Research Topics
Species | D SternSummaryAffiliation: Princeton University Country: USA Publications
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Publications
The loci of evolution: how predictable is genetic evolution?David L Stern
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Evolution 62:2155-77. 2008..Predicting the genetic basis of evolution requires a comprehensive synthesis of molecular developmental biology and population genetics...- Developmental origin and evolution of bacteriocytes in the aphid-Buchnera symbiosisChristian Braendle
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
PLoS Biol 1:E21. 2003..The evolutionary transition to a symbiosis in which bacteria and an aphid cell form a functional unit, similar to the origin of plastids, has apparently involved extensive molecular adaptations on the part of the host cell... - A dual-genome microarray for the pea aphid, Acyrthosiphon pisum, and its obligate bacterial symbiont, Buchnera aphidicolaAlex C C Wilson
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
BMC Genomics 7:50. 2006..Development of this dual-genome array represents a first attempt to characterize gene expression in this emerging model system... - Similar patterns of linkage disequilibrium and nucleotide diversity in native and introduced populations of the pea aphid, Acyrthosiphon pisumJennifer A Brisson
Section of Ecology and Evolution, University of California at Davis, Davis, CA, USA
BMC Genet 10:22. 2009..Because introductions can cause population bottlenecks, we hypothesized that U.S. populations harbor lower levels of nucleotide diversity and higher levels of LD than native populations... - Diapause in the pea aphid (Acyrthosiphon pisum) is a slowing but not a cessation of developmentAlexander W Shingleton
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
BMC Dev Biol 3:7. 2003..We investigated developmental aspects of diapause in sexually-produced embryos of the pea aphid, Acyrthosiphon pisum... - Is genetic evolution predictable?David L Stern
Department of Ecology and Evolutionary Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
Science 323:746-51. 2009..The genetic basis of evolution may be predictable to some extent, and further understanding of this predictability requires incorporation of the specific functions and characteristics of genes into evolutionary theory... - AphidsDavid L Stern
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08540, USA
Curr Biol 18:R504-5. 2008 - Developmental biology. Morphing into shapeDavid L Stern
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Science 313:50-1. 2006 
Body-size evolution: how to evolve a mammoth mothD Stern
Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
Curr Biol 11:R917-9. 2001..These studies highlight the gulf between physiological and genetic studies of growth control and the exciting opportunities for unification of these fields...- Michael Akam and the rise of evolutionary developmental biologyDavid L Stern
Howard Hughes Medical Institute, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA
Int J Dev Biol 54:561-5. 2010.... - The Hox gene Ultrabithorax modulates the shape and size of the third leg of Drosophila by influencing diverse mechanismsDavid L Stern
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Dev Biol 256:355-66. 2003..Total organ size appears to be regulated through mechanisms that operate at the level of the entire leg segment (femur or basitarsus) relatively independently of the behavior of individual subpopulations of cells within the segment... - Body-size control: how an insect knows it has grown enoughDavid Stern
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Curr Biol 13:R267-9. 2003..Recent results have begun to clarify how insulin signaling drives organ growth to match nutrient levels, but have not yet elucidated how insulin signaling controls final body size... - Internal and external constraints in the evolution of morphological allometries in a butterflyW Anthony Frankino
Institute of Biology, Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands
Evolution 61:2958-70. 2007..Our results demonstrate that evolution of this component of the forewing-hindwing allometry is not limited by developmental constraints in the short term and that natural selection on allometry intercepts can be powerful... - The developmental genetics of microevolutionDavid L Stern
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Novartis Found Symp 284:191-200; discussion 200-6. 2007..This evidence for parallel evolution suggests that svb occupies a privileged position in the developmental network patterning larval trichomes that makes it a favourable target of evolutionary change... - Molecular phylogenetic evidence for multiple gains or losses of ant mutualism within the aphid genus ChaitophorusAlexander W Shingleton
Department of Ecology and Evolutionary Biology, Princeton University, Guyot Hall, Princeton, NJ 08544, USA
Mol Phylogenet Evol 26:26-35. 2003..This is the first phylogenetic confirmation that ant tending is an evolutionarily labile trait in aphids... - Common genome-wide patterns of transcript accumulation underlying the wing polyphenism and polymorphism in the pea aphid (Acyrthosiphon pisum)Jennifer A Brisson
Princeton University, Princeton, NJ 08540, USA
Evol Dev 9:338-46. 2007..These data also provide a baseline for future studies of the molecular and physiological basis of life-history trade-offs... - The function and regulation of Ultrabithorax in the legs of Drosophila melanogasterGregory K Davis
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Dev Biol 308:621-31. 2007..While the enhancer could reside within the small regions we have not surveyed, it is also possible that the enhancer is structurally complex and/or acts only within its native genomic context... - Morphological evolution through multiple cis-regulatory mutations at a single geneAlistair P McGregor
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Nature 448:587-90. 2007..These data support the view that alleles of large effect that distinguish species may sometimes reflect the accumulation of multiple mutations of small effect at select genes... - Evolution. An embarrassment of switchesLeonid Kruglyak
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Science 317:758-9. 2007 - The pea aphid, Acyrthosiphon pisum: an emerging genomic model system for ecological, developmental and evolutionary studiesJennifer A Brisson
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Bioessays 28:747-55. 2006..Combined with new genomic approaches, the pea aphid is poised to become an important model system for understanding the molecular and developmental basis of many ecologically and evolutionarily relevant problems... - Large-scale gene discovery in the pea aphid Acyrthosiphon pisum (Hemiptera)Beatriz Sabater-Muñoz
INRA Rennes, UMR INRA Agrocampus BiO3P, BP 35327, F 35653 Le Rheu cedex, France
Genome Biol 7:R21. 2006..This project is the first to address the genetics of the Hemiptera and of a hemimetabolous insect... - Natural selection and developmental constraints in the evolution of allometriesW Anthony Frankino
Section of Evolutionary Biology, Institute of Biology, Leiden University, P O Box 9516, 2300 RA Leiden, Netherlands
Science 307:718-20. 2005..Our results show that the short-term evolution of allometries is not limited by developmental constraints. Instead, scaling relationships are shaped by strong natural selection... - Genetic variation for an aphid wing polyphenism is genetically linked to a naturally occurring wing polymorphismChristian Braendle
Laboratory for Development and Evolution, Department of Zoology, University Museum of Zoology, Downing Street, Cambridge CB2 3EJ, UK
Proc Biol Sci 272:657-64. 2005..This finding is consistent with the hypothesis that genotype by environment interaction at the api locus explains genetic variation in the environmentally cued wing polyphenism... - The origin of a mutualism: a morphological trait promoting the evolution of ant-aphid mutualismsAlexander W Shingleton
Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
Evolution 59:921-6. 2005.... - The temporal requirements for insulin signaling during development in DrosophilaAlexander W Shingleton
Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
PLoS Biol 3:e289. 2005..We hypothesize that the insulin-signaling pathway controls such diverse effects as total developmental time, total body size and organ size through its effects on the rate of cell growth, and proliferation in different organs... - Pleiotropic functions of a conserved insect-specific Hox peptide motifChris Todd Hittinger
Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
Development 132:5261-70. 2005.... - Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelismElio Sucena
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Nature 424:935-8. 2003..Our results indicate that some developmental regulators might preferentially accumulate evolutionary changes and that morphological parallelism might therefore be more common than previously appreciated... - Comparison of diverse protein sequences of the nuclear-encoded subunits of cytochrome C oxidase suggests conservation of structure underlies evolving functional sitesJayatri Das
Department of Ecology and Evolutionary Biology, Princeton University, Princeron, NJ, USA
Mol Biol Evol 21:1572-82. 2004..We, therefore, suggest that selection is acting to maintain the structural foundation of COX across taxa, whereas active sites vary or coevolve within lineages... - Variation in fiber number of a male-specific muscle between Drosophila species: a genetic and developmental analysisVirginie Orgogozo
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Evol Dev 9:368-77. 2007..simulans to two genomic regions on chromosome 2. Our data eliminate the possibility of evolving mutations in the fruitless gene and suggest that a change in the twist might be partly responsible for this evolutionary change... - High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila speciesVirginie Orgogozo
Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544, USA
Genetics 173:197-205. 2006..the absence of the QTL3b D. sechellia allele. This property of QTL3a allows us to reconstruct the probable order of fixation of the QTL alleles during evolution... - A comparison of parthenogenetic and sexual embryogenesis of the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidoidea)Toru Miura
Department of Biology, Graduate School of Arts and Sciences, University of Tokyo, Meguro-ku, Tokyo 153-8902, Japan
J Exp Zoolog B Mol Dev Evol 295:59-81. 2003..The pea aphid is a useful model system for examining how a single genome has evolved to allow divergent modes of development... - Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine A after liver transplantCory A Roberts
ProPath Laboratory, Inc, Department of Pathology, St. Paul Medical Center, Dallas, Texas, USA
Transplantation 74:817-21. 2002..A relatively greater VS hypertrophy than LV was present in both transplant groups. We found no gross or histologic cardiac finding that separated these FK506 from CsA OLT patients at autopsy...
Research Grants
- The molecular basis of morphological evolutionDavid L Stern; Fiscal Year: 2010..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
- The molecular basis of morphological evolutionDavid Stern; Fiscal Year: 2007..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
- The molecular basis of morphological evolutionDavid Stern; Fiscal Year: 2006..abstract_text> ..