taylor

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. doi request reprint Effects of polymer type and storage relative humidity on the kinetics of felodipine crystallization from amorphous solid dispersions
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 26:2599-606. 2009
  2. ncbi request reprint Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 7:477-90. 2010
  3. ncbi request reprint Recrystallization of nifedipine and felodipine from amorphous molecular level solid dispersions containing poly(vinylpyrrolidone) and sorbed water
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana, 47907 USA
    Pharm Res 25:647-56. 2008
  4. doi request reprint Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone)
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907
    J Pharm Sci 99:169-85. 2010
  5. ncbi request reprint Ability of different polymers to inhibit the crystallization of amorphous felodipine in the presence of moisture
    Hajime Konno
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    Pharm Res 25:969-78. 2008
  6. doi request reprint Crystallization of amorphous solid dispersions of resveratrol during preparation and storage-Impact of different polymers
    Lindsay A Wegiel
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 102:171-84. 2013
  7. doi request reprint Dissolution and precipitation behavior of amorphous solid dispersions
    David E Alonzo
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 100:3316-31. 2011
  8. doi request reprint Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 6:1492-505. 2009
  9. doi request reprint Evaluation of drug-polymer miscibility in amorphous solid dispersion systems
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana, 47907, USA
    Pharm Res 26:2523-34. 2009
  10. doi request reprint Determination of hydrate transition temperature using transformation kinetics obtained by Raman spectroscopy
    Håkan Wikström
    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    J Pharm Biomed Anal 49:247-52. 2009

Collaborators

Detail Information

Publications75

  1. doi request reprint Effects of polymer type and storage relative humidity on the kinetics of felodipine crystallization from amorphous solid dispersions
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 26:2599-606. 2009
    ..The objective of this study was to investigate the effects of polymer type and storage relative humidity (RH) on the crystallization kinetics of felodipine from amorphous solid dispersions...
  2. ncbi request reprint Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 7:477-90. 2010
    ....
  3. ncbi request reprint Recrystallization of nifedipine and felodipine from amorphous molecular level solid dispersions containing poly(vinylpyrrolidone) and sorbed water
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana, 47907 USA
    Pharm Res 25:647-56. 2008
    ..To compare the physical stability of amorphous molecular level solid dispersions of nifedipine and felodipine, in the presence of poly(vinylpyrrolidone) (PVP) and small amounts of moisture...
  4. doi request reprint Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone)
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907
    J Pharm Sci 99:169-85. 2010
    ..In conclusion, it appears that felodipine-PVP solid dispersions are susceptible to moisture-induced immiscibility when stored at a relative humidity >or=75%. In contrast, the solid dispersions remained miscible on heating...
  5. ncbi request reprint Ability of different polymers to inhibit the crystallization of amorphous felodipine in the presence of moisture
    Hajime Konno
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    Pharm Res 25:969-78. 2008
    ..To investigate the ability of various polymers to inhibit the crystallization of amorphous felodipine from amorphous molecular dispersions in the presence of absorbed moisture...
  6. doi request reprint Crystallization of amorphous solid dispersions of resveratrol during preparation and storage-Impact of different polymers
    Lindsay A Wegiel
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 102:171-84. 2013
    ..Polymers effective at inhibiting crystallization were identified, and it is rationalized that their effectiveness is based on the type and strength of their intermolecular interactions with resveratrol...
  7. doi request reprint Dissolution and precipitation behavior of amorphous solid dispersions
    David E Alonzo
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 100:3316-31. 2011
    ..The supersaturation generated upon dissolution of the solid dispersions was maintained for biologically relevant timeframes for the HPMC dispersions, whereas PVP appeared to be a less effective crystallization inhibitor...
  8. doi request reprint Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 6:1492-505. 2009
    ..The strength of drug-polymer interactions appears to be important in influencing the phase behavior...
  9. doi request reprint Evaluation of drug-polymer miscibility in amorphous solid dispersion systems
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana, 47907, USA
    Pharm Res 26:2523-34. 2009
    ..To evaluate drug-polymer miscibility behavior in four different drug-polymer amorphous solid dispersion systems, namely felodipine-poly(vinyl pyrrolidone) (PVP), nifedipine-PVP, ketoconazole-PVP, and felodipine-poly(acrylic acid) (PAA)...
  10. doi request reprint Determination of hydrate transition temperature using transformation kinetics obtained by Raman spectroscopy
    Håkan Wikström
    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    J Pharm Biomed Anal 49:247-52. 2009
    ..In general, good correlations with literature values were found. This method was found to be a simple, fast and reliable approach for the determination of crystal hydrate transition temperatures in aqueous environments...
  11. doi request reprint Effect of molecular weight, temperature, and additives on the moisture sorption properties of polyethylene glycol
    Jared A Baird
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 99:154-68. 2010
    ..This phenomenon may have important implications for the stability of PEG containing formulations...
  12. doi request reprint An investigation into the influence of counterion on the properties of some amorphous organic salts
    Christopher S Towler
    Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Mol Pharm 5:946-55. 2008
    ..Important parameters which influenced Tg included counterion pKa and electrophilicity index. In conclusion, it is apparent that, as for crystalline salts, the counterion has an effect on the properties of amorphous materials...
  13. ncbi request reprint Curcumin amorphous solid dispersions: the influence of intra and intermolecular bonding on physical stability
    Lindsay A Wegiel
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN, USA
    Pharm Dev Technol 19:976-86. 2014
    ..Overall, polymers proved to be crystallization inhibitors, but inhibition was limited due to the intramolecular hydrogen bonding in curcumin, which leads to a decrease in the ability of the polymers to interact at a molecular level...
  14. pmc Crystallization and dissolution behavior of naproxen/polyethylene glycol solid dispersions
    Qing Zhu
    School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Phys Chem B 117:1494-500. 2013
    ..The microstructure of the NAP/PEG solid dispersions and the dissolution behavior also showed a dependence on the chemical composition of the solid dispersions...
  15. pmc Understanding the tendency of amorphous solid dispersions to undergo amorphous-amorphous phase separation in the presence of absorbed moisture
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    AAPS PharmSciTech 12:1209-19. 2011
    ..In order to design a more physically stable ASD that is resistant to moisture-induced amorphous-amorphous phase separation, it is important to consider the interplay between these properties...
  16. ncbi request reprint Manipulating theophylline monohydrate formation during high-shear wet granulation through improved understanding of the role of pharmaceutical excipients
    Håkan Wikström
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 25:923-35. 2008
    ..To investigate the effect of common pharmaceutical excipients on the kinetics of theophylline monohydrate formation during high-shear wet granulation...
  17. ncbi request reprint Effect of temperature on the deliquescence properties of food ingredients and blends
    Rebecca A Lipasek
    Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907, United States
    J Agric Food Chem 61:9241-50. 2013
    ..Furthermore, the models can be used as a predictive approach to determine physical stability and deliquescence RHs of deliquescent ingredients and blends if the storage temperature and ingredient ΔH and solubility are known. ..
  18. doi request reprint Deliquescence of pharmaceutical systems
    Lisa J Mauer
    Department of Food Science, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Dev Technol 15:582-94. 2010
    ....
  19. ncbi request reprint Impact of counterion on the chemical stability of crystalline salts of procaine
    Peter Guerrieri
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 99:3719-30. 2010
    ..Thus it can be concluded that for procaine salts, the nature of the counterion plays a significant role in influencing solid-state stability...
  20. ncbi request reprint Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 23:2417-26. 2006
    ....
  21. doi request reprint Kinetic study of catechin stability: effects of pH, concentration, and temperature
    Na Li
    Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907, United States
    J Agric Food Chem 60:12531-9. 2012
    ..These results provide useful approaches for shelf life calculations and catechin loss predictions at given temperature and pH conditions in green tea concentrates...
  22. doi request reprint Small scale screening to determine the ability of different polymers to inhibit drug crystallization upon rapid solvent evaporation
    Bernard Van Eerdenbrugh
    Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Mol Pharm 7:1328-37. 2010
    ..The small scale screening method is thus a potentially useful technique to evaluate the role of drug-polymer chemistry in the stabilization of amorphous solid dispersions...
  23. doi request reprint Influence of simultaneous variations in temperature and relative humidity on chemical stability of two vitamin C forms and implications for shelf life models
    Ashley N Hiatt
    Department of Food Science, Purdue University, West Lafayette, Indiana 47907, USA
    J Agric Food Chem 58:3532-40. 2010
    ..This research highlights the importance of considering phase transformations when constructing shelf life models and maintaining vitamin C in the solid state for enhanced stability...
  24. ncbi request reprint Spontaneous crystallinity loss of drugs in the disordered regions of poly(ethylene oxide) in the presence of water
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 97:3182-94. 2008
    ..The equilibrium phase of several of the crystalline drugs studied here was then altered as evidenced by a loss in crystallinity...
  25. doi request reprint Evaluation and modeling of the eutectic composition of various drug-polyethylene glycol solid dispersions
    Jared A Baird
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Dev Technol 16:201-11. 2011
    ..In conclusion, for compounds with melting points less than 200°C, the model is ideally suited for predicting the eutectic composition of systems where there is an absence of drug-polymer interactions...
  26. doi request reprint Role of viscosity in influencing the glass-forming ability of organic molecules from the undercooled melt state
    Jared A Baird
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 29:271-84. 2012
    ..The objective of this study was to investigate potential links between viscosity and crystallization tendency for organic compounds from the undercooled melt state...
  27. ncbi request reprint Estimation of the transition temperature for an enantiotropic polymorphic system from the transformation kinetics monitored using Raman spectroscopy
    Yuerong Hu
    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907 2091, USA
    J Pharm Biomed Anal 45:546-51. 2007
    ..These results suggest that Raman spectroscopy may be a useful method to determine transition temperatures in systems not amenable to other methods...
  28. doi request reprint Rapid classification of pharmaceutical ingredients with Raman spectroscopy using compressive detection strategy with PLS-DA multivariate filters
    Derya Cebeci Maltaş
    Department of Chemistry, Purdue University, W Lafayette, IN 47907, USA
    J Pharm Biomed Anal 80:63-8. 2013
    ....
  29. ncbi request reprint Molecular weight effects on the miscibility behavior of dextran and maltodextrin with poly(vinylpyrrolidone)
    Bernard Van Eerdenbrugh
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Pharm Res 29:2754-65. 2012
    ..To characterize and interpret the miscibility of dextran and maltodextrin with poly(vinylpyrrolidone) (DEX-PVP) as a function of polymer molecular weights...
  30. doi request reprint Degradation kinetics of catechins in green tea powder: effects of temperature and relative humidity
    Na Li
    Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907, USA
    J Agric Food Chem 59:6082-90. 2011
    ..This study provides a powerful prediction approach for the shelf life of green tea powder and highlights the importance of glass transition in solid state kinetics studies...
  31. doi request reprint Study of water adsorption on organics crystal surfaces using a modified X-ray photoelectron spectroscopy instrument
    Peter Guerrieri
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 83:1144-7. 2011
    ....
  32. pmc Analysis of relationships between solid-state properties, counterion, and developability of pharmaceutical salts
    Peter Guerrieri
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    AAPS PharmSciTech 11:1212-22. 2010
    ..Important properties including aqueous solubility, melting point, hygroscopicity, and glass transition temperature were found to vary considerably between the different salts...
  33. ncbi request reprint Role of salt and excipient properties on disproportionation in the solid-state
    Peter Guerrieri
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 26:2015-26. 2009
    ..The aim of this study was to investigate the contributing factors in the process of disproportionation, whereby the salt converts back to the free form of the drug...
  34. ncbi request reprint A classification system to assess the crystallization tendency of organic molecules from undercooled melts
    Jared A Baird
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 99:3787-806. 2010
    ..In conclusion, the DSC screening method and classification scheme may be a useful tool to quickly assess the GFA and potential GS of new chemical entities during early drug development...
  35. doi request reprint Evaluation of the microstructure of semicrystalline solid dispersions
    Qing Zhu
    School of Chemical Engineering and Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 7:1291-300. 2010
    ..e., interlamellar, interfibrillar or interspherulitic regions) and size of the drug domains within the dispersion...
  36. ncbi request reprint Impact of deliquescence on the chemical stability of vitamins B1, B6, and C in powder blends
    Ashley N Hiatt
    Department of Food Science, Purdue University, 745 Agriculture Mall Drive and Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, W Lafayette, Indiana 47907, USA
    J Agric Food Chem 56:6471-9. 2008
    ....
  37. ncbi request reprint Water-solid interactions between amorphous maltodextrins and crystalline sodium chloride
    Mohamed K Ghorab
    Department of Food Science, Purdue University, 745 Agriculture Mall Drive, W Lafayette, IN 47907, USA Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, W Lafayette, IN 47907, USA
    Food Chem 144:26-35. 2014
    ..This has implications for quality control of many formulated powder products...
  38. doi request reprint Nanoscale mid-infrared evaluation of the miscibility behavior of blends of dextran or maltodextrin with poly(vinylpyrrolidone)
    Bernard Van Eerdenbrugh
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States
    Mol Pharm 9:1459-69. 2012
    ..AFM, combined with nanoscale mid-infrared analysis, thus appears to be a promising technique for the evaluation of miscibility in certain pharmaceutical blends...
  39. doi request reprint Water-solids interactions: deliquescence
    Lisa J Mauer
    Department of Food Science, Purdue University, West Lafayette, Indiana 47907, USA
    Annu Rev Food Sci Technol 1:41-63. 2010
    ....
  40. ncbi request reprint Crystallization tendency of active pharmaceutical ingredients following rapid solvent evaporation--classification and comparison with crystallization tendency from undercooled melts
    Bernard Van Eerdenbrugh
    Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    J Pharm Sci 99:3826-38. 2010
    ..Additional multivariate analysis on the separate classes of compounds indicated some potential in predicting the crystallization tendency of a given compound...
  41. doi request reprint Understanding the behavior of amorphous pharmaceutical systems during dissolution
    David E Alonzo
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Pharm Res 27:608-18. 2010
    ..Felodipine and indomethacin were used as model hydrophobic compounds...
  42. doi request reprint Effect of substrates on naproxen-polyvinylpyrrolidone solid dispersions formed via the drop printing technique
    Hsin Yun Hsu
    Department of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 102:638-48. 2013
    ..Finally, the collective results of the drug were correlated to the release profile of NAP within each sample...
  43. doi request reprint Impact of polymers on crystal growth rate of structurally diverse compounds from aqueous solution
    Grace A Ilevbare
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 10:2381-93. 2013
    ..20 and 0.91 mg min(-1) m(-2), respectively), while the normalized crystal growth rate of efavirenz was significantly higher (2.97 mg min(-1) m(-2)), resulting in lower levels of crystal growth inhibition by the polymers for efavirenz...
  44. doi request reprint pH-Induced precipitation behavior of weakly basic compounds: determination of extent and duration of supersaturation using potentiometric titration and correlation to solid state properties
    Yi Ling Hsieh
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA
    Pharm Res 29:2738-53. 2012
    ..To examine the precipitation and supersaturation behavior of ten weak bases in terms of the relationship between pH-concentration-time profiles and the solid state properties of the precipitated material...
  45. pmc Nonlinear optical imaging for sensitive detection of crystals in bulk amorphous powders
    Umesh S Kestur
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 101:4201-13. 2012
    ..In conclusion, SONICC has been found to be a sensitive technique for detecting low levels (0.1% or lower) of crystallinity, even in the presence of large quantities of a polymer...
  46. ncbi request reprint Effects of anticaking agents and relative humidity on the physical and chemical stability of powdered vitamin C
    Rebecca A Lipasek
    Dept of Food Sci, Purdue Univ, West Lafayette, IN 47907, USA
    J Food Sci 76:C1062-74. 2011
    ..Therefore, monitoring storage environmental conditions and anticaking agent usage are important for understanding the stability of vitamin C...
  47. doi request reprint Modification of crystallization behavior in drug/polyethylene glycol solid dispersions
    Qing Zhu
    School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
    Mol Pharm 9:546-53. 2012
    ....
  48. ncbi request reprint Kinetics of moisture-induced hydrolysis in powder blends stored at and below the deliquescence relative humidity: investigation of sucrose-citric acid mixtures
    Kaho Kwok
    Department of Industrial and Physical Pharmacy, 575 Stadium Mall Drive, Purdue University West Lafayette, IN 47907, USA
    J Agric Food Chem 58:11716-24. 2010
    ..A reaction mechanism initiated by capillary condensation and involving additional deliquescence lowering by the degradation products formed as a result of sucrose hydrolysis (glucose and fructose) was proposed...
  49. doi request reprint Analysis of counterfeit Cialis® tablets using Raman microscopy and multivariate curve resolution
    Kaho Kwok
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
    J Pharm Biomed Anal 66:126-35. 2012
    ..It was concluded that Raman microscopy combined with MCR is a powerful method to detect and analyze counterfeit tablets...
  50. doi request reprint Selective detection and quantitation of organic molecule crystallization by second harmonic generation microscopy
    Duangporn Wanapun
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 82:5425-32. 2010
    ..The results show that SONICC enables simultaneous monitoring of individual crystal growth, nucleation rate, and macroscopic crystallization kinetics...
  51. doi request reprint Phase behavior of ranitidine HCl in the presence of degradants and atmospheric moisture--impact on chemical stability
    Peter P Guerrieri
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    Langmuir 24:3850-6. 2008
    ..The increased mobility of molecules in solution presumably leads to enhanced reactivity relative to the crystalline material...
  52. ncbi request reprint A comparison of the physical stability of amorphous felodipine and nifedipine systems
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 23:2306-16. 2006
    ....
  53. ncbi request reprint Application of partial least-squares (PLS) modeling in quantifying drug crystallinity in amorphous solid dispersions
    Alfred C F Rumondor
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    Int J Pharm 398:155-60. 2010
    ....
  54. ncbi request reprint Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine
    Hajime Konno
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 95:2692-705. 2006
    ..It was speculated that, at the concentrations employed, the polymers reduce the nucleation rate through increasing the kinetic barrier to nucleation...
  55. doi request reprint Complex dielectric properties of microcrystalline cellulose, anhydrous lactose, and α-lactose monohydrate powders using a microwave-based open-reflection resonator sensor
    Pei Fang Sung
    Department of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 100:2920-34. 2011
    ....
  56. doi request reprint Influence of particle size on the ultraviolet spectrum of particulate-containing solutions: implications for in-situ concentration monitoring using UV/Vis fiber-optic probes
    Bernard Van Eerdenbrugh
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Pharm Res 28:1643-52. 2011
    ....
  57. doi request reprint Time-resolved SAXS/WAXS study of the phase behavior and microstructural evolution of drug/PEG solid dispersions
    Qing Zhu
    School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 8:932-9. 2011
    ..These factors are likely to impact the effectiveness of drug/PEG systems as drug delivery systems...
  58. doi request reprint Influence of additives on the properties of nanodroplets formed in highly supersaturated aqueous solutions of ritonavir
    Grace A Ilevbare
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana
    Mol Pharm 10:3392-403. 2013
    ....
  59. doi request reprint Mid-infrared spectroscopy as a polymer selection tool for formulating amorphous solid dispersions
    Lindsay A Wegiel
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN, USA
    J Pharm Pharmacol 66:244-55. 2014
    ..The objective of this study was to evaluate the use of mid-infrared (IR) spectroscopy for this purpose...
  60. doi request reprint Evaluation of amorphous solid dispersion properties using thermal analysis techniques
    Jared A Baird
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Adv Drug Deliv Rev 64:396-421. 2012
    ..Comprehensive characterization of fundamental material descriptors will ultimately lead to the formulation of more robust solid dispersion products...
  61. ncbi request reprint Nanoscale mid-infrared imaging of phase separation in a drug-polymer blend
    Bernard Van Eerdenbrugh
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 101:2066-73. 2012
    ....
  62. ncbi request reprint Monitoring of mannitol phase behavior during freeze-drying using non-invasive Raman spectroscopy
    Saly Romero-Torres
    Department of Chemistry, Purdue University, West Lafayette, IN 47907 2091, USA
    PDA J Pharm Sci Technol 61:131-45. 2007
    ..In conclusion, Raman spectroscopy is a potentially useful technique to monitor physical changes during freeze-drying...
  63. doi request reprint Application of mid-IR spectroscopy for the characterization of pharmaceutical systems
    Bernard Van Eerdenbrugh
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
    Int J Pharm 417:3-16. 2011
    ..Finally, an overview of current trends in FTIR-based imaging applications is provided, with special attention paid to currently emerging FTIR-AFM coupled techniques which have high spatial resolution...
  64. pmc Interaction of environmental moisture with powdered green tea formulations: relationship between catechin stability and moisture-induced phase transformations
    Julieta Ortiz
    Department of Food Science, Purdue University, West Lafayette, Indiana 47907, USA
    J Agric Food Chem 57:4691-7. 2009
    ..Catechin degradation was affected by T(g) of green tea powder and both dissolution and deliquescence of citric and ascorbic acids...
  65. ncbi request reprint Deliquescence-induced caking in binary powder blends
    Adnan K Salameh
    Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    Pharm Dev Technol 11:453-64. 2006
    ..In conclusion, the reduced deliquescence point in deliquescent solid mixtures was found to cause caking...
  66. ncbi request reprint Effect of small levels of impurities on the water vapor sorption behavior of ranitidine HCl
    Peter Guerrieri
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 24:147-56. 2007
    ..For mixtures of two or more deliquescent solids, RH0 will generally be lowered. The goal of this research was to investigate the effect of small amounts of impurities or degradants on RH0 for a model deliquescent pharmaceutical salt...
  67. ncbi request reprint Dissociation of water on the surface of organic salts studied by X-ray photoelectron spectroscopy
    Peter Guerrieri
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Langmuir 26:11998-2002. 2010
    ..The presence of highly reactive dissociated water on organic surfaces has important implications for the solid state chemical stability of these substances...
  68. ncbi request reprint Hyphenation of Raman spectroscopy with gravimetric analysis to interrogate water-solid interactions in pharmaceutical systems
    Alan D Gift
    Purdue University, Industrial and Physical Pharmacy, 575 Stadium Mall Dr, West Lafayette, IN 47907, United States
    J Pharm Biomed Anal 43:14-23. 2007
    ..Principle components analysis was found to be useful to aid in data processing, handling and interpretation of the spectral changes that occurred during the time course of the moisture sorption profile...
  69. ncbi request reprint Role of deliquescence lowering in enhancing chemical reactivity in physical mixtures
    Adnan K Salameh
    Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Phys Chem B 110:10190-6. 2006
    ..In conclusion, mixtures of deliquescent solids showed increased water sorption at lower RHs, which caused solid dissolution and subsequently led to an increase in the chemical reactivity...
  70. ncbi request reprint Comparison of sampling techniques for in-line monitoring using Raman spectroscopy
    Håkan Wikström
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Appl Spectrosc 59:934-41. 2005
    ....
  71. ncbi request reprint Deliquescence in binary mixtures
    Adnan K Salameh
    Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 22:318-24. 2005
    ..The goal of this research was to investigate the reduction in critical relative humidity (RH0) in binary solid mixtures of deliquescent active pharmaceutical ingredients (APIs) and deliquescent excipients...