Nagendra K Prasad

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. ncbi SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:13129-36. 2005
  2. doi High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival
    Nagendra K Prasad
    Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Tumour Biol 29:330-41. 2008
  3. ncbi SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Int J Oncol 34:97-105. 2009
  4. doi Specific tyrosine phosphorylations mediate signal-dependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activity
    Nagendra K Prasad
    Purdue Cancer Center and Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Biochemistry 48:6285-7. 2009
  5. ncbi Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, IN 47907, USA
    Carcinogenesis 29:25-34. 2008
  6. doi Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis
    Chenxu Yu
    Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA
    Biochem Biophys Res Commun 378:376-82. 2009

Detail Information

Publications6

  1. ncbi SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:13129-36. 2005
    ..Accordingly, we suggest that, in HeLa cells, SHIP2 plays a distinct role in signaling pathways mediated by integrins and growth factor receptors...
  2. doi High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival
    Nagendra K Prasad
    Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Tumour Biol 29:330-41. 2008
    ..0025) and overall survival periods (p = 0.0228). In invasive carcinomas, SHIP2 correlated with estrogen receptor absence (p = 0.003) and EGFR presence (p = 0.0147). In conclusion, SHIP2 is an important biomarker for breast cancer...
  3. ncbi SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Int J Oncol 34:97-105. 2009
    ..Finally, cell adhesion and EGF-induced cell migration were suppressed in SHIP2 silenced cells. These results demonstrate a positive role of SHIP2 in EGF-induced Akt activation, CXCR4 expression, and cell migration in breast cancer cells...
  4. doi Specific tyrosine phosphorylations mediate signal-dependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activity
    Nagendra K Prasad
    Purdue Cancer Center and Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Biochemistry 48:6285-7. 2009
    ..Thus, the SH2 domain of SHIP2, in conjunction with the C-terminus, confers an inhibitory effect to maintain a low basal activity, and signal-induced tyrosine phosphorylations overcome this effect to activate SHIP2...
  5. ncbi Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, IN 47907, USA
    Carcinogenesis 29:25-34. 2008
    ..Taken together, our results demonstrate that SHIP2 is a clinically relevant novel anticancer target that links perturbed metabolism to cancer development...
  6. doi Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis
    Chenxu Yu
    Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA
    Biochem Biophys Res Commun 378:376-82. 2009
    ..Surface kinetics could also serve as surrogate markers to predict biological outcome of signaling pathways...