STUART PELTZ

Summary

Affiliation: PTC Therapeutics
Country: USA

Publications

  1. ncbi request reprint Mining the GEMS--a novel platform technology targeting post-transcriptional control mechanisms
    Anuradha Bhattacharyya
    PTC Therapeutics, Inc, 100 Corporate Court, South Plainfield, NJ 07080, USA
    Drug Discov Today 12:553-60. 2007
  2. doi request reprint Ataluren as an agent for therapeutic nonsense suppression
    Stuart W Peltz
    PTC Therapeutics, Inc, South Plainfield, New Jersey 07080, USA
    Annu Rev Med 64:407-25. 2013
  3. ncbi request reprint Targeting post-transcriptional control for drug discovery
    Stuart W Peltz
    PTC Therapeutics Inc, South Plainfield, NJ 07080, USA
    RNA Biol 6:329-34. 2009
  4. ncbi request reprint Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site
    Christopher R Trotta
    PTC Therapeutics, 100 Corporate Court, South Plainfield, New Jersey 07080, USA
    Nature 441:375-7. 2006
  5. pmc Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay
    Weirong Wang
    Department of Biology, University of Puerto Rico, San Juan, PR 00931
    Mol Cell Biol 26:3390-400. 2006
  6. pmc Derepression of the Her-2 uORF is mediated by a novel post-transcriptional control mechanism in cancer cells
    Anuradha Mehta
    PTC Therapeutics, Inc, South Plainfield, New Jersey 07080, USA
    Genes Dev 20:939-53. 2006
  7. pmc p38 mitogen-activated protein kinase/Hog1p regulates translation of the AU-rich-element-bearing MFA2 transcript
    Shobha Vasudevan
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and Rutgers University, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Mol Cell Biol 25:9753-63. 2005
  8. pmc Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability
    Radharani Duttagupta
    Department of Molecular Genetics, Microbiology, and Immunology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Ln, Piscataway, New Jersey 08854 5627, USA
    Mol Cell Biol 25:5499-513. 2005
  9. ncbi request reprint A newly discovered function for RNase L in regulating translation termination
    Florence Le Roy
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nat Struct Mol Biol 12:505-12. 2005
  10. ncbi request reprint Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation
    Sergey V Paushkin
    PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA
    Cell 117:311-21. 2004

Research Grants

  1. HIV FRAMESHIFTING--FROM BIOLOGY TO THERAPEUTICS
    STUART PELTZ; Fiscal Year: 2003
  2. COMPLEX INVOLVED IN MRNA DECAY IN YEAST
    STUART PELTZ; Fiscal Year: 2002
  3. NONSENSE MEDIATED MRNA DECAY PATHWAY
    STUART PELTZ; Fiscal Year: 2005
  4. NONSENSE MEDIATED MRNA DECAY PATHWAY
    STUART PELTZ; Fiscal Year: 2001
  5. NONSENSE-MEDIATED MRNA DECAY PATHWAY
    STUART PELTZ; Fiscal Year: 1993
  6. COMPLEX INVOLVED IN MRNA DECAY IN YEAST
    STUART PELTZ; Fiscal Year: 2006

Collaborators

  • CHRISTOPHER ROBERT TROTTA
  • Miles F Wilkinson
  • Bin Tian
  • Hong Li
  • Anuradha Mehta
  • David Bedwell
  • Catherine Bisbal
  • Anuradha Bhattacharyya
  • Shobha Vasudevan
  • Radharani Duttagupta
  • Ellen M Welch
  • Carol J Wilusz
  • Ming Du
  • Samit Hirawat
  • Weirong Wang
  • Meenal Patel
  • Florence Le Roy
  • Joseph P Dougherty
  • Sergey V Paushkin
  • Xiaoli Liu
  • Stephen Jones
  • Arthur A Branstrom
  • Allan Jacobson
  • Seongwoo Hwang
  • Huisheng Feng
  • Joseph M Colacino
  • William D Ju
  • Jeffrey A Campbell
  • Neil G Almstead
  • Langdon L Miller
  • Young Choon Moon
  • Marla Weetall
  • Anthony A Turpoff
  • Nicole Risher
  • Gary Karp
  • Yuki Tomizawa
  • Feng He
  • Hongyu Ren
  • Westley J Friesen
  • Guangming Chen
  • Anna Mollin
  • James Takasugi
  • John Babiak
  • Sergey Paushkin
  • Phyllis Spatrick
  • Shirley Yeh
  • Elisabeth R Barton
  • Richard G Wilde
  • Masataka Kawana
  • Panayiota Trifillis
  • Valerie J Northcutt
  • Atiyya Khan
  • Donald Corson
  • Jin Zhuo
  • Jean Hedrick
  • H Lee Sweeney
  • M Morgan Conn
  • Iv├ín J Cajigas
  • Carlos I Gonzalez
  • Danny Tu Khounh
  • Tamim Salehzada
  • Nicole Garneau
  • Ming Ouyang
  • Danny T Khounh
  • Patricia Soteropoulos
  • Bansri S Furia

Detail Information

Publications15

  1. ncbi request reprint Mining the GEMS--a novel platform technology targeting post-transcriptional control mechanisms
    Anuradha Bhattacharyya
    PTC Therapeutics, Inc, 100 Corporate Court, South Plainfield, NJ 07080, USA
    Drug Discov Today 12:553-60. 2007
    ..In this review we describe how this technology enables the identification of small-molecules that modulate the levels of proteins involved in disease pathogenesis...
  2. doi request reprint Ataluren as an agent for therapeutic nonsense suppression
    Stuart W Peltz
    PTC Therapeutics, Inc, South Plainfield, New Jersey 07080, USA
    Annu Rev Med 64:407-25. 2013
    ....
  3. ncbi request reprint Targeting post-transcriptional control for drug discovery
    Stuart W Peltz
    PTC Therapeutics Inc, South Plainfield, NJ 07080, USA
    RNA Biol 6:329-34. 2009
    ..Both programs have yielded drug candidates that are presently in clinical testing for human diseases with high unmet clinical needs, thus illustrating the therapeutic potential of targeting post-transcriptional control...
  4. ncbi request reprint Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site
    Christopher R Trotta
    PTC Therapeutics, 100 Corporate Court, South Plainfield, New Jersey 07080, USA
    Nature 441:375-7. 2006
    ..The catalysis of pre-tRNA by the eukaryotic tRNA-splicing endonuclease therefore requires a previously unrecognized composite active site...
  5. pmc Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay
    Weirong Wang
    Department of Biology, University of Puerto Rico, San Juan, PR 00931
    Mol Cell Biol 26:3390-400. 2006
    ..Our results indicate that phosphorylation of UPF1 and UPF2 is a conserved event in eukaryotes and for the first time provide evidence that Upf2p phosphorylation is crucial for NMD...
  6. pmc Derepression of the Her-2 uORF is mediated by a novel post-transcriptional control mechanism in cancer cells
    Anuradha Mehta
    PTC Therapeutics, Inc, South Plainfield, New Jersey 07080, USA
    Genes Dev 20:939-53. 2006
    ..These results define a novel biological mechanism in which translational control of genes harboring a 5' uORF can be modulated by elements in their 3' UTRs...
  7. pmc p38 mitogen-activated protein kinase/Hog1p regulates translation of the AU-rich-element-bearing MFA2 transcript
    Shobha Vasudevan
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and Rutgers University, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Mol Cell Biol 25:9753-63. 2005
    ..These results suggest that the p38 MAPK/Hog1p pathway regulates 3'-UTR-mediated translation by modulating recruitment of Pab1p and Pub1p, which can interact with the translation machinery...
  8. pmc Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability
    Radharani Duttagupta
    Department of Molecular Genetics, Microbiology, and Immunology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Ln, Piscataway, New Jersey 08854 5627, USA
    Mol Cell Biol 25:5499-513. 2005
    ..These results suggest that Pub1p binds to discrete subsets of cellular transcripts and posttranscriptionally regulates their expression at multiple levels...
  9. ncbi request reprint A newly discovered function for RNase L in regulating translation termination
    Florence Le Roy
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nat Struct Mol Biol 12:505-12. 2005
    ..On the basis of our results, we present a model describing how RNase L is involved in regulating gene expression by modulating the translation termination process...
  10. ncbi request reprint Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation
    Sergey V Paushkin
    PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA
    Cell 117:311-21. 2004
    ..These findings demonstrate a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events...
  11. ncbi request reprint Non-stop decay--a new mRNA surveillance pathway
    Shobha Vasudevan
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Bioessays 24:785-8. 2002
    ..The non-stop decay mechanism releases ribosomes stalled at the 3' end of a mRNA and stimulates the exosome to rapidly degrade the transcript...
  12. ncbi request reprint PTC124 targets genetic disorders caused by nonsense mutations
    Ellen M Welch
    PTC Therapeutics, 100 Corporate Court, South Plainfield, New Jersey 07080, USA
    Nature 447:87-91. 2007
    ....
  13. ncbi request reprint Nuclear mRNA surveillance
    Shobha Vasudevan
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, USA
    Curr Opin Cell Biol 15:332-7. 2003
    ..Furthermore, message-specific regulatory mechanisms correspond with the nuclear mRNA synthesis machinery to control gene expression...
  14. pmc PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model
    Ming Du
    Department of Microbiology and Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 105:2064-9. 2008
    ....
  15. pmc A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated region
    Radharani Duttagupta
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 23:2623-32. 2003
    ..Stabilization occurs as a result of slower deadenylation in the ssa1(ts) strain, suggesting that Hsp70 is required for activation of the turnover pathway...

Research Grants26

  1. HIV FRAMESHIFTING--FROM BIOLOGY TO THERAPEUTICS
    STUART PELTZ; Fiscal Year: 2003
    ..Their long-term goal will be to develop compounds that affect frame-shifting to the point that proof of principle has been established and antiviral agents targeting this process will be subsequently developed for clinical use. ..
  2. COMPLEX INVOLVED IN MRNA DECAY IN YEAST
    STUART PELTZ; Fiscal Year: 2002
    ..Biochemical characterization of the "degradosome complex"; C) Molecular, genetic and biochemical characterization of the individual factors that are associated with the degradosome complex. ..
  3. NONSENSE MEDIATED MRNA DECAY PATHWAY
    STUART PELTZ; Fiscal Year: 2005
    ..The goals of the experiments in this grant proposal are to investigate the sequences and factors involved in the NMD pathway in order to dissect its mechanism and how it is regulated. ..
  4. NONSENSE MEDIATED MRNA DECAY PATHWAY
    STUART PELTZ; Fiscal Year: 2001
    ..Third, to utilize a series of genetic and biochemical assays to gather information about the structure and function of those trans-acting factors. ..
  5. NONSENSE-MEDIATED MRNA DECAY PATHWAY
    STUART PELTZ; Fiscal Year: 1993
    ....
  6. COMPLEX INVOLVED IN MRNA DECAY IN YEAST
    STUART PELTZ; Fiscal Year: 2006
    ..The goal is to amass a set of AU-rich elements large enough to facilitate computer analysis of the sequences to identify commonalities between them that might specify the proteins they interact with and their regulation. ..