Kavita Shah

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. Nikhil K, Chang L, Viccaro K, Jacobsen M, McGuire C, Satapathy S, et al. Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer. Cancer Lett. 2019;448:182-196 pubmed publisher
    ..As LIMK2 null mice are viable, targeting LIMK2 should have minimal collateral toxicity, thereby improving the overall survival of CRPC patients. ..
  2. Chaitanya M, Reddy P, Nikhil K, Kumar A, Shah K, Kumar D. Synthesis and anticancer activity studies of indolylisoxazoline analogues. Bioorg Med Chem Lett. 2018;28:2842-2845 pubmed publisher
    ..Finally, we show that compounds 6c and 6i also potently inhibit cell migration, indicating these compounds have the potential to serve as effective anti-cancer agents. ..
  3. Nikhil K, Viccaro K, Shah K. Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer's Disease Pathogenesis. Mol Neurobiol. 2019;56:1366-1390 pubmed publisher
    ..The bad Cdk5 prevails in the end, overriding the good Cdk5 act, suggesting that Cdk5 is an effective therapeutic target for AD. ..
  4. Tantak M, Wang J, Singh R, Kumar A, Shah K, Kumar D. 2-(3'-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities. Bioorg Med Chem Lett. 2015;25:4225-31 pubmed publisher
    ..Preliminary mechanism of action studies of thiazole carboxamide 17i suggested that its cytotoxicity against HeLa cells involves the induction of cell death by apoptosis. ..
  5. Venkataramana Reddy P, Hridhay M, Nikhil K, Khan S, Jha P, Shah K, et al. Synthesis and investigations into the anticancer and antibacterial activity studies of β-carboline chalcones and their bromide salts. Bioorg Med Chem Lett. 2018;28:1278-1282 pubmed publisher
    ..The most cytotoxic compound 13g possessed a relatively high drug score of 0.48. Additionally, the prepared β-carboline chalcones displayed moderate antibacterial activities against tested bacterial strains. ..
  6. Shah K, Lahiri D. A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5. Mol Neurobiol. 2017;54:2255-2268 pubmed publisher
  7. Tantak M, Gupta V, Nikhil K, Arun V, Singh R, Jha P, et al. Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities. Bioorg Med Chem Lett. 2016;26:3167-3171 pubmed publisher
    ..Most importantly, compounds 10d, 10g and 10i were completely ineffective in mammalian cells, suggesting that they target bacterial-specific targets and thus will not display any toxicity in host cells. ..
  8. Shi C, Viccaro K, Lee H, Shah K. Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models. J Cell Sci. 2016;129:1815-1830 pubmed publisher
    ..Collectively, these results show that Cdk5-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant A? processing, thereby contributing to the progression of neurodegenerative pathologies. ..
  9. Wang J, Nikhil K, Viccaro K, Chang L, White J, Shah K. Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer. BMC Biol. 2017;15:10 pubmed publisher

More Information

Publications14

  1. Shah K, Vincent F. Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts. Mol Biol Cell. 2005;16:5418-32 pubmed
    ..Finally, this study reveals a mechanism by which Src family kinases may control PDGF-mediated responses both at transcriptional and translational levels. ..
  2. Wang J, Nikhil K, Viccaro K, Chang L, Jacobsen M, Sandusky G, et al. The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma. J Cell Sci. 2017;130:1078-1093 pubmed publisher
    ..This is the first study that links Twist1 in a feedback loop with its activating kinase, which indicates that concurrent inhibition of AURKA and Twist1 will be synergistic in inhibiting pancreatic tumorigenesis and metastasis. ..
  3. Venkataramana Reddy P, Mishra S, Tantak M, Nikhil K, Sadana R, Shah K, et al. Design, synthesis and in vitro cytotoxicity studies of novel β-carbolinium bromides. Bioorg Med Chem Lett. 2017;27:1379-1384 pubmed publisher
    ..Additionally, the most potent β-carbolines 16l and 16s were found to inhibit tubulin polymerization. ..
  4. Shah K, Rossie S. Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain. Mol Neurobiol. 2018;55:3426-3438 pubmed publisher
    ..These substrates have unraveled the molecular mechanisms by which Cdk5 plays divergent roles in regulating neuronal actin cytoskeletal dynamics both in healthy and diseased states. ..
  5. Nikhil K, Shah K. The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease. J Cell Sci. 2017;130:3023-3039 pubmed publisher
    ..These results emphasize the potential of Mcl-1 upregulation as an attractive therapeutic strategy for delaying or preventing neurodegeneration in AD. ..