MARK DAVID ROSE

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Dynamic localization of yeast Fus2p to an expanding ring at the cell fusion junction during mating
    Joanna Mathis Paterson
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 181:697-709. 2008
  2. pmc Antagonistic regulation of Fus2p nuclear localization by pheromone signaling and the cell cycle
    Casey A Ydenberg
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 184:409-22. 2009
  3. pmc Nuclear fusion during yeast mating occurs by a three-step pathway
    Patricia Melloy
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 179:659-70. 2007
  4. pmc Distinct roles for key karyogamy proteins during yeast nuclear fusion
    Patricia Melloy
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 20:3773-82. 2009
  5. pmc Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion
    Shu Shen
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Biol Cell 20:2438-50. 2009
  6. pmc Reciprocal regulation of nuclear import of the yeast MutSalpha DNA mismatch repair proteins Msh2 and Msh6
    Alicia P Hayes
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, United States
    DNA Repair (Amst) 8:739-51. 2009
  7. pmc Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae
    Alison E Gammie
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Genetics 177:707-21. 2007
  8. pmc Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p
    Dina Matheos
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Cell Biol 165:99-109. 2004
  9. pmc The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response
    Jason M Sheltzer
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Biol Cell 20:2909-19. 2009
  10. pmc Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway
    Ron Lahav
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Cell Biol 27:818-29. 2007

Collaborators

  • Alison E Gammie
  • J Richard McIntosh
  • Casey A Ydenberg
  • Shu Shen
  • Patricia Melloy
  • Sean W Clark
  • Dina Matheos
  • Alicia P Hayes
  • Jason M Sheltzer
  • Joanna Mathis Paterson
  • Erin White
  • Ron Lahav
  • Pamela G Fitch
  • Yukio Kimata
  • Metodi V Metodiev
  • Megan C Feldt
  • Leah A Sevi
  • Cynthia E Tobery
  • Saeed Tavazoie
  • Debbie J Lee
  • Eric Muller
  • Metodi Metodiev
  • David Stone
  • Valeria Brizzio de Candal
  • Kenji Kohno
  • Yuki I Kimata
  • Yusuke Shimizu
  • Ileana C Farcasanu
  • Masato Takeuchi
  • Hiroshi Abe
  • David E Stone

Detail Information

Publications17

  1. pmc Dynamic localization of yeast Fus2p to an expanding ring at the cell fusion junction during mating
    Joanna Mathis Paterson
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 181:697-709. 2008
    ..In zygotes, Fus2p-GFP forms a dilating ring at the cell junction, returning to the nucleus at the completion of cell fusion...
  2. pmc Antagonistic regulation of Fus2p nuclear localization by pheromone signaling and the cell cycle
    Casey A Ydenberg
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 184:409-22. 2009
    ..Our results indicate a novel mechanism by which pheromone-induced proteins are regulated during the transition from mitosis to conjugation...
  3. pmc Nuclear fusion during yeast mating occurs by a three-step pathway
    Patricia Melloy
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 179:659-70. 2007
    ..We conclude that nuclear fusion occurs by a three-step pathway...
  4. pmc Distinct roles for key karyogamy proteins during yeast nuclear fusion
    Patricia Melloy
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 20:3773-82. 2009
    ..These observations suggest that Prm3p acts before initiation of outer NE fusion, Kar5p may help dilation of the initial fusion pore, and Kar2p and Kar8p act after outer NE fusion, during inner NE fusion...
  5. pmc Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion
    Shu Shen
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Biol Cell 20:2438-50. 2009
    ..Genetic analysis, colocalization, and biochemical experiments indicate that Prm3p interacts directly with Kar5p, suggesting that nuclear membrane fusion is mediated by a protein complex...
  6. pmc Reciprocal regulation of nuclear import of the yeast MutSalpha DNA mismatch repair proteins Msh2 and Msh6
    Alicia P Hayes
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, United States
    DNA Repair (Amst) 8:739-51. 2009
    ..Overall, the nuclear levels of Msh2 and Msh6 decline when the other partner is absent. The data suggest a stabilization mechanism to prevent free monomer accumulation in the cytoplasm...
  7. pmc Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae
    Alison E Gammie
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Genetics 177:707-21. 2007
    ..This analysis underscores the importance of functional characterization of missense alleles to ensure that they are the causative factor for disease...
  8. pmc Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p
    Dina Matheos
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Cell Biol 165:99-109. 2004
    ..These data suggest a model wherein activated Fus3p is recruited back to the cortex, where it activates Bni1p to promote polarization and cell fusion...
  9. pmc The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response
    Jason M Sheltzer
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Biol Cell 20:2909-19. 2009
    ..The different velocities, differential sensitivity to mutation and lack of colocalization suggest that Fus2p and Sec4p, another Myo2p cargo associated with exocytotic vesicles, reside predominantly on different cellular organelles...
  10. pmc Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway
    Ron Lahav
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Cell Biol 27:818-29. 2007
    ..Accordingly, we propose that Kar4 plays a critical role in the choreography of the mating response...
  11. doi request reprint Yeast mating: a model system for studying cell and nuclear fusion
    Casey A Ydenberg
    Department of Molecular Biology, Princeton University, Princeton, NJ, USA
    Methods Mol Biol 475:3-20. 2008
    ..An understanding of yeast cell fusion will provide insight into fundamental mechanisms of cell signaling, cell polarization, and membrane fusion...
  12. pmc Alanine scanning of Arp1 delineates a putative binding site for Jnm1/dynamitin and Nip100/p150Glued
    Sean W Clark
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 16:3999-4012. 2005
    ..Unlike the actin mutations, none of the ARP1 alleles disrupt filament formation; however, one pointed-end allele delayed the elution of Arp1p on gel filtration, consistent with loss of additional subunits...
  13. ncbi request reprint Assays of cell and nuclear fusion
    Alison E Gammie
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Methods Enzymol 351:477-98. 2002
  14. pmc Arp10p is a pointed-end-associated component of yeast dynactin
    Sean W Clark
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 17:738-48. 2006
    ..Based on the hRAS-Arp1p assay, loss of Arp10p enhances the apparent association of dynactin with the plasma membrane and suppresses the loss of signaling conferred by cell wall damage...
  15. pmc Lrg1p Is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast
    Pamela G Fitch
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genetics 168:733-46. 2004
    ..We conclude that Lrg1p is a Rho1p-GAP involved in cell fusion and speculate that it acts to locally inhibit cell wall synthesis to aid in the close apposition of the plasma membranes of mating cells...
  16. pmc Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins
    Yukio Kimata
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Japan
    Mol Biol Cell 14:2559-69. 2003
    ..We speculate that recognition of unfolded proteins is based on their competition with Ire1 for binding with BiP/Kar2...
  17. ncbi request reprint Regulation of MAPK function by direct interaction with the mating-specific Galpha in yeast
    Metodi V Metodiev
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, 900 South Ashland Avenue M C 567, Chicago, IL 60607, USA
    Science 296:1483-6. 2002
    ..This interaction contributes both to modulation of the mating signal and to the chemotropic response, and it demonstrates direct communication between the top and bottom of a Galpha-MAPK pathway...

Research Grants34

  1. Mechanisms of Nuclear and Cell Fusion in Yeast
    Mark Rose; Fiscal Year: 2009
    ....
  2. Mechanisms of Nuclear and Cell Fusion in Yeast
    MARK DAVID ROSE; Fiscal Year: 2010
    ....
  3. MECHANISM OF NUCELAR FUSION IN YEAST
    Mark Rose; Fiscal Year: 1993
    ....
  4. MECHANISM OF NUCLEAR AND CELL FUSION IN YEAST
    Mark Rose; Fiscal Year: 2001
    ..Finally, we propose to complete a large screen for bilateral mating defective mutants screen to identify the complete set of genes required for cell and nuclear fusion. ..
  5. GENETICS OF CENTRIN AND THE SPINDLE POLE BODY IN YEAST
    Mark Rose; Fiscal Year: 2000
    ..The MTOC proteins identified here may be important targets for anti-mitotic drugs for the treatment of cancer and fungal infections. ..
  6. GENETICS OF CENTRIN AND THE SPINDLE POLE BODY IN YEAST
    Mark Rose; Fiscal Year: 2001
    ..The MTOC proteins identified here may be important targets for anti-mitotic drugs for the treatment of cancer and fungal infections. ..
  7. MECHANISM OF NUCLEAR AND CELL FUSION IN YEAST
    Mark Rose; Fiscal Year: 2003
    ..Finally, we propose to complete a large screen for bilateral mating defective mutants screen to identify the complete set of genes required for cell and nuclear fusion. ..
  8. Mechanisms of Nuclear and Cell Fusion in Yeast
    Mark Rose; Fiscal Year: 2005
    ..We will use multiple microscopic methods to characterize the events and topology of nuclear envelope fusion. ..
  9. Mechanisms of Nuclear and Cell Fusion in Yeast
    Mark Rose; Fiscal Year: 2006
    ..We will use multiple microscopic methods to characterize the events and topology of nuclear envelope fusion. ..
  10. Mechanisms of Nuclear and Cell Fusion in Yeast
    Mark Rose; Fiscal Year: 2007
    ..We will use multiple microscopic methods to characterize the events and topology of nuclear envelope fusion. ..
  11. Mechanisms of Nuclear and Cell Fusion in Yeast
    Mark Rose; Fiscal Year: 2009
    ....
  12. MECHANISM OF NUCLEAR FUSION IN YEAST
    Mark Rose; Fiscal Year: 1991
    ..Nuclear fusion genes will be isolated and analyzed by in vitro mutagenesis and gene replacement to determine their role in the mitotic functions of the spindle plaque...
  13. MECHANISM OF NUCLEAR FUSION IN YEAST
    Mark Rose; Fiscal Year: 1990
    ..Nuclear fusion genes will be isolated and analyzed by in vitro mutagenesis and gene replacement to determine their role in the mitotic functions of the spindle plaque...
  14. Mechanisms of Nuclear and Cell Fusion in Yeast
    Mark Rose; Fiscal Year: 2009
    ....
  15. MECHANISM OF NUCLEAR FUSION IN YEAST
    Mark Rose; Fiscal Year: 1992
    ....
  16. MECHANISM OF NUCLEAR AND CELL FUSION IN YEAST
    Mark Rose; Fiscal Year: 2000
    ..Finally, we propose to complete a large screen for bilateral mating defective mutants screen to identify the complete set of genes required for cell and nuclear fusion. ..
  17. A DECONVOLUTION MICROSCOPE FOR CELL BIOLOGICAL RESEARCH
    Mark Rose; Fiscal Year: 2001
    ..By these means, the digital deconvolution microscope will provide outstanding research and educational opportunities on one of the most powerful optical microscopes available for use in the life sciences. ..
  18. Zeiss LSM 510 Meta Confocal Microsope
    Mark Rose; Fiscal Year: 2006
    ..Study of each of these biological systems will provide valuable information pertaining to significant human health problems such as birth defects, viral infection and cancer. ..
  19. MECHANISM OF NUCLEAR AND CELL FUSION IN YEAST
    Mark Rose; Fiscal Year: 1999
    ....
  20. GENETICS OF CENTRIN AND THE SPINDLE POLE BODY IN YEAST
    Mark Rose; Fiscal Year: 2002
    ..The MTOC proteins identified here may be important targets for anti-mitotic drugs for the treatment of cancer and fungal infections. ..
  21. MECHANISM OF NUCLEAR AND CELL FUSION IN YEAST
    Mark Rose; Fiscal Year: 2002
    ..Finally, we propose to complete a large screen for bilateral mating defective mutants screen to identify the complete set of genes required for cell and nuclear fusion. ..
  22. GENETICS OF CENTRIN AND THE SPINDLE POLE BODY IN YEAST
    Mark Rose; Fiscal Year: 2003
    ..The MTOC proteins identified here may be important targets for anti-mitotic drugs for the treatment of cancer and fungal infections. ..