Joshua D Rabinowitz

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi Metabolomics in drug target discovery
    J D Rabinowitz
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Cold Spring Harb Symp Quant Biol 76:235-46. 2011
  2. ncbi Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
  3. ncbi Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies
    Peter A DiMaggio
    Department of Chemical Engineering, Princeton University, Princeton, NJ, USA
    BMC Bioinformatics 9:458. 2008
  4. ncbi Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 48:52-62. 2012
  5. ncbi Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    Nat Chem Biol 8:562-8. 2012
  6. ncbi Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase
    Sarah L Grady
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    J Virol 86:8259-68. 2012
  7. ncbi Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection
    Laura J Terry
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 109:3071-6. 2012
  8. ncbi Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function
    Allegra A Petti
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:E1089-98. 2011
  9. ncbi Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress
    Sean T H Liu
    Department of Molecular Biology, Lewis Thomas Laboratory, University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:12869-74. 2011
  10. ncbi α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition
    Christopher D Doucette
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    Nat Chem Biol 7:894-901. 2011

Collaborators

  • James R Broach
  • Eileen White
  • Xin Zhao
  • Rosemary J Redfield
  • Leonid Kruglyak
  • Sunita Sinha
  • H Alex Brown
  • Jurre J Kamphorst
  • David Botstein
  • Marshall Louis Reaves
  • Livia Vastag
  • Yi Fan Xu
  • Thomas Shenk
  • Sarah L Grady
  • Daniel Amador-Noguez
  • Xiao Jiang Feng
  • Laura J Terry
  • Celeste N Peterson
  • Michelle F Clasquin
  • Christopher A Crutchfield
  • Maja M Klosinska
  • Sean T H Liu
  • Christopher D Doucette
  • Allegra A Petti
  • Peter A DiMaggio
  • Eugene Melamud
  • David H Perlman
  • Tania A Baker
  • Jesse Hwang
  • Farnaz Absalan
  • David S Glass
  • Thomas J Silhavy
  • Igor Levchenko
  • Patrick H Bradley
  • Ian A Brasg
  • David J Schwab
  • Thomas E Shenk
  • Ru Wei
  • Emre Koyuncu
  • Stephen B Milne
  • David S Myers
  • H Alex Brown
  • Ronit Sharon-Friling
  • Leonid Peshkin
  • Pavlina Ivanova
  • Paul Jorgensen
  • Ned S Wingreen
  • Nathaniel Roquet
  • Marc W Kirschner
  • Scott R McAllister
  • Herschel A Rabitz
  • Christodoulos A Floudas

Detail Information

Publications20

  1. ncbi Metabolomics in drug target discovery
    J D Rabinowitz
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Cold Spring Harb Symp Quant Biol 76:235-46. 2011
    ..Eventual proof of the value of metabolomics as a drug target discovery strategy will be successful clinical development of therapeutics hitting these new targets...
  2. ncbi Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
    ..A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors...
  3. ncbi Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies
    Peter A DiMaggio
    Department of Chemical Engineering, Princeton University, Princeton, NJ, USA
    BMC Bioinformatics 9:458. 2008
    ....
  4. ncbi Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 48:52-62. 2012
    ..Thus, while yeast pyruvate kinase is covalently modified in response to glucose availability, its activity is controlled almost exclusively by ultrasensitive allostery...
  5. ncbi Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase
    Yi Fan Xu
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    Nat Chem Biol 8:562-8. 2012
    ..Thus, bacterial central carbon metabolism is intrinsically programmed with ultrasensitive allosteric regulation to enable rapid adaptation to changing environmental conditions...
  6. ncbi Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase
    Sarah L Grady
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    J Virol 86:8259-68. 2012
    ....
  7. ncbi Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection
    Laura J Terry
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 109:3071-6. 2012
    ..We propose that HCMV requires AMPK or related activity for viral replication and reprogramming of cellular metabolism...
  8. ncbi Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function
    Allegra A Petti
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:E1089-98. 2011
    ....
  9. ncbi Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress
    Sean T H Liu
    Department of Molecular Biology, Lewis Thomas Laboratory, University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:12869-74. 2011
    ..We propose that cytomegalovirus capsids acquire their envelope by budding into vesicles with a lipid composition similar to that of synaptic vesicles, which subsequently fuse with the plasma membrane to release virions from the cell...
  10. ncbi α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition
    Christopher D Doucette
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    Nat Chem Biol 7:894-901. 2011
    ..Quantitative modeling shows that this previously unidentified regulatory connection is, in principle, sufficient to coordinate carbon and nitrogen utilization...
  11. ncbi Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Science 337:470-3. 2012
    ..Furthermore, mass spectrometry showed that this DNA contains only trace amounts of free arsenate and no detectable covalently bound arsenate...
  12. ncbi Remodeling of the metabolome during early frog development
    Livia Vastag
    Carl Icahn Laboratory, Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e16881. 2011
    ....
  13. ncbi Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism
    Jurre J Kamphorst
    Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Anal Chem 83:9114-22. 2011
    ..This LC/MS method and associated isotope tracer techniques should be broadly applicable to investigating fatty acid metabolism...
  14. ncbi Yeast cells can access distinct quiescent states
    Maja M Klosinska
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 25:336-49. 2011
    ..Moreover, these survival strategies are not unique to quiescence, but are engaged by the cell in proportion to nutrient scarcity...
  15. ncbi LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine
    Michelle F Clasquin
    Department of Chemistry and Integrative Genomics, Carl Icahn Laboratory, Princeton, New Jersey, USA
    Curr Protoc Bioinformatics . 2012
    ..Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis...
  16. ncbi RpoS proteolysis is controlled directly by ATP levels in Escherichia coli
    Celeste N Peterson
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 26:548-53. 2012
    ..In vitro reconstitution assays directly demonstrate that ClpXP fails to degrade RpoS, but not other proteins, at low ATP hydrolysis rates. These data suggest that cellular ATP levels directly control RpoS stability...
  17. ncbi Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism
    Livia Vastag
    Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 7:e1002124. 2011
    ..Although our results confirm that this is a robust target for HSV-1, therapeutic interventions at other points in metabolism might prove more effective for treatment of HCMV...
  18. ncbi Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum
    Daniel Amador-Noguez
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Appl Environ Microbiol 77:7984-97. 2011
    ..Thus, the solventogenic transition involves global remodeling of metabolism to redirect resources (carbon and reducing power) from biomass production into solvent production...
  19. ncbi Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    J Bacteriol 193:4576-81. 2011
    ..We conclude that the ptsN gene product does not regulate organic nitrogen source utilization as previously proposed...
  20. ncbi Metabolomics in systems microbiology
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Curr Opin Biotechnol 22:17-25. 2011
    ..We also indicate enduring challenges concerning unstable and low abundance compounds, subcellular compartmentalization, and quantitative amalgamation of different data types...