C F Babbs

Summary

Affiliation: Purdue University
Country: USA

Publications

  1. pmc Quantitative reappraisal of the helmholtz-guyton resonance theory of frequency tuning in the cochlea
    Charles F Babbs
    Weldon School of Biomedical Engineering and Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    J Biophys 2011:435135. 2011
  2. pmc Subtle paranodal injury slows impulse conduction in a mathematical model of myelinated axons
    Charles F Babbs
    Department of Basic Medical Sciences, Center for Paralysis Research, and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 8:e67767. 2013
  3. pmc Oscillometric measurement of systolic and diastolic blood pressures validated in a physiologic mathematical model
    Charles F Babbs
    Department of Basic Medical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1246, USA
    Biomed Eng Online 11:56. 2012
  4. doi request reprint Optimizing electrode placement for hemodynamic benefit in cardiac resynchronization therapy
    Charles F Babbs
    Department of Basic Medical Sciences, 1246 Lynn Hall, 625 Harrison Street, Purdue University, West Lafayette, Indiana 47907, USA
    Pacing Clin Electrophysiol 35:1135-45. 2012
  5. pmc Predicting success or failure of immunotherapy for cancer: insights from a clinically applicable mathematical model
    Babbs Charles F
    Department of Basic Medical Sciences and Weldon School of Biomedical Engineering, Purdue University West Lafayette, Indiana
    Am J Cancer Res 2:204-13. 2012
  6. pmc Optimization of ectopic gene expression in skeletal muscle through DNA transfer by electroporation
    Jordan Taylor
    Department of Basic Medical Sciences, Purdue University, W Lafayette, IN 47907, USA
    BMC Biotechnol 4:11. 2004
  7. ncbi request reprint A dose-response curve for the negative bias pressure of an intrathoracic pressure regulator during CPR
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 1246, USA
    Resuscitation 71:365-8. 2006
  8. ncbi request reprint Statistical analysis of joint short-term and long-term survival in resuscitation research
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 75:323-31. 2007
  9. ncbi request reprint Consensus evidence evaluation in resuscitation research: analysis of Type I and Type II errors
    C F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 51:193-205. 2001
  10. ncbi request reprint Design of near-optimal waveforms for chest and abdominal compression and decompression in CPR using computer-simulated evolution
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 68:277-93. 2006

Collaborators

Detail Information

Publications32

  1. pmc Quantitative reappraisal of the helmholtz-guyton resonance theory of frequency tuning in the cochlea
    Charles F Babbs
    Weldon School of Biomedical Engineering and Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    J Biophys 2011:435135. 2011
    ..A quantitative rendition of the classical Helmholtz-Guyton model captures the essence of cochlear mechanics and unifies the competing resonance and traveling wave theories...
  2. pmc Subtle paranodal injury slows impulse conduction in a mathematical model of myelinated axons
    Charles F Babbs
    Department of Basic Medical Sciences, Center for Paralysis Research, and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 8:e67767. 2013
    ....
  3. pmc Oscillometric measurement of systolic and diastolic blood pressures validated in a physiologic mathematical model
    Charles F Babbs
    Department of Basic Medical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1246, USA
    Biomed Eng Online 11:56. 2012
    ..Some are closely guarded trade secrets. Accurate extraction of systolic and diastolic pressures from the envelope of cuff pressure oscillations remains an open problem in biomedical engineering...
  4. doi request reprint Optimizing electrode placement for hemodynamic benefit in cardiac resynchronization therapy
    Charles F Babbs
    Department of Basic Medical Sciences, 1246 Lynn Hall, 625 Harrison Street, Purdue University, West Lafayette, Indiana 47907, USA
    Pacing Clin Electrophysiol 35:1135-45. 2012
    ..Research is needed to explore the relative benefits of alternative electrode placements in biventricular and left ventricular (LV) pacing for heart failure with left bundle branch block (LBBB)...
  5. pmc Predicting success or failure of immunotherapy for cancer: insights from a clinically applicable mathematical model
    Babbs Charles F
    Department of Basic Medical Sciences and Weldon School of Biomedical Engineering, Purdue University West Lafayette, Indiana
    Am J Cancer Res 2:204-13. 2012
    ..They may help clinicians understand and predict certain strange and unexpected effects in the world of tumor immunity and lead to the design of clinical trials to test improved treatment protocols for patients...
  6. pmc Optimization of ectopic gene expression in skeletal muscle through DNA transfer by electroporation
    Jordan Taylor
    Department of Basic Medical Sciences, Purdue University, W Lafayette, IN 47907, USA
    BMC Biotechnol 4:11. 2004
    ..Specifically, we investigated the effects of varying injection techniques, electrode surface geometry, and plasmid mediums...
  7. ncbi request reprint A dose-response curve for the negative bias pressure of an intrathoracic pressure regulator during CPR
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 1246, USA
    Resuscitation 71:365-8. 2006
    ..Perfusion pressure increases approximately 50% as baseline airway pressure falls from zero to -10 cm H2O. Thereafter perfusion pressure plateaus. Negative bias pressures exceeding -10 cm H2O are not needed in ITPR-CPR...
  8. ncbi request reprint Statistical analysis of joint short-term and long-term survival in resuscitation research
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 75:323-31. 2007
    ....
  9. ncbi request reprint Consensus evidence evaluation in resuscitation research: analysis of Type I and Type II errors
    C F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 51:193-205. 2001
    ....
  10. ncbi request reprint Design of near-optimal waveforms for chest and abdominal compression and decompression in CPR using computer-simulated evolution
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 68:277-93. 2006
    ..To discover design principles underlying the optimal waveforms for external chest and abdominal compression and decompression during cardiac arrest and cardiopulmonary resuscitation (CPR)...
  11. doi request reprint Quantitative prediction of body surface potentials from myocardial action potentials using a summed dipole model
    Charles F Babbs
    Department of Basic Medical Sciences and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
    Cardiovasc Eng 9:59-71. 2009
    ....
  12. doi request reprint Neonatal CPR: room at the top--a mathematical study of optimal chest compression frequency versus body size
    Charles F Babbs
    Department of Basic Medical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1246, USA
    Resuscitation 80:1280-4. 2009
    ..To explore in detail the expected magnitude of systemic perfusion pressure during standard CPR as a function of compression frequency for different sized people from neonate to adult...
  13. doi request reprint Anterior-posterior impedance cardiography: a new approach to accurate, non-invasive monitoring of cardiac function
    Charles F Babbs
    Department of Basic Medical Sciences and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
    Cardiovasc Eng 10:52-65. 2010
    ....
  14. pmc Behavior of a viscoelastic valveless pump: a simple theory with experimental validation
    Charles F Babbs
    Weldon School of Biomedical Engineering, Department of Basic Medical Sciences, 1426 Lynn Hall, Purdue University, West Lafayette, IN 47907 1246, USA
    Biomed Eng Online 9:42. 2010
    ..The tubing must have at least two sections with two different stiffnesses. When a short segment of the tube is squeezed asymmetrically at certain frequencies, net flow of fluid around the loop can occur without valves...
  15. ncbi request reprint Circulatory adjuncts. Newer methods of cardiopulmonary resuscitation
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana, USA
    Cardiol Clin 20:37-59. 2002
    ..Standard CPR is clearly not the ultimate form of external CPR. There is real, credible evidence that substantial improvements in resuscitation methods and results will be possible in the next decade...
  16. ncbi request reprint Biophysics of cardiopulmonary resuscitation with periodic z-axis acceleration or abdominal compression at aortic resonant frequencies
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1426 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 69:455-69. 2006
    ..The method is able to sustain blood flow and long-term survival during and after prolonged cardiac arrest in anesthetized pigs. However, the exact mechanism by which circulation of blood is created has remained unknown...
  17. ncbi request reprint Optimum compression to ventilation ratios in CPR under realistic, practical conditions: a physiological and mathematical analysis
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1426 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 54:147-57. 2002
    ..The optimum value of a variable is that for which a desired result is maximized. Here the desired result is assumed to be either oxygen delivery to peripheral tissues or a combination of oxygen delivery and waste product removal...
  18. ncbi request reprint Simplified meta-analysis of clinical trials in resuscitation
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 57:245-55. 2003
    ..To present and demonstrate a new simplified method for synthesizing results of multiple clinical trials in resuscitation research...
  19. ncbi request reprint Biomechanics of heading a soccer ball: implications for player safety
    C F Babbs
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907 1246, USA
    ScientificWorldJournal 1:281-322. 2001
    ....
  20. ncbi request reprint Interposed abdominal compression CPR: a comprehensive evidence based review
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 59:71-82. 2003
    ..Cost and logistical considerations discourage use of IAC-CPR outside of hospitals...
  21. ncbi request reprint Optimizing chest compression to rescue ventilation ratios during one-rescuer CPR by professionals and lay persons: children are not just little adults
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, and Indiana University School of Medicine, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 61:173-81. 2004
    ..To estimate the optimum ratio of chest compressions to ventilations for one-rescuer CPR that maximizes systemic oxygen delivery in children...
  22. ncbi request reprint Meta-analysis of 2-treatment clinical trials including both continuous and dichotomous results
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907 12461, USA
    Med Decis Making 24:299-312. 2004
    ..These features are demonstrated for studies of interposed abdominal compression-cardiopulmonary resuscitation...
  23. ncbi request reprint Relative effectiveness of interposed abdominal compression CPR: sensitivity analysis and recommended compression rates
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 66:347-55. 2005
    ..The technique has been generally successful in improving blood flow and survival compared to standard CPR; however, some questions remain...
  24. ncbi request reprint Effects of an impedance threshold valve upon hemodynamics in Standard CPR: studies in a refined computational model
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 66:335-45. 2005
    ..An impedance threshold valve (ITV) is a new airway adjunct for resuscitation that permits generation of a small vacuum in the chest during the recoil phase of chest compression...
  25. doi request reprint Methods for calculating coronary perfusion pressure during CPR
    Michael P Otlewski
    MED Institute, Inc, West Lafayette, IN 47906, USA
    Cardiovasc Eng 9:98-103. 2009
    ..Electronically derived true mean coronary perfusion pressure is arguably the gold standard method for representing coronary perfusion pressure...
  26. ncbi request reprint Efficacy of interposed abdominal compression-cardiopulmonary resuscitation (CPR), active compression and decompression-CPR and Lifestick CPR: basic physiology in a spreadsheet model
    C F Babbs
    Indiana University School of Medicine, West Lafayette, USA
    Crit Care Med 28:N199-202. 2000
    ..These positive effects are explained by improved pump priming and are consequences of fundamental principles of cardiovascular physiology...
  27. doi request reprint High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival
    Nagendra K Prasad
    Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Tumour Biol 29:330-41. 2008
    ..0025) and overall survival periods (p = 0.0228). In invasive carcinomas, SHIP2 correlated with estrogen receptor absence (p = 0.003) and EGFR presence (p = 0.0147). In conclusion, SHIP2 is an important biomarker for breast cancer...
  28. ncbi request reprint Sustained abdominal compression during CPR raises coronary perfusion pressures as much as vasopressor drugs
    Aaron E Lottes
    Weldon School of Biomedical Engineering, Purdue University, 206 S Intramural Drive, West Lafayette, IN 47907 2032, USA
    Resuscitation 75:515-24. 2007
    ....
  29. ncbi request reprint Self-sealing, large bore arterial punctures: a counterintuitive new phenomenon
    Blayne A Roeder
    School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907 1288, USA
    J Biomech Eng 124:342-6. 2002
    ..It is postulated that a flap-valve of tissue created by the modified technique produced this self-sealing behavior. Sophisticated modeling studies are needed to fully understand this new phenomenon...
  30. ncbi request reprint CPR techniques that combine chest and abdominal compression and decompression: hemodynamic insights from a spreadsheet model
    C F Babbs
    Indiana University School of Medicine and the Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 1246, USA
    Circulation 100:2146-52. 1999
    ....
  31. doi request reprint A new paradigm for human resuscitation research using intelligent devices
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 77:306-15. 2008
    ....
  32. ncbi request reprint Optimal strategy for cardiopulmonary resuscitation with continuous chest compression
    Eunok Jung
    Department of Mathematics, Konkuk University, Seoul, Republic of Korea
    Acad Emerg Med 13:715-21. 2006
    ....