Joshua D Rabinowitz

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. doi request reprint Metabolomics in drug target discovery
    J D Rabinowitz
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Cold Spring Harb Symp Quant Biol 76:235-46. 2011
  2. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
  3. pmc Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies
    Peter A DiMaggio
    Department of Chemical Engineering, Princeton University, Princeton, NJ, USA
    BMC Bioinformatics 9:458. 2008
  4. pmc Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection
    Sarah L Grady
    Departments of Molecular Biology and Chemistry, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 110:E5006-15. 2013
  5. pmc Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
    Jurre J Kamphorst
    Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 110:8882-7. 2013
  6. doi request reprint Pyrimidine homeostasis is accomplished by directed overflow metabolism
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 500:237-41. 2013
  7. pmc Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 48:52-62. 2012
  8. pmc Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny
    Emre Koyuncu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 9:e1003333. 2013
  9. doi request reprint Nucleotide degradation and ribose salvage in yeast
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Mol Syst Biol 9:665. 2013
  10. pmc Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    Nat Chem Biol 8:562-8. 2012

Collaborators

  • Eileen White
  • Jurre J Kamphorst
  • James R Broach
  • Marc W Kirschner
  • Tomer Shlomi
  • Xin Zhao
  • Rosemary J Redfield
  • Leonid Kruglyak
  • Sunita Sinha
  • H Alex Brown
  • David Botstein
  • Amy A Caudy
  • Marshall Louis Reaves
  • Yi Fan Xu
  • Livia Vastag
  • Thomas Shenk
  • Sarah L Grady
  • Emre Koyuncu
  • Daniel Amador-Noguez
  • Xiao Jiang Feng
  • Jing Fan
  • John G Purdy
  • Farnaz Absalan
  • Celeste N Peterson
  • Laura J Terry
  • Michelle F Clasquin
  • Christopher A Crutchfield
  • Allegra A Petti
  • Sean T H Liu
  • Christopher D Doucette
  • Maja M Klosinska
  • Peter A DiMaggio
  • Wenyun Lu
  • Robin Mathew
  • Greg Brown
  • Fabien Letisse
  • Alexander F Yakunin
  • Ekaterina Kuznetsova
  • Aaron M Hosios
  • Brian D Young
  • Michelle K Chung
  • Thomas J Silhavy
  • Eugene Melamud
  • Jesse Hwang
  • Igor Levchenko
  • David S Glass
  • Tania A Baker
  • David H Perlman
  • Patrick H Bradley
  • David S Myers
  • Stephen B Milne
  • Paul Jorgensen
  • Leonid Peshkin
  • Ru Wei
  • Ned S Wingreen
  • Thomas E Shenk
  • Nathaniel Roquet
  • Pavlina Ivanova
  • David J Schwab
  • Ian A Brasg
  • Ronit Sharon-Friling
  • Herschel A Rabitz
  • Scott R McAllister
  • Christodoulos A Floudas

Detail Information

Publications26

  1. doi request reprint Metabolomics in drug target discovery
    J D Rabinowitz
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Cold Spring Harb Symp Quant Biol 76:235-46. 2011
    ..Eventual proof of the value of metabolomics as a drug target discovery strategy will be successful clinical development of therapeutics hitting these new targets...
  2. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
    ..A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors...
  3. pmc Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies
    Peter A DiMaggio
    Department of Chemical Engineering, Princeton University, Princeton, NJ, USA
    BMC Bioinformatics 9:458. 2008
    ....
  4. pmc Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection
    Sarah L Grady
    Departments of Molecular Biology and Chemistry, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 110:E5006-15. 2013
    ..Together with the observation that AS1 protein and mRNA levels decrease during wild-type infection, this work suggests that reduced AS1 activity is partially responsible for the metabolic program induced by infection. ..
  5. pmc Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
    Jurre J Kamphorst
    Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 110:8882-7. 2013
    ..This renders Ras-driven cells, both in culture and in allografts, resistant to SCD1 inhibition. Thus, a mechanism by which oncogenic Ras confers metabolic robustness is through lipid scavenging...
  6. doi request reprint Pyrimidine homeostasis is accomplished by directed overflow metabolism
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 500:237-41. 2013
    ..Thus, pyrimidine homeostasis involves dual regulatory strategies, with classical feedback inhibition enhancing metabolic efficiency and directed overflow metabolism ensuring end-product homeostasis. ..
  7. pmc Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 48:52-62. 2012
    ..Thus, while yeast pyruvate kinase is covalently modified in response to glucose availability, its activity is controlled almost exclusively by ultrasensitive allostery...
  8. pmc Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny
    Emre Koyuncu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 9:e1003333. 2013
    ..These results reveal a dependence of cytomegalovirus on very long chain fatty acid metabolism...
  9. doi request reprint Nucleotide degradation and ribose salvage in yeast
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Mol Syst Biol 9:665. 2013
    ..Thus, ribose salvage provides means of surviving nutrient starvation and oxidative stress...
  10. pmc Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    Nat Chem Biol 8:562-8. 2012
    ..Thus, bacterial central carbon metabolism is intrinsically programmed with ultrasensitive allosteric regulation to enable rapid adaptation to changing environmental conditions...
  11. pmc Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase
    Sarah L Grady
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    J Virol 86:8259-68. 2012
    ....
  12. pmc Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection
    Laura J Terry
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 109:3071-6. 2012
    ..We propose that HCMV requires AMPK or related activity for viral replication and reprogramming of cellular metabolism...
  13. pmc Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
    Jing Fan
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Mol Syst Biol 9:712. 2013
    ..Thus, glutamine-driven oxidative phosphorylation is a major means of ATP production even in hypoxic cancer cells. ..
  14. pmc Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function
    Allegra A Petti
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:E1089-98. 2011
    ....
  15. pmc Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress
    Sean T H Liu
    Department of Molecular Biology, Lewis Thomas Laboratory, University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:12869-74. 2011
    ..We propose that cytomegalovirus capsids acquire their envelope by budding into vesicles with a lipid composition similar to that of synaptic vesicles, which subsequently fuse with the plasma membrane to release virions from the cell...
  16. pmc α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition
    Christopher D Doucette
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    Nat Chem Biol 7:894-901. 2011
    ..Quantitative modeling shows that this previously unidentified regulatory connection is, in principle, sufficient to coordinate carbon and nitrogen utilization...
  17. pmc Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Science 337:470-3. 2012
    ..Furthermore, mass spectrometry showed that this DNA contains only trace amounts of free arsenate and no detectable covalently bound arsenate...
  18. pmc Remodeling of the metabolome during early frog development
    Livia Vastag
    Carl Icahn Laboratory, Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e16881. 2011
    ....
  19. pmc Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism
    Jurre J Kamphorst
    Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Anal Chem 83:9114-22. 2011
    ..This LC/MS method and associated isotope tracer techniques should be broadly applicable to investigating fatty acid metabolism...
  20. pmc Yeast cells can access distinct quiescent states
    Maja M Klosinska
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 25:336-49. 2011
    ..Moreover, these survival strategies are not unique to quiescence, but are engaged by the cell in proportion to nutrient scarcity...
  21. doi request reprint LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine
    Michelle F Clasquin
    Department of Chemistry and Integrative Genomics, Carl Icahn Laboratory, Princeton, New Jersey, USA
    Curr Protoc Bioinformatics . 2012
    ..Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis...
  22. pmc RpoS proteolysis is controlled directly by ATP levels in Escherichia coli
    Celeste N Peterson
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 26:548-53. 2012
    ..In vitro reconstitution assays directly demonstrate that ClpXP fails to degrade RpoS, but not other proteins, at low ATP hydrolysis rates. These data suggest that cellular ATP levels directly control RpoS stability...
  23. pmc Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism
    Livia Vastag
    Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 7:e1002124. 2011
    ..Although our results confirm that this is a robust target for HSV-1, therapeutic interventions at other points in metabolism might prove more effective for treatment of HCMV...
  24. pmc Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum
    Daniel Amador-Noguez
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Appl Environ Microbiol 77:7984-97. 2011
    ..Thus, the solventogenic transition involves global remodeling of metabolism to redirect resources (carbon and reducing power) from biomass production into solvent production...
  25. pmc Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    J Bacteriol 193:4576-81. 2011
    ..We conclude that the ptsN gene product does not regulate organic nitrogen source utilization as previously proposed...
  26. pmc Metabolomics in systems microbiology
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Curr Opin Biotechnol 22:17-25. 2011
    ..We also indicate enduring challenges concerning unstable and low abundance compounds, subcellular compartmentalization, and quantitative amalgamation of different data types...