CELESTE NELSON

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. doi request reprint Forces in epithelial origami
    Celeste M Nelson
    Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA Electronic address
    Dev Cell 26:554-6. 2013
  2. doi request reprint Sculpting organs: mechanical regulation of tissue development
    Celeste M Nelson
    Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Annu Rev Biomed Eng 14:129-54. 2012
  3. pmc Geometric control of tissue morphogenesis
    Celeste M Nelson
    Department of Chemical Engineering, Princeton University, A321 Engineering Quadrangle, Princeton, NJ 08544, USA
    Biochim Biophys Acta 1793:903-10. 2009
  4. pmc Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biochem 105:25-33. 2008
  5. pmc Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression
    Celeste M Nelson
    Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Nat Protoc 3:674-8. 2008
  6. pmc Endogenous patterns of mechanical stress are required for branching morphogenesis
    Nikolce Gjorevski
    Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA
    Integr Biol (Camb) 2:424-34. 2010
  7. pmc Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 314:298-300. 2006
  8. pmc Bidirectional extracellular matrix signaling during tissue morphogenesis
    Nikolce Gjorevski
    Departments of Chemical Engineering and Molecular Biology, Princeton University, A321 Engineering Quadrangle, Princeton, NJ 08544, United States
    Cytokine Growth Factor Rev 20:459-65. 2009
  9. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
  10. pmc Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    Connie S Chen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 284:6877-84. 2009

Research Grants

  1. In Vitro Synthesis of Fibrosis Genesis
    CELESTE NELSON; Fiscal Year: 2007
  2. Spatial patterning of branching morphogenesis
    CELESTE NELSON; Fiscal Year: 2009

Collaborators

Detail Information

Publications30

  1. doi request reprint Forces in epithelial origami
    Celeste M Nelson
    Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA Electronic address
    Dev Cell 26:554-6. 2013
    ..Reporting in Science, Shyer et al. (2013) show that differences between the mechanical properties of the developing intestinal epithelium and surrounding smooth muscle fold the epithelium into villi via mucosal buckling. ..
  2. doi request reprint Sculpting organs: mechanical regulation of tissue development
    Celeste M Nelson
    Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Annu Rev Biomed Eng 14:129-54. 2012
    ..We describe the essential role of endogenous cellular contractility in the formation of branching tubes. We also highlight the role of exogenous forces in normal and aberrant branching...
  3. pmc Geometric control of tissue morphogenesis
    Celeste M Nelson
    Department of Chemical Engineering, Princeton University, A321 Engineering Quadrangle, Princeton, NJ 08544, USA
    Biochim Biophys Acta 1793:903-10. 2009
    ..The geometry of a tissue thus acts as both a template and instructive cue for further morphogenesis...
  4. pmc Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biochem 105:25-33. 2008
    ..Our data reveal a previously unanticipated cell shape-dependent mechanism that controls this key phenotypic alteration and provide insight into the distinct mechanisms activated by different EMT-inducing agents...
  5. pmc Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression
    Celeste M Nelson
    Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Nat Protoc 3:674-8. 2008
    ..Patterned tissue arrays can be produced in 3-4 h and will undergo morphogenesis over the following 1-3 d. The protocol can easily be adapted to study a variety of tissues and aspects of normal and neoplastic development...
  6. pmc Endogenous patterns of mechanical stress are required for branching morphogenesis
    Nikolce Gjorevski
    Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA
    Integr Biol (Camb) 2:424-34. 2010
    ..These data suggest that the pattern and magnitude of mechanical stress across epithelial tissues cooperate with biochemical signals to specify branching pattern...
  7. pmc Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 314:298-300. 2006
    ..These results reveal that tissue geometry can control organ morphogenesis by defining the local cellular microenvironment, a finding that has relevance to control of invasion and metastasis...
  8. pmc Bidirectional extracellular matrix signaling during tissue morphogenesis
    Nikolce Gjorevski
    Departments of Chemical Engineering and Molecular Biology, Princeton University, A321 Engineering Quadrangle, Princeton, NJ 08544, United States
    Cytokine Growth Factor Rev 20:459-65. 2009
    ..We also discuss the implications for successful engineering of functional tissues ex vivo...
  9. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
    ..Our data indicate that tissue-specific gene expression is controlled by both the tissues' unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis...
  10. pmc Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    Connie S Chen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 284:6877-84. 2009
    ..These results provide a dramatic demonstration of the use of structural information about one molecule to define a functional motif of a second molecule that is related at the sequence level but highly divergent functionally...
  11. pmc Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Semin Cancer Biol 15:342-52. 2005
    ..We propose the need for engineered tissues that faithfully recapitulate their native structures to allow a greater understanding of tissue function, dysfunction, and potential therapeutic intervention...
  12. pmc Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction
    Esther W Gomez
    Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, USA
    J Cell Biochem 110:44-51. 2010
    ..These data suggest a causal role for tissue geometry and endogenous mechanical stresses in the spatial patterning of EMT...
  13. pmc Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments
    Mark A Labarge
    Lawrence Berkeley National Laboratory, Division of Life Sciences, Berkeley, CA 94720, USA
    Integr Biol (Camb) 1:70-9. 2009
    ..We report on the functional ability of those proteins of the mammary gland that maintain quiescence, maintain the progenitor state, and guide progenitor differentiation towards myoepithelial and luminal lineages...
  14. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
    ..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...
  15. pmc The mechanics of development: Models and methods for tissue morphogenesis
    Nikolce Gjorevski
    Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Birth Defects Res C Embryo Today 90:193-202. 2010
    ..We highlight recent technological advances to measure tissue elasticity and endogenous mechanical stresses in real time during organ development. We also discuss recent progress in manipulating forces in intact embryos...
  16. pmc Self-organization of engineered epithelial tubules by differential cellular motility
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:14890-5. 2009
    ..These results indicate that differential directional persistence can give rise to patterns within model developing tissues...
  17. pmc Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function
    Ren Xu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Cell Biol 184:57-66. 2009
    ..These results underscore the crucial role of continuous laminin signaling and polarized tissue architecture in maintenance of transcription factor activation, chromatin organization, and tissue-specific gene expression...
  18. pmc Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    Hong Liu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4134-9. 2006
    ....
  19. pmc Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Mammary Gland Biol Neoplasia 9:361-74. 2004
    ....
  20. pmc Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells
    Masahiko Itoh
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 67:4759-66. 2007
    ..Thus, Rap1 acts as a central regulator of breast architecture, with normal levels of activation instructing polarity during acinar morphogenesis, and increased activation inducing tumor formation and progression to malignancy...
  21. pmc Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Annu Rev Cell Dev Biol 22:287-309. 2006
    ..We expand on the concept of "dynamic reciprocity" to present an integrated view of development, cancer, and aging and posit that genes are like the keys on a piano: Although they are essential, it is the context that makes the music...
  22. ncbi request reprint Microstructured extracellular matrices in tissue engineering and development
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Biotechnol 17:518-23. 2006
    ....
  23. ncbi request reprint Simple approach to micropattern cells on common culture substrates by tuning substrate wettability
    John L Tan
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205 2196, USA
    Tissue Eng 10:865-72. 2004
    ..This technique therefore may allow for wider adoption of cell patterning...
  24. pmc Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA
    Celeste M Nelson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 15:2943-53. 2004
    ....
  25. pmc Emergent patterns of growth controlled by multicellular form and mechanics
    Celeste M Nelson
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:11594-9. 2005
    ..Thus, tissue form is not only a consequence but also an active regulator of tissue growth...
  26. pmc Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton
    Darren S Gray
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Exp Cell Res 314:2846-54. 2008
    ..In all, these results demonstrate that cell-cell contact signals through VE-cadherin, RhoA, and intracellular tension in the actin cytoskeleton to regulate proliferation...
  27. pmc Cell shape regulates global histone acetylation in human mammary epithelial cells
    Johanne Le Beyec
    Centre de Recherche des Cordeliers, Université Piere et Marie Curie Paris 6, ULMRS872, Paris F 75006, France
    Exp Cell Res 313:3066-75. 2007
    ..These results reveal a novel link between ECM-controlled cell shape and chromatin structure and suggest that this link is mediated by changes in the actin cytoskeleton...
  28. pmc E-cadherin engagement stimulates proliferation via Rac1
    Wendy F Liu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 173:431-41. 2006
    ..Together, these findings demonstrate a stimulatory role for E-cadherin in proliferative regulation, and identify a simple mechanism by which cell-cell contact may trigger or inhibit epithelial cell proliferation in different settings...
  29. ncbi request reprint Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    Rowena McBeath
    The Cellular and Molecular Medicine Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 6:483-95. 2004
    ..These studies demonstrate that mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate...

Research Grants5

  1. In Vitro Synthesis of Fibrosis Genesis
    CELESTE NELSON; Fiscal Year: 2007
    ..We present here a three-dimensional, microlithography-based model that can be used to break down the key steps involved in the earliest stages of fibrosis genesis. ..
  2. Spatial patterning of branching morphogenesis
    CELESTE NELSON; Fiscal Year: 2009
    ..Here we present studies aimed at understanding how mammary epithelial cells perceive inhibitory signals and translate them into patterned differences in gene expression during branching morphogenesis. ..