Jonathan Drachman

Summary

Affiliation: Puget Sound Blood Center
Country: USA

Publications

  1. ncbi Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation
    Jonathan G Drachman
    Puget Sound Blood Center, Seattle, Washington 98104, USA
    J Biol Chem 277:23544-53. 2002
  2. ncbi Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656
    Brian J Lannutti
    Puget Sound Blood Center, 921 Terry Ave, Seattle, WA 98104, USA
    Blood 105:3875-8. 2005
  3. ncbi Inherited thrombocytopenia: when a low platelet count does not mean ITP
    Jonathan G Drachman
    Puget Sound Blood Center, 921 Terry Ave, Seattle, WA 98104, USA
    Blood 103:390-8. 2004
  4. ncbi A novel strategy for generating platelet-like fragments from megakaryocytic cell lines and human progenitor cells
    Manish J Gandhi
    Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104, USA
    Blood Cells Mol Dis 35:70-3. 2005
  5. ncbi Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation
    Paula G Heller
    Division of Hematology, Instituto de Investigaciones Medicas Alfredo Lanari, University of Buenos Aires, Argentina
    Blood 105:4664-70. 2005
  6. ncbi Gene expression profile of primary human CD34+CD38lo cells differentiating along the megakaryocyte lineage
    Mi Hyun Shim
    Puget Sound Blood Center, Seattle, WA 98104, USA
    Exp Hematol 32:638-48. 2004
  7. ncbi Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors
    Brian J Lannutti
    Puget Sound Blood Center, Seattle, WA 98104 1256, USA
    Blood 103:3736-43. 2004
  8. ncbi Identification and activation of Src family kinases in primary megakaryocytes
    Brian J Lannutti
    Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104 1256, USA
    Exp Hematol 31:1268-74. 2003
  9. ncbi Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs
    Debra D Dahlen
    Division of Hematology, University of Washington, Seattle, WA 98104, USA
    Blood 102:102-8. 2003
  10. ncbi X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP)
    Jennifer N Luthi
    Puget Sound Blood Center and Program, 921 Terry Avenue, Seattle, WA 98104, USA
    Exp Hematol 31:150-8. 2003

Research Grants

  1. MOLECULAR MECHANISMS OF MEGAKARYOCYTE DEVELOPMENT
    Jonathan Drachman; Fiscal Year: 2003
  2. Abnormal Megakaryocyte Development
    Jonathan Drachman; Fiscal Year: 2003

Collaborators

  • Amy E Geddis
  • Kenneth Kaushansky
  • C L Balduini
  • Virginia C Broudy
  • Rosana F Marta
  • Manish J Gandhi
  • Brian J Lannutti
  • Jo Anna Reems
  • Noel Blake
  • Mi Hyun Shim
  • Paula G Heller
  • Carrie L Cummings
  • Mi-Hyun Shim
  • Debra D Dahlen
  • Jennifer N Luthi
  • Laura I Kornblihtt
  • Carlos J Pirola
  • Carrie C Cummings
  • Thomas W Pendergrass
  • Jo-Anna Reems
  • C Anthony Blau
  • Kenji Ihara
  • Ana C Glembotsky
  • Felisa C Molinas
  • David Thorning
  • Aubree Hoover

Detail Information

Publications14

  1. ncbi Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation
    Jonathan G Drachman
    Puget Sound Blood Center, Seattle, Washington 98104, USA
    J Biol Chem 277:23544-53. 2002
    ..Although the nature of the signal transduction pathway is not yet known, this second proliferative event is likely to regulate c-myc expression...
  2. ncbi Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656
    Brian J Lannutti
    Puget Sound Blood Center, 921 Terry Ave, Seattle, WA 98104, USA
    Blood 105:3875-8. 2005
    ..Our data suggest that SU6656 might be useful as a differentiation-inducing agent for MKs and is an important tool for understanding the molecular basis of MK endomitosis...
  3. ncbi Inherited thrombocytopenia: when a low platelet count does not mean ITP
    Jonathan G Drachman
    Puget Sound Blood Center, 921 Terry Ave, Seattle, WA 98104, USA
    Blood 103:390-8. 2004
    ..The mutated genes responsible for each syndrome are reviewed as well as the potential implications for using gene therapy or gene repair in the future...
  4. ncbi A novel strategy for generating platelet-like fragments from megakaryocytic cell lines and human progenitor cells
    Manish J Gandhi
    Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104, USA
    Blood Cells Mol Dis 35:70-3. 2005
    ..These studies provide evidence that SU6656 promotes megakaryocytic differentiation and thrombopoiesis in vitro...
  5. ncbi Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation
    Paula G Heller
    Division of Hematology, Instituto de Investigaciones Medicas Alfredo Lanari, University of Buenos Aires, Argentina
    Blood 105:4664-70. 2005
    ..In conclusion, we identified a C-terminal AML1 mutation that leads to a decrease in Mpl receptor expression, providing a potential explanation for thrombocytopenia in this FPD/AML pedigree...
  6. ncbi Gene expression profile of primary human CD34+CD38lo cells differentiating along the megakaryocyte lineage
    Mi Hyun Shim
    Puget Sound Blood Center, Seattle, WA 98104, USA
    Exp Hematol 32:638-48. 2004
    ..To identify genes involved in megakaryopoiesis, high-density oligonucleotide microarrays were used to compare transcript profiles from undifferentiated CD34+CD38lo cells and culture-derived megakaryocytes (MKs)...
  7. ncbi Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors
    Brian J Lannutti
    Puget Sound Blood Center, Seattle, WA 98104 1256, USA
    Blood 103:3736-43. 2004
    ..These data suggest that SFKs modify the rate of TPO-induced proliferation and are likely to affect cell cycle regulation during megakaryocytopoiesis...
  8. ncbi Identification and activation of Src family kinases in primary megakaryocytes
    Brian J Lannutti
    Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104 1256, USA
    Exp Hematol 31:1268-74. 2003
    ..In this study, we examine which of the eight Src family members are expressed in primary megakaryocytes (MKs) and determine which of these become activated in response to TPO...
  9. ncbi Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs
    Debra D Dahlen
    Division of Hematology, University of Washington, Seattle, WA 98104, USA
    Blood 102:102-8. 2003
    ..These data help identify the receptor motifs involved in TPO-induced internalization of Mpl and suggest that Mpl translocation may be necessary for normal cellular proliferation...
  10. ncbi X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP)
    Jennifer N Luthi
    Puget Sound Blood Center and Program, 921 Terry Avenue, Seattle, WA 98104, USA
    Exp Hematol 31:150-8. 2003
    ..Despite the absence of eczema or immunodeficiency, a mutation of the Wiskott-Aldrich syndrome (WAS) gene was suspected because of the presence of microthrombocytes...
  11. ncbi The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production
    Kenneth Kaushansky
    Division of Hematology, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, Washington, WA 98195, USA
    Oncogene 21:3359-67. 2002
    ..This review attempts to distill what has been learned of the molecular and cellular biology of TPO and its receptor during the past several years, and links this information to several new insights into human disease and its treatment...
  12. ncbi Congenital amegakaryocytic thrombocytopenia in three siblings: molecular analysis of atypical clinical presentation
    Manish J Gandhi
    Puget Sound Blood Center, Seattle, WAash, USA Division of Hematology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Exp Hematol 33:1215-21. 2005
    ..We evaluated this pedigree to understand the unusually late presentation of congenital amegakaryocytic thrombocytopenia (CAMT)...
  13. ncbi FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10
    Manish J Gandhi
    Puget Sound Blood Center, Seattle, Wash 98104, USA
    Hum Hered 55:66-70. 2003
    ..A substitution of cytosine for guanidine (G to C) at nucleotide position 565 was present in all thrombocytopenic family members, causing a predicted substitution of aspartic acid for glutamic acid (E167D) in exon four...
  14. ncbi Role of splenectomy in inherited thrombocytopenias
    Carlo L Balduini
    Blood 104:1227; author reply 1227-8. 2004

Research Grants5

  1. MOLECULAR MECHANISMS OF MEGAKARYOCYTE DEVELOPMENT
    Jonathan Drachman; Fiscal Year: 2003
    ..These studies will help answer important questions about hematopoiesis and the role of cytokines in regulating proliferation and lineage-specific differentiation. ..
  2. Abnormal Megakaryocyte Development
    Jonathan Drachman; Fiscal Year: 2003
    ..Finally, these studies may help in the targeted development of better platelet lowering drugs using rational design to improve on currently available options such as anagrelide, hydroxyurea, and interferon. ..