MICHAEL ROSSMANN

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. pmc Capturing a flavivirus pre-fusion intermediate
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Pathog 5:e1000672. 2009
  2. pmc Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization
    Siyang Sun
    Department of Biological Sciences, Purdue University, West Lafayette, United States
    elife 2:e00435. 2013
  3. pmc Structural changes of envelope proteins during alphavirus fusion
    Long Li
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, Indiana 47907 2054, USA
    Nature 468:705-8. 2010
  4. doi request reprint Structure of viruses: a short history
    Michael G Rossmann
    Department of Biological Sciences, 240 S Martin Jischke Drive, Purdue University, West Lafayette, IN 47907 2032, USA
    Q Rev Biophys 46:133-80. 2013
  5. doi request reprint Super-secondary structure: a historical perspective
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, West Lafayette, IN, USA
    Methods Mol Biol 932:1-4. 2013
  6. pmc Crystallography, evolution, and the structure of viruses
    Michael G Rossmann
    Department of Biological Sciences, Hockmeyer Hall of Structural Biology, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 287:9552-9. 2012
  7. doi request reprint Viruses: sophisticated biological machines
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2032, USA
    Adv Exp Med Biol 726:1-3. 2012
  8. pmc Morphogenesis of the T4 tail and tail fibers
    Petr G Leiman
    Ecole Polytechnique Federale de Lausanne EPFL, Institut de Physique des Systemes Biologiques, BSP 415, CH 1015 Lausanne, Switzerland
    Virol J 7:355. 2010
  9. pmc From structure of the complex to understanding of the biology
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Acta Crystallogr D Biol Crystallogr 63:9-16. 2007
  10. doi request reprint Structure of the immature dengue virus at low pH primes proteolytic maturation
    I Mei Yu
    Department of Biological Sciences, 915 West State Street, Purdue University, West Lafayette, IN 47907 2054, USA
    Science 319:1834-7. 2008

Research Grants

Collaborators

Detail Information

Publications81

  1. pmc Capturing a flavivirus pre-fusion intermediate
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Pathog 5:e1000672. 2009
    ..The trapping of structural transition states by antibody fragments will be applicable for other processes in the flavivirus life cycle and delineating other cellular events that involve conformational rearrangements...
  2. pmc Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization
    Siyang Sun
    Department of Biological Sciences, Purdue University, West Lafayette, United States
    elife 2:e00435. 2013
    ..The CHK-9, m10 and m242 antibodies surround the receptor-attachment site, probably inhibiting infection by blocking cell attachment. DOI:http://dx.doi.org/10.7554/eLife.00435.001...
  3. pmc Structural changes of envelope proteins during alphavirus fusion
    Long Li
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, Indiana 47907 2054, USA
    Nature 468:705-8. 2010
    ..The amino- and carboxy-terminal domains of E2 each form immunoglobulin-like folds, consistent with the receptor attachment properties of E2...
  4. doi request reprint Structure of viruses: a short history
    Michael G Rossmann
    Department of Biological Sciences, 240 S Martin Jischke Drive, Purdue University, West Lafayette, IN 47907 2032, USA
    Q Rev Biophys 46:133-80. 2013
    ..Currently some of these viruses are starting to be studied by combining X-ray crystallography with cryo-electron tomography. ..
  5. doi request reprint Super-secondary structure: a historical perspective
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, West Lafayette, IN, USA
    Methods Mol Biol 932:1-4. 2013
    ..Each fold can usually be associated with a specific function. Thus the active site of an enzyme is likely to be at the boundary between domains, each contributing a simple function to a more complex process...
  6. pmc Crystallography, evolution, and the structure of viruses
    Michael G Rossmann
    Department of Biological Sciences, Hockmeyer Hall of Structural Biology, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 287:9552-9. 2012
    ....
  7. doi request reprint Viruses: sophisticated biological machines
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2032, USA
    Adv Exp Med Biol 726:1-3. 2012
    ..This chapter provides an introduction to various viral molecular machines described in this book...
  8. pmc Morphogenesis of the T4 tail and tail fibers
    Petr G Leiman
    Ecole Polytechnique Federale de Lausanne EPFL, Institut de Physique des Systemes Biologiques, BSP 415, CH 1015 Lausanne, Switzerland
    Virol J 7:355. 2010
    ..Structure determination of the rest of the subunits and intermediate complexes and the assembly of the hub still require further study...
  9. pmc From structure of the complex to understanding of the biology
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Acta Crystallogr D Biol Crystallogr 63:9-16. 2007
    ....
  10. doi request reprint Structure of the immature dengue virus at low pH primes proteolytic maturation
    I Mei Yu
    Department of Biological Sciences, 915 West State Street, Purdue University, West Lafayette, IN 47907 2054, USA
    Science 319:1834-7. 2008
    ..These results suggest a mechanism by which flaviviruses are processed and stabilized in the host cell secretory pathway...
  11. ncbi request reprint Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its host
    Petr G Leiman
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
    Cell 118:419-29. 2004
    ..A comparison with the metastable hexagonal baseplate of the mature virus shows that the baseplate proteins move as rigid bodies relative to each other during the structural change...
  12. doi request reprint The flavivirus precursor membrane-envelope protein complex: structure and maturation
    Long Li
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Science 319:1830-4. 2008
    ..The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host...
  13. doi request reprint The structure of gene product 6 of bacteriophage T4, the hinge-pin of the baseplate
    Anastasia A Aksyuk
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    Structure 17:800-8. 2009
    ..However, the hinge angle between the N- and C-terminal parts of gp6 changes by approximately 15 degrees , accounting for a 10 A radial increase in the diameter of the gp6 ring...
  14. pmc Conformational changes of the flavivirus E glycoprotein
    Ying Zhang
    Department of Biological Sciences, Lilly Hall, 915 West State Street, Purdue University, West Lafayette, IN 47907, USA
    Structure 12:1607-18. 2004
    ..Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses...
  15. ncbi request reprint Structure and location of gene product 8 in the bacteriophage T4 baseplate
    Petr G Leiman
    Department of Biological Sciences, Purdue University, Lilly Hall of Life Sciences, West Lafayette, IN 47907 2054, USA
    J Mol Biol 328:821-33. 2003
    ..With the structure determination of gp8, a total of 53% of the volume of the baseplate has now been interpreted in terms of its atomic structure...
  16. ncbi request reprint Structure of the cell-puncturing device of bacteriophage T4
    Shuji Kanamaru
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 1392, USA
    Nature 415:553-7. 2002
    ..The amino-terminal, antiparallel beta-barrel domain of gp5 is inserted into a cylinder formed by three gp27 monomers, which may serve as a channel for DNA ejection...
  17. ncbi request reprint Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN
    Elena Pokidysheva
    Department of Biological Sciences, Lilly Hall, 915 W State Street, Purdue University, West Lafayette, IN 47907, USA
    Cell 124:485-93. 2006
    ..The use of carbohydrate moieties for receptor binding sites suggests a mechanism for avoiding immune surveillance...
  18. ncbi request reprint The phiX174 protein J mediates DNA packaging and viral attachment to host cells
    Ricardo A Bernal
    Department of Biological Sciences, Purdue University, Lilly Hall, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Mol Biol 337:1109-22. 2004
    ..Hence, the function of the J protein is to facilitate DNA packaging, as well as to mediate surface properties such as cell attachment and infection...
  19. pmc Structures of immature flavivirus particles
    Ying Zhang
    Department of Biological Sciences, Lilly Hall, 915 West State Street, Purdue University, West Lafayette, IN 47907 2054, USA
    EMBO J 22:2604-13. 2003
    ....
  20. ncbi request reprint Parvovirus B19 does not bind to membrane-associated globoside in vitro
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    Virology 332:189-98. 2005
    ..The biochemical results were further confirmed by cryo-electron microscopy image reconstructions at 10 A resolution, in which the structures of empty capsids were compared with empty capsids incubated with Gb4Cer...
  21. ncbi request reprint Combining X-ray crystallography and electron microscopy
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 2054, USA
    Structure 13:355-62. 2005
    ..Factors affecting the quality of cryo-electron microscopy maps and limits of accuracy in fitting known structural fragments are discussed...
  22. ncbi request reprint Determinants of bacteriophage phi29 head morphology
    Kyung H Choi
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907
    Structure 14:1723-7. 2006
    ..One of the functions of the scaffolding protein, present in the prohead, may be to stabilize skewed hexamers during assembly...
  23. pmc Structural studies of bacteriophage alpha3 assembly
    Ricardo A Bernal
    Department of Biological Sciences, Purdue University, 1392 Lilly Hall, West Lafayette, IN 47907 1392, USA
    J Mol Biol 325:11-24. 2003
    ..The icosahedrally ordered structural component of the ssDNA appears to be substantially increased in alpha3 compared to phiX174, allowing the building of about 10% of the ribose-phosphate backbone...
  24. doi request reprint The structure of the phage T4 DNA packaging motor suggests a mechanism dependent on electrostatic forces
    Siyang Sun
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    Cell 135:1251-62. 2008
    ..Similar mechanisms may occur in other molecular motors...
  25. pmc Structural studies of the giant mimivirus
    Chuan Xiao
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Biol 7:e92. 2009
    ..The three-dimensional cryoEM reconstruction reported here is of a virus with a volume that is one order of magnitude larger than any previously reported molecular assembly studied at a resolution of equal to or better than 65 Angstroms...
  26. pmc West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 103:12400-4. 2006
    ..The structure suggests that the E16 antibody neutralizes WNV by blocking the initial rearrangement of the E glycoprotein before fusion with a cellular membrane...
  27. ncbi request reprint Bacteriophage phi29 scaffolding protein gp7 before and after prohead assembly
    Marc C Morais
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
    Nat Struct Biol 10:572-6. 2003
    ....
  28. pmc Structure of dengue virus: implications for flavivirus organization, maturation, and fusion
    Richard J Kuhn
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Cell 108:717-25. 2002
    ..The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane...
  29. pmc In vitro-assembled alphavirus core-like particles maintain a structure similar to that of nucleocapsid cores in mature virus
    Suchetana Mukhopadhyay
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 1392, USA
    J Virol 76:11128-32. 2002
    ..This suggested that in the absence of membrane and glycoproteins, nucleocapsid core particles are fragile, lacking accurate icosahedral symmetry...
  30. pmc Asymmetric binding of transferrin receptor to parvovirus capsids
    Susan Hafenstein
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 104:6585-9. 2007
    ....
  31. ncbi request reprint John Edsall's influence
    Michael G Rossmann
    Department of Biological Science, Purdue University, West Lafayette, IN 47907 1392, USA
    Biophys Chem 100:105-8. 2003
  32. ncbi request reprint The bacteriophage T4 DNA injection machine
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
    Curr Opin Struct Biol 14:171-80. 2004
    ..In the center of the dome, there is a membrane-puncturing device, containing three lysozyme domains, which disrupts the intermembrane peptidoglycan layer during infection...
  33. pmc Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule
    Chuan Xiao
    Department of Biological Sciences, Purdue University, 915 W State St, West Layfayette, IN 47909 2054, USA
    J Virol 78:10034-44. 2004
    ..As HRV16 has fewer overall interactions with ICAM-1 than HRV14, the absence of this charge interaction has a greater impact on the binding of ICAM-1Kilifi to HRV16 than to HRV14...
  34. ncbi request reprint Picornavirus-receptor interactions
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    Trends Microbiol 10:324-31. 2002
    ..Binding into the canyon destabilizes the virus and thus initiates the uncoating process. By contrast, non-IgSF molecules, when used by picornaviruses as receptors, bind outside the canyon and do not cause viral instability...
  35. pmc Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail
    Ye Xiang
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:9552-7. 2008
    ..Comparisons of the gp13(-) mutants with the phi29 mature and emptied phage structures suggest the sequence of events that occur during the penetration of the tail through the peptidoglycan layer...
  36. pmc Visualization of the externalized VP2 N termini of infectious human parvovirus B19
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    J Virol 82:7306-12. 2008
    ..The conserved glycine-rich region is positioned between two neighboring, fivefold-symmetrically related VP subunits and not in the fivefold channel as observed for other parvoviruses...
  37. pmc The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein
    Sergei P Boudko
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    J Mol Biol 366:1538-44. 2007
    ..Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule...
  38. ncbi request reprint The structure of the ATPase that powers DNA packaging into bacteriophage T4 procapsids
    Siyang Sun
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907, USA
    Mol Cell 25:943-9. 2007
    ..The similarity of the packaging machines in the double-stranded DNA (dsDNA) bacteriophage T4 and dsRNA bacteriophage varphi12 is consistent with the evolution of many virions from a common ancestor...
  39. pmc The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria
    Anastasia A Aksyuk
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    EMBO J 28:821-9. 2009
    ..It was shown that during contraction, gp18 subunits slide over each other with no apparent change in their structure...
  40. pmc Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses
    Ping Zhang
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 105:18284-9. 2008
    ..These results provide a detailed analysis of how a nonenveloped virus can enter its host cell...
  41. ncbi request reprint Structure of the bacteriophage phi KZ lytic transglycosylase gp144
    Andrei Fokine
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 2054, USA
    J Biol Chem 283:7242-50. 2008
    ..The x-ray structure of the phi KZ transglycosylase complexed with the chitotetraose (N-acetylglucosamine)(4) has been determined to 2.6-A resolution. The N-acetylglucosamine residues of the chitotetraose bind in sites A-D...
  42. ncbi request reprint Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins
    Shee Mei Lok
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
    Nat Struct Mol Biol 15:312-7. 2008
    ..The changes in the structure of the viral surface are presumably responsible for inhibiting attachment to cells...
  43. pmc Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody
    Mickaël V Cherrier
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    EMBO J 28:3269-76. 2009
    ..As these highly cross-reactive antibodies are often weakly neutralizing they also may contribute to antibody-dependent enhancement and flavi virus pathogenesis thereby complicating development of safe and effective vaccines...
  44. ncbi request reprint Structure of West Nile virus
    Suchetana Mukhopadhyay
    Department of Biological Sciences, Purdue University, USA West Lafayette, IN 47907, USA
    Science 302:248. 2003
  45. ncbi request reprint A structural perspective of the flavivirus life cycle
    Suchetana Mukhopadhyay
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
    Nat Rev Microbiol 3:13-22. 2005
    ..This review focuses mainly on structural studies of dengue virus...
  46. ncbi request reprint Conservation of the capsid structure in tailed dsDNA bacteriophages: the pseudoatomic structure of phi29
    Marc C Morais
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA
    Mol Cell 18:149-59. 2005
    ..7 A, respectively. Thus, phi29 joins the growing number of phages that utilize the HK97 capsid structure, suggesting that this protein fold may be as prevalent in capsids of dsDNA phages as the jelly roll fold is in eukaryotic viruses...
  47. ncbi request reprint The crystal structure of coxsackievirus A21 and its interaction with ICAM-1
    Chuan Xiao
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
    Structure 13:1019-33. 2005
    ..The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1...
  48. pmc Interpretation of electron density with stereographic roadmap projections
    Chuan Xiao
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Struct Biol 158:182-7. 2007
    ..The procedure can also be adapted for the investigation of various molecular interactions...
  49. pmc Structural changes of bacteriophage phi29 upon DNA packaging and release
    Ye Xiang
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    EMBO J 25:5229-39. 2006
    ..Gene product 3, bound to the 5' ends of the genome, appears to be positioned within the expanded connector, which may potentiate the release of DNA-packaging machine components, creating a binding site for attachment of the tail...
  50. pmc Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses
    Suchetana Mukhopadhyay
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Structure 14:63-73. 2006
    ..The long E2 monomers, containing the cell receptor recognition motif at their extremities, are shown to rotate by about 180 degrees and to move away from the center of the spikes during fusion...
  51. pmc Visualization of membrane protein domains by cryo-electron microscopy of dengue virus
    Wei Zhang
    Department of Biological Sciences, Lilly Hall, 915 W State Street, Purdue University, West Lafayette, Indiana 47907, USA
    Nat Struct Biol 10:907-12. 2003
    ..This is one of only a few determinations of the disposition of transmembrane proteins in situ and shows that the nucleocapsid core and envelope proteins do not have a direct interaction in the mature virus...
  52. ncbi request reprint Cryo-EM structure of a bacteriophage T4 gp24 bypass mutant: the evolution of pentameric vertex proteins in icosahedral viruses
    Andrei Fokine
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Struct Biol 154:255-9. 2006
    ..There are additional SOC molecules around the gp23* pentamers in the mutant virus that were not present around the gp24* pentamers in the wild-type virus...
  53. ncbi request reprint Evolution of bacteriophage tails: Structure of T4 gene product 10
    Petr G Leiman
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Mol Biol 358:912-21. 2006
    ..Such events are usual in the evolution of complex organelles from a common primordial molecule...
  54. pmc Structural studies of the Sputnik virophage
    Siyang Sun
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Virol 84:894-7. 2010
    ..Hence, the origin of Sputnik's capsid might have been derived from other viruses prior to its association with mimivirus...
  55. pmc The structure of human parvovirus B19
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 101:11628-33. 2004
    ..8 A. Both viruses require an integrin as a coreceptor, and conserved surface features suggest a common receptor-binding region...
  56. pmc Structural comparison of different antibodies interacting with parvovirus capsids
    Susan Hafenstein
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    J Virol 83:5556-66. 2009
    ..Most of the exposed surface area was antigenic, although each of the antibodies had a common area of overlap that coincided with the positions of the previously mapped escape mutations...
  57. pmc The structure and evolution of the major capsid protein of a large, lipid-containing DNA virus
    Narayanasamy Nandhagopal
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 99:14758-63. 2002
    ....
  58. pmc Genome packaging in viruses
    Siyang Sun
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    Curr Opin Struct Biol 20:114-20. 2010
    ..Here we discuss various aspects of genome packaging and compare the mechanisms proposed for packaging motors on the basis of structural information...
  59. pmc Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex
    Yongning He
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    Proc Natl Acad Sci U S A 99:10325-9. 2002
    ..Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF...
  60. ncbi request reprint Cryo-electron microscopy of the giant Mimivirus
    Chuan Xiao
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Mol Biol 353:493-6. 2005
    ..A unique vertex, presumably for attachment and infection of the host, can be seen for particles that have a suitable orientation on the micrographs...
  61. ncbi request reprint The tail structure of bacteriophage T4 and its mechanism of contraction
    Victor A Kostyuchenko
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, Indiana 47907 2054, USA
    Nat Struct Mol Biol 12:810-3. 2005
    ..During contraction, the tail tube extends beneath the baseplate by about one-half of its total length and rotates by 345 degrees , allowing it to cross the host's periplasmic space...
  62. pmc Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds
    Ying Zhang
    Department of Biological Sciences, Lilly Hall, Purdue University, 915 W State St, West Lafayette, IN 47907 2054, USA
    J Virol 78:11061-9. 2004
    ..These data suggest that drug integration into the binding pocket during assembly, or at some other late stage in virus replication, may contribute to the antiviral activity of capsid binding compounds...
  63. ncbi request reprint Structural analyses of Phycodnaviridae and Iridoviridae
    Alan A Simpson
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Acta Crystallogr D Biol Crystallogr 59:2053-9. 2003
    ..The adoption of pseudo-hexagonal capsomers places these viruses into a subset of the Caspar and Klug surface lattices...
  64. pmc Structure of immature West Nile virus
    Ying Zhang
    Department of Biological Sciences, Purdue University, 915 W State St, West Lafayette, IN 47907 2054, USA
    J Virol 81:6141-5. 2007
    ..Comparison with the cryo-EM reconstruction of immature dengue virus established the locations of the N-linked glycosylation sites of these viruses, verifying the interpretation of the reconstructions of the immature flaviviruses...
  65. ncbi request reprint Conformational switching by the scaffolding protein D directs the assembly of bacteriophage phiX174
    Marc C Morais
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
    Mol Cell 15:991-7. 2004
    ..Hence, comparison with the procapsid structure provides a rare opportunity to follow the conformational switching events necessary for the construction of complex macromolecular assemblies...
  66. pmc Minute virus of mice, a parvovirus, in complex with the Fab fragment of a neutralizing monoclonal antibody
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Virol 81:9851-8. 2007
    ..This finding suggests that the interaction of B7 with three symmetry-related viral subunits at each spike hinders structural transitions in the viral capsid essential during viral entry...
  67. pmc The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation
    Kyung H Choi
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 101:4425-30. 2004
    ..The putative binding sites of previously reported BVDV inhibitors are also discussed...
  68. pmc Interaction of decay-accelerating factor with coxsackievirus B3
    Susan Hafenstein
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Virol 81:12927-35. 2007
    ..The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes...
  69. pmc Cryo-electron microscopy study of bacteriophage T4 displaying anthrax toxin proteins
    Andrei Fokine
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    Virology 367:422-7. 2007
    ....
  70. pmc Structure of Bombyx mori densovirus 1, a silkworm pathogen
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 240 S Martin Jischke Drive, West Lafayette, IN 47907 2032, USA
    J Virol 85:4691-7. 2011
    ....
  71. pmc Structural studies of Hantaan virus
    Anthony J Battisti
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Virol 85:835-41. 2011
    ..However, a comparison of our results with the previous tomographic studies of the nonpathogenic Tula hantavirus indicates a common structural organization for hantaviruses...
  72. ncbi request reprint The functional domains of bacteriophage t4 terminase
    Shuji Kanamaru
    Department of Biology, The Catholic University of America, Washington, D C 20064, USA
    J Biol Chem 279:40795-801. 2004
    ..In conjunction with genetic evidence, these data suggest that the domains compete with the full-length gp17 for binding sites on the portal protein. A model for the assembly of the T4 DNA-packaging machine is presented...
  73. ncbi request reprint Structure and assembly of icosahedral enveloped RNA viruses
    Richard J Kuhn
    Markey Center for Structural Biology, Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Adv Virus Res 64:263-84. 2005
  74. pmc Multifunctional roles of a bacteriophage phi 29 morphogenetic factor in assembly and infection
    Daniel N Cohen
    Department of Microbiology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Mol Biol 378:804-17. 2008
    ..gp13 may facilitate juxtaposition of the tail knob onto the cytoplasmic membrane and the triggering of genome injection...
  75. ncbi request reprint Three-dimensional structure of bacteriophage T4 baseplate
    Victor A Kostyuchenko
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, 16 10 Miklukho Maklaya str, 117997 Moscow, Russia
    Nat Struct Biol 10:688-93. 2003
    ..The baseplate structure suggests a mechanism of baseplate triggering and structural transition during the initial stages of T4 infection...
  76. pmc Structural analysis of viral nucleocapsids by subtraction of partial projections
    Ying Zhang
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Struct Biol 157:356-64. 2007
    ..Furthermore, there was no evidence of any icosahedral symmetry within the nucleocapsid core...
  77. ncbi request reprint The tail lysozyme complex of bacteriophage T4
    Fumio Arisaka
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, 226 8510, Yokohama, Japan
    Int J Biochem Cell Biol 35:16-21. 2003
    ....
  78. pmc Molecular dissection of ø29 scaffolding protein function in an in vitro assembly system
    Chi Yu Fu
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, AL35294, USA
    J Mol Biol 366:1161-73. 2007
    ..However, the secondary structure and the dimerization ability of these mutants are unchanged relative to wild-type, which suggests that the C terminus is the likely site of interaction with the capsid protein...
  79. pmc Defining molecular and domain boundaries in the bacteriophage phi29 DNA packaging motor
    Marc C Morais
    Department of Biochemistry and Molecular Biology, 301 University Boulevard, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Structure 16:1267-74. 2008
    ..They suggest an assembly pathway for the packaging motor and a mechanism for DNA translocation into empty proheads...
  80. ncbi request reprint The headful packaging nuclease of bacteriophage T4
    Tanfis I Alam
    Department of Biology, The Catholic University of America, Washington, DC 20064, USA
    Mol Microbiol 69:1180-90. 2008
    ..These results lead to hypotheses concerning how phage headful nucleases cut the viral genomes before and after, but not during, DNA packaging...
  81. ncbi request reprint The structure of porcine parvovirus: comparison with related viruses
    Alan A Simpson
    Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    J Mol Biol 315:1189-98. 2002
    ..These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions...

Research Grants17

  1. An Electron Microscope for the study of Complex Biological Assemblies
    MICHAEL ROSSMANN; Fiscal Year: 2006
    ..The instrument would also allow us to perform tomographic studies at about 50 A resolution on pleomorphic viruses and cell organelles that lack structural homogeneity. ..
  2. HIV GAG PROTEINS FOR USE IN TARGETED DRUG DESIGN
    MICHAEL ROSSMANN; Fiscal Year: 2001
    ....
  3. STRUCTURE OF HIV GAG PROTEINS AS ANTIVIRAL TARGETS
    MICHAEL ROSSMANN; Fiscal Year: 1993
    ..Work on other gag related proteins, particularly of HIV pl7 and the p55 gag precursor, has been initiated with the same objective of eventually finding assembly and uncoating inhibitors...
  4. Structure and function of icosahedral viruses
    MICHAEL ROSSMANN; Fiscal Year: 2007
    ..The human B19 parvovirus and other mammalian parvoviruses will be examined for their interactions with neutralizing antibodies. ..
  5. Structure and Function of Flaviviruses
    MICHAEL ROSSMANN; Fiscal Year: 2009
    ..Such information is essential for the development of antiviral drugs and vaccines and for determining the best response in the event of any possible epidemic. ..
  6. Structural studies of bacteriophage T4 and their potential medical applications
    Michael G Rossmann; Fiscal Year: 2010
    ....
  7. Structure and Function of Flaviviruses
    Michael G Rossmann; Fiscal Year: 2010
    ..Such information is essential for the development of antiviral drugs and vaccines and for determining the best response in the event of any possible epidemic. ..
  8. HIV GAG PROTEINS FOR USE IN TARGETED DRUG DESIGN
    MICHAEL ROSSMANN; Fiscal Year: 2000
    ....
  9. HIV GAG PROTEINS FOR USE IN TARGETED DRUG DESIGN
    MICHAEL ROSSMANN; Fiscal Year: 1999
    ....
  10. Structural studies of bacteriophage T4 and their potential medical applications
    Michael G Rossmann; Fiscal Year: 2011
    ....