JEFFRY STOCK

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi request reprint A receptor scaffold mediates stimulus-response coupling in bacterial chemotaxis
    J Stock
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell Calcium 26:157-64. 1999
  2. doi request reprint The biochemistry of memory
    Jeffry B Stock
    Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA Electronic address
    Curr Biol 23:R741-5. 2013
  3. pmc Histidine protein kinases: key signal transducers outside the animal kingdom
    Peter M Wolanin
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 3:REVIEWS3013. 2002
  4. ncbi request reprint Information processing in bacterial chemotaxis
    Jeffry B Stock
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Sci STKE 2002:pe25. 2002
  5. pmc Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism
    Sandra Da Re
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Protein Sci 11:2644-54. 2002
  6. ncbi request reprint Organization of the receptor-kinase signaling array that regulates Escherichia coli chemotaxis
    Mikhail N Levit
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 277:36748-54. 2002
  7. ncbi request reprint Bacterial chemosensing: cooperative molecular logic
    Peter M Wolanin
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 14:R486-7. 2004
  8. ncbi request reprint Motion to form a quorum
    Sungsu Park
    Department of Physics, Princeton University, Princeton, NJ 08544, USA
    Science 301:188. 2003
  9. ncbi request reprint Modulated receptor interactions in bacterial transmembrane signaling
    Daniel J Webre
    Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
    Trends Cell Biol 14:478-82. 2004
  10. ncbi request reprint Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease
    Scott B Vafai
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    FEBS Lett 518:1-4. 2002

Research Grants

  1. ROLE OF PP2A METHYLATION IN CELL REGULATION
    JEFFRY STOCK; Fiscal Year: 2003
  2. MECHANISMS OF SENSORY PROCESSING IN CHEMOTAXIS
    JEFFRY STOCK; Fiscal Year: 2001
  3. MECHANISMS OF SENSORY PROCESSING IN CHEMOTAXIS
    JEFFRY STOCK; Fiscal Year: 2006

Collaborators

  • Yigong Shi
  • Philip D Jeffrey
  • Stefan Strack
  • Satoshi Sawai
  • Scott B Vafai
  • S Napper
  • Peter A Thomason
  • E H Postel
  • Peter M Wolanin
  • Melinda D Baker
  • Yongna Xing
  • Mikhail N Levit
  • Yu Chen
  • Noreen R Francis
  • Daniel J Webre
  • Sungsu Park
  • Zhu Li
  • David J Derosier
  • Michael Voronkov
  • Ying Chen
  • Zheng Lin
  • Yanhui Xu
  • Dennis R Thomas
  • Pascal Silberzan
  • Emil A Yuzbashyan
  • Sandra Da Re
  • Steven P Braithwaite
  • Edward C Cox
  • Xiao Juan Guan
  • Michael S Wert
  • Qing Bao
  • Kyle J McQuade
  • Yang Chao
  • Robert Austin
  • Nicholas C Darnton
  • Robert H Austin
  • Hai Lin
  • Tatiana Tolstykh
  • Thorsten W Grebe
  • Bozena M Abramczyk
  • Linda A Melanson
  • Tanvir R Shaikh

Detail Information

Publications29

  1. ncbi request reprint A receptor scaffold mediates stimulus-response coupling in bacterial chemotaxis
    J Stock
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell Calcium 26:157-64. 1999
    ..Results suggest that stimuli are detected through the perturbations they induce in scaffolding architecture...
  2. doi request reprint The biochemistry of memory
    Jeffry B Stock
    Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA Electronic address
    Curr Biol 23:R741-5. 2013
    ..Adler's initiative at least raised the prospect that, because of the numerous experimental advantages provided by E. coli, it would be the first organism whose behavior could be understood at molecular resolution. ..
  3. pmc Histidine protein kinases: key signal transducers outside the animal kingdom
    Peter M Wolanin
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 3:REVIEWS3013. 2002
    ..The proteins divide into at least 11 subfamilies, only one of which is present in eukaryotes, suggesting that lateral gene transfer gave rise to two-component signaling in these organisms...
  4. ncbi request reprint Information processing in bacterial chemotaxis
    Jeffry B Stock
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Sci STKE 2002:pe25. 2002
    ....
  5. pmc Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism
    Sandra Da Re
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Protein Sci 11:2644-54. 2002
    ..Our findings argue against the two-state hypothesis for response regulator activation. We propose an alternative intermolecular mechanism that involves a dynamic interplay between response regulators and their effector targets...
  6. ncbi request reprint Organization of the receptor-kinase signaling array that regulates Escherichia coli chemotaxis
    Mikhail N Levit
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 277:36748-54. 2002
    ..Our results indicate that information from numerous receptors is integrated to control the activity of a relatively small number of kinase molecules...
  7. ncbi request reprint Bacterial chemosensing: cooperative molecular logic
    Peter M Wolanin
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 14:R486-7. 2004
    ..Each cell contains thousands of receptor subunits that form a tightly packed array at one pole. Recent studies of bacterial behavior have begun to reveal the molecular logic of this sensory architecture...
  8. ncbi request reprint Motion to form a quorum
    Sungsu Park
    Department of Physics, Princeton University, Princeton, NJ 08544, USA
    Science 301:188. 2003
  9. ncbi request reprint Modulated receptor interactions in bacterial transmembrane signaling
    Daniel J Webre
    Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
    Trends Cell Biol 14:478-82. 2004
    ....
  10. ncbi request reprint Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease
    Scott B Vafai
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    FEBS Lett 518:1-4. 2002
    ..We propose that the PP2A methylation system is the link relating elevated plasma homocysteine to AD...
  11. ncbi request reprint Signal transduction in bacterial chemotaxis
    Melinda D Baker
    Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
    Bioessays 28:9-22. 2006
    ..This is an exciting field of study because the depth of knowledge now allows the detailed molecular mechanisms of transmembrane signaling and signal processing to be investigated...
  12. ncbi request reprint Receptor methylation controls the magnitude of stimulus-response coupling in bacterial chemotaxis
    Mikhail N Levit
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 277:36760-5. 2002
    ..The cooperative effects of ligand binding appear to be minimal with Hill coefficients for kinase inhibition less than 2, independent of the state of glutamyl modification...
  13. ncbi request reprint Systems biology of bacterial chemotaxis
    Melinda D Baker
    Princeton University, Department of Molecular Biology, Lewis Thomas Laboratory, Princeton, NJ 08544, USA
    Curr Opin Microbiol 9:187-92. 2006
    ..The robustness or insensitivity of the chemotaxis system to perturbations in biochemical parameters is a product of the system's hierarchical network architecture...
  14. ncbi request reprint Interactions between Escherichia coli nucleoside-diphosphate kinase and DNA
    Mikhail N Levit
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    J Biol Chem 277:5163-7. 2002
    ..The conservation of the DNA binding and DNA cleavage activities between human and bacterial NDP kinases argues strongly for the hypothesis that these activities play an essential role in NDP kinase function in vivo...
  15. ncbi request reprint Mechanism of phosphatase activity in the chemotaxis response regulator CheY
    Peter M Wolanin
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Biochemistry 42:14075-82. 2003
    ..Thus, CheY dephosphorylation does not usually proceed via a succinimide or any other intramolecular attack...
  16. pmc Influence of topology on bacterial social interaction
    Sungsu Park
    Department of Physics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 100:13910-5. 2003
    ..Our results thus show that under nutrient-deprived conditions bacteria search out each other in a collective manner and that the bacteria can dynamically confine themselves to highly enclosed spaces...
  17. ncbi request reprint Signal transduction: networks and integrated circuits in bacterial cognition
    Melinda D Baker
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 17:R1021-4. 2007
    ..Recent studies have focused on mechanisms that allow crosstalk between different information-processing modalities...
  18. pmc Isoprenylcysteine carboxy methylation is essential for development in Dictyostelium discoideum
    Ying Chen
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 18:4106-18. 2007
    ..These data indicate that isoprenylcysteine methylation is required for intercellular signaling and development in Dictyostelium...
  19. ncbi request reprint Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
    Yongna Xing
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, NJ 08544, USA
    Cell 127:341-53. 2006
    ..These structures, together with biochemical analyses, reveal significant insights into PP2A function and serve as a framework for deciphering the diverse roles of PP2A in cellular physiology...
  20. pmc Self-assembly of receptor/signaling complexes in bacterial chemotaxis
    Peter M Wolanin
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 103:14313-8. 2006
    ..To understand this structure in its cellular context, we propose a model involving parallel membrane segments in receptor-mediated CheA activation in vivo...
  21. ncbi request reprint The histidine kinase homologue DhkK/Sombrero controls morphogenesis in Dictyostelium
    Peter A Thomason
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Biol 292:358-70. 2006
    ..Uniquely for a histidine kinase, DhkK is located in the nuclear envelope. Entry into culmination requires the DhkK response regulator domain, which appears to directly regulate cyclic AMP signaling...
  22. ncbi request reprint Bacterial chemotaxis
    Daniel J Webre
    Molecular Biology, Lewis Thomas Labs Rm 347, Princeton University, 08544, Princeton, NJ, USA
    Curr Biol 13:R47-9. 2003
  23. ncbi request reprint Signal transduction: receptor clusters as information processing arrays
    Peter A Thomason
    Molecular Biology Department, Princeton University, Princeton, NY 08544, USA
    Curr Biol 12:R399-401. 2002
    ..What are the implications of receptor clustering for short-term and long-term signaling processes that occur in response to ligand binding?..
  24. pmc Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease
    Michael Voronkov
    Signum Biosciences, Monmouth Junction, NJ 08852, USA
    Future Med Chem 3:821-33. 2011
    ..These results indicate that PP2A may provide a useful target that can be safely, selectively and effectively modulated through pharmaceutical intervention to treat Alzheimer's disease...
  25. ncbi request reprint Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
    Yu Chen
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Nat Struct Mol Biol 14:527-34. 2007
    ..These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes...
  26. doi request reprint Structural mechanism of demethylation and inactivation of protein phosphatase 2A
    Yongna Xing
    Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, NJ 08544, USA
    Cell 133:154-63. 2008
    ..These observations identify a dual role of PME-1 that regulates PP2A activation, methylation, and holoenzyme assembly in cells...
  27. ncbi request reprint Subunit organization in a soluble complex of tar, CheW, and CheA by electron microscopy
    Noreen R Francis
    W M Keck Institute for Cellular Visualization, Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Biol Chem 277:36755-9. 2002
    ..Coupled with atomic models of the subunits, our results provide insights into the functional architecture by which the receptor regulates CheA kinase activity during bacterial chemotaxis...
  28. pmc Three-dimensional structure and organization of a receptor/signaling complex
    Noreen R Francis
    Rosenstiel Biomedical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 101:17480-5. 2004
    ..This structure of the receptor/signaling complex provides an additional basis for understanding the architecture of the large arrays of chemotaxis receptors, CheA, and CheW found at the cell poles in motile bacteria...
  29. ncbi request reprint Intramolecular rearrangements as a consequence of the dephosphorylation of phosphoaspartate residues in proteins
    Scott Napper
    Department of Biochemistry, Health Sciences Building, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    FEBS Lett 538:77-80. 2003
    ..We show here that dephosphorylation of the phosphoaspartate in the chemotaxis response regulator CheY can result in the loss of a water molecule that may be due to formation of a succinimide intermediate...

Research Grants13

  1. ROLE OF PP2A METHYLATION IN CELL REGULATION
    JEFFRY STOCK; Fiscal Year: 2003
    ..abstract_text> ..
  2. MECHANISMS OF SENSORY PROCESSING IN CHEMOTAXIS
    JEFFRY STOCK; Fiscal Year: 2001
    ..These studies will parallel ongoing X-ray crystallographic research on these proteins. ..
  3. MECHANISMS OF SENSORY PROCESSING IN CHEMOTAXIS
    JEFFRY STOCK; Fiscal Year: 2006
    ..These studies will provide a foundation for understanding general mechanisms that underlie Type I receptor function in both prokaryotic and eukaryotic regulatory systems. ..