Frank Fan

Summary

Affiliation: Promega Corporation
Country: USA

Publications

  1. ncbi Bioluminescent assays for high-throughput screening
    Frank Fan
    Promega Corporation, Madison, WI 53711, USA
    Assay Drug Dev Technol 5:127-36. 2007
  2. ncbi Luminescent biosensors for real-time monitoring of intracellular cAMP
    Brock F Binkowski
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 756:263-71. 2011
  3. ncbi Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate
    Mary P Hall
    Promega Corporation, Madison, Wisconsin 53711, United States
    ACS Chem Biol 7:1848-57. 2012
  4. ncbi Improved dual-luciferase reporter assays for nuclear receptors
    Aileen Paguio
    Promega Corporation, Madison, Wisconsin, USA
    Curr Chem Genomics 4:43-9. 2010
  5. ncbi Engineered luciferases for molecular sensing in living cells
    Brock Binkowski
    Promega Corporation, Madison, WI 53711, USA
    Curr Opin Biotechnol 20:14-8. 2009
  6. ncbi A novel bioluminescent protease assay using engineered firefly luciferase
    Susan S Wigdal
    Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA
    Curr Chem Genomics 2:16-28. 2008
  7. ncbi Luciferase Reporter Assay System for Deciphering GPCR Pathways
    Zhijie Cheng
    Department of Research, Promega Corporation, Madison, WI53711, USA
    Curr Chem Genomics 4:84-91. 2010
  8. ncbi A luminescent biosensor with increased dynamic range for intracellular cAMP
    Brock F Binkowski
    Promega Corporation, 2800 Woods Hollow Rd, Madison, Wisconsin 53711, United States
    ACS Chem Biol 6:1193-7. 2011
  9. ncbi Novel genetically encoded biosensors using firefly luciferase
    Frank Fan
    ACS Chem Biol 3:346-51. 2008

Collaborators

  • Brock F Binkowski
  • Michael P Valley
  • Thomas Machleidt
  • Keith V Wood
  • Aileen Paguio
  • Mary P Hall
  • Zhijie Cheng
  • Pete Stecha
  • Susan S Wigdal
  • James Unch
  • Christopher T Eggers
  • Dieter H Klaubert
  • Braeden L Butler
  • Hélène A Benink
  • Monika G Wood
  • Matthew B Robers
  • Paul Otto
  • Kristopher Zimmerman
  • Lance P Encell
  • Michael R Slater
  • Poncho L Meisenheimer
  • Gediminas Vidugiris
  • Keith Wood
  • Denise Garvin
  • John Shultz
  • Gediminas J Vidugiris
  • Jessica L Anderson

Detail Information

Publications9

  1. ncbi Bioluminescent assays for high-throughput screening
    Frank Fan
    Promega Corporation, Madison, WI 53711, USA
    Assay Drug Dev Technol 5:127-36. 2007
    ..Finally, new methods for modulating the specific activity of luciferases are leading to the development of intracellular biosensors for dynamic detection of physiological processes...
  2. ncbi Luminescent biosensors for real-time monitoring of intracellular cAMP
    Brock F Binkowski
    Promega Corporation, Madison, WI, USA
    Methods Mol Biol 756:263-71. 2011
    ..Here we present the use of genetically encoded, luminescent biosensors that allow a facile, non-lytic assay format for monitoring cAMP dynamics in living cells...
  3. ncbi Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate
    Mary P Hall
    Promega Corporation, Madison, Wisconsin 53711, United States
    ACS Chem Biol 7:1848-57. 2012
    ..Reporter quantitation is achievable even at very low expression levels to facilitate more reliable coupling with endogenous cellular processes...
  4. ncbi Improved dual-luciferase reporter assays for nuclear receptors
    Aileen Paguio
    Promega Corporation, Madison, Wisconsin, USA
    Curr Chem Genomics 4:43-9. 2010
    ..These luciferase reporter assays provided better research and drug discovery tools for studying the functions of full length nuclear receptors and ligand binding domains...
  5. ncbi Engineered luciferases for molecular sensing in living cells
    Brock Binkowski
    Promega Corporation, Madison, WI 53711, USA
    Curr Opin Biotechnol 20:14-8. 2009
    ..Building on successes achieved in cell culture, these sensors are now beginning to reveal molecular processes within living organisms...
  6. ncbi A novel bioluminescent protease assay using engineered firefly luciferase
    Susan S Wigdal
    Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA
    Curr Chem Genomics 2:16-28. 2008
    ....
  7. ncbi Luciferase Reporter Assay System for Deciphering GPCR Pathways
    Zhijie Cheng
    Department of Research, Promega Corporation, Madison, WI53711, USA
    Curr Chem Genomics 4:84-91. 2010
    ..Furthermore, we demonstrated that these assays can be readily used for potency rankings of agonists and antagonists, and for high throughput screening...
  8. ncbi A luminescent biosensor with increased dynamic range for intracellular cAMP
    Brock F Binkowski
    Promega Corporation, 2800 Woods Hollow Rd, Madison, Wisconsin 53711, United States
    ACS Chem Biol 6:1193-7. 2011
    ..We demonstrate the utility of this construct to detect a broad range of receptor activity, together with showing suitability for use in high-throughput screening...
  9. ncbi Novel genetically encoded biosensors using firefly luciferase
    Frank Fan
    ACS Chem Biol 3:346-51. 2008
    ..These and other luminescent biosensors will be useful for the sensitive detection of cellular physiology in research and drug discovery...