Chang Kim

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. ncbi Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity
    Chang H Kim
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    Blood 100:11-6. 2002
  2. ncbi Cytokine control of memory B cell homing machinery
    Meenakshi P Roy
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 169:1676-82. 2002
  3. ncbi Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology and Purdue Cancer Center, and Biochemistry and Molecular Biology Program, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 171:152-8. 2003
  4. ncbi Characterization of monoclonal antibody specific to the Z39Ig protein, a member of immunoglobulin superfamily
    Jin Kyung Kim
    Immunomodulation Research Center, University of Ulsan, South Korea
    Immunol Lett 99:153-61. 2005
  5. ncbi Migration and function of th17 cells
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology School of Veterinary Medicine Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Inflamm Allergy Drug Targets 8:221-8. 2009
  6. pmc BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA
    J Exp Med 210:475-89. 2013
  7. pmc Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e30793. 2012
  8. pmc Homeostatic and pathogenic extramedullary hematopoiesis
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology Purdue Cancer Center, Purdue University, West Lafayette, IN, USA
    J Blood Med 1:13-9. 2010
  9. pmc Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells
    S G Kang
    Department of Comparative Pathobiology, The Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA
    Mucosal Immunol 4:66-82. 2011
  10. pmc Host and microbial factors in regulation of T cells in the intestine
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Center for Cancer Research, Purdue University West Lafayette, IN, USA
    Front Immunol 4:141. 2013

Research Grants

Collaborators

Detail Information

Publications44

  1. ncbi Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity
    Chang H Kim
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    Blood 100:11-6. 2002
    ..Our results identify chemokine receptors that are potentially important for trafficking of human blood NKT cell subsets and reveal their function (cytokine production capacity)-dependent differential trafficking potentials...
  2. ncbi Cytokine control of memory B cell homing machinery
    Meenakshi P Roy
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 169:1676-82. 2002
    ..CCR7 expression, responsiveness to CCL19, and L-selectin/alpha(4)beta(7) phenotype are coordinately regulated. Thus, IL-2/IL-10 and IL-4 play important and distinctive roles in developing the migratory capacities of memory B cells...
  3. ncbi Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology and Purdue Cancer Center, and Biochemistry and Molecular Biology Program, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 171:152-8. 2003
    ....
  4. ncbi Characterization of monoclonal antibody specific to the Z39Ig protein, a member of immunoglobulin superfamily
    Jin Kyung Kim
    Immunomodulation Research Center, University of Ulsan, South Korea
    Immunol Lett 99:153-61. 2005
    ..These data suggest that the Z39Ig protein might be a critical molecule to regulate an immune response mediated by phagocytosis and/or antigen presentation...
  5. ncbi Migration and function of th17 cells
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology School of Veterinary Medicine Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Inflamm Allergy Drug Targets 8:221-8. 2009
    ..Thus, chemokine receptors appear to play complex roles in the biology of Th17 cells...
  6. pmc BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA
    J Exp Med 210:475-89. 2013
    ..Our results establish BATF as a cellular factor required for normal expression of CCR9 and α4β7 and for the homeostasis and effector functions of T cell populations in the intestine...
  7. pmc Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e30793. 2012
    ..Taken together, our results indicate that population of tumors with thymus-generated FoxP3(+) T cells requires an antigen priming-dependent trafficking receptor switch in lymphoid tissues...
  8. pmc Homeostatic and pathogenic extramedullary hematopoiesis
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology Purdue Cancer Center, Purdue University, West Lafayette, IN, USA
    J Blood Med 1:13-9. 2010
    ..Thus, EH occurs either actively or passively in response to diverse changes in the hematopoietic environment. This article reviews the key features and regulators of the major types of EH...
  9. pmc Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells
    S G Kang
    Department of Comparative Pathobiology, The Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA
    Mucosal Immunol 4:66-82. 2011
    ..The retinoic acid-mediated regulation of α(4) integrins is required for specific migration of T cells in vitro and in vivo. These results provide central regulatory mechanisms for coordinated expression of the major mucosal integrins...
  10. pmc Host and microbial factors in regulation of T cells in the intestine
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Center for Cancer Research, Purdue University West Lafayette, IN, USA
    Front Immunol 4:141. 2013
    ..Coordinated regulation of immune responses by these factors promotes well-balanced immunity and immune tolerance. Dysregulation of this process can increase infection and inflammatory diseases...
  11. pmc Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Center for Cancer Research, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA
    BMC Immunol 12:53. 2011
    ..We investigated the expression modality and function of PD-1 expressed by human T cells specialized in helping B cells...
  12. pmc Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination
    Jong R Kim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, BioScience Center, VPTH Room 126, 725 Harrison St, Purdue University, West Lafayette, IN 47907, USA
    BMC Immunol 6:3. 2005
    ..To clarify and gain more insight into their function in helping B cells, we systematically investigated the capacity of human tonsil CD57+ GC-Th cells in inducing B cell Ig synthesis...
  13. ncbi The greater chemotactic network for lymphocyte trafficking: chemokines and beyond
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    Curr Opin Hematol 12:298-304. 2005
    ..This review examines our current understanding of the chemoattractant network for lymphocyte trafficking and discusses the recent findings in this area...
  14. ncbi Molecular targets of FoxP3+ regulatory T cells
    Chang H Kim
    Department of Comparative Pathobiology, 725 Harrison Street, Purdue University, West Lafayette, IN 47907, USA
    Mini Rev Med Chem 7:1136-43. 2007
    ..Potential molecular targets to regulate FoxP3+ T cells are reviewed in this article...
  15. ncbi Trafficking of FoxP3+ regulatory T cells: myths and facts
    Chang H Kim
    Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA
    Arch Immunol Ther Exp (Warsz) 55:151-9. 2007
    ..The recent progress in trafficking receptors and migratory behavior of FoxP3(+) Tregs is reviewed here and the validity of these myths is examined...
  16. ncbi Migration and function of Th17 cells
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology School of Veterinary Medicine, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Inflamm Allergy Drug Targets 8:221-8. 2009
    ..Thus, chemokine receptors appear to play complex roles in the biology of Th17 cells...
  17. ncbi Roles of retinoic acid in induction of immunity and immune tolerance
    Chang H Kim
    Department of Comparative Pathobiology, 725 Harrison Street, Purdue University, West Lafayette, IN 47907, USA
    Endocr Metab Immune Disord Drug Targets 8:289-94. 2008
    ..Therefore, retinoids provide both positive and negative regulatory signals to fine-control the mucosal immune system...
  18. ncbi Chemokine-chemokine receptor network in immune cell trafficking
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Curr Drug Targets Immune Endocr Metabol Disord 4:343-61. 2004
    ....
  19. ncbi FOXP3 and its role in the immune system
    Chang H Kim
    Department of Comparative Pathobiology, 725 Harrison Street, Purdue University, West Lafayette, Indiana 47907, USA
    Adv Exp Med Biol 665:17-29. 2009
    ..FOXP3+ T-cells can be produced in vitro from autologous naive T-cells and, therefore, have great therapeutic potentials in treating a number of inflammatory diseases and grafi rejection...
  20. ncbi Unique gene expression program of human germinal center T helper cells
    Chang H Kim
    Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Blood 104:1952-60. 2004
    ..This study revealed for the first time the unique gene expression program of GC-Th cells...
  21. ncbi Regulation of humoral immunity by FoxP3(+) regulatory T cells
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Expert Rev Clin Immunol 2:859-68. 2006
    ..Therefore, FoxP3(+) T cells are an important immune component that reins in potentially over-active or self-reactive humoral immunity...
  22. pmc Regulation of FoxP3 regulatory T cells and Th17 cells by retinoids
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Clin Dev Immunol 2008:416910. 2008
    ....
  23. ncbi Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Dept of Veterinary Pathobiology, Biochemistry and Molecular Biology Program, Purdue University, 1243 VPTH, West Lafayette, IN 47907 1243, USA
    Trends Immunol 23:516-9. 2002
    ..NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions...
  24. ncbi Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN, USA
    Exp Hematol 34:1033-40. 2006
    ..Therefore, FoxP3+ T cells play essential roles in regulation of the hematolymphoid system in health and diseases, and are likely to be utilized as effective therapeutics for many diseases in the hematolymphoid system in the future...
  25. pmc Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
    Hyung W Lim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA
    J Clin Invest 114:1640-9. 2004
    ..Our results have identified a subset of Tregs that is physiologically relevant to GC-Th cell-dependent B cell responses and a potential regulation mechanism for the trafficking of these Tregs to GCs...
  26. pmc High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation
    Seung G Kang
    Department of Comparative Pathobiology, Laboratory of Immunology and Hematopoiesis, Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    Gastroenterology 137:1391-402.e1-6. 2009
    ....
  27. ncbi FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to nonlymphoid tissue homing receptors in secondary lymphoid tissues
    Jee H Lee
    Department of Comparative Pathobiology, Laboratory of Immunology and Hematopoiesis, Purdue Cancer Center, and Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 178:301-11. 2007
    ....
  28. ncbi Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue
    Hyung W Lim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 179:7448-56. 2007
    ..The selective loss of CD127 on the B cell-helping effector T cells would have implications in regulation and termination of Ig responses...
  29. ncbi Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells
    Seung G Kang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Bindley Bioscience Center and Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 179:3724-33. 2007
    ..Taken together, these results identify retinoids as positive regulatory factors for generation of gut-homing FoxP3+ T cells...
  30. ncbi Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells
    Hyung W Lim
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 180:122-9. 2008
    ..These findings have important implications in their distribution in the human body in relation to other regulatory T cell subsets...
  31. ncbi Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells
    Hyung W Lim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA
    J Immunol 177:840-51. 2006
    ..The orderly regulation of trafficking receptors in FOXP3(+) T cells according to stages of differentiation and activation is potentially important for their tissue-specific migration and regulation of immune responses in humans...
  32. pmc Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
    Briana C Betz
    Department of Biological Sciences, Purdue University West Lafayette, IN 47907, USA
    J Exp Med 207:933-42. 2010
    ..We conclude that loss of Batf disrupts multiple components of the lymphocyte communication network that are required for a robust immune response...
  33. pmc Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 184:5519-26. 2010
    ..The results indicate also that specific gut tropism of Th17 cells is determined by the combination of trafficking receptors regulated by the RA signal...
  34. ncbi Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine
    Seung G Kang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University Life Science Program, Purdue University, West Lafayette, Indiana 47907, USA
    Gastroenterology 132:966-81. 2007
    ..Using these mice, we investigated the gut chemokine network involved in specific migration of T-cell subsets to the inflamed lesion of the intestine...
  35. ncbi Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells
    Hyung W Lim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 175:4180-3. 2005
    ..The direct suppression of B cell Ig production by Tregs is accompanied by inhibition of Ig class switch recombination...
  36. pmc FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells
    Jee H Lee
    Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 183:6377-86. 2009
    ..Our results provide new insights into regulation of extramedullary myelopoiesis...
  37. pmc CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 111:1001-10. 2003
    ....
  38. ncbi Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets
    Brent Johnston
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 171:2960-9. 2003
    ..Our results identify subsets of NKT cells with distinct homing and localization patterns, suggesting that these populations play specialized roles in immunological processes in vivo...
  39. ncbi Chemokines in the systemic organization of immunity
    Daniel J Campbell
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Immunol Rev 195:58-71. 2003
    ..Here, we summarize the role of chemokines and their receptors in the spatial organization of the immune system and consider the implications for immune function...
  40. ncbi Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 14:199-203. 2005
    ..Thus, SDF-1/CXCL12 differentially and selectively regulates suppression of HPC proliferation by chemokines. These effects may counter myelosuppressive effects of certain chemokines in vivo, where proliferation of HPCs must be sustained...
  41. ncbi Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells
    Hal E Broxmeyer
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Leukoc Biol 73:630-8. 2003
    ..These results extend information on the survival effects mediated through the SDF-1/CXCL12-CXCR4 axis and may be of relevance for ex vivo expansion and gene-transduction procedures...
  42. ncbi Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo
    Hal E Broxmeyer
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 170:421-9. 2003
    ..These results substantiate survival effects of SDF-1/CXCL12, now extended to progenitors engineered to endogenously produce low levels of this cytokine, and demonstrate activity in vivo for SDF-1/CXCL12 in addition to cell trafficking...
  43. ncbi Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines and chemokine-accelerated recovery of progenitors after treatment of mice with Ara-C
    Hal E Broxmeyer
    Departments of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Exp Hematol 34:1069-77. 2006
    ..We also evaluated three chemokines in vivo for myeloprotection against Ara-C-induced decreases in HPCs...
  44. ncbi 4-1BB costimulation enhances HSV-1-specific CD8+ T cell responses by the induction of CD11c+CD8+ T cells
    Young H Kim
    The Immunomodulation Research Center, University of Ulsan, Ulsan 680 749, Republic of Korea
    Cell Immunol 238:76-86. 2005
    ..Our studies demonstrated that 4-1BB stimulation enhanced both primary and memory anti-HSV-1 CD8+ T cell responses, which was mediated by a massive expansion of antigen-specific CD11c+CD8+ T cells...

Research Grants8

  1. Therapeutic delivery of FoxP3+ T cells to the intestine
    Chang Kim; Fiscal Year: 2009
    ..In addition, the outcomes will have far-reaching implications for treatment of other chronic inflammatory disorders. ..
  2. FoxP3+ T cells of mucosal tissues
    Chang Kim; Fiscal Year: 2009
    ..Since vitamin A is widely consumed by humans, the impact of the project on human health will be high. ..
  3. Organ-specific migration of CD4+CD25+ regulatory T cells
    Chang Kim; Fiscal Year: 2006
    ..These studies have the potential to provide important information on organ or tissue-specific trafficking of CD4+CD25+ suppressor T cells and its impact on immune tolerance. ..
  4. FoxP3+ T cells of mucosal tissues
    Chang H Kim; Fiscal Year: 2010
    ..Since vitamin A is widely consumed by humans, the impact of the project on human health will be high. ..
  5. Therapeutic delivery of FoxP3+ T cells to the intestine
    Chang H Kim; Fiscal Year: 2010
    ..In addition, the outcomes will have far-reaching implications for treatment of other chronic inflammatory disorders. ..
  6. Migration and function of Th17 cells in the gut
    Chang H Kim; Fiscal Year: 2010
    ..The outcomes can also be applied to control of Th17-cell-regulated inflammation and immunity in other tissues. ..