Xiaoqi Liu

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. pmc Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease
    Bing Song
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Aging (Albany NY) 3:846-51. 2011
  2. pmc Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication
    Bing Song
    Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA
    Cell Div 7:3. 2012
  3. ncbi request reprint The nuclear localization signal of mitotic kinesin-like protein Mklp-1: effect on Mklp-1 function during cytokinesis
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Biochem Biophys Res Commun 353:960-4. 2007
  4. pmc Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase
    Hongchang Li
    Department of Biochemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 107:14633-8. 2010
  5. ncbi request reprint Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    J Cell Sci 117:3233-46. 2004
  6. ncbi request reprint Ectopic expression of Plk1 leads to activation of the spindle checkpoint
    Jiabin Tang
    Department of Biochemistry and the Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    Cell Cycle 5:2484-8. 2006
  7. pmc Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments
    Hongchang Li
    Department of Biochemistry and Center for Cancer Research, Purdue University, West Lafayette, IN, USA
    EMBO J 29:2953-65. 2010
  8. pmc Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, IN, USA
    Mol Cell Biol 32:4053-67. 2012
  9. pmc Plk1 phosphorylation of TRF1 is essential for its binding to telomeres
    Zhao Qiu Wu
    Department of Biochemistry and the Cancer Center, Purdue University, 175 S University Street, West Lafayette, IN 47907, USA
    J Biol Chem 283:25503-13. 2008
  10. pmc Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
    EMBO Rep 11:626-32. 2010

Research Grants

Collaborators

Detail Information

Publications33

  1. pmc Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease
    Bing Song
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Aging (Albany NY) 3:846-51. 2011
    ..Significantly, inhibition of Plk1 kinase activity or depletion of Plk1 by RNAi reduces β-amyloid (Aβ)-induced neuronal cell death. These results validate Plk1 as a possible target for AD therapy...
  2. pmc Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication
    Bing Song
    Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA
    Cell Div 7:3. 2012
    ..This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole...
  3. ncbi request reprint The nuclear localization signal of mitotic kinesin-like protein Mklp-1: effect on Mklp-1 function during cytokinesis
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Biochem Biophys Res Commun 353:960-4. 2007
    ..Furthermore, mutation of two serine residues in the first NLS to aspartic acid, which mimics phosphorylation, attenuated its nuclear localization function, suggesting that the function of this NLS might be regulated by phosphorylation...
  4. pmc Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase
    Hongchang Li
    Department of Biochemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 107:14633-8. 2010
    ..Taking these data together, we conclude that Plk1 phosphorylation of p150(Glued) might be one major pathway of NEBD regulation...
  5. ncbi request reprint Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    J Cell Sci 117:3233-46. 2004
    ..These data provide more detailed information about the interaction between Plk1 and CHO1/MKLP-1, and the significance of this is discussed...
  6. ncbi request reprint Ectopic expression of Plk1 leads to activation of the spindle checkpoint
    Jiabin Tang
    Department of Biochemistry and the Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    Cell Cycle 5:2484-8. 2006
    ..Epitopic expression of Plk1 led to mitotic arrest, whereas coexpression of Chk1 could release this mitotic block. Moreover, the Plk1 expression-induced mitotic block was also released by inactivation of the spindle-assembly checkpoint...
  7. pmc Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments
    Hongchang Li
    Department of Biochemistry and Center for Cancer Research, Purdue University, West Lafayette, IN, USA
    EMBO J 29:2953-65. 2010
    ....
  8. pmc Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, IN, USA
    Mol Cell Biol 32:4053-67. 2012
    ..Our results demonstrate a mechanism for Plk1 in promoting kinetochore-microtubule attachment to ensure chromosome stability...
  9. pmc Plk1 phosphorylation of TRF1 is essential for its binding to telomeres
    Zhao Qiu Wu
    Department of Biochemistry and the Cancer Center, Purdue University, 175 S University Street, West Lafayette, IN 47907, USA
    J Biol Chem 283:25503-13. 2008
    ..These results demonstrate that Plk1 interacts with and phosphorylates TRF1 and suggest that Plk1-mediated phosphorylation is involved in both TRF1 overexpression-induced apoptosis and its telomeric DNA binding ability...
  10. pmc Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
    EMBO Rep 11:626-32. 2010
    ....
  11. ncbi request reprint Polo-like kinase 1 in the life and death of cancer cells
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell Cycle 2:424-5. 2003
    ....
  12. pmc Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer
    Bing Song
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Cancer Ther 12:58-68. 2013
    ..In short, our study provides a mechanism for Plk1-mediated gemcitabine resistance, suggesting that Plk1 is a promising target for treatment of gemcitabine-resistant pancreatic cancer...
  13. pmc Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)
    Jiabin Tang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 103:11964-9. 2006
    ..Finally, Chk1 depletion leads to the activation of the spindle checkpoint because codepletion of spindle checkpoint proteins rescues the Chk1 depletion-induced mitotic arrest...
  14. pmc CCT chaperonin complex is required for the biogenesis of functional Plk1
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
    Mol Cell Biol 25:4993-5010. 2005
    ..Finally, the CCT-depleted cells reenter the cell cycle upon reintroduction of the purified constitutively active form of Plk1, indicating that Plk1 might be a CCT substrate...
  15. pmc Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy
    Leo Studach
    Department of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 285:30282-93. 2010
    ..We propose this novel Plk1 mechanism initiates pX-mediated hepatocyte transformation...
  16. pmc Normal cells, but not cancer cells, survive severe Plk1 depletion
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
    Mol Cell Biol 26:2093-108. 2006
    ..Therefore, these data further support suggestions that Plk1 may be a feasible cancer therapy target...
  17. ncbi request reprint A role for Plk1 phosphorylation of NudC in cytokinesis
    Tianhua Zhou
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 5:127-38. 2003
    ..These results suggest that Plk1 phosphorylation of NudC may influence cytokinesis...
  18. pmc Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress
    Bing Song
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Cell Biol 31:4844-56. 2011
    ..Our study suggests a novel role of Plk1 in facilitating DNA replication under conditions of stress to maintain genomic integrity...
  19. doi request reprint Plk1-dependent phosphorylation regulates functions of DNA topoisomerase IIalpha in cell cycle progression
    Hongchang Li
    Department of Biochemistry and the Cancer Center, Purdue University, 175 S University Street, West Lafayette, IN 47907, USA
    J Biol Chem 283:6209-21. 2008
    ....
  20. pmc A mammalian NudC-like protein essential for dynein stability and cell viability
    Tianhua Zhou
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 103:9039-44. 2006
    ..Taken together, these data suggest a previously undescribed mechanism whereby NudCL appears to influence the stabilization of dynein intermediate chain...
  21. pmc Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:5789-94. 2003
    ..Although p53 is stabilized in Plk1-depleted cells, DNA damage also occurs in p53(-/-) cells. These data support the notion that disruption of Plk1 function could be an important application in cancer therapy...
  22. pmc Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing
    Zhao Qiu Wu
    Department of Biochemistry and Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:1919-24. 2008
    ..These results suggest that Plk1 phosphorylation of Hbo1 may be required for prereplicative complex (pre-RC) formation and DNA replication licensing...
  23. pmc Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 286:35795-800. 2011
    ..These findings identify a role of Plk1 in facilitating loss of Pten-induced prostate cancer formation, which suggests that Plk1 might be a promising target for prostate cancer patients with inactivating Pten mutations...
  24. doi request reprint Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development
    Jijing Luo
    Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA
    Protein Cell 3:182-97. 2012
    ..And finally, the newly chemotherapeutic development of small-molecule Plk1 inhibitors to target Plk1 in cancer treatment and their translational studies are also briefly reviewed...
  25. doi request reprint The substrates of Plk1, beyond the functions in mitosis
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Protein Cell 1:999-1010. 2010
    ..Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event...
  26. pmc Plk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancer
    Xianzeng Hou
    Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA
    Prostate 73:1352-63. 2013
    ..Of note, we have previously shown that Plk1 phosphorylates CLIP-170 and p150(Glued) , two important regulators of microtubule dynamics...
  27. pmc Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:8672-6. 2002
    ..These data provide direct evidence that Plk is required for multiple mitotic processes in mammalian cells and their significance is discussed...
  28. ncbi request reprint The MAP kinase pathway is required for entry into mitosis and cell survival
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Oncogene 23:763-76. 2004
    ..Mek1 and Erk1 depletion also caused cell cycle arrest at G2, suggesting that these enzymes are required for the G2/M transition, whereas the loss of Mek2 or Erk2 caused arrest at G1...
  29. pmc The role of polo-like kinase 1 in carcinogenesis: cause or consequence?
    Brian D Cholewa
    Authors Affiliations Department of Dermatology Molecular and Environmental Toxicology Center, University of Wisconsin William S Middleton Memorial VA Hospital, Madison, Wisconsin and Department of Biochemistry, Purdue University, West Lafayette, Indiana
    Cancer Res 73:6848-55. 2013
    ..However, evidence supports the notion that oncogene dependence on Plk1 is not a late occurrence in carcinogenesis and it is likely that Plk1 plays an active role in carcinogenic transformation...
  30. pmc Chemical visualization of phosphoproteomes on membrane
    Anton Iliuk
    Department of Biochemistry and Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA
    Mol Cell Proteomics 11:629-39. 2012
    ....
  31. pmc A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes
    Weiyi Liu
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Cell Sci 126:3527-32. 2013
    ..Taken together, these results demonstrate widespread heterogeneity in Pax3 lineage origin, and its inverse association with BAT gene expression within and among subcutaneous adipose depots. ..
  32. ncbi request reprint Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness
    Shuhua Yue
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Cell Metab 19:393-406. 2014
    ..These findings open opportunities for diagnosing and treating prostate cancer by targeting the altered cholesterol metabolism...
  33. pmc Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation
    Weiyi Liu
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    Development 139:2857-65. 2012
    ....

Research Grants2

  1. Functional studies of Plk1 and its interacting proteins
    Xiaoqi Liu; Fiscal Year: 2006
    ..Kid also appears to be a novel Plk1 substrate. Whether the function of Kid during mitosis is affected by Plk1 will be analyzed. ..