Research Topics
| Philip Stewart LowSummaryAffiliation: Purdue University Country: USA Publications
Research Grants
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Detail Information
Publications
Folate-mediated delivery of macromolecular anticancer therapeutic agentsYingjuan Lu
Department of Chemistry, 1393 Brown Building, Purdue University, West Lafayette, IN 47907, USA
Adv Drug Deliv Rev 54:675-93. 2002..This review presents a brief mechanistic background of folate-targeted macromolecular therapeutics and then summarizes the successes and failures observed with each major application of the technology...- Folate receptor-targeted drugs for cancer and inflammatory diseasesPhilip S Low
Indiana University School of Medicine, 1044 West Walnut Street, R4-266, Indianapolis, IN 46202, USA
Adv Drug Deliv Rev 56:1055-8. 2004 - Depletion of folate-receptor-positive macrophages leads to alleviation of symptoms and prolonged survival in two murine models of systemic lupus erythematosusBindu Varghese
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Mol Pharm 4:679-85. 2007.... 
Label-free detection of a bacterial pathogen using an immobilized siderophore, deferoxamineYoungsoon Kim
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
Lab Chip 12:971-6. 2012....
A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicityYang Feng
Protein Interactions Group, CCRNP, NCI Frederick, NIH, 1050 Boyle Street, Frederick, MD 21702, USA
Arthritis Res Ther 13:R59. 2011..In this study we aimed to develop an FRβ-specific human monoclonal antibody (mAb) that could be used as a therapeutic agent to treat rheumatoid arthritis and other autoimmune diseases, as well as FRβ positive cancers...- Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugateYingjuan Lu
Endocyte, Inc, 3000 Kent Avenue, West Lafayette, IN 47906, USA
Arthritis Res Ther 13:R56. 2011..To target such a macrophage population, we designed and evaluated the biologic activity of EC0746, a novel folic acid conjugate of the highly potent antifolate, aminopterin... - Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritisChrystal M Paulos
Department of Chemistry, 560 Oval Drive, 1393 Brown Bldg, Purdue University, West Lafayette, IN 47907 1175, USA
Arthritis Res Ther 8:R77. 2006..We conclude that reduction of activated macrophages by folate-targeted immunotherapy can ameliorate the symptoms of arthritis in two rodent models of the disease... - Folate-targeted therapeutic and imaging agents for cancerPhilip Stewart Low
Department of Chemistry, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA
Curr Opin Chem Biol 13:256-62. 2009..Based on this strategy, six folate-targeted drugs are currently in human clinical trials... - Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseasesPhilip S Low
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
Acc Chem Res 41:120-9. 2008..This Account summarizes the discovery and development of a variety of folate-targeted drugs for the diagnosis and therapy of cancers and inflammatory/autoimmune diseases... - Folate receptor-mediated drug targeting: from therapeutics to diagnosticsAndrew R Hilgenbrink
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
J Pharm Sci 94:2135-46. 2005..This review will summarize the applications of folic acid as a targeting ligand and highlight the various methods being developed for delivery of therapeutic and imaging agents to FR-expressing cells... - Tumor detection using folate receptor-targeted imaging agentsEmanuela I Sega
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Cancer Metastasis Rev 27:655-64. 2008.... - Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cellsDina A Andrews
Department of Veterinary Pathobiology, Purdue University, 1243 Veterinary Pathology Building, West Lafayette, IN 47907 1243, USA
Blood 100:3392-9. 2002..These studies indicate that an omega-agatoxin-TK-sensitive, Ca(v)2.1-like calcium permeability pathway is present in the RBC membrane and that it may function under the control of kinases and phosphatases... - Targeting of nanoparticles: folate receptorSumith A Kularatne
Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN, USA
Methods Mol Biol 624:249-65. 2010.... - Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinomaMary Jo Turk
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
Cancer Lett 213:165-72. 2004..These results demonstrate that, in addition to their cancer cell-targeting properties, folate-liposomes may be useful for targeting drugs to tumor-associated macrophages in vivo... - Real time, noninvasive imaging and quantitation of the accumulation of ligand-targeted drugs into receptor-expressing solid tumorsErina Vlashi
Department of Chemistry and Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47907, USA
Mol Pharm 6:1868-75. 2009..We conclude that low molecular weight ligand-targeted drugs have appropriate pharmacokinetic properties for tumor-selective delivery... - Low-dose radiation potentiates the therapeutic efficacy of folate receptor-targeted hapten therapyEmanuela I Sega
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Int J Radiat Oncol Biol Phys 71:559-66. 2008..In an effort to enhance the efficacy of folate-targeted hapten immunotherapy (FTHI) against large tumors, we explored the combination of targeted hapten immunotherapy with low-dose radiotherapy... - Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritisChrystal M Paulos
Department of Chemistry, 560 Oval Drive, 1393 Brown Bldg, Purdue University, West Lafayette, IN 47907, USA
Adv Drug Deliv Rev 56:1205-17. 2004.... - Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potentialYingjuan Lu
Endocyte, Inc, 1205 Ken Avenue, West Lafayette, IN 47906, USA
Adv Drug Deliv Rev 56:1161-76. 2004.... - A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophagesWei Xia
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Blood 113:438-46. 2009..This trial was registered at www.clinicaltrials.gov as #NCT00588393... - Optical imaging of metastatic tumors using a folate-targeted fluorescent probeMichael D Kennedy
Purdue University, Department of Chemistry, West Lafayette, Indiana 47907, USA
J Biomed Opt 8:636-41. 2003..The sharp distinction between tumor and normal tissues provided by this technique could find application in the localization and resection of tumor tissue during surgery or in the enhanced endoscopic detection and staging of cancers... - Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticalsCarla J Mathias
Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
Nucl Med Biol 30:725-31. 2003..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers... - Ligand-targeted delivery of small interfering RNAs to malignant cells and tissuesMini Thomas
Department of Chemistry, Purdue University, West Lafayette, Indiana, USA
Ann N Y Acad Sci 1175:32-9. 2009..Using these ligands, we show remarkable receptor-mediated targeting of siRNA to cancer tissues in vitro and in vivo... - Synthesis and activity of a folate peptide camptothecin prodrugWalter A Henne
Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Bioorg Med Chem Lett 16:5350-5. 2006..Activity of the prodrug was completely blocked by excess folic acid, demonstrating receptor-mediated uptake... - Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritisMary Jo Turk
Purdue University, West Lafayette, Indiana 47907, USA
Arthritis Rheum 46:1947-55. 2002.... - Synthesis and evaluation of 99mTc(CO)(3)-DTPA-folate as a folate-receptor-targeted radiopharmaceuticalDavid P Trump
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, USA
Nucl Med Biol 29:569-73. 2002..Tumor uptake was reduced when folic acid was co-administered with the intravenous [99mTc]Tc(CO)(3)DTPA-folate, consistent with radiopharmaceutical localization being mediated by the folate receptor... - Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophagesWilfredo Ayala-López
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
J Nucl Med 51:768-74. 2010.... - Folate receptor-targeted immunotherapy: induction of humoral and cellular immunity against hapten-decorated cancer cellsYingjuan Lu
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Int J Cancer 116:710-9. 2005.... - Folate-targeted dinitrophenyl hapten immunotherapy: effect of linker chemistry on antitumor activity and allergic potentialYingjuan Lu
Endocyte Inc, West Lafayette, IN 47906, USA
Mol Pharm 4:695-706. 2007.... - Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug deliveryChrystal M Paulos
Department of Chemistry, Purdue University, West Lafayette, Indiana, USA
Mol Pharmacol 66:1406-14. 2004.... - Folate-targeted hapten immunotherapy of adjuvant-induced arthritis: comparison of hapten potenciesYoung Su Yi
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 2084, USA
Mol Pharm 6:1228-36. 2009..We conclude that both folate-TNP and folate-FITC constitute promising haptens for use in FR-targeted immunotherapy of arthritis... - Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospectsYingjuan Lu
Endocyte, Inc, 1205 Kent Ave, West Lafayette, IN 47906, USA
J Control Release 91:17-29. 2003.... - Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugatesJun Yang
Department of Chemistry, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
J Pharmacol Exp Ther 321:462-8. 2007..5). Taken together, these data argue that the FR-trafficking pathway does not involve acidic compartments and that acyl hydrazone linkers may constitute a poor option for FR-mediated drug delivery... - Immunomagnetic diffractometry for detection of diagnostic serum markersGhanashyam Acharya
Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA
J Am Chem Soc 129:15824-9. 2007..With this approach, a detection sensitivity of 700 fM (20 pg/mL) was achieved. The potential use of this approach in clinical diagnostics was demonstrated by measuring FR concentration in blood samples obtained from cancer patients... - Characterization of the deoxyhemoglobin binding site on human erythrocyte band 3: implications for O2 regulation of erythrocyte propertiesHaiyan Chu
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Blood 111:932-8. 2008..1 and ankyrin, suggesting possible mechanisms through which multifarious erythrocyte properties might be regulated by the oxygenation state of the cell... - Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assayNikki Parker
Endocyte Inc, West Lafayette, IN 47906, USA
Anal Biochem 338:284-93. 2005..Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics... - Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHsMary Jo Turk
Department of Chemistry, Purdue University, 1393 Brown Building, West Lafayette, IN 47907, USA
Biochim Biophys Acta 1559:56-68. 2002..We conclude that intracellular unloading of liposomal contents can be significantly improved by co-encapsulation of an optimally designed, pH-sensitive peptide... - Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumorsYingjuan Lu
Department of Chemistry, 1393 Brown Building, Purdue University, West Lafayette, IN 47907, USA
Cancer Immunol Immunother 51:153-62. 2002..These data suggest that retargeting of haptens to folate receptor-expressing cancers might constitute a method for mobilizing the immune system specifically against poorly immunogenic tumors... - Identification of a critical ankyrin-binding loop on the cytoplasmic domain of erythrocyte membrane band 3 by crystal structure analysis and site-directed mutagenesisSeon Hee Chang
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
J Biol Chem 278:6879-84. 2003..These data thus suggest that the NH(2) terminus of cdb3 is proximal to but not required for the cdb3-ankyrin interaction... - Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imagingHongtao Chen
Department of Chemistry, Weldon School of Biomedical Engineering, and Oncological Sciences Center, Purdue University, West Lafayette, Indiana 47907, USA
Langmuir 24:5213-7. 2008..These results provide useful information for developing blood-stable micelles to deliver hydrophobic drugs to the target site via prolonged circulation and extravasation from the vascular system... - Strategy to prevent drug-related hypersensitivity in folate-targeted hapten immunotherapy of cancerYingjuan Lu
Endocyte Inc, West Lafayette, IN 47906, USA
AAPS J 11:628-38. 2009..In addition, such manipulation in vivo did not appear to negatively alter the effectiveness of immunotherapy. This study provided confidence on the safety of folate-hapten-targeted cancer immunotherapy in an actively immunized host... - Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopyRuben M Sandoval
Division of Nephrology, Department of Medicine, Indiana University School of Medicine, 950 W. Walnut Street, R2 Bldg. E202-C, Indianapolis, IN 46202, USA
Am J Physiol Cell Physiol 287:C517-26. 2004..Together, these data support the argument that folate conjugates (and, by extrapolation, physiological folate) bind to the apical surface of proximal tubule cells and are transported into and across the cells in endocytic compartments... - Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesionWilliam A Anong
Department of Chemistry, Purdue University, West Lafayette, IN 47907 2084, USA
Blood 114:1904-12. 2009..The required relocation of part of the band 3 population to the spectrin/actin junctional complex and its formation of a new bridge with adducin necessitates a significant revision of accepted models of the erythrocyte membrane... - Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligandsWei He
Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA
Int J Cancer 123:1968-73. 2008..Use of tumor-specific fluorescent ligands to label CTCs in peripheral blood can provide a simple, accurate and sensitive method for determining the number of cancer cells circulating in the bloodstream... - Targeted immunotherapy of cancer: development of antibody-induced cellular immunityYingjuan Lu
Endocyte, Inc, West Lafayette, IN 47906, USA
J Pharm Pharmacol 55:163-7. 2003.... - Evaluation of folate conjugate uptake and transport by the choroid plexus of miceMichael D Kennedy
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
Pharm Res 20:714-9. 2003..Furthermore, no uptake of larger folate-linked proteins by choroid plexus cells is observed, suggesting folate conjugate size may strongly influence access to CP folate receptors... - An osmotically induced cytosolic Ca2+ transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance of Saccharomyces cerevisiaeTracie K Matsumoto
Center for Plant Environmental Stress Physiology, Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-1165, USA
J Biol Chem 277:33075-80. 2002..NaCl-induced ENA1 expression was inhibited by EGTA, cch1Delta mutation, and FK506, indicating that the [Ca(2+)](cyt) transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance... - Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imagingJun Yang
Department of Chemistry and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
Proc Natl Acad Sci U S A 103:13872-7. 2006..Finally, colocalization of folate and transferrin receptors suggest that conclusions derived from this study may apply to other endocytic pathways... - Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugsSumith A Kularatne
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States
J Med Chem 53:7767-77. 2010..These results suggest that flexibility can be designed into ligand-targeted therapeutics, enabling adaptation of a single targeting ligand for the treatment of patients with different sensitivities to different chemotherapies... - Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate-targeted immunotherapy in hapten-immunized miceYingjuan Lu
Endocyte, Inc, Suite A1-100, 3000 Kent Avenue, West Lafayette, IN 47906, USA
Mol Cancer Ther 5:3258-67. 2006..Overall, results from the present study may help to guide clinicians through on-going clinical investigations of folate-targeted immunotherapy... - Detection of folate binding protein with enhanced sensitivity using a functionalized quartz crystal microbalance sensorWalter A Henne
Department of Chemistry, School of Chemical Engineering, and School of Mechanical Engineering and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA
Anal Chem 78:4880-4. 2006..Given the overexpression of FBP in certain malignancies and inflammatory disorders, we expect the methodology described here to be useful to detect FBP as a possible biomarker for disease diagnosis... - An 11-amino acid beta-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytesMarko Stefanovic
Department of Chemistry, Purdue University, 1393 BRWN Building, West Lafayette, IN 47907, USA
Proc Natl Acad Sci U S A 104:13972-7. 2007..Our data indicate that as yet uncharacterized interactions between other membrane proteins must significantly contribute to linkage of the spectrin-actin-based membrane cytoskeleton to the plasma membrane... - Increased uptake of folate conjugates by activated macrophages in experimental hyperlipemiaFelicia Antohe
Institute of Cellular Biology and Pathology N Simionescu, Bucharest, Romania
Cell Tissue Res 320:277-85. 2005..This increase in FR expression can be exploited to deliver folate-linked compounds selectively to atherosclerotic lesions... - Protein kinase C activation induces phosphatidylserine exposure on red blood cellsKitty de Jong
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
Biochemistry 41:12562-7. 2002..Moreover, PKC inhibition could prevent PS exposure induced by calcium and ionophore treatment of RBCs. We conclude that PKC is implicated in the mechanism of membrane phospholipid scrambling... - Folate receptor-mediated targeting of liposomal drugs to cancer cellsStacy M Stephenson
Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, 43210, USA
Methods Enzymol 387:33-50. 2004 - Headpiece domain of dematin is required for the stability of the erythrocyte membraneRichie Khanna
Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Proc Natl Acad Sci U S A 99:6637-42. 2002..Together, these results provide evidence for the physiological significance of dematin and demonstrate a role for the headpiece domain in the maintenance of structural integrity and mechanical properties of erythrocytes in vivo... - Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosisPatrick G Gallagher
Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 333 Cedar St, New Haven, CT 06520 8064
Blood 101:4625-7. 2003..Increased phosphatidylserine exposure accelerating thrombin-forming processes has been proposed as a mechanism for thrombosis in sickle cell disease and beta-thalassemia and may play a similar role in hereditary hydrocytosis... - Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infectionSean C Murphy
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Blood 103:1920-8. 2004.... - Folate receptor overexpression is associated with poor outcome in breast cancerLynn C Hartmann
Division of Medical Oncology, Mayo Clinic Cancer Center and Mayo Clinic College of Medicine, Rochester, MN
Int J Cancer 121:938-42. 2007..001. Our work requires validation in a larger cohort, but supports the possibility of using folate receptor-targeted approaches in the management of breast cancer... - Erythrocyte adhesion is modified by alterations in cellular tonicity and volumeNancy J Wandersee
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Br J Haematol 131:366-77. 2005..In summary, these findings demonstrate that changes in hydration can significantly impact adhesion, causing normal erythrocytes to display adhesive properties similar to those of sickle cells and vice versa... - The optimal strategy for drug targetingPhilip S Low
Mol Pharm 4:629-30. 2007 - Effector-induced Syk-mediated phosphorylation in human erythrocytesLuciana Bordin
Department of Biological Chemistry, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
Biochim Biophys Acta 1745:20-8. 2005..Together these data reveal a complex process controlling the association and catalytic activity of protein tyrosine kinases syk and lyn with the human erythrocyte membrane... - Osteopontin regulates actin cytoskeleton and contributes to cell proliferation in primary erythroblastsJeong Ah Kang
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 283:6997-7006. 2008..Together these results provide evidence for signal transduction by OPN and contribution to multiple functions during the erythroid differentiation program in human and mouse... - Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactionsKexiong Zhang
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06511, USA
RNA 14:577-83. 2008..The method is simple, economical, and can be easily adapted for other cell surface receptors. Here we show the application of this method for the delivery of siRNAs to folate receptor-expressing cells... - Folate receptor alpha as a tumor target in epithelial ovarian cancerKimberly R Kalli
Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Gynecol Oncol 108:619-26. 2008..The goal of this study is to improve historical data that lack specific information about FRalpha expression in rare histological subtypes, primary disease versus metastatic foci, and recurrent disease... - T-cell immunity to the folate receptor alpha is prevalent in women with breast or ovarian cancerKeith L Knutson
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Oncol 24:4254-61. 2006..A candidate antigen is the folate receptor alpha (FRalpha), which is overexpressed in breast and ovarian cancers. Our goal in this study was to attain a better understanding of the extent of endogenous FRalpha immunity... - Modulation of red cell glycolysis: interactions between vertebrate hemoglobins and cytoplasmic domains of band 3 red cell membrane proteinsRoy E Weber
Zoophysiology Department, Institute of Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
Am J Physiol Regul Integr Comp Physiol 287:R454-64. 2004.... - Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significanceJinru Shia
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Hum Pathol 39:498-505. 2008..The significance of such an association as well as the prognostic value of FRalpha expression deserves further exploration...
Research Grants
- Studies of Erythrocyte Membrane StructurePhilip Stewart Low; Fiscal Year: 2010..Our research seeks to understand the molecular basis of each of these important functions, and where possible, to define clinical interventions that might enable treatment of conditions where the above processes malfunction. ..
- ERYTHROCYTE MEMBRANE STRUCTUREPhilip Low; Fiscal Year: 2007..As a consequence of these studies, a more thorough understanding of the factors that regulate RBC shape and mechanical stability should ensue. ..
- Tumor-Specific Targeting of Folate-Derivatized DrugsPhilip Low; Fiscal Year: 2004..And finally, we will define the molecular and cellular bases of a novel folate-targeted immunotherapy that we have already shown can eradicate established tumors in mice without damaging normal tissues. ..
- STUDIES OF ERYTHROCYTE MEMBRANE BAND 3Philip Low; Fiscal Year: 1990..Methods used to investigate the above issues involve predominately protein chemistry, with contributions from immunology and molecular biology...
- Studies of Erythrocyte Membrane StructurePhilip Low; Fiscal Year: 2009..Our research seeks to understand the molecular basis of each of these important functions, and where possible, to define clinical interventions that might enable treatment of conditions where the above processes malfunction. ..