Andrew L Niles

Summary

Affiliation: Promega Corporation
Country: USA

Publications

  1. ncbi request reprint A homogeneous assay to measure live and dead cells in the same sample by detecting different protease markers
    Andrew L Niles
    Promega Corp, Madison, WI 53711, USA
    Anal Biochem 366:197-206. 2007
  2. doi request reprint Update on in vitro cytotoxicity assays for drug development
    Andrew L Niles
    Senior Research Scientist Promega Corporation, Research and Development, 2800 Woods Hollow Road, Madison, Wisconsin, 53711, USA 1 608 247 4330, ext 1447 1 608 298 4818
    Expert Opin Drug Discov 3:655-69. 2008
  3. ncbi request reprint Multiplex caspase activity and cytotoxicity assays
    Andrew L Niles
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 414:151-62. 2008
  4. doi request reprint Cytotoxicity testing: measuring viable cells, dead cells, and detecting mechanism of cell death
    Terry L Riss
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 740:103-14. 2011
  5. pmc In vitro viability and cytotoxicity testing and same-well multi-parametric combinations for high throughput screening
    Andrew L Niles
    Research Department, Promega Corporation, 2800 Woods Hollow Road, Madison, WI, USA
    Curr Chem Genomics 3:33-41. 2009
  6. ncbi request reprint Caspase activity assays
    Andrew L Niles
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 414:137-50. 2008

Detail Information

Publications6

  1. ncbi request reprint A homogeneous assay to measure live and dead cells in the same sample by detecting different protease markers
    Andrew L Niles
    Promega Corp, Madison, WI 53711, USA
    Anal Biochem 366:197-206. 2007
    ..Ratiometric measurement of viable and dead cells in the same sample provides an internal control that can be used to normalize data from other cell-based assays...
  2. doi request reprint Update on in vitro cytotoxicity assays for drug development
    Andrew L Niles
    Senior Research Scientist Promega Corporation, Research and Development, 2800 Woods Hollow Road, Madison, Wisconsin, 53711, USA 1 608 247 4330, ext 1447 1 608 298 4818
    Expert Opin Drug Discov 3:655-69. 2008
    ..Results/conclusion: Each of these methods has its relative merits and detractions; however multi-parametric methods using both viability and cytotoxicity markers may mitigate the inherent shortcomings of single parameter measures...
  3. ncbi request reprint Multiplex caspase activity and cytotoxicity assays
    Andrew L Niles
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 414:151-62. 2008
    ..Furthermore, multiplexing caspase activity assays with viability and/or cytotoxicity assays can support conclusions regarding cytotoxic mechanism and provide normalization that may help correct for differences in cell number...
  4. doi request reprint Cytotoxicity testing: measuring viable cells, dead cells, and detecting mechanism of cell death
    Terry L Riss
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 740:103-14. 2011
    ..Data analysis from the measurement of three marker protease activities from the same sample provides a useful tool to help uncover the mechanism of cell death and can serve as an internal control to help identify assay artifacts...
  5. pmc In vitro viability and cytotoxicity testing and same-well multi-parametric combinations for high throughput screening
    Andrew L Niles
    Research Department, Promega Corporation, 2800 Woods Hollow Road, Madison, WI, USA
    Curr Chem Genomics 3:33-41. 2009
    ..Lastly, we discuss the advantages of combining specific HTS compatible assays into multi-parametric, same-well formats...
  6. ncbi request reprint Caspase activity assays
    Andrew L Niles
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 414:137-50. 2008
    ..The highlighted techniques in this chapter are cost efficient and allow for the rapid exploration of thousands of combinations and conditions...