LEONARD E MINDICH

Summary

Affiliation: Public Health Research Institute
Country: USA

Publications

  1. pmc In vivo studies of genomic packaging in the dsRNA bacteriophage Phi8
    Jian Qiao
    Department of Microbiology, The Public Health Research Institute, Newark, New Jersey 07103, USA
    BMC Microbiol 5:10. 2005
  2. ncbi request reprint Packaging, replication and recombination of the segmented genome of bacteriophage Phi6 and its relatives
    Leonard Mindich
    Department of Microbiology, The Public Health Research Institute, International Centre for Public Health, 225 Warren Street, Newark, NJ 07103, USA
    Virus Res 101:83-92. 2004
  3. ncbi request reprint Unique properties of the inner core of bacteriophage phi8, a virus with a segmented dsRNA genome
    Yang Sun
    Department of Microbiology, The Public Health Research Institute, Newark, NJ 07103, USA
    Virology 308:354-61. 2003
  4. ncbi request reprint Construction of carrier state viruses with partial genomes of the segmented dsRNA bacteriophages
    Yang Sun
    Department of Microbiology, The Public Health Research Institute, Newark, NJ 07103, USA
    Virology 319:274-9. 2004
  5. pmc Analysis of specific binding involved in genomic packaging of the double-stranded-RNA bacteriophage phi6
    Xueying Qiao
    Department of Microbiology, Public Health Research Institute, Newark, New Jersey 07103, USA
    J Bacteriol 185:6409-14. 2003
  6. pmc Isolation and analysis of mutants of double-stranded-RNA bacteriophage phi6 with altered packaging specificity
    Jian Qiao
    Department of Microbiology, Public Health Research Institute, Newark, New Jersey 07103, USA
    J Bacteriol 185:4572-7. 2003
  7. pmc Characterization of Phi2954, a newly isolated bacteriophage containing three dsRNA genomic segments
    Xueying Qiao
    Department of Microbiology, The Public Health Research Institute Center, UMDNJ, Newark NJ, USA
    BMC Microbiol 10:55. 2010
  8. pmc Temporal control of message stability in the life cycle of double-stranded RNA bacteriophage phi8
    Xueying Qiao
    Department of Microbiology, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Virol 83:633-9. 2009
  9. pmc The role of host protein YajQ in the temporal control of transcription in bacteriophage Phi6
    Xueying Qiao
    Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 105:15956-60. 2008
  10. pmc Role of host protein glutaredoxin 3 in the control of transcription during bacteriophage Phi2954 infection
    Jian Qiao
    Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 107:6000-4. 2010

Research Grants

Collaborators

  • Jian Qiao
  • Xueying Qiao
  • Yang Sun
  • Fabiana Di Sanzo
  • Shiroh Onodera

Detail Information

Publications11

  1. pmc In vivo studies of genomic packaging in the dsRNA bacteriophage Phi8
    Jian Qiao
    Department of Microbiology, The Public Health Research Institute, Newark, New Jersey 07103, USA
    BMC Microbiol 5:10. 2005
    ..Unique sequences (pac) near the 5' ends of plus strands are necessary and sufficient for Phi6 genomic packaging and the RNA binding sites are located on P1, the major structural protein of the procapsid...
  2. ncbi request reprint Packaging, replication and recombination of the segmented genome of bacteriophage Phi6 and its relatives
    Leonard Mindich
    Department of Microbiology, The Public Health Research Institute, International Centre for Public Health, 225 Warren Street, Newark, NJ 07103, USA
    Virus Res 101:83-92. 2004
    ..The in vitro packaging and replication system has facilitated the application of reverse genetics and the study of recombination in the family of Cystoviridae...
  3. ncbi request reprint Unique properties of the inner core of bacteriophage phi8, a virus with a segmented dsRNA genome
    Yang Sun
    Department of Microbiology, The Public Health Research Institute, Newark, NJ 07103, USA
    Virology 308:354-61. 2003
    ..The inner core of bacteriophage phi8 differs from that of its relatives in the Cystoviridae in that the major structural protein P1 is able to interact with the host cell membrane to effect penetration of the inner core into the cell...
  4. ncbi request reprint Construction of carrier state viruses with partial genomes of the segmented dsRNA bacteriophages
    Yang Sun
    Department of Microbiology, The Public Health Research Institute, Newark, NJ 07103, USA
    Virology 319:274-9. 2004
    ..In Phi8, carrier state formation requires the activity of genes 8 and 12 of segment S...
  5. pmc Analysis of specific binding involved in genomic packaging of the double-stranded-RNA bacteriophage phi6
    Xueying Qiao
    Department of Microbiology, Public Health Research Institute, Newark, New Jersey 07103, USA
    J Bacteriol 185:6409-14. 2003
    ..Antibodies to peptide sequences were prepared, and their abilities to bind to the exterior of procapsids were determined. Sites sensitive to trypsin and to factor Xa were determined as well...
  6. pmc Isolation and analysis of mutants of double-stranded-RNA bacteriophage phi6 with altered packaging specificity
    Jian Qiao
    Department of Microbiology, Public Health Research Institute, Newark, New Jersey 07103, USA
    J Bacteriol 185:4572-7. 2003
    ..It appears that P1 is the determinant of the RNA binding sites, and it is suggested that the binding sites overlap or are conformational changes of the same domains...
  7. pmc Characterization of Phi2954, a newly isolated bacteriophage containing three dsRNA genomic segments
    Xueying Qiao
    Department of Microbiology, The Public Health Research Institute Center, UMDNJ, Newark NJ, USA
    BMC Microbiol 10:55. 2010
    ..We have recently isolated a number of related phages and five showed high similarity to Phi12 in the amino acid sequences of several proteins. Bacteriophage Phi2954 is a member of this group...
  8. pmc Temporal control of message stability in the life cycle of double-stranded RNA bacteriophage phi8
    Xueying Qiao
    Department of Microbiology, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Virol 83:633-9. 2009
    ..In addition to having a role as a negative regulator, Hb functions to neutralize the activity of protein J, encoded by segment S, which causes the degradation of all viral transcripts...
  9. pmc The role of host protein YajQ in the temporal control of transcription in bacteriophage Phi6
    Xueying Qiao
    Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 105:15956-60. 2008
    ..Previous studies have shown that the activity of the polymerase in the core is controlled by the conformation of the core particle structure...
  10. pmc Role of host protein glutaredoxin 3 in the control of transcription during bacteriophage Phi2954 infection
    Jian Qiao
    Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 107:6000-4. 2010
    ..The binding of GrxC to the particle results in changes in polymerase activity. Mutations resulting in independence of GrxC are found in the gene for protein P1, the major structural protein of the inner core particle...
  11. pmc Interaction of a host protein with core complexes of bacteriophage phi6 to control transcription
    Xueying Qiao
    Public Health Research Institute Center at UMDNJ, 225 Warren Street, Newark, NJ 07103, USA
    J Virol 84:4821-5. 2010
    ..Punctate fluorescence develops when cells are infected with YajQ-dependent viruses. It appears that the host protein binds to the infecting particles and remains with them during the entire infection period...

Research Grants2

  1. Packaging of the Segmented Genome of Bacteriophage Phi6
    Leonard Mindich; Fiscal Year: 2007
    ..There is no current understanding of the genomic packaging of the reoviridae, segmented dsRNA viruses that cause disease in plants and animals, including humans. ..