Christopher M Waters

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi request reprint Quorum sensing: cell-to-cell communication in bacteria
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Annu Rev Cell Dev Biol 21:319-46. 2005
  2. pmc A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi
    Kimberly C Tu
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton, NJ 08544 1014, USA
    Mol Microbiol 70:896-907. 2008
  3. pmc Control of the type 3 secretion system in Vibrio harveyi by quorum sensing through repression of ExsA
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Appl Environ Microbiol 76:4996-5004. 2010
  4. pmc Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT
    Christopher M Waters
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    J Bacteriol 190:2527-36. 2008
  5. pmc A negative feedback loop involving small RNAs accelerates Vibrio cholerae's transition out of quorum-sensing mode
    Sine L Svenningsen
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Genes Dev 22:226-38. 2008
  6. pmc The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 20:2754-67. 2006
  7. ncbi request reprint An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid
    Christopher M Waters
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Mol Microbiol 52:1159-71. 2004
  8. pmc The aggregation domain of aggregation substance, not the RGD motifs, is critical for efficient internalization by HT-29 enterocytes
    Christopher M Waters
    Department of Microbiology, University of Minnesota Medical School, 1420 Delaware Street SE, Minneapolis, MN 55455, USA
    Infect Immun 71:5682-9. 2003
  9. pmc Role of the Enterococcus faecalis GelE protease in determination of cellular chain length, supernatant pheromone levels, and degradation of fibrin and misfolded surface proteins
    Christopher M Waters
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 185:3613-23. 2003
  10. pmc Enterococcus faecalis plasmid pAD1-encoded Fst toxin affects membrane permeability and alters cellular responses to lantibiotics
    Keith E Weaver
    Division of Basic Biomedical Sciences, School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, USA
    J Bacteriol 185:2169-77. 2003

Research Grants

  1. Analysis of Vibro harveyi quorum sensing
    Christopher Waters; Fiscal Year: 2006

Detail Information

Publications10

  1. ncbi request reprint Quorum sensing: cell-to-cell communication in bacteria
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Annu Rev Cell Dev Biol 21:319-46. 2005
    ....
  2. pmc A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi
    Kimberly C Tu
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton, NJ 08544 1014, USA
    Mol Microbiol 70:896-907. 2008
    ..Our results suggest that feedback is essential for optimizing the dynamics of the transitions between individual and group behaviours...
  3. pmc Control of the type 3 secretion system in Vibrio harveyi by quorum sensing through repression of ExsA
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Appl Environ Microbiol 76:4996-5004. 2010
    ..harveyi QS regulon and elucidates a mechanism demonstrating how multiple regulators can be linked in series to direct the expression of QS target genes specifically at low or high cell density...
  4. pmc Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT
    Christopher M Waters
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    J Bacteriol 190:2527-36. 2008
    ..cholerae integrates information about the vicinal bacterial community contained in extracellular QS autoinducers with the intracellular environmental information encoded in c-di-GMP to control biofilm formation...
  5. pmc A negative feedback loop involving small RNAs accelerates Vibrio cholerae's transition out of quorum-sensing mode
    Sine L Svenningsen
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Genes Dev 22:226-38. 2008
    ..In this state, the HapR feedback loop dramatically accelerates V. cholerae's transition from the high to the low cell density mode...
  6. pmc The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 20:2754-67. 2006
    ..harveyi a mechanism to respond uniquely to different AI input states...
  7. ncbi request reprint An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid
    Christopher M Waters
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Mol Microbiol 52:1159-71. 2004
    ..Thus, Asc10 possess two distinct domains required for aggregation and eukaryotic cell internalization: an N-terminal domain that promotes binding to LTA and a second domain located near the middle of the protein...
  8. pmc The aggregation domain of aggregation substance, not the RGD motifs, is critical for efficient internalization by HT-29 enterocytes
    Christopher M Waters
    Department of Microbiology, University of Minnesota Medical School, 1420 Delaware Street SE, Minneapolis, MN 55455, USA
    Infect Immun 71:5682-9. 2003
    ..These data show that Asc10 directs internalization of E. faecalis into HT-29 enterocytes through a non-RGD-dependent mechanism...
  9. pmc Role of the Enterococcus faecalis GelE protease in determination of cellular chain length, supernatant pheromone levels, and degradation of fibrin and misfolded surface proteins
    Christopher M Waters
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 185:3613-23. 2003
    ..These new functions attributed to GelE suggest that it acts to increase the dissemination of E. faecalis in high-density environments...
  10. pmc Enterococcus faecalis plasmid pAD1-encoded Fst toxin affects membrane permeability and alters cellular responses to lantibiotics
    Keith E Weaver
    Division of Basic Biomedical Sciences, School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, USA
    J Bacteriol 185:2169-77. 2003
    ..Interestingly, overproduction of Fst sensitized cells to the lantibiotic nisin, and Fst-resistant mutants were cross-resistant to nisin and the pAD1-encoded cytolysin...

Research Grants1

  1. Analysis of Vibro harveyi quorum sensing
    Christopher Waters; Fiscal Year: 2006
    ..Importantly, as quorum sensing has been shown to regulate virulence in a number of different bacterial pathogens, these finding will be directly applicable to the understanding, and prevention, of disease. ..