D Stern

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc The loci of evolution: how predictable is genetic evolution?
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Evolution 62:2155-77. 2008
  2. pmc Large-scale gene discovery in the pea aphid Acyrthosiphon pisum (Hemiptera)
    Beatriz Sabater-Muñoz
    INRA Rennes, UMR INRA Agrocampus BiO3P, BP 35327, F 35653 Le Rheu cedex, France
    Genome Biol 7:R21. 2006
  3. pmc Developmental origin and evolution of bacteriocytes in the aphid-Buchnera symbiosis
    Christian Braendle
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 1:E21. 2003
  4. pmc A dual-genome microarray for the pea aphid, Acyrthosiphon pisum, and its obligate bacterial symbiont, Buchnera aphidicola
    Alex C C Wilson
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 7:50. 2006
  5. pmc Similar patterns of linkage disequilibrium and nucleotide diversity in native and introduced populations of the pea aphid, Acyrthosiphon pisum
    Jennifer A Brisson
    Section of Ecology and Evolution, University of California at Davis, Davis, CA, USA
    BMC Genet 10:22. 2009
  6. pmc Diapause in the pea aphid (Acyrthosiphon pisum) is a slowing but not a cessation of development
    Alexander W Shingleton
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    BMC Dev Biol 3:7. 2003
  7. pmc Developmental biology. Morphing into shape
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 313:50-1. 2006
  8. pmc Aphids
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08540, USA
    Curr Biol 18:R504-5. 2008
  9. pmc Is genetic evolution predictable?
    David L Stern
    Department of Ecology and Evolutionary Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Science 323:746-51. 2009
  10. ncbi request reprint Body-size evolution: how to evolve a mammoth moth
    D Stern
    Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 11:R917-9. 2001

Research Grants

  1. The molecular basis of morphological evolution
    David L Stern; Fiscal Year: 2010
  2. The molecular basis of morphological evolution
    David Stern; Fiscal Year: 2007
  3. The molecular basis of morphological evolution
    David Stern; Fiscal Year: 2006

Collaborators

Detail Information

Publications32

  1. pmc The loci of evolution: how predictable is genetic evolution?
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Evolution 62:2155-77. 2008
    ..Predicting the genetic basis of evolution requires a comprehensive synthesis of molecular developmental biology and population genetics...
  2. pmc Large-scale gene discovery in the pea aphid Acyrthosiphon pisum (Hemiptera)
    Beatriz Sabater-Muñoz
    INRA Rennes, UMR INRA Agrocampus BiO3P, BP 35327, F 35653 Le Rheu cedex, France
    Genome Biol 7:R21. 2006
    ..This project is the first to address the genetics of the Hemiptera and of a hemimetabolous insect...
  3. pmc Developmental origin and evolution of bacteriocytes in the aphid-Buchnera symbiosis
    Christian Braendle
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 1:E21. 2003
    ..The evolutionary transition to a symbiosis in which bacteria and an aphid cell form a functional unit, similar to the origin of plastids, has apparently involved extensive molecular adaptations on the part of the host cell...
  4. pmc A dual-genome microarray for the pea aphid, Acyrthosiphon pisum, and its obligate bacterial symbiont, Buchnera aphidicola
    Alex C C Wilson
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 7:50. 2006
    ..Development of this dual-genome array represents a first attempt to characterize gene expression in this emerging model system...
  5. pmc Similar patterns of linkage disequilibrium and nucleotide diversity in native and introduced populations of the pea aphid, Acyrthosiphon pisum
    Jennifer A Brisson
    Section of Ecology and Evolution, University of California at Davis, Davis, CA, USA
    BMC Genet 10:22. 2009
    ..Because introductions can cause population bottlenecks, we hypothesized that U.S. populations harbor lower levels of nucleotide diversity and higher levels of LD than native populations...
  6. pmc Diapause in the pea aphid (Acyrthosiphon pisum) is a slowing but not a cessation of development
    Alexander W Shingleton
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    BMC Dev Biol 3:7. 2003
    ..We investigated developmental aspects of diapause in sexually-produced embryos of the pea aphid, Acyrthosiphon pisum...
  7. pmc Developmental biology. Morphing into shape
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 313:50-1. 2006
  8. pmc Aphids
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08540, USA
    Curr Biol 18:R504-5. 2008
  9. pmc Is genetic evolution predictable?
    David L Stern
    Department of Ecology and Evolutionary Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Science 323:746-51. 2009
    ..The genetic basis of evolution may be predictable to some extent, and further understanding of this predictability requires incorporation of the specific functions and characteristics of genes into evolutionary theory...
  10. ncbi request reprint Body-size evolution: how to evolve a mammoth moth
    D Stern
    Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 11:R917-9. 2001
    ..These studies highlight the gulf between physiological and genetic studies of growth control and the exciting opportunities for unification of these fields...
  11. pmc Michael Akam and the rise of evolutionary developmental biology
    David L Stern
    Howard Hughes Medical Institute, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA
    Int J Dev Biol 54:561-5. 2010
    ....
  12. ncbi request reprint The Hox gene Ultrabithorax modulates the shape and size of the third leg of Drosophila by influencing diverse mechanisms
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Biol 256:355-66. 2003
    ..Total organ size appears to be regulated through mechanisms that operate at the level of the entire leg segment (femur or basitarsus) relatively independently of the behavior of individual subpopulations of cells within the segment...
  13. ncbi request reprint Body-size control: how an insect knows it has grown enough
    David Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 13:R267-9. 2003
    ..Recent results have begun to clarify how insulin signaling drives organ growth to match nutrient levels, but have not yet elucidated how insulin signaling controls final body size...
  14. pmc The function and regulation of Ultrabithorax in the legs of Drosophila melanogaster
    Gregory K Davis
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Biol 308:621-31. 2007
    ..While the enhancer could reside within the small regions we have not surveyed, it is also possible that the enhancer is structurally complex and/or acts only within its native genomic context...
  15. ncbi request reprint Common genome-wide patterns of transcript accumulation underlying the wing polyphenism and polymorphism in the pea aphid (Acyrthosiphon pisum)
    Jennifer A Brisson
    Princeton University, Princeton, NJ 08540, USA
    Evol Dev 9:338-46. 2007
    ..These data also provide a baseline for future studies of the molecular and physiological basis of life-history trade-offs...
  16. ncbi request reprint Evolution. An embarrassment of switches
    Leonid Kruglyak
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 317:758-9. 2007
  17. ncbi request reprint The developmental genetics of microevolution
    David L Stern
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Novartis Found Symp 284:191-200; discussion 200-6. 2007
    ..This evidence for parallel evolution suggests that svb occupies a privileged position in the developmental network patterning larval trichomes that makes it a favourable target of evolutionary change...
  18. pmc Internal and external constraints in the evolution of morphological allometries in a butterfly
    W Anthony Frankino
    Institute of Biology, Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands
    Evolution 61:2958-70. 2007
    ..Our results demonstrate that evolution of this component of the forewing-hindwing allometry is not limited by developmental constraints in the short term and that natural selection on allometry intercepts can be powerful...
  19. ncbi request reprint Molecular phylogenetic evidence for multiple gains or losses of ant mutualism within the aphid genus Chaitophorus
    Alexander W Shingleton
    Department of Ecology and Evolutionary Biology, Princeton University, Guyot Hall, Princeton, NJ 08544, USA
    Mol Phylogenet Evol 26:26-35. 2003
    ..This is the first phylogenetic confirmation that ant tending is an evolutionarily labile trait in aphids...
  20. ncbi request reprint Morphological evolution through multiple cis-regulatory mutations at a single gene
    Alistair P McGregor
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 448:587-90. 2007
    ..These data support the view that alleles of large effect that distinguish species may sometimes reflect the accumulation of multiple mutations of small effect at select genes...
  21. ncbi request reprint The pea aphid, Acyrthosiphon pisum: an emerging genomic model system for ecological, developmental and evolutionary studies
    Jennifer A Brisson
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Bioessays 28:747-55. 2006
    ..Combined with new genomic approaches, the pea aphid is poised to become an important model system for understanding the molecular and developmental basis of many ecologically and evolutionarily relevant problems...
  22. pmc Genetic variation for an aphid wing polyphenism is genetically linked to a naturally occurring wing polymorphism
    Christian Braendle
    Laboratory for Development and Evolution, Department of Zoology, University Museum of Zoology, Downing Street, Cambridge CB2 3EJ, UK
    Proc Biol Sci 272:657-64. 2005
    ..This finding is consistent with the hypothesis that genotype by environment interaction at the api locus explains genetic variation in the environmentally cued wing polyphenism...
  23. pmc The origin of a mutualism: a morphological trait promoting the evolution of ant-aphid mutualisms
    Alexander W Shingleton
    Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
    Evolution 59:921-6. 2005
    ....
  24. pmc The temporal requirements for insulin signaling during development in Drosophila
    Alexander W Shingleton
    Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 3:e289. 2005
    ..We hypothesize that the insulin-signaling pathway controls such diverse effects as total developmental time, total body size and organ size through its effects on the rate of cell growth, and proliferation in different organs...
  25. ncbi request reprint Pleiotropic functions of a conserved insect-specific Hox peptide motif
    Chris Todd Hittinger
    Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 132:5261-70. 2005
    ....
  26. ncbi request reprint Comparison of diverse protein sequences of the nuclear-encoded subunits of cytochrome C oxidase suggests conservation of structure underlies evolving functional sites
    Jayatri Das
    Department of Ecology and Evolutionary Biology, Princeton University, Princeron, NJ, USA
    Mol Biol Evol 21:1572-82. 2004
    ..We, therefore, suggest that selection is acting to maintain the structural foundation of COX across taxa, whereas active sites vary or coevolve within lineages...
  27. ncbi request reprint Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelism
    Elio Sucena
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 424:935-8. 2003
    ..Our results indicate that some developmental regulators might preferentially accumulate evolutionary changes and that morphological parallelism might therefore be more common than previously appreciated...
  28. pmc Natural selection and developmental constraints in the evolution of allometries
    W Anthony Frankino
    Section of Evolutionary Biology, Institute of Biology, Leiden University, P O Box 9516, 2300 RA Leiden, Netherlands
    Science 307:718-20. 2005
    ..Our results show that the short-term evolution of allometries is not limited by developmental constraints. Instead, scaling relationships are shaped by strong natural selection...
  29. pmc High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species
    Virginie Orgogozo
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544, USA
    Genetics 173:197-205. 2006
    ..the absence of the QTL3b D. sechellia allele. This property of QTL3a allows us to reconstruct the probable order of fixation of the QTL alleles during evolution...
  30. ncbi request reprint Variation in fiber number of a male-specific muscle between Drosophila species: a genetic and developmental analysis
    Virginie Orgogozo
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Evol Dev 9:368-77. 2007
    ..simulans to two genomic regions on chromosome 2. Our data eliminate the possibility of evolving mutations in the fruitless gene and suggest that a change in the twist might be partly responsible for this evolutionary change...
  31. ncbi request reprint A comparison of parthenogenetic and sexual embryogenesis of the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidoidea)
    Toru Miura
    Department of Biology, Graduate School of Arts and Sciences, University of Tokyo, Meguro ku, Tokyo 153 8902, Japan
    J Exp Zool B Mol Dev Evol 295:59-81. 2003
    ..The pea aphid is a useful model system for examining how a single genome has evolved to allow divergent modes of development...
  32. ncbi request reprint Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine A after liver transplant
    Cory A Roberts
    ProPath Laboratory, Inc, Department of Pathology, St Paul Medical Center, Dallas, Texas, USA
    Transplantation 74:817-21. 2002
    ..Cardiotoxicity has been described in a group of pediatric patients receiving FK506 as a part of immunosuppression for orthotopic liver transplantation (OLT). Information regarding the cardiac pathology related to this agent is limited...

Research Grants10

  1. The molecular basis of morphological evolution
    David L Stern; Fiscal Year: 2010
    ..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
  2. The molecular basis of morphological evolution
    David Stern; Fiscal Year: 2007
    ..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
  3. The molecular basis of morphological evolution
    David Stern; Fiscal Year: 2006
    ..abstract_text> ..