R G Cooks

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. doi request reprint Ion/molecule reactions for detecting ammonia using miniature cylindrical ion trap mass spectrometers
    Jonell N Smith
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Analyst 136:120-7. 2011
  2. pmc Paper spray ionization of polar analytes using non-polar solvents
    Anyin Li
    Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA
    Chem Commun (Camb) 47:2811-3. 2011
  3. ncbi request reprint Emerging capabilities of mass spectrometry for natural products
    Alan K Jarmusch
    Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN, USA
    Nat Prod Rep 31:730-8. 2014
  4. pmc Touch spray mass spectrometry for in situ analysis of complex samples
    Kevin S Kerian
    Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN, USA
    Analyst 139:2714-20. 2014
  5. pmc Desorption electrospray ionization mass spectrometry reveals lipid metabolism of individual oocytes and embryos
    Andrés Felipe González-Serrano
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut, Neustadt, Germany
    PLoS ONE 8:e74981. 2013
  6. doi request reprint Direct analysis of 4-methylimidazole in foods using paper spray mass spectrometry
    Anyin Li
    Chemistry Department, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Analyst 138:4624-30. 2013
  7. doi request reprint Direct analysis of steviol glycosides from Stevia leaves by ambient ionization mass spectrometry performed on whole leaves
    J Isabella Zhang
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Analyst 137:3091-8. 2012
  8. doi request reprint Rapid analysis of whole blood by paper spray mass spectrometry for point-of-care therapeutic drug monitoring
    Ryan D Espy
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Analyst 137:2344-9. 2012
  9. ncbi request reprint In situ Raman spectroscopy of surfaces modified by ion soft landing
    Jobin Cyriac
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Analyst 137:1363-9. 2012
  10. doi request reprint Rapid detection of urushiol allergens of Toxicodendron genus using leaf spray mass spectrometry
    Fatkhulla K Tadjimukhamedov
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Analyst 137:1082-4. 2012

Collaborators

  • Wei Xu
  • Risto Kostiainen
  • Xin Li
  • Anne Francoise Aubry
  • Zoltan Takats
  • Alexander S Misharin
  • Stephen J Valentine
  • Weiguo Andy Tao
  • J A Ramos-Vara
  • G J Van Berkel
  • Zheng Ouyang
  • Demian R Ifa
  • Nari Talaty
  • Allison L Dill
  • Nicholas E Manicke
  • Robert J Noll
  • Richard H Perry
  • Justin M Wiseman
  • Anthony B Costa
  • Livia S Eberlin
  • Liang Gao
  • Qingyu Song
  • Anyin Li
  • J Isabella Zhang
  • Christopher C Mulligan
  • Santosh Soparawalla
  • Leah S Riter
  • Scott A Smith
  • Hao Chen
  • Alan K Jarmusch
  • Ayanna U Jackson
  • Tiina J Kauppila
  • Guangming Huang
  • Chunping Wu
  • Sergio C Nanita
  • Thomas A Blake
  • Gary A Salazar
  • Jason D Harper
  • Lianming Wu
  • Sameer Kothari
  • Qizhi Hu
  • Zhengzheng Pan
  • Huanwen Chen
  • Kevin S Kerian
  • Ismael Cotte-Rodriguez
  • Sunnie Myung
  • Andrés Felipe González-Serrano
  • Jobin Cyriac
  • Fatkhulla K Tadjimukhamedov
  • Ryan D Espy
  • Jonell N Smith
  • Brian C Laughlin
  • Bogdan Gologan
  • Nathaniel L Sanders
  • Adam Keil
  • Dina R Justes
  • Brandy L Young
  • Daniel Raftery
  • Tapio Kotiaho
  • Amy M Tabert
  • Pengxiang Yang
  • David E Clemmer
  • Ester Marotta
  • Eduardo C Meurer
  • Marcos N Eberlin
  • Heiner Niemann
  • Valentina Pirro
  • Christina R Ferreira
  • Julia Heinzmann
  • Andrea Lucas-Hahn
  • Paolo Oliveri
  • Hsu Chen Hsu
  • Pu Wei
  • Michael Wleklinski
  • Guangtao Li
  • Y I Lee
  • He Wang
  • Adam D Keil
  • William J Chappell
  • Timothy Masterson
  • Michael Koch
  • Timothy L Ratliff
  • Liang Cheng
  • Ewa Sokol
  • Jason Duncan
  • Mark Nicholas
  • Jonathan W Amy
  • Yu Xia
  • Miriam Fico
  • Dennis Taylor

Detail Information

Publications75

  1. doi request reprint Ion/molecule reactions for detecting ammonia using miniature cylindrical ion trap mass spectrometers
    Jonell N Smith
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Analyst 136:120-7. 2011
    ..Product ion identity was verified using tandem mass spectrometry. Similar reactions with methylamine, ethylamine and the two nitriles, acetonitrile and benzonitrile, were explored...
  2. pmc Paper spray ionization of polar analytes using non-polar solvents
    Anyin Li
    Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA
    Chem Commun (Camb) 47:2811-3. 2011
    ..Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper...
  3. ncbi request reprint Emerging capabilities of mass spectrometry for natural products
    Alan K Jarmusch
    Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN, USA
    Nat Prod Rep 31:730-8. 2014
    ..The survey concludes with a discussion of new experiments and capabilities including ion soft landing, preparative mass spectrometry, and accelerated ionic reactions in confined volumes...
  4. pmc Touch spray mass spectrometry for in situ analysis of complex samples
    Kevin S Kerian
    Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN, USA
    Analyst 139:2714-20. 2014
    ..Performance tests include disease state of tissue, microorganism identification, and therapeutic drug quantitation. Chemical derivatization is performed simultaneously with ionization. ..
  5. pmc Desorption electrospray ionization mass spectrometry reveals lipid metabolism of individual oocytes and embryos
    Andrés Felipe González-Serrano
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut, Neustadt, Germany
    PLoS ONE 8:e74981. 2013
    ..These results should assist in the production of viable and healthy embryos by elucidating in vivo embryonic lipid metabolism. ..
  6. doi request reprint Direct analysis of 4-methylimidazole in foods using paper spray mass spectrometry
    Anyin Li
    Chemistry Department, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Analyst 138:4624-30. 2013
    ..As another alternative, a rapid qualitative screening method based on the use of high-resolution measurements instead of tandem mass spectrometry using an Orbitrap was also tested and found to give a detection limit of 100 pg μL⁻¹...
  7. doi request reprint Direct analysis of steviol glycosides from Stevia leaves by ambient ionization mass spectrometry performed on whole leaves
    J Isabella Zhang
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Analyst 137:3091-8. 2012
    ..The potential for the application of leaf spray mass spectrometry to direct and rapid screening of plant materials is here realized in the case of Stevia sweet glycosides...
  8. doi request reprint Rapid analysis of whole blood by paper spray mass spectrometry for point-of-care therapeutic drug monitoring
    Ryan D Espy
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Analyst 137:2344-9. 2012
    ..This one-step method requires 10 μL of blood, a drop of solvent, and takes 45 seconds per trial. These results indicate applicability to point-of-care therapeutic drug monitoring in a clinical setting...
  9. ncbi request reprint In situ Raman spectroscopy of surfaces modified by ion soft landing
    Jobin Cyriac
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Analyst 137:1363-9. 2012
    ..By contrast, in the case of methyl orange which is landed as an anion, the SERS spectra suggest that the SL species has been neutralized...
  10. doi request reprint Rapid detection of urushiol allergens of Toxicodendron genus using leaf spray mass spectrometry
    Fatkhulla K Tadjimukhamedov
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Analyst 137:1082-4. 2012
    ..Tandem mass spectrometry analysis of the leaf spray ions confirms the identifications. Enhanced detection of some urushiols was achieved in the negative mode with the addition of chloride anions to the spray solvent...
  11. ncbi request reprint New ionization methods and miniature mass spectrometers for biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring
    R Graham Cooks
    Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907, USA
    Faraday Discuss 149:247-67; discussion 333-56. 2011
    ..Data on cholesterol sulfate, a new possible prostate biomarker seen at elevated levels in diseased prostate tissue, but not in healthy prostate tissue in serum are reported using paper spray ionization...
  12. ncbi request reprint Perspectives and retrospectives in mass spectrometry: one view
    R Graham Cooks
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47906, USA
    Eur J Mass Spectrom (Chichester, Eng) 16:283-300. 2010
    ..Personal mass spectrometers appear to be just over the horizon as is the large-scale use of mass spectrometry in field-based analysis, including point-of-care medical diagnostics...
  13. ncbi request reprint Chiroselective self-directed octamerization of serine: implications for homochirogenesis
    R G Cooks
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 73:3646-55. 2001
    ..g., the protonated 7:1 cluster is 2.1 kcal/mol less stable than the 8:0 analogue). The implications of these results for the origin of homochirality are discussed...
  14. ncbi request reprint Detection Technologies. Ambient mass spectrometry
    R Graham Cooks
    Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA
    Science 311:1566-70. 2006
    ..Future possible uses of DESI for in vivo clinical analysis and its adaptation to portable mass spectrometers are described...
  15. ncbi request reprint International Mass Spectrometry Society (IMSS)
    R G Cooks
    Department of Chemistry, Purdue University, 1393 Brown Laboratory, West Lafayette, Indiana 47907 1393, USA
    J Mass Spectrom 36:119-23. 2001
    ..Similar material has been provided to the Editors of other journals that cover mass spectrometry...
  16. ncbi request reprint Metal-assisted esterification: glutaric acid-iron(II) complexes in the gas phase
    Y I Lee
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 15:484-8. 2001
    ..Other transition metal ions, such as NiII, ZnII, CoII and CuII, also show distinctive metal-assisted reactions...
  17. ncbi request reprint Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology
    Zoltan Takats
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    J Mass Spectrom 40:1261-75. 2005
    ..Instrumentation is also discussed. Forensic applications as well as emerging areas of application including tissue imaging are given emphasis...
  18. ncbi request reprint Mass spectrometric quantitation of chiral drugs by the kinetic method
    W A Tao
    Aston Laboratory for Mass Spectrometry, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 73:1692-8. 2001
    ..The chiral sensitivity of the method is such as to allow determination of mixtures with a few percent enantiomeric contamination...
  19. ncbi request reprint Differentiation and quantitation of isomeric dipeptides by low-energy dissociation of copper(II)-bound complexes
    W A Tao
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Soc Mass Spectrom 12:490-6. 2001
    ..Calibration curves are constructed by relating the branching ratio measured by the kinetic method, to the isomeric composition of the mixture to allow rapid quantitative isomer analysis...
  20. doi request reprint Ion trap mass analysis at high pressure: an experimental characterization
    Qingyu Song
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    J Mass Spectrom 45:26-34. 2010
    ..Operations at 50 mtorr demonstrated improved CID efficiency in addition to peak widths of 2 and 5 m/z units (full width at half-maximum, FWHM) for protonated caffeine (m/z 195) and Ultramark (m/z 1521) respectively...
  21. ncbi request reprint Chiral purity assay for Flindokalner using tandem mass spectrometry: method development, validation, and benchmarking
    Brandy L Young
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States
    J Pharm Biomed Anal 43:1602-8. 2007
    ..This method represents an alternative to commonly used chromatographic techniques as a means of chiral purity determination and is particularly useful in rapid screening experiments...
  22. ncbi request reprint Neutral fragment mass spectra via ambient thermal dissociation of peptide and protein ions
    Hao Chen
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Chem Soc 129:5880-6. 2007
    ..It yields increased structural information from the resulting mass spectra in both the positive and the negative ion modes...
  23. ncbi request reprint Non-proximate detection of small and large molecules by desorption electrospray ionization and desorption atmospheric pressure chemical ionization mass spectrometry: instrumentation and applications in forensics, chemistry, and biology
    Ismael Cotte-Rodriguez
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 79:7069-77. 2007
    ..Low nanogram detection limits were obtained for the compounds studied from a wide variety of surfaces, even those present in complex matrixes...
  24. doi request reprint Quantitative analysis of small molecules by desorption electrospray ionization mass spectrometry from polytetrafluoroethylene surfaces
    Demian R Ifa
    Department of Chemistry, Purdue University, Bindley Biosciences Center, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 22:503-10. 2008
    ..The use of the analog atenolol as an internal standard and further considerations that should improve quantitation by DESI-MS are also presented...
  25. doi request reprint Fabric analysis by ambient mass spectrometry for explosives and drugs
    Nari Talaty
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Analyst 133:1532-40. 2008
    ..DESI was also used to examine cotton transfer swabs used for travel security sample collection in the screening process. High throughput quantitative analysis of fabric surfaces for targeted analytes is also reported...
  26. ncbi request reprint Forensic applications of ambient ionization mass spectrometry
    Demian R Ifa
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Anal Bioanal Chem 394:1995-2008. 2009
    ..Aspects of ambient ionization currently undergoing rapid development include molecular imaging and increased detection specificity through simultaneous chemical reaction and ionization by addition of appropriate chemical reagents...
  27. doi request reprint Low-temperature plasma probe for ambient desorption ionization
    Jason D Harper
    Weldon School of Biomedical Engineering, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 80:9097-104. 2008
    ..Large surface area sampling and control of fragmentation by a simple adjustment of the electrode configuration during operation are other demonstrated characteristics of the method...
  28. doi request reprint Direct detection of benzene, toluene, and ethylbenzene at trace levels in ambient air by atmospheric pressure chemical ionization using a handheld mass spectrometer
    Guangming Huang
    Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, Indiana, USA
    J Am Soc Mass Spectrom 21:132-5. 2010
    ..The linear dynamic ranges of benzene, toluene, and ethylbenzene are limited to approximately two orders of magnitude by saturation of the detection electronics...
  29. pmc Cholesterol sulfate imaging in human prostate cancer tissue by desorption electrospray ionization mass spectrometry
    Livia S Eberlin
    Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 82:3430-4. 2010
    ..The presence of cholesterol sulfate in prostate tissues might serve as a tool for prostate cancer diagnosis although confirmation through larger and more diverse cohorts and correlations with clinical outcome data is needed...
  30. ncbi request reprint Ion soft-landing into liquids: Protein identification, separation, and purification with retention of biological activity
    Bogdan Gologan
    Department of Chemistry, Purdue University, West Lafayette, IN 47907 1393, USA
    J Am Soc Mass Spectrom 15:1874-84. 2004
    ....
  31. ncbi request reprint Dual-source mass spectrometer with MALDI-LIT-ESI configuration
    Scott A Smith
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    J Proteome Res 6:837-45. 2007
    ....
  32. ncbi request reprint Preparing protein microarrays by soft-landing of mass-selected ions
    Zheng Ouyang
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Science 301:1351-4. 2003
    ..Multiply charged ions of protein kinase A catalytic subunit and hexokinase were also soft-landed into glycerol-based liquid surfaces. These soft-landed kinases phosphorylated LRRASLG oligopeptide and D-fructose, respectively...
  33. ncbi request reprint Chiral analysis by MS
    W Andy Tao
    Purdue University, West Lafayette, IN 47907, USA
    Anal Chem 75:25A-31A. 2003
  34. ncbi request reprint Gentle protein ionization assisted by high-velocity gas flow
    Pengxiang Yang
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 77:6174-83. 2005
    ....
  35. ncbi request reprint Electrosonic spray ionization. A gentle technique for generating folded proteins and protein complexes in the gas phase and for studying ion-molecule reactions at atmospheric pressure
    Zoltan Takats
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 76:4050-8. 2004
    ..This allows the technique to be used for the study of ion-molecule reactions at atmospheric pressure and examples of this are shown...
  36. ncbi request reprint Preparative linear ion trap mass spectrometer for separation and collection of purified proteins and peptides in arrays using ion soft landing
    Thomas A Blake
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 76:6293-305. 2004
    ..The ability to retain bioactivity in the mass-selected and collected biomolecules has been demonstrated in particular cases. The reported instrument has also been characterized as an analytical mass spectrometer...
  37. ncbi request reprint Coupling desorption electrospray ionization with ion mobility/mass spectrometry for analysis of protein structure: evidence for desorption of folded and denatured States
    Sunnie Myung
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Phys Chem B 110:5045-51. 2006
    ..Mechanisms that are consistent with these results are discussed...
  38. doi request reprint Origin of chiral selectivity in gas-phase serine tetramers
    Anthony B Costa
    Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, Indiana, USA
    Phys Chem Chem Phys 13:877-85. 2011
    ..These calculations elucidate a large barrier for reorganization of the cage, completing the theoretical understanding of the tetramers...
  39. doi request reprint Direct detection of fatty acid ethyl esters using low temperature plasma (LTP) ambient ionization mass spectrometry for rapid bacterial differentiation
    J Isabella Zhang
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Analyst 136:3091-7. 2011
    ..Gram-positive and gram-negative bacteria are readily distinguished, and 11 out of 13 Salmonella strains show distinctive patterns. Growth media effects are observed but do not interfere with species recognition based on the PCA results...
  40. doi request reprint Perspectives in imaging using mass spectrometry
    Allison L Dill
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Chem Commun (Camb) 47:2741-6. 2011
    ....
  41. ncbi request reprint Rectilinear ion trap: concepts, calculations, and analytical performance of a new mass analyzer
    Zheng Ouyang
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 2084, USA
    Anal Chem 76:4595-605. 2004
    ..The demonstrated capabilities of the RIT include tandem mass spectrometry, a mass resolution in excess of 1000, and a mass/charge range of 650 Th, all in a simple structure that is only 3.5 cm(3) in internal volume...
  42. ncbi request reprint Trace detection of non-uniformly distributed analytes on surfaces using mass transfer and large-area desorption electrospray ionization (DESI) mass spectrometry
    Santosh Soparawalla
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Analyst 135:1953-60. 2010
    ..The concentration of residue from large surface areas in this technique allowed the detection of 100 ng of explosives from surfaces with areas ranging from 1.00 x 10(3) cm(2) to 1.40 x 10(4) cm(2)...
  43. ncbi request reprint Amino acid clusters formed by sonic spray ionization
    Zoltan Takats
    Purdue University, Department of Chemistry, West Lafayette, Indiana 47907, USA
    Anal Chem 75:1514-23. 2003
    ..Phenylalanine, asparagine, tryptophan, and tyrosine also substitute into the serine octamer; however, the process yields only two incorporations and only small chiral effects...
  44. ncbi request reprint High-throughput mass spectrometer using atmospheric pressure ionization and a cylindrical ion trap array
    Alexander S Misharin
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 2084, USA
    Anal Chem 77:459-70. 2005
    ..Further refinement of the vacuum system and ion optics will allow the addition of more channels of parallel mass analysis and facilitate applications in fields such as proteomics and metabolomics...
  45. ncbi request reprint Chiral enrichment of serine via formation, dissociation, and soft-landing of octameric cluster ions
    Sergio C Nanita
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Soc Mass Spectrom 15:1360-5. 2004
    ....
  46. ncbi request reprint Direct analysis of volatile organic compounds in human breath using a miniaturized cylindrical ion trap mass spectrometer with a membrane inlet
    Leah S Riter
    Chemistry Department, Purdue University, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 16:2370-3. 2002
    ..Additional specificity needed for complex samples was gained by using tandem mass spectrometry...
  47. ncbi request reprint John Beynon at Purdue
    R Graham Cooks
    Purdue University, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 18:7-10. 2004
  48. ncbi request reprint Solid phase micro-extraction in a miniature ion trap mass spectrometer
    Leah S Riter
    Chemistry Department, Purdue University, West Lafayette, IN 47907, USA
    Analyst 128:1119-22. 2003
    ....
  49. ncbi request reprint Ion/molecule reactions performed in a miniature cylindrical ion trap mass spectrometer
    Leah S Riter
    Chemistry Department, Purdue University, West Lafayette, IN 47907, USA
    Analyst 128:1112-8. 2003
    ..Evidence is provided that these reactions occur to give the products described and their potential analytical utility is discussed...
  50. ncbi request reprint Direct monitoring of toxic compounds in air using a portable mass spectrometer
    Christopher C Mulligan
    Department of Chemistry, Purdue University, West Lafayette, IN 47907 2084, USA
    Analyst 131:556-67. 2006
    ..Tandem mass spectrometry based both on collision-induced dissociation and on selective atmospheric pressure ion/molecule reactions is also used to increase selectivity and sensitivity...
  51. ncbi request reprint Ketalization of phosphonium ions by 1,4-dioxane: selective detection of the chemical warfare agent simulant DMMP in mixtures using ion/molecule reactions
    Hao Chen
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 1393, USA
    J Am Soc Mass Spectrom 14:182-8. 2003
    ..This method of DMMP analysis can be applied to aqueous solutions using electrospray ionization; it shows a detection limit in the low ppb range and a linear response over the range 10 to 500 ppb...
  52. ncbi request reprint Recognition and quantification of binary and ternary mixtures of isomeric peptides by the kinetic method: metal ion and ligand effects on the dissociation of metal-bound complexes
    Lianming Wu
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Soc Mass Spectrom 14:152-60. 2003
    ..These data form the basis for possible future quantitative analyses of mixtures of larger peptides such as are generated, for example, in combinatorial synthesis of peptides and peptide mimics...
  53. pmc Lipid profiles of canine invasive transitional cell carcinoma of the urinary bladder and adjacent normal tissue by desorption electrospray ionization imaging mass spectrometry
    Allison L Dill
    Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 81:8758-64. 2009
    ....
  54. doi request reprint Desorption electrospray ionization and other ambient ionization methods: current progress and preview
    Demian R Ifa
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Analyst 135:669-81. 2010
    ..Extensions of the methodology to solution-phase analysis, to stand-off detection and to therapeutic drug analysis using miniature mass spectrometers are also treated...
  55. ncbi request reprint Salt tolerance of desorption electrospray ionization (DESI)
    Ayanna U Jackson
    Department of Chemistry, Purdue University and Bindley Bioscience Center, Discovery Park at Purdue University, West Lafayette, Indiana 47907, USA
    J Am Soc Mass Spectrom 18:2218-25. 2007
    ..The already high salt tolerance of DESI can be optimized further by appropriate choices of surface and spray solution...
  56. ncbi request reprint Ambient mass spectrometry with a handheld mass spectrometer at high pressure
    Adam Keil
    Chemistry Department, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA
    Anal Chem 79:7734-9. 2007
    ..A geometry-independent version of the DESI ion source was also coupled to the miniature mass spectrometer. These results demonstrate that atmospheric pressure ionization can be implemented on simple portable mass spectrometry systems...
  57. ncbi request reprint Desorption electrospray ionization mass spectrometry for the analysis of pharmaceuticals and metabolites
    Tiina J Kauppila
    Department of Chemistry, Purdue University, West Lafayette, IN 47907 2084, USA
    Rapid Commun Mass Spectrom 20:387-92. 2006
    ..Ionization of neutral compounds was less efficient and in many cases it was achieved through adduct formation with simple anions or cations...
  58. ncbi request reprint Serine octamers: cluster formation, reactions, and implications for biomolecule homochirality
    Sergio C Nanita
    Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN 47907, USA
    Angew Chem Int Ed Engl 45:554-69. 2006
    ..This Review evaluates the chemistry of Ser8 clusters and the experimental evidence that supports their possible role in homochirogenesis...
  59. ncbi request reprint Desorption electrospray ionization using an Orbitrap mass spectrometer: Exact mass measurements on drugs and peptides
    Qizhi Hu
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 20:3403-8. 2006
    ..Measurements are made in less than 1 s at a resolution of 60,000. The implications of the data for the mechanisms of DESI are discussed...
  60. ncbi request reprint Multiplexed rectilinear ion trap mass spectrometer for high-throughput analysis
    Amy M Tabert
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907 2084, USA
    Anal Chem 78:4830-8. 2006
    ..The differential experiment presented offers proof of principle of comparative mass spectra in high-throughput screening applications while reducing data storage requirements...
  61. ncbi request reprint Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism
    Zhengzheng Pan
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Anal Bioanal Chem 387:539-49. 2007
    ..The combined approach discussed here may prove useful in the rapid screening of biological fluids from sick patients and may help to improve the understanding of these rare diseases...
  62. ncbi request reprint New surfaces for desorption electrospray ionization mass spectrometry: porous silicon and ultra-thin layer chromatography plates
    Tiina J Kauppila
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 20:2143-50. 2006
    ..This took place immediately at the UTLC surface and it could be achieved rapidly by gently heating the pSi surface. The presence of salts in the sample did not cause suppression of the analyte signal with any of the surfaces...
  63. ncbi request reprint Combining desorption electrospray ionization mass spectrometry and nuclear magnetic resonance for differential metabolomics without sample preparation
    Huanwen Chen
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 20:1577-84. 2006
    ..Over 80 different metabolites were successfully identified by DESI-MS and tandem mass spectrometry experiments, with no prior sample preparation...
  64. ncbi request reprint Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization
    Justin M Wiseman
    Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA
    Angew Chem Int Ed Engl 44:7094-7. 2005
  65. doi request reprint Orbitrap mass spectrometry: instrumentation, ion motion and applications
    Richard H Perry
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Mass Spectrom Rev 27:661-99. 2008
    ..Finally, some specific applications are reviewed to illustrate the performance and versatility of the orbitrap mass spectrometers...
  66. ncbi request reprint Rephasing ion packets in the Orbitrap mass analyzer to improve resolution and peak shape
    Richard H Perry
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Soc Mass Spectrom 20:1397-404. 2009
    ....
  67. ncbi request reprint Chiral and isomeric analysis by electrospray ionization and sonic spray ionization using the fixed-ligand kinetic method
    Lianming Wu
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Eur J Mass Spectrom (Chichester, Eng) 11:231-42. 2005
    ..The fixed-ligand kinetic method is not restricted to any particular kinds of isomers and, hence, represents a general procedure for improving molecular recognition and chiral analysis in the gas phase...
  68. doi request reprint Mass selection of ions from beams using waveform isolation in radiofrequency quadrupoles
    Qingyu Song
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Anal Chem 81:1833-40. 2009
    ..70% of ion transfer to a surface for ion soft landing surface can be achieved. The upper mass range is limited by axial acceleration arising from the stretched geometry, and one solution to this problem is provided...
  69. doi request reprint Multiplexed four-channel rectilinear ion trap mass spectrometer
    Sameer Kothari
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 2084, USA
    Anal Chem 81:1570-9. 2009
    ..These capabilities were demonstrated by examining lipids produced by Escherichia coli and complex mixtures containing drugs of abuse...
  70. pmc Mass spectrometric imaging of lipids using desorption electrospray ionization
    Allison L Dill
    Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2883-9. 2009
    ..DESI-MS has been used to image a variety of tissue samples including human liver adenocarcinoma, rat brain, human breast tissue and canine abdominal tumor tissue. Comparisons between diseased and normal tissue are made in these studies...
  71. doi request reprint Pharmaceutical cleaning validation using non-proximate large-area desorption electrospray ionization mass spectrometry
    Santosh Soparawalla
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Rapid Commun Mass Spectrom 23:131-7. 2009
    ..These levels were achieved from surfaces resembling the equipment used in API manufacturing processes at a rate of 30 s per analysis...
  72. doi request reprint Characterization of electrode surface roughness and its impact on ion trap mass analysis
    Wei Xu
    Department of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA
    J Mass Spectrom 44:353-60. 2009
    ..Application of this method to arrays of large numbers of micro-scale ion traps has enabled the impact of fabrication methodology to be evaluated in terms of mass resolution for the ion trap arrays...
  73. doi request reprint High-throughput quantitative analysis by desorption electrospray ionization mass spectrometry
    Nicholas E Manicke
    Department of Chemistry, Purdue University, Bindley Biosciences Center, West Lafayette, Indiana, USA
    J Am Soc Mass Spectrom 20:321-5. 2009
    ..The LOD for PRN and CBZ when analyzed without chemical background was 10 and 30 fmol, respectively. The LOD of PRN increased to 400 fmol analyzed in 10% urine, and 200 fmol when analyzed in the brain lipid extract...
  74. doi request reprint Molecular imaging of adrenal gland by desorption electrospray ionization mass spectrometry
    Chunping Wu
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Analyst 135:28-32. 2010
    ..The results agree with and extend information available from histological studies...
  75. ncbi request reprint Novel CFCs-substitutes recommended by EPA (hydrofluorocarbon-245fa and hydrofluoroether-7100): ion chemistry in air plasma and reactions with atmospheric ions
    Ester Marotta
    INTM del CNR Sezione di Padova, Dipartimento di Scienze Chimiche, Universita di Padova, Padova, Italy
    J Am Soc Mass Spectrom 16:1081-92. 2005
    ..Interestingly, isomeric pentafluoropropanes form in the reaction with O2-*, either O2-*(HF) or F-(HF), depending on the specific pattern of the fluoro substitution...