Amy Davidson

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. pmc Functional reconstitution of an ABC transporter in nanodiscs for use in electron paramagnetic resonance spectroscopy
    Frances Joan D Alvarez
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47906, USA
    J Am Chem Soc 132:9513-5. 2010
  2. pmc Structure, function, and evolution of bacterial ATP-binding cassette systems
    Amy L Davidson
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Microbiol Mol Biol Rev 72:317-64, table of contents. 2008
  3. ncbi request reprint Crystal structure of a catalytic intermediate of the maltose transporter
    Michael L Oldham
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Nature 450:515-21. 2007
  4. pmc ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation
    Gang Lu
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:17969-74. 2005
  5. pmc Alternating access in maltose transporter mediated by rigid-body rotations
    Dheeraj Khare
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Cell 33:528-36. 2009
  6. pmc Both maltose-binding protein and ATP are required for nucleotide-binding domain closure in the intact maltose ABC transporter
    Cedric Orelle
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:12837-42. 2008
  7. pmc Structural insights into ABC transporter mechanism
    Michael L Oldham
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907, USA
    Curr Opin Struct Biol 18:726-33. 2008
  8. ncbi request reprint A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle
    Jue Chen
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Cell 12:651-61. 2003
  9. ncbi request reprint ABC transporters: how small machines do a big job
    Amy L Davidson
    Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Trends Microbiol 15:448-55. 2007
  10. ncbi request reprint Structural biology. Flipping lipids: is the third time the charm?
    Amy L Davidson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 308:963-5. 2005

Research Grants

  1. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 1999
  2. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2000
  3. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2001
  4. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2002
  5. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2003
  6. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2004
  7. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2005
  8. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2006

Collaborators

  • Michael L Oldham
  • Florante Quiocho
  • Gang Lu
  • Jue Chen
  • E Dassa
  • Olivier Lichtarge
  • Michael Ehrmann
  • Cedric Orelle
  • Erin E Fetsch
  • Tulin Ayvaz
  • Frances Joan D Alvarez
  • Dheeraj Khare
  • Lavanya Rajagopalan
  • Candice S Klug
  • Susan Sharma
  • Mariana I Austermuhle
  • Susmita Samanta
  • Rainer Ehrle
  • Sonia Rahmati
  • R Michael Everly
  • Cindy Shope
  • Srinivasan Madabushi
  • Brenda Farrell
  • Julie Anne Goddard
  • William E Brownell
  • Feng Lin
  • Venkat Anjan
  • Fred A Pereira
  • Nimish Patel
  • Beth Traxler
  • Johnny A Davis
  • Jason A Hall
  • Natasha Mikhaleva
  • Howard A Shuman
  • Moriama Reyes
  • Dana Boyd
  • Shirley Yang
  • E Lynn Zechiedrich

Detail Information

Publications21

  1. pmc Functional reconstitution of an ABC transporter in nanodiscs for use in electron paramagnetic resonance spectroscopy
    Frances Joan D Alvarez
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47906, USA
    J Am Chem Soc 132:9513-5. 2010
    ..We describe the functional reconstitution of the maltose transporter into nanodiscs and demonstrate that this system is ideally suited to study conformational changes and intramolecular distances by EPR...
  2. pmc Structure, function, and evolution of bacterial ATP-binding cassette systems
    Amy L Davidson
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Microbiol Mol Biol Rev 72:317-64, table of contents. 2008
    ..These advances are also important for elucidating the mechanism of action of eukaryotic ABC proteins, because functional defects in many of them are responsible for severe human inherited diseases...
  3. ncbi request reprint Crystal structure of a catalytic intermediate of the maltose transporter
    Michael L Oldham
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Nature 450:515-21. 2007
    ..These results provide direct evidence for a concerted mechanism of transport in which solute is transferred from the binding protein to the transmembrane subunits when the cassette dimer closes to hydrolyse ATP...
  4. pmc ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation
    Gang Lu
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:17969-74. 2005
    ....
  5. pmc Alternating access in maltose transporter mediated by rigid-body rotations
    Dheeraj Khare
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Cell 33:528-36. 2009
    ..The comparison also reveals that point mutations enabling binding protein-independent transport line dynamic interfaces in the TM region...
  6. pmc Both maltose-binding protein and ATP are required for nucleotide-binding domain closure in the intact maltose ABC transporter
    Cedric Orelle
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:12837-42. 2008
    ..We propose that P(i) release coincides with the reorientation of transmembrane helices to an inward-facing conformation and the final step of maltose translocation into the cell...
  7. pmc Structural insights into ABC transporter mechanism
    Michael L Oldham
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907, USA
    Curr Opin Struct Biol 18:726-33. 2008
    ..It appears that rigid-body rotations of the transmembrane subunits, coinciding with the opening and closing of the nucleotide-binding subunits, couples ATP hydrolysis to substrate translocation...
  8. ncbi request reprint A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle
    Jue Chen
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Cell 12:651-61. 2003
    ..The two nucleotide binding domains of the dimer open and close like a pair of tweezers, suggesting a regulatory mechanism for ATPase activity that may be tightly coupled to translocation...
  9. ncbi request reprint ABC transporters: how small machines do a big job
    Amy L Davidson
    Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Trends Microbiol 15:448-55. 2007
    ..ATP binding and ATP hydrolysis have distinct roles in this cycle: binding favors the outward-facing orientation, whereas hydrolysis returns the transporter to an inward-facing conformation...
  10. ncbi request reprint Structural biology. Flipping lipids: is the third time the charm?
    Amy L Davidson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 308:963-5. 2005
  11. pmc Functional reassembly of the Escherichia coli maltose transporter following purification of a MalF-MalG subassembly
    Susan Sharma
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Bacteriol 187:2908-11. 2005
    ..This MalF-MalG complex was competent for efficient reassembly of a functional MalFGK(2) maltose transporter complex both in detergent solution and in proteoliposomes...
  12. pmc Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transporters
    Amy L Davidson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Bacteriol 184:1225-33. 2002
  13. ncbi request reprint Structural biology. Not just another ABC transporter
    Amy L Davidson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 296:1038-40. 2002
  14. pmc Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter
    Erin E Fetsch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:9685-90. 2002
    ..This architecture provides a basis for the cooperativity observed in the nucleotide-binding domains of ABC transporters and a function for this highly conserved family signature motif...
  15. ncbi request reprint Maltose transport through the inner membrane of E. coli
    Erin E Fetsch
    Department of Molecular Virology and Microbiology, One Baylor Plaza, Houston, TX 77030, USA
    Front Biosci 8:d652-60. 2003
    ..This review discusses the current knowledge of the mechanism of maltose transport, as it relates to the ABC superfamily of transporters as a whole...
  16. ncbi request reprint Disulfide cross-linking reveals a site of stable interaction between C-terminal regulatory domains of the two MalK subunits in the maltose transport complex
    Susmita Samanta
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:35265-71. 2003
    ..These data support a model for ATP hydrolysis in which the C-terminal domains of MalK remain in contact whereas the N-terminal domains of MalK open and close to allow nucleotide binding and dissociation...
  17. ncbi request reprint Context-dependent effects of charged residues in transmembrane segments of MalF-PhoA fusions
    Rainer Ehrle
    School of Biosciences, Cardiff University, Cardiff, UK
    Res Microbiol 154:654-7. 2003
    ..Implications of this finding for the biogenesis of polytopic membrane proteins are discussed...
  18. ncbi request reprint Maltose-binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport
    Mariana I Austermuhle
    Department of Molecular Virology and Microbiology, Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 279:28243-50. 2004
    ..Taken together, these data suggest that closure of the MalK dimer interface coincides with opening of MBP and maltose release to the transporter...
  19. pmc Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis
    Lavanya Rajagopalan
    Department of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:12727-34. 2006
    ..These data suggest that packing of helices and interactions between residues surrounding the "sulfate transporter motif" is essential for normal prestin activity...
  20. ncbi request reprint Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA
    Sonia Rahmati
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030 3411, USA
    Mol Microbiol 43:677-85. 2002
    ..Xenobiotics expelled by pumps may resemble the communication molecules that they normally efflux...
  21. ncbi request reprint ATP-binding cassette transporters in bacteria
    Amy L Davidson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Biochem 73:241-68. 2004
    ..Recent advances in structural determination and functional analysis of bacterial ABC transporters, reviewed herein, have greatly increased our understanding of the molecular mechanism of transport in this transport superfamily...

Research Grants8

  1. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 1999
    ..These purified preparations will also be used in collaborative efforts to obtain a high resolution structure of the multi-subunit complex. ..
  2. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2000
    ..These purified preparations will also be used in collaborative efforts to obtain a high resolution structure of the multi-subunit complex. ..
  3. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2001
    ..These purified preparations will also be used in collaborative efforts to obtain a high resolution structure of the multi-subunit complex. ..
  4. MOLECULAR MECHANISM OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2002
    ..These purified preparations will also be used in collaborative efforts to obtain a high resolution structure of the multi-subunit complex. ..
  5. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2003
    ..The purified preparations will also be used in collaborative efforts to obtain high-resolution structures of the multi-subunit complex in different conformational states. ..
  6. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2004
    ..The purified preparations will also be used in collaborative efforts to obtain high-resolution structures of the multi-subunit complex in different conformational states. ..
  7. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2005
    ..The purified preparations will also be used in collaborative efforts to obtain high-resolution structures of the multi-subunit complex in different conformational states. ..
  8. MOLECULAR MECHANISMS OF MALTOSE TRANSPORT
    Amy Davidson; Fiscal Year: 2006
    ..The purified preparations will also be used in collaborative efforts to obtain high-resolution structures of the multi-subunit complex in different conformational states. ..