Philip Stewart Low

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. ncbi request reprint Folate-mediated delivery of macromolecular anticancer therapeutic agents
    Yingjuan Lu
    Department of Chemistry, 1393 Brown Building, Purdue University, West Lafayette, IN 47907, USA
    Adv Drug Deliv Rev 54:675-93. 2002
  2. ncbi request reprint Folate receptor-targeted drugs for cancer and inflammatory diseases
    Philip S Low
    Indiana University School of Medicine, 1044 West Walnut Street, R4 266, Indianapolis, IN 46202, USA
    Adv Drug Deliv Rev 56:1055-8. 2004
  3. ncbi request reprint Depletion of folate-receptor-positive macrophages leads to alleviation of symptoms and prolonged survival in two murine models of systemic lupus erythematosus
    Bindu Varghese
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Mol Pharm 4:679-85. 2007
  4. doi request reprint Label-free detection of a bacterial pathogen using an immobilized siderophore, deferoxamine
    Youngsoon Kim
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Lab Chip 12:971-6. 2012
  5. pmc A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity
    Yang Feng
    Protein Interactions Group, CCRNP, NCI Frederick, NIH, 1050 Boyle Street, Frederick, MD 21702, USA
    Arthritis Res Ther 13:R59. 2011
  6. pmc Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate
    Yingjuan Lu
    Endocyte, Inc, 3000 Kent Avenue, West Lafayette, IN 47906, USA
    Arthritis Res Ther 13:R56. 2011
  7. pmc Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis
    Chrystal M Paulos
    Department of Chemistry, 560 Oval Drive, 1393 Brown Bldg, Purdue University, West Lafayette, IN 47907 1175, USA
    Arthritis Res Ther 8:R77. 2006
  8. doi request reprint Folate-targeted therapeutic and imaging agents for cancer
    Philip Stewart Low
    Department of Chemistry, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA
    Curr Opin Chem Biol 13:256-62. 2009
  9. ncbi request reprint Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases
    Philip S Low
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Acc Chem Res 41:120-9. 2008
  10. ncbi request reprint Folate receptor-mediated drug targeting: from therapeutics to diagnostics
    Andrew R Hilgenbrink
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 94:2135-46. 2005

Research Grants

  1. Studies of Erythrocyte Membrane Structure
    Philip Stewart Low; Fiscal Year: 2010
  2. ERYTHROCYTE MEMBRANE STRUCTURE
    Philip Low; Fiscal Year: 2007
  3. Tumor-Specific Targeting of Folate-Derivatized Drugs
    Philip Low; Fiscal Year: 2004
  4. STUDIES OF ERYTHROCYTE MEMBRANE BAND 3
    Philip Low; Fiscal Year: 1990
  5. Studies of Erythrocyte Membrane Structure
    Philip Low; Fiscal Year: 2009

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Folate-mediated delivery of macromolecular anticancer therapeutic agents
    Yingjuan Lu
    Department of Chemistry, 1393 Brown Building, Purdue University, West Lafayette, IN 47907, USA
    Adv Drug Deliv Rev 54:675-93. 2002
    ..This review presents a brief mechanistic background of folate-targeted macromolecular therapeutics and then summarizes the successes and failures observed with each major application of the technology...
  2. ncbi request reprint Folate receptor-targeted drugs for cancer and inflammatory diseases
    Philip S Low
    Indiana University School of Medicine, 1044 West Walnut Street, R4 266, Indianapolis, IN 46202, USA
    Adv Drug Deliv Rev 56:1055-8. 2004
  3. ncbi request reprint Depletion of folate-receptor-positive macrophages leads to alleviation of symptoms and prolonged survival in two murine models of systemic lupus erythematosus
    Bindu Varghese
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Mol Pharm 4:679-85. 2007
    ....
  4. doi request reprint Label-free detection of a bacterial pathogen using an immobilized siderophore, deferoxamine
    Youngsoon Kim
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Lab Chip 12:971-6. 2012
    ....
  5. pmc A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity
    Yang Feng
    Protein Interactions Group, CCRNP, NCI Frederick, NIH, 1050 Boyle Street, Frederick, MD 21702, USA
    Arthritis Res Ther 13:R59. 2011
    ..In this study we aimed to develop an FRβ-specific human monoclonal antibody (mAb) that could be used as a therapeutic agent to treat rheumatoid arthritis and other autoimmune diseases, as well as FRβ positive cancers...
  6. pmc Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate
    Yingjuan Lu
    Endocyte, Inc, 3000 Kent Avenue, West Lafayette, IN 47906, USA
    Arthritis Res Ther 13:R56. 2011
    ..To target such a macrophage population, we designed and evaluated the biologic activity of EC0746, a novel folic acid conjugate of the highly potent antifolate, aminopterin...
  7. pmc Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis
    Chrystal M Paulos
    Department of Chemistry, 560 Oval Drive, 1393 Brown Bldg, Purdue University, West Lafayette, IN 47907 1175, USA
    Arthritis Res Ther 8:R77. 2006
    ..We conclude that reduction of activated macrophages by folate-targeted immunotherapy can ameliorate the symptoms of arthritis in two rodent models of the disease...
  8. doi request reprint Folate-targeted therapeutic and imaging agents for cancer
    Philip Stewart Low
    Department of Chemistry, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA
    Curr Opin Chem Biol 13:256-62. 2009
    ..Based on this strategy, six folate-targeted drugs are currently in human clinical trials...
  9. ncbi request reprint Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases
    Philip S Low
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Acc Chem Res 41:120-9. 2008
    ..This Account summarizes the discovery and development of a variety of folate-targeted drugs for the diagnosis and therapy of cancers and inflammatory/autoimmune diseases...
  10. ncbi request reprint Folate receptor-mediated drug targeting: from therapeutics to diagnostics
    Andrew R Hilgenbrink
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 94:2135-46. 2005
    ..This review will summarize the applications of folic acid as a targeting ligand and highlight the various methods being developed for delivery of therapeutic and imaging agents to FR-expressing cells...
  11. doi request reprint Tumor detection using folate receptor-targeted imaging agents
    Emanuela I Sega
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Cancer Metastasis Rev 27:655-64. 2008
    ....
  12. ncbi request reprint Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells
    Dina A Andrews
    Department of Veterinary Pathobiology, Purdue University, 1243 Veterinary Pathology Building, West Lafayette, IN 47907 1243, USA
    Blood 100:3392-9. 2002
    ..These studies indicate that an omega-agatoxin-TK-sensitive, Ca(v)2.1-like calcium permeability pathway is present in the RBC membrane and that it may function under the control of kinases and phosphatases...
  13. doi request reprint Targeting of nanoparticles: folate receptor
    Sumith A Kularatne
    Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN, USA
    Methods Mol Biol 624:249-65. 2010
    ....
  14. ncbi request reprint Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinoma
    Mary Jo Turk
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Cancer Lett 213:165-72. 2004
    ..These results demonstrate that, in addition to their cancer cell-targeting properties, folate-liposomes may be useful for targeting drugs to tumor-associated macrophages in vivo...
  15. doi request reprint Real time, noninvasive imaging and quantitation of the accumulation of ligand-targeted drugs into receptor-expressing solid tumors
    Erina Vlashi
    Department of Chemistry and Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Pharm 6:1868-75. 2009
    ..We conclude that low molecular weight ligand-targeted drugs have appropriate pharmacokinetic properties for tumor-selective delivery...
  16. doi request reprint Low-dose radiation potentiates the therapeutic efficacy of folate receptor-targeted hapten therapy
    Emanuela I Sega
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Int J Radiat Oncol Biol Phys 71:559-66. 2008
    ..In an effort to enhance the efficacy of folate-targeted hapten immunotherapy (FTHI) against large tumors, we explored the combination of targeted hapten immunotherapy with low-dose radiotherapy...
  17. ncbi request reprint Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis
    Chrystal M Paulos
    Department of Chemistry, 560 Oval Drive, 1393 Brown Bldg, Purdue University, West Lafayette, IN 47907, USA
    Adv Drug Deliv Rev 56:1205-17. 2004
    ....
  18. ncbi request reprint Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential
    Yingjuan Lu
    Endocyte, Inc, 1205 Ken Avenue, West Lafayette, IN 47906, USA
    Adv Drug Deliv Rev 56:1161-76. 2004
    ....
  19. doi request reprint A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
    Wei Xia
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Blood 113:438-46. 2009
    ..This trial was registered at www.clinicaltrials.gov as #NCT00588393...
  20. ncbi request reprint Optical imaging of metastatic tumors using a folate-targeted fluorescent probe
    Michael D Kennedy
    Purdue University, Department of Chemistry, West Lafayette, Indiana 47907, USA
    J Biomed Opt 8:636-41. 2003
    ..The sharp distinction between tumor and normal tissues provided by this technique could find application in the localization and resection of tumor tissue during surgery or in the enhanced endoscopic detection and staging of cancers...
  21. ncbi request reprint Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals
    Carla J Mathias
    Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
    Nucl Med Biol 30:725-31. 2003
    ..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers...
  22. doi request reprint Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues
    Mini Thomas
    Department of Chemistry, Purdue University, West Lafayette, Indiana, USA
    Ann N Y Acad Sci 1175:32-9. 2009
    ..Using these ligands, we show remarkable receptor-mediated targeting of siRNA to cancer tissues in vitro and in vivo...
  23. ncbi request reprint Synthesis and activity of a folate peptide camptothecin prodrug
    Walter A Henne
    Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Bioorg Med Chem Lett 16:5350-5. 2006
    ..Activity of the prodrug was completely blocked by excess folic acid, demonstrating receptor-mediated uptake...
  24. ncbi request reprint Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis
    Mary Jo Turk
    Purdue University, West Lafayette, Indiana 47907, USA
    Arthritis Rheum 46:1947-55. 2002
    ..To determine whether overexpression of the high-affinity folate receptor (FR) on activated macrophages can be exploited to selectively target imaging agents to sites of inflammation in rats with adjuvant-induced arthritis (AIA)...
  25. ncbi request reprint Synthesis and evaluation of 99mTc(CO)(3)-DTPA-folate as a folate-receptor-targeted radiopharmaceutical
    David P Trump
    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, USA
    Nucl Med Biol 29:569-73. 2002
    ..Tumor uptake was reduced when folic acid was co-administered with the intravenous [99mTc]Tc(CO)(3)DTPA-folate, consistent with radiopharmaceutical localization being mediated by the folate receptor...
  26. doi request reprint Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophages
    Wilfredo Ayala-López
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Nucl Med 51:768-74. 2010
    ....
  27. ncbi request reprint Folate receptor-targeted immunotherapy: induction of humoral and cellular immunity against hapten-decorated cancer cells
    Yingjuan Lu
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Int J Cancer 116:710-9. 2005
    ....
  28. ncbi request reprint Folate-targeted dinitrophenyl hapten immunotherapy: effect of linker chemistry on antitumor activity and allergic potential
    Yingjuan Lu
    Endocyte Inc, West Lafayette, IN 47906, USA
    Mol Pharm 4:695-706. 2007
    ....
  29. ncbi request reprint Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery
    Chrystal M Paulos
    Department of Chemistry, Purdue University, West Lafayette, Indiana, USA
    Mol Pharmacol 66:1406-14. 2004
    ....
  30. doi request reprint Folate-targeted hapten immunotherapy of adjuvant-induced arthritis: comparison of hapten potencies
    Young Su Yi
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 2084, USA
    Mol Pharm 6:1228-36. 2009
    ..We conclude that both folate-TNP and folate-FITC constitute promising haptens for use in FR-targeted immunotherapy of arthritis...
  31. ncbi request reprint Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects
    Yingjuan Lu
    Endocyte, Inc, 1205 Kent Ave, West Lafayette, IN 47906, USA
    J Control Release 91:17-29. 2003
    ....
  32. ncbi request reprint Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates
    Jun Yang
    Department of Chemistry, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    J Pharmacol Exp Ther 321:462-8. 2007
    ..5). Taken together, these data argue that the FR-trafficking pathway does not involve acidic compartments and that acyl hydrazone linkers may constitute a poor option for FR-mediated drug delivery...
  33. ncbi request reprint Immunomagnetic diffractometry for detection of diagnostic serum markers
    Ghanashyam Acharya
    Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Chem Soc 129:15824-9. 2007
    ..With this approach, a detection sensitivity of 700 fM (20 pg/mL) was achieved. The potential use of this approach in clinical diagnostics was demonstrated by measuring FR concentration in blood samples obtained from cancer patients...
  34. pmc Characterization of the deoxyhemoglobin binding site on human erythrocyte band 3: implications for O2 regulation of erythrocyte properties
    Haiyan Chu
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Blood 111:932-8. 2008
    ..1 and ankyrin, suggesting possible mechanisms through which multifarious erythrocyte properties might be regulated by the oxygenation state of the cell...
  35. ncbi request reprint Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    Nikki Parker
    Endocyte Inc, West Lafayette, IN 47906, USA
    Anal Biochem 338:284-93. 2005
    ..Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics...
  36. ncbi request reprint Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHs
    Mary Jo Turk
    Department of Chemistry, Purdue University, 1393 Brown Building, West Lafayette, IN 47907, USA
    Biochim Biophys Acta 1559:56-68. 2002
    ..We conclude that intracellular unloading of liposomal contents can be significantly improved by co-encapsulation of an optimally designed, pH-sensitive peptide...
  37. ncbi request reprint Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors
    Yingjuan Lu
    Department of Chemistry, 1393 Brown Building, Purdue University, West Lafayette, IN 47907, USA
    Cancer Immunol Immunother 51:153-62. 2002
    ..These data suggest that retargeting of haptens to folate receptor-expressing cancers might constitute a method for mobilizing the immune system specifically against poorly immunogenic tumors...
  38. ncbi request reprint Identification of a critical ankyrin-binding loop on the cytoplasmic domain of erythrocyte membrane band 3 by crystal structure analysis and site-directed mutagenesis
    Seon Hee Chang
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 278:6879-84. 2003
    ..These data thus suggest that the NH(2) terminus of cdb3 is proximal to but not required for the cdb3-ankyrin interaction...
  39. doi request reprint Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imaging
    Hongtao Chen
    Department of Chemistry, Weldon School of Biomedical Engineering, and Oncological Sciences Center, Purdue University, West Lafayette, Indiana 47907, USA
    Langmuir 24:5213-7. 2008
    ..These results provide useful information for developing blood-stable micelles to deliver hydrophobic drugs to the target site via prolonged circulation and extravasation from the vascular system...
  40. pmc Strategy to prevent drug-related hypersensitivity in folate-targeted hapten immunotherapy of cancer
    Yingjuan Lu
    Endocyte Inc, West Lafayette, IN 47906, USA
    AAPS J 11:628-38. 2009
    ..In addition, such manipulation in vivo did not appear to negatively alter the effectiveness of immunotherapy. This study provided confidence on the safety of folate-hapten-targeted cancer immunotherapy in an actively immunized host...
  41. ncbi request reprint Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy
    Ruben M Sandoval
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, 950 W Walnut Street, R2 Bldg E202 C, Indianapolis, IN 46202, USA
    Am J Physiol Cell Physiol 287:C517-26. 2004
    ..Together, these data support the argument that folate conjugates (and, by extrapolation, physiological folate) bind to the apical surface of proximal tubule cells and are transported into and across the cells in endocytic compartments...
  42. pmc Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion
    William A Anong
    Department of Chemistry, Purdue University, West Lafayette, IN 47907 2084, USA
    Blood 114:1904-12. 2009
    ..The required relocation of part of the band 3 population to the spectrin/actin junctional complex and its formation of a new bridge with adducin necessitates a significant revision of accepted models of the erythrocyte membrane...
  43. pmc Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligands
    Wei He
    Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA
    Int J Cancer 123:1968-73. 2008
    ..Use of tumor-specific fluorescent ligands to label CTCs in peripheral blood can provide a simple, accurate and sensitive method for determining the number of cancer cells circulating in the bloodstream...
  44. ncbi request reprint Targeted immunotherapy of cancer: development of antibody-induced cellular immunity
    Yingjuan Lu
    Endocyte, Inc, West Lafayette, IN 47906, USA
    J Pharm Pharmacol 55:163-7. 2003
    ....
  45. ncbi request reprint Evaluation of folate conjugate uptake and transport by the choroid plexus of mice
    Michael D Kennedy
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 20:714-9. 2003
    ..Because the choroid plexus (CP) is enriched in cell surface folate receptors, an investigation was initiated to evaluate whether folate receptor-mediated transcytosis might be exploited to deliver folate conjugates into the brain...
  46. ncbi request reprint An osmotically induced cytosolic Ca2+ transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance of Saccharomyces cerevisiae
    Tracie K Matsumoto
    Center for Plant Environmental Stress Physiology, Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 1165, USA
    J Biol Chem 277:33075-80. 2002
    ..NaCl-induced ENA1 expression was inhibited by EGTA, cch1Delta mutation, and FK506, indicating that the [Ca(2+)](cyt) transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance...
  47. pmc Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging
    Jun Yang
    Department of Chemistry and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 103:13872-7. 2006
    ..Finally, colocalization of folate and transferrin receptors suggest that conclusions derived from this study may apply to other endocytic pathways...
  48. doi request reprint Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs
    Sumith A Kularatne
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States
    J Med Chem 53:7767-77. 2010
    ..These results suggest that flexibility can be designed into ligand-targeted therapeutics, enabling adaptation of a single targeting ligand for the treatment of patients with different sensitivities to different chemotherapies...
  49. ncbi request reprint Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate-targeted immunotherapy in hapten-immunized mice
    Yingjuan Lu
    Endocyte, Inc, Suite A1 100, 3000 Kent Avenue, West Lafayette, IN 47906, USA
    Mol Cancer Ther 5:3258-67. 2006
    ..Overall, results from the present study may help to guide clinicians through on-going clinical investigations of folate-targeted immunotherapy...
  50. ncbi request reprint Detection of folate binding protein with enhanced sensitivity using a functionalized quartz crystal microbalance sensor
    Walter A Henne
    Department of Chemistry, School of Chemical Engineering, and School of Mechanical Engineering and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 78:4880-4. 2006
    ..Given the overexpression of FBP in certain malignancies and inflammatory disorders, we expect the methodology described here to be useful to detect FBP as a possible biomarker for disease diagnosis...
  51. pmc An 11-amino acid beta-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytes
    Marko Stefanovic
    Department of Chemistry, Purdue University, 1393 BRWN Building, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 104:13972-7. 2007
    ..Our data indicate that as yet uncharacterized interactions between other membrane proteins must significantly contribute to linkage of the spectrin-actin-based membrane cytoskeleton to the plasma membrane...
  52. ncbi request reprint Increased uptake of folate conjugates by activated macrophages in experimental hyperlipemia
    Felicia Antohe
    Institute of Cellular Biology and Pathology N Simionescu, Bucharest, Romania
    Cell Tissue Res 320:277-85. 2005
    ..This increase in FR expression can be exploited to deliver folate-linked compounds selectively to atherosclerotic lesions...
  53. ncbi request reprint Protein kinase C activation induces phosphatidylserine exposure on red blood cells
    Kitty de Jong
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
    Biochemistry 41:12562-7. 2002
    ..Moreover, PKC inhibition could prevent PS exposure induced by calcium and ionophore treatment of RBCs. We conclude that PKC is implicated in the mechanism of membrane phospholipid scrambling...
  54. ncbi request reprint Folate receptor-mediated targeting of liposomal drugs to cancer cells
    Stacy M Stephenson
    Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, 43210, USA
    Methods Enzymol 387:33-50. 2004
  55. pmc Headpiece domain of dematin is required for the stability of the erythrocyte membrane
    Richie Khanna
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Proc Natl Acad Sci U S A 99:6637-42. 2002
    ..Together, these results provide evidence for the physiological significance of dematin and demonstrate a role for the headpiece domain in the maintenance of structural integrity and mechanical properties of erythrocytes in vivo...
  56. ncbi request reprint Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis
    Patrick G Gallagher
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 333 Cedar St, New Haven, CT 06520 8064
    Blood 101:4625-7. 2003
    ..Increased phosphatidylserine exposure accelerating thrombin-forming processes has been proposed as a mechanism for thrombosis in sickle cell disease and beta-thalassemia and may play a similar role in hereditary hydrocytosis...
  57. ncbi request reprint Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infection
    Sean C Murphy
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 103:1920-8. 2004
    ....
  58. ncbi request reprint Folate receptor overexpression is associated with poor outcome in breast cancer
    Lynn C Hartmann
    Division of Medical Oncology, Mayo Clinic Cancer Center and Mayo Clinic College of Medicine, Rochester, MN
    Int J Cancer 121:938-42. 2007
    ..001. Our work requires validation in a larger cohort, but supports the possibility of using folate receptor-targeted approaches in the management of breast cancer...
  59. ncbi request reprint Erythrocyte adhesion is modified by alterations in cellular tonicity and volume
    Nancy J Wandersee
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Br J Haematol 131:366-77. 2005
    ..In summary, these findings demonstrate that changes in hydration can significantly impact adhesion, causing normal erythrocytes to display adhesive properties similar to those of sickle cells and vice versa...
  60. ncbi request reprint The optimal strategy for drug targeting
    Philip S Low
    Mol Pharm 4:629-30. 2007
  61. ncbi request reprint Effector-induced Syk-mediated phosphorylation in human erythrocytes
    Luciana Bordin
    Department of Biological Chemistry, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
    Biochim Biophys Acta 1745:20-8. 2005
    ..Together these data reveal a complex process controlling the association and catalytic activity of protein tyrosine kinases syk and lyn with the human erythrocyte membrane...
  62. pmc Osteopontin regulates actin cytoskeleton and contributes to cell proliferation in primary erythroblasts
    Jeong Ah Kang
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:6997-7006. 2008
    ..Together these results provide evidence for signal transduction by OPN and contribution to multiple functions during the erythroid differentiation program in human and mouse...
  63. pmc Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions
    Kexiong Zhang
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    RNA 14:577-83. 2008
    ..The method is simple, economical, and can be easily adapted for other cell surface receptors. Here we show the application of this method for the delivery of siRNAs to folate receptor-expressing cells...
  64. pmc Folate receptor alpha as a tumor target in epithelial ovarian cancer
    Kimberly R Kalli
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gynecol Oncol 108:619-26. 2008
    ..The goal of this study is to improve historical data that lack specific information about FRalpha expression in rare histological subtypes, primary disease versus metastatic foci, and recurrent disease...
  65. ncbi request reprint T-cell immunity to the folate receptor alpha is prevalent in women with breast or ovarian cancer
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 24:4254-61. 2006
    ..A candidate antigen is the folate receptor alpha (FRalpha), which is overexpressed in breast and ovarian cancers. Our goal in this study was to attain a better understanding of the extent of endogenous FRalpha immunity...
  66. ncbi request reprint Modulation of red cell glycolysis: interactions between vertebrate hemoglobins and cytoplasmic domains of band 3 red cell membrane proteins
    Roy E Weber
    Zoophysiology Department, Institute of Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R454-64. 2004
    ....
  67. doi request reprint Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 39:498-505. 2008
    ..The significance of such an association as well as the prognostic value of FRalpha expression deserves further exploration...

Research Grants12

  1. Studies of Erythrocyte Membrane Structure
    Philip Stewart Low; Fiscal Year: 2010
    ..Our research seeks to understand the molecular basis of each of these important functions, and where possible, to define clinical interventions that might enable treatment of conditions where the above processes malfunction. ..
  2. ERYTHROCYTE MEMBRANE STRUCTURE
    Philip Low; Fiscal Year: 2007
    ..As a consequence of these studies, a more thorough understanding of the factors that regulate RBC shape and mechanical stability should ensue. ..
  3. Tumor-Specific Targeting of Folate-Derivatized Drugs
    Philip Low; Fiscal Year: 2004
    ..And finally, we will define the molecular and cellular bases of a novel folate-targeted immunotherapy that we have already shown can eradicate established tumors in mice without damaging normal tissues. ..
  4. STUDIES OF ERYTHROCYTE MEMBRANE BAND 3
    Philip Low; Fiscal Year: 1990
    ..Methods used to investigate the above issues involve predominately protein chemistry, with contributions from immunology and molecular biology...
  5. Studies of Erythrocyte Membrane Structure
    Philip Low; Fiscal Year: 2009
    ..Our research seeks to understand the molecular basis of each of these important functions, and where possible, to define clinical interventions that might enable treatment of conditions where the above processes malfunction. ..