James J Cali

Summary

Affiliation: Promega Corporation
Country: USA

Publications

  1. ncbi Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates
    James J Cali
    Promega Corporation, Madison, WI 53711, USA
    Expert Opin Drug Metab Toxicol 8:1115-30. 2012
  2. ncbi Luminogenic cytochrome P450 assays
    James J Cali
    Promega Corp, Madison, WI 53711, USA
    Expert Opin Drug Metab Toxicol 2:629-45. 2006
  3. ncbi Bioluminescent assays for ADMET
    James J Cali
    Promega Corp, 2800 Woods Hollow Road, Madison, WI 53711, USA
    Expert Opin Drug Metab Toxicol 4:103-20. 2008
  4. ncbi Society for biomolecular sciences--14th Annual Conference and Exhibition. Enhancing research productivity: quality tools, leads and candidates
    James J Cali
    Promega Corp, 2800 Woods Hollow Road, Madison, WI 53711, USA
    IDrugs 11:418-21. 2008
  5. ncbi A bioluminescent assay for the sensitive detection of proteases
    Donna M Leippe
    Research and Development, Promega Corporation, Madison, WI, USA
    Biotechniques 51:105-10. 2011
  6. ncbi A bioluminescent assay for monoamine oxidase activity
    Michael P Valley
    Promega Corporation, Madison, WI 53711, USA
    Anal Biochem 359:238-46. 2006
  7. ncbi A bioluminescence assay for aldehyde dehydrogenase activity
    Sarah J Duellman
    Promega Corp, Madison, WI 53711, USA
    Anal Biochem 434:226-32. 2013
  8. ncbi N-Alkylated 6'-aminoluciferins are bioluminescent substrates for Ultra-Glo and QuantiLum luciferase: new potential scaffolds for bioluminescent assays
    Carolyn C Woodroofe
    Promega Biosciences, Inc, 277 Granada Drive, San Luis Obispo, California 93401, USA
    Biochemistry 47:10383-93. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates
    James J Cali
    Promega Corporation, Madison, WI 53711, USA
    Expert Opin Drug Metab Toxicol 8:1115-30. 2012
    ..Furthermore, they support highly sensitive, rapid and scalable assays for cell-based and cell-free biochemical applications, which offer an alternative and often enabling option over conventional assay strategies...
  2. ncbi Luminogenic cytochrome P450 assays
    James J Cali
    Promega Corp, Madison, WI 53711, USA
    Expert Opin Drug Metab Toxicol 2:629-45. 2006
    ..These homogenous assays are sensitive and robust tools for high-throughput CYP screening in early drug discovery...
  3. ncbi Bioluminescent assays for ADMET
    James J Cali
    Promega Corp, 2800 Woods Hollow Road, Madison, WI 53711, USA
    Expert Opin Drug Metab Toxicol 4:103-20. 2008
    ..The bioluminescent ADMET assays are rapid and sensitive, amenable to automated high-throughput applications and offer significant advantages over alternative methods...
  4. ncbi Society for biomolecular sciences--14th Annual Conference and Exhibition. Enhancing research productivity: quality tools, leads and candidates
    James J Cali
    Promega Corp, 2800 Woods Hollow Road, Madison, WI 53711, USA
    IDrugs 11:418-21. 2008
  5. ncbi A bioluminescent assay for the sensitive detection of proteases
    Donna M Leippe
    Research and Development, Promega Corporation, Madison, WI, USA
    Biotechniques 51:105-10. 2011
    ..This sensitive, bioluminescent, protease assay should be useful for applications in which contaminating proteases are detrimental and protein purity is essential...
  6. ncbi A bioluminescent assay for monoamine oxidase activity
    Michael P Valley
    Promega Corporation, Madison, WI 53711, USA
    Anal Biochem 359:238-46. 2006
    ..Other advantages of this bioluminescent assay over comparable fluorescent assays are discussed...
  7. ncbi A bioluminescence assay for aldehyde dehydrogenase activity
    Sarah J Duellman
    Promega Corp, Madison, WI 53711, USA
    Anal Biochem 434:226-32. 2013
    ..The assay also shows an accurate pharmacological response for a common ALDH inhibitor and is robust, with a large assay window (S/B=64) and Z'=0.75...
  8. ncbi N-Alkylated 6'-aminoluciferins are bioluminescent substrates for Ultra-Glo and QuantiLum luciferase: new potential scaffolds for bioluminescent assays
    Carolyn C Woodroofe
    Promega Biosciences, Inc, 277 Granada Drive, San Luis Obispo, California 93401, USA
    Biochemistry 47:10383-93. 2008
    ..73-10.8 microM) also plays a role. Molecular modeling results suggest that interactions of the side chain with a hydrogen-bonding network at the base of the luciferin binding pocket may influence substrate-enzyme binding...