Research Topics
Species | Chang KimSummaryAffiliation: Purdue University Country: USA Publications
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Publications
Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacityChang H Kim
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
Blood 100:11-6. 2002..Our results identify chemokine receptors that are potentially important for trafficking of human blood NKT cell subsets and reveal their function (cytokine production capacity)-dependent differential trafficking potentials...- Cytokine control of memory B cell homing machineryMeenakshi P Roy
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 169:1676-82. 2002..CCR7 expression, responsiveness to CCL19, and L-selectin/alpha(4)beta(7) phenotype are coordinately regulated. Thus, IL-2/IL-10 and IL-4 play important and distinctive roles in developing the migratory capacities of memory B cells... - Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiationChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology and Purdue Cancer Center, and Biochemistry and Molecular Biology Program, Purdue University, West Lafayette, IN 47907, USA
J Immunol 171:152-8. 2003.... - Characterization of monoclonal antibody specific to the Z39Ig protein, a member of immunoglobulin superfamilyJin Kyung Kim
Immunomodulation Research Center, University of Ulsan, South Korea
Immunol Lett 99:153-61. 2005..These data suggest that the Z39Ig protein might be a critical molecule to regulate an immune response mediated by phagocytosis and/or antigen presentation... - Migration and function of th17 cellsChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology School of Veterinary Medicine Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Inflamm Allergy Drug Targets 8:221-8. 2009..Thus, chemokine receptors appear to play complex roles in the biology of Th17 cells... 
Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsetsChuanwu Wang
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Center for Cancer Research, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA
BMC Immunol 12:53. 2011..We investigated the expression modality and function of PD-1 expressed by human T cells specialized in helping B cells...
Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombinationJong R Kim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, BioScience Center, VPTH Room 126, 725 Harrison St, Purdue University, West Lafayette, IN 47907, USA
BMC Immunol 6:3. 2005..To clarify and gain more insight into their function in helping B cells, we systematically investigated the capacity of human tonsil CD57+ GC-Th cells in inducing B cell Ig synthesis...- FOXP3 and its role in the immune systemChang H Kim
Department of Comparative Pathobiology, 725 Harrison Street, Purdue University, West Lafayette, Indiana 47907, USA
Adv Exp Med Biol 665:17-29. 2009..FOXP3+ T-cells can be produced in vitro from autologous naive T-cells and, therefore, have great therapeutic potentials in treating a number of inflammatory diseases and grafi rejection... - The greater chemotactic network for lymphocyte trafficking: chemokines and beyondChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
Curr Opin Hematol 12:298-304. 2005..This review examines our current understanding of the chemoattractant network for lymphocyte trafficking and discusses the recent findings in this area... - Migration and function of FoxP3+ regulatory T cells in the hematolymphoid systemChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN, USA
Exp Hematol 34:1033-40. 2006..Therefore, FoxP3+ T cells play essential roles in regulation of the hematolymphoid system in health and diseases, and are likely to be utilized as effective therapeutics for many diseases in the hematolymphoid system in the future... - Trafficking of FoxP3+ regulatory T cells: myths and factsChang H Kim
Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA
Arch Immunol Ther Exp (Warsz) 55:151-9. 2007..The recent progress in trafficking receptors and migratory behavior of FoxP3(+) Tregs is reviewed here and the validity of these myths is examined... - Molecular targets of FoxP3+ regulatory T cellsChang H Kim
Department of Comparative Pathobiology, 725 Harrison Street, Purdue University, West Lafayette, IN 47907, USA
Mini Rev Med Chem 7:1136-43. 2007..Potential molecular targets to regulate FoxP3+ T cells are reviewed in this article... - Regulation of humoral immunity by FoxP3(+) regulatory T cellsChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Expert Rev Clin Immunol 2:859-68. 2006..Therefore, FoxP3(+) T cells are an important immune component that reins in potentially over-active or self-reactive humoral immunity... - Roles of retinoic acid in induction of immunity and immune toleranceChang H Kim
Department of Comparative Pathobiology, 725 Harrison Street, Purdue University, West Lafayette, IN 47907, USA
Endocr Metab Immune Disord Drug Targets 8:289-94. 2008..Therefore, retinoids provide both positive and negative regulatory signals to fine-control the mucosal immune system... - Migration and function of Th17 cellsChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology School of Veterinary Medicine, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Inflamm Allergy Drug Targets 8:221-8. 2009..Thus, chemokine receptors appear to play complex roles in the biology of Th17 cells... - Regulation of FoxP3 regulatory T cells and Th17 cells by retinoidsChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Clin Dev Immunol 2008:416910. 2008.... - Chemokine-chemokine receptor network in immune cell traffickingChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Curr Drug Targets Immune Endocr Metabol Disord 4:343-61. 2004.... - Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expressionChang H Kim
Laboratory of Immunology and Hematopoiesis, Dept of Veterinary Pathobiology, Biochemistry and Molecular Biology Program, Purdue University, 1243 VPTH, West Lafayette, IN 47907 1243, USA
Trends Immunol 23:516-9. 2002..NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions... - Unique gene expression program of human germinal center T helper cellsChang H Kim
Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Blood 104:1952-60. 2004..This study revealed for the first time the unique gene expression program of GC-Th cells... - Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responsesHyung W Lim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA
J Clin Invest 114:1640-9. 2004..Our results have identified a subset of Tregs that is physiologically relevant to GC-Th cell-dependent B cell responses and a potential regulation mechanism for the trafficking of these Tregs to GCs... - High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammationSeung G Kang
Department of Comparative Pathobiology, Laboratory of Immunology and Hematopoiesis, Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
Gastroenterology 137:1391-402.e1-6. 2009.... - FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to nonlymphoid tissue homing receptors in secondary lymphoid tissuesJee H Lee
Department of Comparative Pathobiology, Laboratory of Immunology and Hematopoiesis, Purdue Cancer Center, and Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA
J Immunol 178:301-11. 2007.... - Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissueHyung W Lim
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
J Immunol 179:7448-56. 2007..The selective loss of CD127 on the B cell-helping effector T cells would have implications in regulation and termination of Ig responses... - Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cellsSeung G Kang
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Bindley Bioscience Center and Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907, USA
J Immunol 179:3724-33. 2007..Taken together, these results identify retinoids as positive regulatory factors for generation of gut-homing FoxP3+ T cells... - Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cellsHyung W Lim
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
J Immunol 180:122-9. 2008..These findings have important implications in their distribution in the human body in relation to other regulatory T cell subsets... - Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cellsHyung W Lim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue Cancer Center, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA
J Immunol 177:840-51. 2006..The orderly regulation of trafficking receptors in FOXP3(+) T cells according to stages of differentiation and activation is potentially important for their tissue-specific migration and regulation of immune responses in humans... - Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestineSeung G Kang
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University Life Science Program, Purdue University, West Lafayette, Indiana 47907, USA
Gastroenterology 132:966-81. 2007..Using these mice, we investigated the gut chemokine network involved in specific migration of T-cell subsets to the inflamed lesion of the intestine... - Batf coordinates multiple aspects of B and T cell function required for normal antibody responsesBriana C Betz
Department of Biological Sciences, Purdue University West Lafayette, IN 47907, USA
J Exp Med 207:933-42. 2010..We conclude that loss of Batf disrupts multiple components of the lymphocyte communication network that are required for a robust immune response... - Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestineChuanwu Wang
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
J Immunol 184:5519-26. 2010..The results indicate also that specific gut tropism of Th17 cells is determined by the combination of trafficking receptors regulated by the RA signal... - Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cellsHyung W Lim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue University, West Lafayette, IN 47907, USA
J Immunol 175:4180-3. 2005..The direct suppression of B cell Ig production by Tregs is accompanied by inhibition of Ig class switch recombination... - FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cellsJee H Lee
Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
J Immunol 183:6377-86. 2009..Our results provide new insights into regulation of extramedullary myelopoiesis... - Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitroHal E Broxmeyer
Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Stem Cells Dev 14:199-203. 2005..Thus, SDF-1/CXCL12 differentially and selectively regulates suppression of HPC proliferation by chemokines. These effects may counter myelosuppressive effects of certain chemokines in vivo, where proliferation of HPCs must be sustained... - CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cellsEric J Kunkel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 111:1001-10. 2003.... - Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsetsBrent Johnston
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 171:2960-9. 2003..Our results identify subsets of NKT cells with distinct homing and localization patterns, suggesting that these populations play specialized roles in immunological processes in vivo... - Chemokines in the systemic organization of immunityDaniel J Campbell
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Immunol Rev 195:58-71. 2003..Here, we summarize the role of chemokines and their receptors in the spatial organization of the immune system and consider the implications for immune function... - Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivoHal E Broxmeyer
Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Immunol 170:421-9. 2003..These results substantiate survival effects of SDF-1/CXCL12, now extended to progenitors engineered to endogenously produce low levels of this cytokine, and demonstrate activity in vivo for SDF-1/CXCL12 in addition to cell trafficking... - Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cellsHal E Broxmeyer
Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
J Leukoc Biol 73:630-8. 2003..These results extend information on the survival effects mediated through the SDF-1/CXCL12-CXCR4 axis and may be of relevance for ex vivo expansion and gene-transduction procedures... - 4-1BB costimulation enhances HSV-1-specific CD8+ T cell responses by the induction of CD11c+CD8+ T cellsYoung H Kim
The Immunomodulation Research Center, University of Ulsan, Ulsan 680 749, Republic of Korea
Cell Immunol 238:76-86. 2005..Our studies demonstrated that 4-1BB stimulation enhanced both primary and memory anti-HSV-1 CD8+ T cell responses, which was mediated by a massive expansion of antigen-specific CD11c+CD8+ T cells... - Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines and chemokine-accelerated recovery of progenitors after treatment of mice with Ara-CHal E Broxmeyer
Departments of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
Exp Hematol 34:1069-77. 2006..We also evaluated three chemokines in vivo for myeloprotection against Ara-C-induced decreases in HPCs...
Research Grants
- FoxP3+ T cells of mucosal tissuesChang Kim; Fiscal Year: 2009..Since vitamin A is widely consumed by humans, the impact of the project on human health will be high. ..
- Organ-specific migration of CD4+CD25+ regulatory T cellsChang Kim; Fiscal Year: 2006..These studies have the potential to provide important information on organ or tissue-specific trafficking of CD4+CD25+ suppressor T cells and its impact on immune tolerance. ..
- Therapeutic delivery of FoxP3+ T cells to the intestineChang Kim; Fiscal Year: 2009..In addition, the outcomes will have far-reaching implications for treatment of other chronic inflammatory disorders. ..
- FoxP3+ T cells of mucosal tissuesChang H Kim; Fiscal Year: 2010..Since vitamin A is widely consumed by humans, the impact of the project on human health will be high. ..
- Therapeutic delivery of FoxP3+ T cells to the intestineChang H Kim; Fiscal Year: 2010..In addition, the outcomes will have far-reaching implications for treatment of other chronic inflammatory disorders. ..
- Migration and function of Th17 cells in the gutChang H Kim; Fiscal Year: 2010..The outcomes can also be applied to control of Th17-cell-regulated inflammation and immunity in other tissues. ..