Research Topics
Species | MICHAEL ROSSMANNSummaryAffiliation: Purdue University Country: USA Publications
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Publications
Super-secondary structure: a historical perspectiveMichael G Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, IN, USA
Methods Mol Biol 932:1-4. 2013..Each fold can usually be associated with a specific function. Thus the active site of an enzyme is likely to be at the boundary between domains, each contributing a simple function to a more complex process...
Crystallography, evolution, and the structure of virusesMichael G Rossmann
Department of Biological Sciences, Hockmeyer Hall of Structural Biology, Purdue University, West Lafayette, Indiana 47907, USA
J Biol Chem 287:9552-9. 2012....- Viruses: sophisticated biological machinesMichael G Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2032, USA
Adv Exp Med Biol 726:1-3. 2012..This chapter provides an introduction to various viral molecular machines described in this book... - Morphogenesis of the T4 tail and tail fibersPetr G Leiman
Ecole Polytechnique Federale de Lausanne EPFL, Institut de Physique des Systemes Biologiques, BSP 415, CH 1015 Lausanne, Switzerland
Virol J 7:355. 2010..Structure determination of the rest of the subunits and intermediate complexes and the assembly of the hub still require further study... - From structure of the complex to understanding of the biologyMichael G Rossmann
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
Acta Crystallogr D Biol Crystallogr 63:9-16. 2007.... - Structure of the immature dengue virus at low pH primes proteolytic maturationI Mei Yu
Department of Biological Sciences, 915 West State Street, Purdue University, West Lafayette, IN 47907 2054, USA
Science 319:1834-7. 2008..These results suggest a mechanism by which flaviviruses are processed and stabilized in the host cell secretory pathway... 
Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its hostPetr G Leiman
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
Cell 118:419-29. 2004..A comparison with the metastable hexagonal baseplate of the mature virus shows that the baseplate proteins move as rigid bodies relative to each other during the structural change...- The flavivirus precursor membrane-envelope protein complex: structure and maturationLong Li
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Science 319:1830-4. 2008..The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host... - Structure and location of gene product 8 in the bacteriophage T4 baseplatePetr G Leiman
Department of Biological Sciences, Purdue University, Lilly Hall of Life Sciences, West Lafayette, IN 47907 2054, USA
J Mol Biol 328:821-33. 2003..With the structure determination of gp8, a total of 53% of the volume of the baseplate has now been interpreted in terms of its atomic structure... - Conformational changes of the flavivirus E glycoproteinYing Zhang
Department of Biological Sciences, Lilly Hall, 915 West State Street, Purdue University, West Lafayette, IN 47907, USA
Structure 12:1607-18. 2004..Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses... - The structure of gene product 6 of bacteriophage T4, the hinge-pin of the baseplateAnastasia A Aksyuk
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
Structure 17:800-8. 2009..However, the hinge angle between the N- and C-terminal parts of gp6 changes by approximately 15 degrees , accounting for a 10 A radial increase in the diameter of the gp6 ring... - Structure of the cell-puncturing device of bacteriophage T4Shuji Kanamaru
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-1392, USA
Nature 415:553-7. 2002..The amino-terminal, antiparallel beta-barrel domain of gp5 is inserted into a cylinder formed by three gp27 monomers, which may serve as a channel for DNA ejection... - Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGNElena Pokidysheva
Department of Biological Sciences, Lilly Hall, 915 W State Street, Purdue University, West Lafayette, IN 47907, USA
Cell 124:485-93. 2006..The use of carbohydrate moieties for receptor binding sites suggests a mechanism for avoiding immune surveillance... - The phiX174 protein J mediates DNA packaging and viral attachment to host cellsRicardo A Bernal
Department of Biological Sciences, Purdue University, Lilly Hall, 915 W State Street, West Lafayette, IN 47907-2054, USA
J Mol Biol 337:1109-22. 2004..Hence, the function of the J protein is to facilitate DNA packaging, as well as to mediate surface properties such as cell attachment and infection... - Structures of immature flavivirus particlesYing Zhang
Department of Biological Sciences, Lilly Hall, 915 West State Street, Purdue University, West Lafayette, IN 47907 2054, USA
EMBO J 22:2604-13. 2003.... - Asymmetric binding of transferrin receptor to parvovirus capsidsSusan Hafenstein
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
Proc Natl Acad Sci U S A 104:6585-9. 2007.... - Capturing a flavivirus pre-fusion intermediateBärbel Kaufmann
Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
PLoS Pathog 5:e1000672. 2009..The trapping of structural transition states by antibody fragments will be applicable for other processes in the flavivirus life cycle and delineating other cellular events that involve conformational rearrangements... - Parvovirus B19 does not bind to membrane-associated globoside in vitroBärbel Kaufmann
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
Virology 332:189-98. 2005..The biochemical results were further confirmed by cryo-electron microscopy image reconstructions at 10 A resolution, in which the structures of empty capsids were compared with empty capsids incubated with Gb4Cer... - Combining X-ray crystallography and electron microscopyMichael G Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 2054, USA
Structure 13:355-62. 2005..Factors affecting the quality of cryo-electron microscopy maps and limits of accuracy in fitting known structural fragments are discussed... - West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibodyBärbel Kaufmann
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
Proc Natl Acad Sci U S A 103:12400-4. 2006..The structure suggests that the E16 antibody neutralizes WNV by blocking the initial rearrangement of the E glycoprotein before fusion with a cellular membrane... - Structural studies of the giant mimivirusChuan Xiao
Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
PLoS Biol 7:e92. 2009..The three-dimensional cryoEM reconstruction reported here is of a virus with a volume that is one order of magnitude larger than any previously reported molecular assembly studied at a resolution of equal to or better than 65 Angstroms... - Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tailYe Xiang
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Proc Natl Acad Sci U S A 105:9552-7. 2008..Comparisons of the gp13(-) mutants with the phi29 mature and emptied phage structures suggest the sequence of events that occur during the penetration of the tail through the peptidoglycan layer... - Determinants of bacteriophage phi29 head morphologyKyung H Choi
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907
Structure 14:1723-7. 2006..One of the functions of the scaffolding protein, present in the prohead, may be to stabilize skewed hexamers during assembly... - The structure of the phage T4 DNA packaging motor suggests a mechanism dependent on electrostatic forcesSiyang Sun
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
Cell 135:1251-62. 2008..Similar mechanisms may occur in other molecular motors... - Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor moleculeChuan Xiao
Department of Biological Sciences, Purdue University, 915 W State St, West Layfayette, IN 47909 2054, USA
J Virol 78:10034-44. 2004..As HRV16 has fewer overall interactions with ICAM-1 than HRV14, the absence of this charge interaction has a greater impact on the binding of ICAM-1Kilifi to HRV16 than to HRV14... - In vitro-assembled alphavirus core-like particles maintain a structure similar to that of nucleocapsid cores in mature virusSuchetana Mukhopadhyay
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 1392, USA
J Virol 76:11128-32. 2002..This suggested that in the absence of membrane and glycoproteins, nucleocapsid core particles are fragile, lacking accurate icosahedral symmetry... - Structural studies of bacteriophage alpha3 assemblyRicardo A Bernal
Department of Biological Sciences, Purdue University, 1392 Lilly Hall, West Lafayette, IN 47907 1392, USA
J Mol Biol 325:11-24. 2003..The icosahedrally ordered structural component of the ssDNA appears to be substantially increased in alpha3 compared to phiX174, allowing the building of about 10% of the ribose-phosphate backbone... - The bacteriophage T4 DNA injection machineMichael G Rossmann
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
Curr Opin Struct Biol 14:171-80. 2004..In the center of the dome, there is a membrane-puncturing device, containing three lysozyme domains, which disrupts the intermembrane peptidoglycan layer during infection... - Picornavirus-receptor interactionsMichael G Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
Trends Microbiol 10:324-31. 2002..Binding into the canyon destabilizes the virus and thus initiates the uncoating process. By contrast, non-IgSF molecules, when used by picornaviruses as receptors, bind outside the canyon and do not cause viral instability... - John Edsall's influenceMichael G Rossmann
Department of Biological Science, Purdue University, West Lafayette, IN 47907-1392, USA
Biophys Chem 100:105-8. 2003 - Bacteriophage phi29 scaffolding protein gp7 before and after prohead assemblyMarc C Morais
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907-2054, USA
Nat Struct Biol 10:572-6. 2003.... - Structure of dengue virus: implications for flavivirus organization, maturation, and fusionRichard J Kuhn
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Cell 108:717-25. 2002..The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane... - Interpretation of electron density with stereographic roadmap projectionsChuan Xiao
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Struct Biol 158:182-7. 2007..The procedure can also be adapted for the investigation of various molecular interactions... - Visualization of membrane protein domains by cryo-electron microscopy of dengue virusWei Zhang
Department of Biological Sciences, Lilly Hall, 915 W State Street, Purdue University, West Lafayette, Indiana 47907, USA
Nat Struct Biol 10:907-12. 2003..This is one of only a few determinations of the disposition of transmembrane proteins in situ and shows that the nucleocapsid core and envelope proteins do not have a direct interaction in the mature virus... - The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteriaAnastasia A Aksyuk
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
EMBO J 28:821-9. 2009..It was shown that during contraction, gp18 subunits slide over each other with no apparent change in their structure... - Structure of the bacteriophage phi KZ lytic transglycosylase gp144Andrei Fokine
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 2054, USA
J Biol Chem 283:7242-50. 2008..The x-ray structure of the phi KZ transglycosylase complexed with the chitotetraose (N-acetylglucosamine)(4) has been determined to 2.6-A resolution. The N-acetylglucosamine residues of the chitotetraose bind in sites A-D... - The coiled-coil domain structure of the Sin Nombre virus nucleocapsid proteinSergei P Boudko
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
J Mol Biol 366:1538-44. 2007..Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule... - Crystal structure of CD155 and electron microscopic studies of its complexes with poliovirusesPing Zhang
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
Proc Natl Acad Sci U S A 105:18284-9. 2008..These results provide a detailed analysis of how a nonenveloped virus can enter its host cell... - The structure of the ATPase that powers DNA packaging into bacteriophage T4 procapsidsSiyang Sun
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907, USA
Mol Cell 25:943-9. 2007..The similarity of the packaging machines in the double-stranded DNA (dsDNA) bacteriophage T4 and dsRNA bacteriophage varphi12 is consistent with the evolution of many virions from a common ancestor... - Visualization of the externalized VP2 N termini of infectious human parvovirus B19Bärbel Kaufmann
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
J Virol 82:7306-12. 2008..The conserved glycine-rich region is positioned between two neighboring, fivefold-symmetrically related VP subunits and not in the fivefold channel as observed for other parvoviruses... - Structure of West Nile virusSuchetana Mukhopadhyay
Department of Biological Sciences, Purdue University, USA. West Lafayette, IN 47907, USA
Science 302:248. 2003 - Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibodyMickaël V Cherrier
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
EMBO J 28:3269-76. 2009..As these highly cross-reactive antibodies are often weakly neutralizing they also may contribute to antibody-dependent enhancement and flavi virus pathogenesis thereby complicating development of safe and effective vaccines... - Structural changes of bacteriophage phi29 upon DNA packaging and releaseYe Xiang
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-2054, USA
EMBO J 25:5229-39. 2006..Gene product 3, bound to the 5' ends of the genome, appears to be positioned within the expanded connector, which may potentiate the release of DNA-packaging machine components, creating a binding site for attachment of the tail... - A structural perspective of the flavivirus life cycleSuchetana Mukhopadhyay
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
Nat Rev Microbiol 3:13-22. 2005..This review focuses mainly on structural studies of dengue virus... - The structure of human parvovirus B19Bärbel Kaufmann
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
Proc Natl Acad Sci U S A 101:11628-33. 2004..8 A. Both viruses require an integrin as a coreceptor, and conserved surface features suggest a common receptor-binding region... - The crystal structure of coxsackievirus A21 and its interaction with ICAM-1Chuan Xiao
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
Structure 13:1019-33. 2005..The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1... - Structural studies of the Sputnik virophageSiyang Sun
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Virol 84:894-7. 2010..Hence, the origin of Sputnik's capsid might have been derived from other viruses prior to its association with mimivirus... - Conservation of the capsid structure in tailed dsDNA bacteriophages: the pseudoatomic structure of phi29Marc C Morais
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA
Mol Cell 18:149-59. 2005..7 A, respectively. Thus, phi29 joins the growing number of phages that utilize the HK97 capsid structure, suggesting that this protein fold may be as prevalent in capsids of dsDNA phages as the jelly roll fold is in eukaryotic viruses... - Mapping the structure and function of the E1 and E2 glycoproteins in alphavirusesSuchetana Mukhopadhyay
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Structure 14:63-73. 2006..The long E2 monomers, containing the cell receptor recognition motif at their extremities, are shown to rotate by about 180 degrees and to move away from the center of the spikes during fusion... - Cryo-EM structure of a bacteriophage T4 gp24 bypass mutant: the evolution of pentameric vertex proteins in icosahedral virusesAndrei Fokine
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Struct Biol 154:255-9. 2006..There are additional SOC molecules around the gp23* pentamers in the mutant virus that were not present around the gp24* pentamers in the wild-type virus... - Evolution of bacteriophage tails: Structure of T4 gene product 10Petr G Leiman
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Mol Biol 358:912-21. 2006..Such events are usual in the evolution of complex organelles from a common primordial molecule... - Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteinsShee Mei Lok
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
Nat Struct Mol Biol 15:312-7. 2008..The changes in the structure of the viral surface are presumably responsible for inhibiting attachment to cells... - Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complexYongning He
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
Proc Natl Acad Sci U S A 99:10325-9. 2002..Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF... - Structural comparison of different antibodies interacting with parvovirus capsidsSusan Hafenstein
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
J Virol 83:5556-66. 2009..Most of the exposed surface area was antigenic, although each of the antibodies had a common area of overlap that coincided with the positions of the previously mapped escape mutations... - The structure and evolution of the major capsid protein of a large, lipid-containing DNA virusNarayanasamy Nandhagopal
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Proc Natl Acad Sci U S A 99:14758-63. 2002.... - Interaction of decay-accelerating factor with coxsackievirus B3Susan Hafenstein
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Virol 81:12927-35. 2007..The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes... - Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compoundsYing Zhang
Department of Biological Sciences, Lilly Hall, Purdue University, 915 W. State St, West Lafayette, IN 47907-2054, USA
J Virol 78:11061-9. 2004..These data suggest that drug integration into the binding pocket during assembly, or at some other late stage in virus replication, may contribute to the antiviral activity of capsid binding compounds... - The tail structure of bacteriophage T4 and its mechanism of contractionVictor A Kostyuchenko
Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, Indiana 47907-2054, USA
Nat Struct Mol Biol 12:810-3. 2005..During contraction, the tail tube extends beneath the baseplate by about one-half of its total length and rotates by 345 degrees , allowing it to cross the host's periplasmic space... - Cryo-electron microscopy of the giant MimivirusChuan Xiao
Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907-2054, USA
J Mol Biol 353:493-6. 2005..A unique vertex, presumably for attachment and infection of the host, can be seen for particles that have a suitable orientation on the micrographs... - The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiationKyung H Choi
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
Proc Natl Acad Sci U S A 101:4425-30. 2004..The putative binding sites of previously reported BVDV inhibitors are also discussed... - Structural analyses of Phycodnaviridae and IridoviridaeAlan A Simpson
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054, USA
Acta Crystallogr D Biol Crystallogr 59:2053-9. 2003..The adoption of pseudo-hexagonal capsomers places these viruses into a subset of the Caspar and Klug surface lattices... - Minute virus of mice, a parvovirus, in complex with the Fab fragment of a neutralizing monoclonal antibodyBärbel Kaufmann
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Virol 81:9851-8. 2007..This finding suggests that the interaction of B7 with three symmetry-related viral subunits at each spike hinders structural transitions in the viral capsid essential during viral entry... - Structure of immature West Nile virusYing Zhang
Department of Biological Sciences, Purdue University, 915 W State St, West Lafayette, IN 47907 2054, USA
J Virol 81:6141-5. 2007..Comparison with the cryo-EM reconstruction of immature dengue virus established the locations of the N-linked glycosylation sites of these viruses, verifying the interpretation of the reconstructions of the immature flaviviruses... - Conformational switching by the scaffolding protein D directs the assembly of bacteriophage phiX174Marc C Morais
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
Mol Cell 15:991-7. 2004..Hence, comparison with the procapsid structure provides a rare opportunity to follow the conformational switching events necessary for the construction of complex macromolecular assemblies... - Genome packaging in virusesSiyang Sun
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
Curr Opin Struct Biol 20:114-20. 2010..Here we discuss various aspects of genome packaging and compare the mechanisms proposed for packaging motors on the basis of structural information... - Cryo-electron microscopy study of bacteriophage T4 displaying anthrax toxin proteinsAndrei Fokine
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
Virology 367:422-7. 2007.... - Structure of Bombyx mori densovirus 1, a silkworm pathogenBärbel Kaufmann
Department of Biological Sciences, Purdue University, 240 S Martin Jischke Drive, West Lafayette, IN 47907 2032, USA
J Virol 85:4691-7. 2011.... - Structural studies of Hantaan virusAnthony J Battisti
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Virol 85:835-41. 2011..However, a comparison of our results with the previous tomographic studies of the nonpathogenic Tula hantavirus indicates a common structural organization for hantaviruses... - The functional domains of bacteriophage t4 terminaseShuji Kanamaru
Department of Biology, The Catholic University of America, Washington, D C 20064, USA
J Biol Chem 279:40795-801. 2004..In conjunction with genetic evidence, these data suggest that the domains compete with the full-length gp17 for binding sites on the portal protein. A model for the assembly of the T4 DNA-packaging machine is presented... - Molecular dissection of ø29 scaffolding protein function in an in vitro assembly systemChi Yu Fu
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, AL35294, USA
J Mol Biol 366:1161-73. 2007..However, the secondary structure and the dimerization ability of these mutants are unchanged relative to wild-type, which suggests that the C terminus is the likely site of interaction with the capsid protein... - Multifunctional roles of a bacteriophage phi 29 morphogenetic factor in assembly and infectionDaniel N Cohen
Department of Microbiology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
J Mol Biol 378:804-17. 2008..gp13 may facilitate juxtaposition of the tail knob onto the cytoplasmic membrane and the triggering of genome injection... - Structure and assembly of icosahedral enveloped RNA virusesRichard J Kuhn
Markey Center for Structural Biology, Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Adv Virus Res 64:263-84. 2005 - Three-dimensional structure of bacteriophage T4 baseplateVictor A Kostyuchenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, 16/10 Miklukho-Maklaya Str, 117997 Moscow, Russia
Nat Struct Biol 10:688-93. 2003..The baseplate structure suggests a mechanism of baseplate triggering and structural transition during the initial stages of T4 infection... - The headful packaging nuclease of bacteriophage T4Tanfis I Alam
Department of Biology, The Catholic University of America, Washington, DC 20064, USA
Mol Microbiol 69:1180-90. 2008..These results lead to hypotheses concerning how phage headful nucleases cut the viral genomes before and after, but not during, DNA packaging... - Structural analysis of viral nucleocapsids by subtraction of partial projectionsYing Zhang
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Struct Biol 157:356-64. 2007..Furthermore, there was no evidence of any icosahedral symmetry within the nucleocapsid core... - Defining molecular and domain boundaries in the bacteriophage phi29 DNA packaging motorMarc C Morais
Department of Biochemistry and Molecular Biology, 301 University Boulevard, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
Structure 16:1267-74. 2008..They suggest an assembly pathway for the packaging motor and a mechanism for DNA translocation into empty proheads... - The tail lysozyme complex of bacteriophage T4Fumio Arisaka
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, 226 8510, Yokohama, Japan
Int J Biochem Cell Biol 35:16-21. 2003.... - The structure of porcine parvovirus: comparison with related virusesAlan A Simpson
Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, IN 47907-1392, USA
J Mol Biol 315:1189-98. 2002..These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions...
Research Grants
- Structure and Function of FlavivirusesMichael G Rossmann; Fiscal Year: 2010..Such information is essential for the development of antiviral drugs and vaccines and for determining the best response in the event of any possible epidemic. ..
- Structural studies of bacteriophage T4 and their potential medical applicationsMichael G Rossmann; Fiscal Year: 2010....
- Structure and Function of FlavivirusesMICHAEL ROSSMANN; Fiscal Year: 2009..Such information is essential for the development of antiviral drugs and vaccines and for determining the best response in the event of any possible epidemic. ..
- Structure and function of icosahedral virusesMICHAEL ROSSMANN; Fiscal Year: 2007..The human B19 parvovirus and other mammalian parvoviruses will be examined for their interactions with neutralizing antibodies. ..
- An Electron Microscope for the study of Complex Biological AssembliesMICHAEL ROSSMANN; Fiscal Year: 2006..The instrument would also allow us to perform tomographic studies at about 50 A resolution on pleomorphic viruses and cell organelles that lack structural homogeneity. ..
- HIV GAG PROTEINS FOR USE IN TARGETED DRUG DESIGNMICHAEL ROSSMANN; Fiscal Year: 2001....
- STRUCTURE OF HIV GAG PROTEINS AS ANTIVIRAL TARGETSMICHAEL ROSSMANN; Fiscal Year: 1993..Work on other gag related proteins, particularly of HIV pl7 and the p55 gag precursor, has been initiated with the same objective of eventually finding assembly and uncoating inhibitors...
- Structural studies of bacteriophage T4 and their potential medical applicationsMichael G Rossmann; Fiscal Year: 2011....