Matthew V Rockman

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Breeding designs for recombinant inbred advanced intercross lines
    Matthew V Rockman
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genetics 179:1069-78. 2008
  2. pmc Ancient and recent positive selection transformed opioid cis-regulation in humans
    Matthew V Rockman
    Department of Biology, Duke University, Durham, North Carolina, USA
    PLoS Biol 3:e387. 2005
  3. ncbi Positive selection on MMP3 regulation has shaped heart disease risk
    Matthew V Rockman
    Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
    Curr Biol 14:1531-9. 2004
  4. ncbi Positive selection on a human-specific transcription factor binding site regulating IL4 expression
    Matthew V Rockman
    Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
    Curr Biol 13:2118-23. 2003
  5. pmc Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region
    Dagan A Loisel
    Department of Biology, Duke University, Durham, NC 27705, USA
    Proc Natl Acad Sci U S A 103:16331-6. 2006
  6. doi Multiple Functional Variants in cis Modulate PDYN Expression
    Courtney C Babbitt
    Institute for Genome Sciences and Policy, Duke University, USA
    Mol Biol Evol 27:465-79. 2010
  7. pmc Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans
    Matthew W Hahn
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 167:867-77. 2004
  8. pmc Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans
    Michael F Palopoli
    Department of Biology, Bowdoin College, 6500 College Station, Brunswick, Maine 04011, USA
    Nature 454:1019-22. 2008
  9. pmc Resistance to germline RNA interference in a Caenorhabditis elegans wild isolate exhibits complexity and nonadditivity
    Daniel A Pollard
    Department of Biology, New York University, New York, NY 10003, USA
    G3 (Bethesda) 3:941-7. 2013
  10. pmc Widespread genetic incompatibility in C. elegans maintained by balancing selection
    Hannah S Seidel
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 319:589-94. 2008

Detail Information

Publications19

  1. pmc Breeding designs for recombinant inbred advanced intercross lines
    Matthew V Rockman
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genetics 179:1069-78. 2008
    ..We find that the easiest crosses to perform are well suited to the task of generating populations of highly recombinant inbred lines...
  2. pmc Ancient and recent positive selection transformed opioid cis-regulation in humans
    Matthew V Rockman
    Department of Biology, Duke University, Durham, North Carolina, USA
    PLoS Biol 3:e387. 2005
    ....
  3. ncbi Positive selection on MMP3 regulation has shaped heart disease risk
    Matthew V Rockman
    Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
    Curr Biol 14:1531-9. 2004
    ..The polymorphism contributes to variation in arterial traits and to the risk of coronary heart disease and its progression...
  4. ncbi Positive selection on a human-specific transcription factor binding site regulating IL4 expression
    Matthew V Rockman
    Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
    Curr Biol 13:2118-23. 2003
    ..The allele frequencies of this binding site represent local adaptation to diverse pathogenic challenges; disease states associated with the common derived allele are side-effects of positive selection on other IL4 functions...
  5. pmc Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region
    Dagan A Loisel
    Department of Biology, Duke University, Durham, NC 27705, USA
    Proc Natl Acad Sci U S A 103:16331-6. 2006
    ....
  6. doi Multiple Functional Variants in cis Modulate PDYN Expression
    Courtney C Babbitt
    Institute for Genome Sciences and Policy, Duke University, USA
    Mol Biol Evol 27:465-79. 2010
    ....
  7. pmc Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans
    Matthew W Hahn
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 167:867-77. 2004
    ..Our results thus further support the hypothesis that regulatory mutations have been important in human evolution...
  8. pmc Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans
    Michael F Palopoli
    Department of Biology, Bowdoin College, 6500 College Station, Brunswick, Maine 04011, USA
    Nature 454:1019-22. 2008
    ..The reduced selection on male?male competition associated with the origin of hermaphroditism may have permitted the global spread of a loss-of-function mutation with restricted pleiotropy...
  9. pmc Resistance to germline RNA interference in a Caenorhabditis elegans wild isolate exhibits complexity and nonadditivity
    Daniel A Pollard
    Department of Biology, New York University, New York, NY 10003, USA
    G3 (Bethesda) 3:941-7. 2013
    ..We conclude that the variation in RNA interference sensitivity between CB4856 and N2 likely involves the nonadditive interactions of eight or more genes in addition to ppw-1. ..
  10. pmc Widespread genetic incompatibility in C. elegans maintained by balancing selection
    Hannah S Seidel
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 319:589-94. 2008
    ..Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome...
  11. pmc Recombinational landscape and population genomics of Caenorhabditis elegans
    Matthew V Rockman
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 5:e1000419. 2009
    ..elegans strains...
  12. ncbi The evolution of transcriptional regulation in eukaryotes
    Gregory A Wray
    Department of Biology, Duke University, USA
    Mol Biol Evol 20:1377-419. 2003
    ..Despite these challenges, important insights have already been gained into the evolution of transcriptional regulation, and the pace of discovery is accelerating...
  13. ncbi Idiomatic (gene) expressions
    Matthew V Rockman
    Department of Biology, Duke University, Durham, NC 27708, USA
    Bioessays 25:421-4. 2003
    ..While we will continue to require a diverse arsenal of experimental methods, this versatile method will speed the identification of functional genetic variation...
  14. ncbi Genetics of global gene expression
    Matthew V Rockman
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Genet 7:862-72. 2006
    ....
  15. ncbi Abundant raw material for cis-regulatory evolution in humans
    Matthew V Rockman
    Department of Biology, Duke University, Durham, NC 27708, USA
    Mol Biol Evol 19:1991-2004. 2002
    ..Ordinary small-scale mutations contribute to pervasive variation in transcription rates and consequently to patterns of human phenotypic variation...
  16. doi Reverse engineering the genotype-phenotype map with natural genetic variation
    Matthew V Rockman
    Center for Genomics and Systems Biology, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Nature 456:738-44. 2008
    ..It is then possible to use this information about causes and effects to build models of probabilistic 'causal networks'. These networks are beginning to define the outlines of the 'genotype-phenotype map'...
  17. pmc A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits
    Karin C Kiontke
    Department of Biology, New York University, 100 Washington Square East New York, New York 10003, USA
    BMC Evol Biol 11:339. 2011
    ..Only ten Caenorhabditis species were available in culture at the onset of this study. Many of them, like C. elegans, were mostly isolated from artificial compost heaps, and their more natural habitat was unknown...
  18. pmc Tinker where the tinkering's good
    Matthew V Rockman
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Trends Genet 24:317-9. 2008
    ..Multiple mutations that disrupt an abdominal enhancer of the pleiotropic gene tan partly explain the reduced pigmentation observed in this species...
  19. ncbi Analysis of common IL-6 promoter SNP variants and the AnTn tract in humans and primates and effects on plasma IL-6 levels following coronary artery bypass graft surgery
    Daniel Kelberman
    Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JF, UK
    Biochim Biophys Acta 1688:160-7. 2004
    ..The conserved length of the AnTn tract and the association in vivo with IL-6 levels strongly suggest the functionality of the tract on IL-6 expression, independent of contributions from other polymorphic sites within the promoter...