R J Phillips

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. pmc Sympathetic axonopathies and hyperinnervation in the small intestine smooth muscle of aged Fischer 344 rats
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, United States Electronic address
    Auton Neurosci 179:108-21. 2013
  2. pmc Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?
    R J Phillips
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2091, USA
    Neurogastroenterol Motil 25:e621-33. 2013
  3. pmc Macrophages are unsuccessful in clearing aggregated alpha-synuclein from the gastrointestinal tract of healthy aged Fischer 344 rats
    Robert J Phillips
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2081, USA
    Anat Rec (Hoboken) 296:654-69. 2013
  4. ncbi request reprint Plasticity of vagal afferents at the site of an incision in the wall of the stomach
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, USA
    Auton Neurosci 123:44-53. 2005
  5. ncbi request reprint Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, United States
    Neurobiol Aging 28:1124-37. 2007
  6. ncbi request reprint Effects of age on sympathetic innervation of the myenteric plexus and gastrointestinal smooth muscle of Fischer 344 rats
    Robert J Phillips
    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Anat Embryol (Berl) 211:673-83. 2006
  7. pmc Innervation of the gastrointestinal tract: patterns of aging
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Auton Neurosci 136:1-19. 2007
  8. pmc Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease?
    R J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, USA
    Neuroscience 153:733-50. 2008
  9. pmc Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Exp Neurol 220:109-19. 2009
  10. pmc Age-related changes in vagal afferents innervating the gastrointestinal tract
    Robert J Phillips
    Purdue University, Ingestive Behavior Research Center, Department of Psychological Sciences, West Lafayette, IN 47907 2081, USA
    Auton Neurosci 153:90-8. 2010

Detail Information

Publications29

  1. pmc Sympathetic axonopathies and hyperinnervation in the small intestine smooth muscle of aged Fischer 344 rats
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, United States Electronic address
    Auton Neurosci 179:108-21. 2013
    ....
  2. pmc Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?
    R J Phillips
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2091, USA
    Neurogastroenterol Motil 25:e621-33. 2013
    ..The observations address age-associated changes in bowel function and are relevant to evaluations of SMP-containing colonic biopsies for SYNC or synucleinopathies associated with aging and peripheral neurodegenerative diseases...
  3. pmc Macrophages are unsuccessful in clearing aggregated alpha-synuclein from the gastrointestinal tract of healthy aged Fischer 344 rats
    Robert J Phillips
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2081, USA
    Anat Rec (Hoboken) 296:654-69. 2013
    ..Thus, accumulating deposits of insoluble α-SYNC in the wall of the GI tract may contribute, especially when compounded by disease or inflammation, to the age-associated neuropathies in the gut that compromise GI function...
  4. ncbi request reprint Plasticity of vagal afferents at the site of an incision in the wall of the stomach
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, USA
    Auton Neurosci 123:44-53. 2005
    ..Overall, the remodeling of afferents was aberrant in nature, and such neural pathology could contribute to the neuropathic symptoms and hyperalgesias associated with gastrointestinal trauma and bariatric surgery...
  5. ncbi request reprint Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, United States
    Neurobiol Aging 28:1124-37. 2007
    ..These findings point to selective deterioration of the SMP and its extrinsic inputs as one possible mechanism for the age-related decline in large intestinal function evidenced in the elderly...
  6. ncbi request reprint Effects of age on sympathetic innervation of the myenteric plexus and gastrointestinal smooth muscle of Fischer 344 rats
    Robert J Phillips
    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Anat Embryol (Berl) 211:673-83. 2006
    ..Therefore, in the aged rat, deterioration of the sympathetic innervation of the myenteric plexus could be one possible mechanism for the age-related decline in gastrointestinal motor function evidenced in the elderly...
  7. pmc Innervation of the gastrointestinal tract: patterns of aging
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Auton Neurosci 136:1-19. 2007
    ..These dramatic and consistent patterns of neuropathy that characterize the aging autonomic nervous system of the GI tract are candidate mechanisms for some of the age-related declines in function evidenced in the elderly...
  8. pmc Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease?
    R J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, USA
    Neuroscience 153:733-50. 2008
    ....
  9. pmc Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Exp Neurol 220:109-19. 2009
    ..Finally, this study establishes the utility of the aging Fischer 344 rat for the study of synucleopathies and tauopathies in the GI tract...
  10. pmc Age-related changes in vagal afferents innervating the gastrointestinal tract
    Robert J Phillips
    Purdue University, Ingestive Behavior Research Center, Department of Psychological Sciences, West Lafayette, IN 47907 2081, USA
    Auton Neurosci 153:90-8. 2010
    ..Given the clinical relevance of GI tract aging, a more complete understanding both of how aging alters the innervation of the gut and of how such changes might be mitigated should be made research priorities...
  11. ncbi request reprint Loss of glia and neurons in the myenteric plexus of the aged Fischer 344 rat
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Anat Embryol (Berl) 209:19-30. 2004
    ..Thus, an understanding of the nature of the neuron-glia interaction in the enteric nervous system may provide insight into the deterioration of function seen in the aged gut...
  12. ncbi request reprint Quantification of neurons in the myenteric plexus: an evaluation of putative pan-neuronal markers
    Robert J Phillips
    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907 2081, USA
    J Neurosci Methods 133:99-107. 2004
    ..Because the two protocols have different strengths and weaknesses, Cuprolinic Blue and HuC/D provide a complementary set of labels to study the total neuronal population of the ENS...
  13. ncbi request reprint Vagal afferent innervation of smooth muscle in the stomach and duodenum of the mouse: morphology and topography
    E A Fox
    Laboratory of Regulatory Psychobiology, Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Comp Neurol 428:558-76. 2000
    ..This survey should make it practical to assay the effects of genetic (e.g., knockout) and experimental (e.g., regeneration) manipulations affecting visceral afferents and their target tissues...
  14. ncbi request reprint Gastrointestinal projection maps of the vagus nerve are specified permanently in the perinatal period
    T L Powley
    Department of Psychological Sciences, Purdue University, 165 Peirce Hall, West Lafayette, IN 47907, USA
    Brain Res Dev Brain Res 129:57-72. 2001
    ....
  15. ncbi request reprint C-Kit mutant mice have a selective loss of vagal intramuscular mechanoreceptors in the forestomach
    E A Fox
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Anat Embryol (Berl) 204:11-26. 2001
    ....
  16. ncbi request reprint As the gut ages: timetables for aging of innervation vary by organ in the Fischer 344 rat
    R J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, Indiana 47907, USA
    J Comp Neurol 434:358-77. 2001
    ....
  17. ncbi request reprint Long-term regeneration of abdominal vagus: efferents fail while afferents succeed
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, Indiana 47907, USA
    J Comp Neurol 455:222-37. 2003
    ..Furthermore, the functional measures of disordered energy regulation did not normalize over the 45 weeks during which afferent but not efferent innervation was restored...
  18. ncbi request reprint Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety
    E A Fox
    Behavioral Neurogenetics Laboratory, Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurosci 21:8602-15. 2001
    ....
  19. ncbi request reprint Ultrastructural evidence for communication between intramuscular vagal mechanoreceptors and interstitial cells of Cajal in the rat fundus
    T L Powley
    Department of Psychological Sciences, Purdue University, West Lafayette, IN, USA
    Neurogastroenterol Motil 20:69-79. 2008
    ..Intraganglionic laminar ending varicosities contacted neuronal somata and dendrites in the myenteric plexus of the fundus, but no contacts with ICC associated with Auerbach's plexus were encountered...
  20. pmc Vagal intramuscular array afferents form complexes with interstitial cells of Cajal in gastrointestinal smooth muscle: analogues of muscle spindle organs?
    T L Powley
    Purdue University, West Lafayette, IN 47906, USA
    Neuroscience 186:188-200. 2011
    ..For electrophysiological assessments of IMA functions, experiments will need protocols that preserve both the complex architecture and the dynamic operations of IMA-ICC complexes...
  21. pmc Vagal sensory innervation of the gastric sling muscle and antral wall: implications for gastro-esophageal reflux disease?
    T L Powley
    Department of Psychological Sciences, Purdue University, West Lafayette, IN, USA
    Neurogastroenterol Motil 24:e526-37. 2012
    ..Thus, the present experiment used tracing techniques to label vagal afferents and survey their projections in the lesser curvature...
  22. pmc Versatile, high-resolution anterograde labeling of vagal efferent projections with dextran amines
    Gary C Walter
    Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907 2081, United States
    J Neurosci Methods 178:1-9. 2009
    ....
  23. ncbi request reprint Selective loss of vagal intramuscular mechanoreceptors in mice mutant for steel factor, the c-Kit receptor ligand
    Edward A Fox
    Behavioral Neurogenetics Laboratory, 1364 Psychological Sciences Building, Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Anat Embryol (Berl) 205:325-42. 2002
    ..These alterations suggest short-term feeding controls are affected by the loss of intramuscular arrays and/or intramuscular interstitial cells of Cajal, though long-term controls are unimpaired...
  24. ncbi request reprint Musings on the wanderer: what's new in our understanding of vago-vagal reflexes? I. Morphology and topography of vagal afferents innervating the GI tract
    Terry L Powley
    Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1217-25. 2002
    ..A full appreciation of vago-vagal reflexes will require thorough structural and regional analyses of each of the types of vagal receptors within the GI tract...
  25. ncbi request reprint Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons
    Robert J Phillips
    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907 2004, USA
    Auton Neurosci 106:69-83. 2003
    ..It appears, however, from the somatic hypertrophy and the presence of swollen axons that the nitrergic neurons are not completely spared from the effects of age...
  26. ncbi request reprint Obesity: should treatments target visceral afferents?
    Terry L Powley
    Purdue University, Department of Psychological Sciences, 703 Third St, West Lafayette, IN 47907, United States
    Physiol Behav 86:698-708. 2005
    ....
  27. ncbi request reprint Gastrointestinal tract innervation of the mouse: afferent regeneration and meal patterning after vagotomy
    Terry L Powley
    Dept of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
    Am J Physiol Regul Integr Comp Physiol 289:R563-R574. 2005
    ..Overall, the spatial and temporal patterns of structural and functional changes observed during regeneration verify that the mouse provides a useful preparation for examining the control of vagal plasticity...
  28. ncbi request reprint Gastric satiation is volumetric, intestinal satiation is nutritive
    Terry L Powley
    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Physiol Behav 82:69-74. 2004
    ..The two types of negative feedback synergize in the control of feeding, and both are carried by vagal afferents...
  29. ncbi request reprint The gastrointestinal tract "tastes" nutrients: evidence from the intestinal taste aversion paradigm
    Andrea L Tracy
    Department of Psychological Sciences, Purdue University, W Lafayette, IN 47907, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1086-100. 2004
    ..These results, along with additional controls, suggest that nutrient tastes detected in the intestines can be recognized centrally based on oropharyngeal gustatory stimulation...