Virginia Zakian

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres
    Angela Chan
    Department of Molecular Biology, Princeton University, Princeton, NJ, USA
    PLoS Genet 4:e1000236. 2008
  2. pmc Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair
    Jean S McGee
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Struct Mol Biol 17:1438-45. 2010
  3. pmc The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro
    Creighton T Tuzon
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Genet 7:e1002060. 2011
  4. pmc Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end
    Raymund J Wellinger
    Department of Microbiology and Infectiology, RNA Group, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Genetics 191:1073-105. 2012
  5. pmc Pif1 family helicases suppress genome instability at G-quadruplex motifs
    Katrin Paeschke
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 497:458-62. 2013
  6. pmc Telomeres: the beginnings and ends of eukaryotic chromosomes
    Virginia A Zakian
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Exp Cell Res 318:1456-60. 2012

Research Grants

  1. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2004
  2. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2005
  3. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2005
  4. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2006
  5. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2007
  6. Structure and Behaviour of Yeast Telomeres
    Virginia Zakian; Fiscal Year: 2009
  7. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2010
  8. DNA REPLICATION AND CHROMOSOME STRUCTURE IN YEAST
    Virginia A Zakian; Fiscal Year: 2010
  9. Structure and Behaviour of Yeast Telomeres
    Virginia Zakian; Fiscal Year: 2009
  10. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2011

Collaborators

Detail Information

Publications6

  1. pmc Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres
    Angela Chan
    Department of Molecular Biology, Princeton University, Princeton, NJ, USA
    PLoS Genet 4:e1000236. 2008
    ..Finally, the G1 and late S/G2 phase pathways for telomerase recruitment are distinct and are likely the only ones that bring telomerase to telomeres in wild-type cells...
  2. pmc Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair
    Jean S McGee
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Struct Mol Biol 17:1438-45. 2010
    ..Binding of replication protein A was also much lower at short telomeres. The absence of Mec1 at short telomeres could explain why they do not trigger a checkpoint-mediated cell-cycle arrest...
  3. pmc The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro
    Creighton T Tuzon
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Genet 7:e1002060. 2011
    ..Taken together, these data indicate that Est3 acts downstream of both Est2 and Est1 and that the putative activation function of Est1 can be explained by its role in recruiting Est3 to telomeres...
  4. pmc Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end
    Raymund J Wellinger
    Department of Microbiology and Infectiology, RNA Group, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Genetics 191:1073-105. 2012
    ..We present a comprehensive review of yeast telomere biology that covers capping, replication, recombination, and transcription. We think of it as yeast telomeres--soup to nuts...
  5. pmc Pif1 family helicases suppress genome instability at G-quadruplex motifs
    Katrin Paeschke
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 497:458-62. 2013
    ..Furthermore, when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening...
  6. pmc Telomeres: the beginnings and ends of eukaryotic chromosomes
    Virginia A Zakian
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Exp Cell Res 318:1456-60. 2012
    ..These studies culminated in the 2009 Nobel Prize in Medicine. Critical findings that moved the field forward and that suggest directions for future research are emphasized...

Research Grants26

  1. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2004
    ..Analysis of proteins that affect yeast telomeres is likely to be relevant to an understanding of genetic instability in humans. ..
  2. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2005
    ..Analysis of proteins that affect yeast telomeres is likely to be relevant to an understanding of genetic instability in humans. ..
  3. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2005
    ..Analysis of proteins that affect yeast telomeres is likely to be relevant to an understanding of genetic instability in humans. ..
  4. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2006
    ..Analysis of proteins that affect yeast telomeres is likely to be relevant to an understanding of genetic instability in humans. ..
  5. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2007
    ..Analysis of proteins that affect yeast telomeres is likely to be relevant to an understanding of genetic instability in humans. city, state) ..
  6. Structure and Behaviour of Yeast Telomeres
    Virginia Zakian; Fiscal Year: 2009
    ..Many of the proteins involved in telomere length regulation in humans were first identified in yeast, which continues to serve as key model for understanding the human enzyme. ..
  7. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2010
    ..Many of the proteins involved in telomere length regulation in humans were first identified in yeast, which continues to serve as key model for understanding the human enzyme. ..
  8. DNA REPLICATION AND CHROMOSOME STRUCTURE IN YEAST
    Virginia A Zakian; Fiscal Year: 2010
    ..These studies will lay the groundwork for the identification and analysis of human proteins with similar functions. ..
  9. Structure and Behaviour of Yeast Telomeres
    Virginia Zakian; Fiscal Year: 2009
    ..In addition, telomerase is expressed but at very low levels in human stem cells, and even modest reductions in this level can lead to stem cell failure with dire effects on life span. ..
  10. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2011
    ..Many of the proteins involved in telomere length regulation in humans were first identified in yeast, which continues to serve as key model for understanding the human enzyme. ..
  11. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2003
    ..Analysis of proteins that affect yeast telomeres is likely to be relevant to an understanding of genetic instability in humans. ..
  12. STRUCTURE & BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2002
    ..Telomeres are well conserved from yeast to humans. An analysis of yeast proteins that affect telomere structure or function is likely to be relevant to an understanding of genetic instability in humans. ..
  13. STRUCTURE & BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 1999
    ..Telomeres are well conserved from yeast to humans. An analysis of yeast proteins that affect telomere structure or function is likely to be relevant to an understanding of genetic instability in humans. ..
  14. TRI-NUCLEOTIDE REPEAT AND FRAGILE SITES IN YEAST
    Virginia Zakian; Fiscal Year: 1999
    ..This model will be tested using density transfer and two-dimensional gel electrophoresis to determine if replication timing or replication fork progression is affected by the presence of TNRs. ..
  15. TRI-NUCLEOTIDE REPEAT AND FRAGILE SITES IN YEAST
    Virginia Zakian; Fiscal Year: 2000
    ..This model will be tested using density transfer and two-dimensional gel electrophoresis to determine if replication timing or replication fork progression is affected by the presence of TNRs. ..
  16. STRUCTURE & BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2000
    ..Telomeres are well conserved from yeast to humans. An analysis of yeast proteins that affect telomere structure or function is likely to be relevant to an understanding of genetic instability in humans. ..
  17. TRI-NUCLEOTIDE REPEAT AND FRAGILE SITES IN YEAST
    Virginia Zakian; Fiscal Year: 2001
    ..This model will be tested using density transfer and two-dimensional gel electrophoresis to determine if replication timing or replication fork progression is affected by the presence of TNRs. ..
  18. STRUCTURE & BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2001
    ..Telomeres are well conserved from yeast to humans. An analysis of yeast proteins that affect telomere structure or function is likely to be relevant to an understanding of genetic instability in humans. ..
  19. TRI-NUCLEOTIDE REPEAT AND FRAGILE SITES IN YEAST
    Virginia Zakian; Fiscal Year: 2002
    ..This model will be tested using density transfer and two-dimensional gel electrophoresis to determine if replication timing or replication fork progression is affected by the presence of TNRs. ..
  20. DNA REPLICATION AND CHROMOSOME STRUCTURE IN YEAST
    Virginia A Zakian; Fiscal Year: 2011
    ..These studies will lay the groundwork for the identification and analysis of human proteins with similar functions. ..