Huaping Mo

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. pmc Receiver gain function: the actual NMR receiver gain
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    Magn Reson Chem 48:235-8. 2010
  2. pmc Solvent signal as an NMR concentration reference
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 80:9835-9. 2008
  3. doi request reprint Improved residual water suppression: WET180
    Huaping Mo
    Purdue Inter Departmental NMR Facility, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
    J Biomol NMR 41:105-11. 2008
  4. pmc R: A quantitative measure of NMR signal receiving efficiency
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    J Magn Reson 200:239-44. 2009
  5. pmc Pre-SAT180, a simple and effective method for residual water suppression
    Huaping Mo
    Purdue Inter Departmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    J Magn Reson 190:1-6. 2008
  6. pmc A quick diagnostic test for NMR receiver gain compression
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    Magn Reson Chem 48:782-6. 2010
  7. doi request reprint A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, United States
    Bioorg Med Chem Lett 20:6712-5. 2010
  8. doi request reprint NMR quantitation: influence of RF inhomogeneity
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    Magn Reson Chem 49:655-8. 2011
  9. pmc 13C-formylation for improved nuclear magnetic resonance profiling of amino metabolites in biofluids
    Tao Ye
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 82:2303-9. 2010
  10. pmc Synthesis of 15-methylene-eburnamonine from (+)-vincamine, evaluation of anticancer activity, and investigation of mechanism of action by quantitative NMR
    James R Woods
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States
    Bioorg Med Chem Lett 23:5865-9. 2013

Collaborators

  • G A Nagana Gowda
  • Daniel Raftery
  • Yi Gao
  • Lynne S Taylor
  • James R Woods
  • Tao Ye
  • Edward R Zartler
  • Jiangli Yan
  • Lingyan Liu
  • David A Colby
  • Markondaiah Bekkam
  • David E Alonzo
  • Shucha Zhang
  • David Flora
  • Gerard J A Kroon
  • Allen D Kline
  • Michael J Shapiro
  • Mary M Zheng
  • Julia Kirshner
  • Mark V Riofski
  • Melissa A O'Banion
  • David E Nichols
  • Siwei Wei
  • Andrew A Bieberich
  • Geoff G Z Zhang
  • Deliang Zhou
  • Tanja Alavanja
  • Fariba Tayyari
  • Narasimhamurthy Shanaiah
  • Liang Z Yan
  • M Amin Khan
  • John P Mayer
  • H Jane Dyson
  • Maria A Martinez-Yamout
  • Peter E Wright

Detail Information

Publications20

  1. pmc Receiver gain function: the actual NMR receiver gain
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    Magn Reson Chem 48:235-8. 2010
    ..The application of receiver gain function, along with the definition of receiving efficiency, allows easy concentration determination by a single internal or external concentration reference...
  2. pmc Solvent signal as an NMR concentration reference
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 80:9835-9. 2008
    ..The proposed method is robust and indifferent to probe tuning and does not require any additional concentration standard...
  3. doi request reprint Improved residual water suppression: WET180
    Huaping Mo
    Purdue Inter Departmental NMR Facility, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
    J Biomol NMR 41:105-11. 2008
    ..In addition, the principle of WET180 can be applied in multidimensional experiments to improve residual water suppression and reduce artifacts around water...
  4. pmc R: A quantitative measure of NMR signal receiving efficiency
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    J Magn Reson 200:239-44. 2009
    ....
  5. pmc Pre-SAT180, a simple and effective method for residual water suppression
    Huaping Mo
    Purdue Inter Departmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    J Magn Reson 190:1-6. 2008
    ....
  6. pmc A quick diagnostic test for NMR receiver gain compression
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    Magn Reson Chem 48:782-6. 2010
    ..As such, NMR signals, regardless of their observed amplitude difference in frequency domain, can be accurately compared in quantitative analysis...
  7. doi request reprint A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, United States
    Bioorg Med Chem Lett 20:6712-5. 2010
    ..Our proposed method is made possible by the combination of state-of-the-art NMR techniques including the solvent concentration reference and robust solvent suppressions...
  8. doi request reprint NMR quantitation: influence of RF inhomogeneity
    Huaping Mo
    Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA
    Magn Reson Chem 49:655-8. 2011
    ..Hence, a simple calibration of I(θ) can eliminate such errors and allow an accurate description of the observed NMR signal's dependence on the excitation angle in quantitative analysis...
  9. pmc 13C-formylation for improved nuclear magnetic resonance profiling of amino metabolites in biofluids
    Tao Ye
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 82:2303-9. 2010
    ..As amino compounds comprise an important class of metabolites and small molecules of biological roles, this new method therefore should be amenable to a variety of applications...
  10. pmc Synthesis of 15-methylene-eburnamonine from (+)-vincamine, evaluation of anticancer activity, and investigation of mechanism of action by quantitative NMR
    James R Woods
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States
    Bioorg Med Chem Lett 23:5865-9. 2013
    ..In the key synthetic step, a modified Peterson olefination was accomplished through the facile release of trifluoroacetate to create the requisite enone in the presence of substantial steric hindrance. ..
  11. doi request reprint Quantitative analysis of urea in human urine and serum by 1H nuclear magnetic resonance
    Lingyan Liu
    Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Dr, West Lafayette, IN 47907, USA
    Analyst 137:595-600. 2012
    ..With an ability to measure other metabolites simultaneously, this NMR method is also likely to find applications in metabolic profiling and system biology...
  12. pmc Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments
    James R Woods
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States
    J Med Chem 54:7934-41. 2011
    ..These mechanistic data with glutathione may contribute to the conversion of the amino-derivative to parthenolide, the active pharmacological agent, in glutathione-rich cancer cells...
  13. pmc Chemoselective 15N tag for sensitive and high-resolution nuclear magnetic resonance profiling of the carboxyl-containing metabolome
    Tao Ye
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 81:4882-8. 2009
    ..Carboxyl-containing compounds are found in almost all metabolic pathways, and thus this new approach should find a variety of applications...
  14. pmc A reported "new synthesis of lysergic acid" yields only the derailment product: methyl 5-methoxy-4,5-dihydroindolo[4,3-f,g]quinoline-9-carboxylate
    Markondaiah Bekkam
    Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Org Lett 14:296-8. 2012
    ....
  15. doi request reprint Dissolution and precipitation behavior of amorphous solid dispersions
    David E Alonzo
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 100:3316-31. 2011
    ..The supersaturation generated upon dissolution of the solid dispersions was maintained for biologically relevant timeframes for the HPMC dispersions, whereas PVP appeared to be a less effective crystallization inhibitor...
  16. pmc Changes in structure and dynamics of the Fv fragment of a catalytic antibody upon binding of inhibitor
    Gerard J A Kroon
    Department of Molecular Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Protein Sci 12:1386-94. 2003
    ..We conclude that the slow timescale motions in the antigen-binding site are very different in the bound and free forms of the Fv, presumably due to the damping of large-amplitude motions by the bound inhibitor...
  17. ncbi request reprint The effect of relaxation on the epitope mapping by saturation transfer difference NMR
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Co, Indianapolis, IN 46285, USA
    J Magn Reson 163:270-6. 2003
    ..A saturation time shorter than T1s is suggested for improving the potential epitope map. Reduction in temperature was seen to enhance the saturation efficiency in small to medium size targets...
  18. ncbi request reprint Detection and control of aspartimide formation in the synthesis of cyclic peptides
    David Flora
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 15:1065-8. 2005
    ..A straightforward protocol modification was developed to minimize aspartimide formation during the synthesis of cyclic peptides...
  19. ncbi request reprint Practical aspects of NMR-based fragment discovery
    Edward R Zartler
    Tessera Drug Discovery Consulting, Indianapolis, Indiana 46236, USA
    Curr Top Med Chem 7:1592-9. 2007
    ..The choice of which method to use will be different for every need. We discuss the different methods, the data they produce, and how they are best utilized in a FBDD setting...
  20. ncbi request reprint A novel method for the determination of stereochemistry in six-membered chairlike rings using residual dipolar couplings
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Org Chem 68:1786-95. 2003
    ..It was demonstrated that direct measurement of HMQC was quick and accurate for small molecules at natural abundance...