NIKOLAOS A PEPPAS

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. ncbi request reprint Hydrogels in pharmaceutical formulations
    N A Peppas
    Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette IN 47907 1283, USA
    Eur J Pharm Biopharm 50:27-46. 2000
  2. ncbi request reprint Physicochemical foundations and structural design of hydrogels in medicine and biology
    N A Peppas
    Program on Therapeutic and Diagnostic Devices, Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907 1283, USA
    Annu Rev Biomed Eng 2:9-29. 2000
  3. ncbi request reprint Polymers and gels as molecular recognition agents
    Nicholas A Peppas
    Department of Biochemical Engineering, Purdue University, West Lafayette, Indiana 47907 1283, USA
    Pharm Res 19:578-87. 2002
  4. ncbi request reprint Responsive and recognitive hydrogels using star polymers
    Ebru Oral
    School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Biomed Mater Res A 68:439-47. 2004
  5. ncbi request reprint Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems
    Bumsang Kim
    Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 1283, USA
    J Biomater Sci Polym Ed 13:1271-81. 2002
  6. ncbi request reprint Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins
    Madeline Torres-Lugo
    NSF Program on Therapeutic and Diagnostic Devices, School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 1283, USA
    J Control Release 80:197-205. 2002
  7. ncbi request reprint Applications of biomimetic systems in drug delivery
    Siddarth Venkatesh
    Biomedical Devices and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn University, Auburn, AL 36849 5127, USA
    Expert Opin Drug Deliv 2:1085-96. 2005
  8. ncbi request reprint Assemblage of novel release modules for the development of adaptable drug delivery systems
    Elena Losi
    Pharmaceutical Department, University of Parma, Via delle Scienze 27 A, 43100 Parma, Italy
    J Control Release 111:212-8. 2006
  9. ncbi request reprint Is the oral route possible for peptide and protein drug delivery?
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Drug Discov Today 11:905-10. 2006
  10. ncbi request reprint Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems
    Laura Serra
    Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition Laboratories, University of Texas at Austin, Austin, TX 78712, USA
    Eur J Pharm Biopharm 63:11-8. 2006

Collaborators

  • M Morishita
  • James Blanchette
  • Michael H Smolensky
  • Laura Serra
  • Elena Losi
  • Siddarth Venkatesh
  • Aaron C Foss
  • Ebru Oral
  • Koji Nakamura
  • Bumsang Kim
  • Saia Baumgartner
  • Madeline Torres-Lugo
  • Kristine Lofthus
  • Fabio Sonvico
  • Jose Doménech
  • Paolo Colombo
  • Patrizia Santi
  • Ruggero Bettini
  • Gaia Colombo
  • J Zach Hilt
  • Mark E Byrne
  • Nikhil Kavimandan
  • Anthony M Lowman
  • Jeffrey I Joseph
  • Robert J Murray
  • Rae Record
  • Marcos Garcia
  • Julijana Kristl

Detail Information

Publications22

  1. ncbi request reprint Hydrogels in pharmaceutical formulations
    N A Peppas
    Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette IN 47907 1283, USA
    Eur J Pharm Biopharm 50:27-46. 2000
    ..The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices...
  2. ncbi request reprint Physicochemical foundations and structural design of hydrogels in medicine and biology
    N A Peppas
    Program on Therapeutic and Diagnostic Devices, Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907 1283, USA
    Annu Rev Biomed Eng 2:9-29. 2000
    ..Meanwhile, intelligent biohydrogels with pH- or temperature-sensitivity continue to be important materials in medical applications...
  3. ncbi request reprint Polymers and gels as molecular recognition agents
    Nicholas A Peppas
    Department of Biochemical Engineering, Purdue University, West Lafayette, Indiana 47907 1283, USA
    Pharm Res 19:578-87. 2002
    ..The results are encouraging for further investigation and design of synthetic gels with programmable collapsed structure might be achieved...
  4. ncbi request reprint Responsive and recognitive hydrogels using star polymers
    Ebru Oral
    School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Biomed Mater Res A 68:439-47. 2004
    ..Using copolymerization with methacrylic acid, we prepared star polymer networks with pH-sensitivity, which showed a sharp transition in swelling around a pH of 4.5...
  5. ncbi request reprint Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems
    Bumsang Kim
    Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 1283, USA
    J Biomater Sci Polym Ed 13:1271-81. 2002
    ..2) and between 70 and 111 A in the swollen state (at pH 7.0). Finally, as the cross-linking ratio of the copolymer increased, the swelling ratio of the hydrogels decreased at both pH 2.2 and 7.0...
  6. ncbi request reprint Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins
    Madeline Torres-Lugo
    NSF Program on Therapeutic and Diagnostic Devices, School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 1283, USA
    J Control Release 80:197-205. 2002
    ....
  7. ncbi request reprint Applications of biomimetic systems in drug delivery
    Siddarth Venkatesh
    Biomedical Devices and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn University, Auburn, AL 36849 5127, USA
    Expert Opin Drug Deliv 2:1085-96. 2005
    ..Biomimetic materials and systems are presented as exceptional candidates for various controlled drug delivery applications and have enormous potential in medicine for the treatment of disease...
  8. ncbi request reprint Assemblage of novel release modules for the development of adaptable drug delivery systems
    Elena Losi
    Pharmaceutical Department, University of Parma, Via delle Scienze 27 A, 43100 Parma, Italy
    J Control Release 111:212-8. 2006
    ..The module assemblage shows different drug release behavior depending on the geometry of assembled systems...
  9. ncbi request reprint Is the oral route possible for peptide and protein drug delivery?
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Drug Discov Today 11:905-10. 2006
    ..Clearly, it is essential that these approaches maintain the biological activity of the proteins...
  10. ncbi request reprint Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems
    Laura Serra
    Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition Laboratories, University of Texas at Austin, Austin, TX 78712, USA
    Eur J Pharm Biopharm 63:11-8. 2006
    ..AA functional groups allowed the polymer to form multiple hydrogen bonds with the glycoproteins present in the mucus. PEG tethers possibly acted as mucoadhesive promoters, enhancing interpenetration of polymer chains into the mucus...
  11. ncbi request reprint Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara, Shinagawa, Tokyo, Japan
    J Control Release 110:587-94. 2006
    ..These results indicate that the blood glucose levels of diabetic rats can be effectively controlled by oral SS-ILP administration, and thus SS-ILP would be a promising delivery carrier of insulin via the oral route...
  12. ncbi request reprint Oral chemotherapeutic delivery: design and cellular response
    James Blanchette
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712 0231, USA
    Ann Biomed Eng 33:142-9. 2005
    ..Complexation hydrogels are promising carriers to expand the number of chemotherapeutics capable of being administered orally...
  13. ncbi request reprint Biomimetic materials and micropatterned structures using iniferters
    Nicholas A Peppas
    Department of Chemical Engineering, CPE 3 466, 1 University Station, C 0400, The University of Texas at Austin, Austin, TX 78712 0231, USA
    Adv Drug Deliv Rev 56:1587-97. 2004
    ..The block copolymers would be used in the synthesis of micropatterned polymer films for use in biomaterials and other biomedical applications...
  14. ncbi request reprint Hydrogels for oral delivery of therapeutic proteins
    Nicholas A Peppas
    University of Texas at Austin, Laboratory for Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition, Department of Chemical Engineering, Austin, TX 78712, USA
    Expert Opin Biol Ther 4:881-7. 2004
    ..Most popular carriers include advanced designs of swollen hydrogels prepared from neutral or intelligent polymeric networks. In this review, the most successful of such systems are presented and their promise in the field described...
  15. ncbi request reprint Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 97:115-24. 2004
    ..These results imply that the particle size and delivery site are very important factors for ILP with respect to increasing the bioavailability of insulin following oral administration...
  16. ncbi request reprint Stimuli-sensitive hydrogels: ideal carriers for chronobiology and chronotherapy
    Nicholas A Peppas
    The University of Texas, Departments of Chemical Engineering and Biomedical Engineering and Division of Pharmaceutics, 1 University Station, C0400, CPE 3 466, Austin, TX 78712 0231, USA
    J Biomater Sci Polym Ed 15:125-44. 2004
    ..Here we examine how to design novel chrono-pharmacological drug-delivery systems that should be able to release the therapeutic agents at predetermined intervals...
  17. ncbi request reprint Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with Caco-2 cultures
    Aaron C Foss
    Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712 0231, USA
    Eur J Pharm Biopharm 57:447-55. 2004
    ..The copolymers were shown to open the tight junctions between cells, increasing the available area for diffusion across the cell monolayer, and thus increasing the permeability of insulin across the monolayer...
  18. ncbi request reprint Principles of transmucosal delivery of therapeutic agents
    James Blanchette
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Biomed Pharmacother 58:142-51. 2004
    ..The foundations of this research as well as recent advances are reviewed along with a discussion of the challenges of oral administration and other emerging strategies for oral administration...
  19. ncbi request reprint Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
    Koji Nakamura
    Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    J Control Release 95:589-99. 2004
    ..In these studies, bioavailabilities ranged from 4.6% to 7.2% and were dependent on reaction solvent content...
  20. ncbi request reprint Network structure of cellulose ethers used in pharmaceutical applications during swelling and at equilibrium
    Saia Baumgartner
    University of Ljubljana, Faculty of Pharmacy, Slovenia
    Pharm Res 19:1084-90. 2002
    ....
  21. ncbi request reprint Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, 142 8501, Tokyo, Japan
    J Control Release 81:25-32. 2002
    ..These data suggest that gels containing equimolar amounts of MAA:EG have the potential to be used as an oral carrier of peptide drugs, especially for insulin...
  22. ncbi request reprint Chronobiology, drug delivery, and chronotherapeutics
    Michael H Smolensky
    School of Public Health, RAS, W606, Division of Environmental and Occupational Health Sciences, The University of Texas Health Science Center at Houston, 1200 Herman Pressler, Houston, Texas 77030, USA
    Adv Drug Deliv Rev 59:828-51. 2007
    ....