COLEEN TARA MURPHY

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging
    Shijing Luo
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Genet 5:e1000789. 2009
  2. pmc Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans
    Maria D Chikina
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Comput Biol 5:e1000417. 2009
  3. pmc The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans
    Geneva M Stein
    Glenn Laboratories for Aging Research, Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University Princeton, NJ, USA
    Front Genet 3:259. 2012
  4. ncbi request reprint The search for DAF-16/FOXO transcriptional targets: approaches and discoveries
    Coleen T Murphy
    Department of Molecular Biology, Lewis Sigler Institute of Genomics, 148 Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA
    Exp Gerontol 41:910-21. 2006
  5. doi request reprint Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms
    Shijing Luo
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jeresy, USA
    Genesis 49:53-65. 2011
  6. pmc Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age
    Amanda L Kauffman
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Biol 8:e1000372. 2010
  7. pmc TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
    Shijing Luo
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 143:299-312. 2010
  8. doi request reprint The role of insulin/IGF-like signaling in C. elegans longevity and aging
    Rachel Kaletsky
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Dis Model Mech 3:415-9. 2010
  9. pmc Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO
    Jessica N Landis
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Dev Dyn 239:1405-12. 2010
  10. pmc The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling
    Wendy M Shaw
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 17:1635-45. 2007

Collaborators

Detail Information

Publications16

  1. pmc TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging
    Shijing Luo
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Genet 5:e1000789. 2009
    ..Our results suggest that longevity and reproductive span regulation can be uncoupled, although they appear to normally be linked through regulatory pathways...
  2. pmc Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans
    Maria D Chikina
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Comput Biol 5:e1000417. 2009
    ..To our knowledge, this is the first study producing high-accuracy predictions of tissue-specific expression and interactions for a metazoan organism based on whole-animal data...
  3. pmc The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans
    Geneva M Stein
    Glenn Laboratories for Aging Research, Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University Princeton, NJ, USA
    Front Genet 3:259. 2012
    ..Here we review what is known about the effects of longevity pathways and the decline of these complex learned behaviors with age, and we highlight outstanding questions in the field...
  4. ncbi request reprint The search for DAF-16/FOXO transcriptional targets: approaches and discoveries
    Coleen T Murphy
    Department of Molecular Biology, Lewis Sigler Institute of Genomics, 148 Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA
    Exp Gerontol 41:910-21. 2006
    ..These mechanisms may act cooperatively or cumulatively to increase longevity, and are likely to be at least partially conserved in higher organisms...
  5. doi request reprint Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms
    Shijing Luo
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jeresy, USA
    Genesis 49:53-65. 2011
    ..elegans. Finally, we extend the relevance of C. elegans reproductive aging studies to the issue of human female reproductive decline, and we discuss ideas concerning the relationship between reproductive aging and somatic longevity...
  6. pmc Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age
    Amanda L Kauffman
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Biol 8:e1000372. 2010
    ..Our results suggest that specific longevity treatments have acute and long-term effects on cognitive functions that decline with age through their regulation of rate-limiting genes required for learning and memory...
  7. pmc TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
    Shijing Luo
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 143:299-312. 2010
    ..Our data suggest that C. elegans and humans share many aspects of reproductive aging, including the correlation between reproductive aging and declining oocyte quality and mechanisms determining oocyte quality...
  8. doi request reprint The role of insulin/IGF-like signaling in C. elegans longevity and aging
    Rachel Kaletsky
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Dis Model Mech 3:415-9. 2010
    ..In this review, we discuss how C. elegans has contributed to our understanding of insulin signaling and aging...
  9. pmc Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO
    Jessica N Landis
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Dev Dyn 239:1405-12. 2010
    ..Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output...
  10. pmc The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling
    Wendy M Shaw
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 17:1635-45. 2007
    ..elegans TGF-beta Dauer pathway is responsible solely for the regulation of dauer formation, with no role in longevity regulation, whereas the insulin/IGF-1 signaling (IIS) pathway regulates both dauer formation and longevity...
  11. ncbi request reprint Enrichment of regulatory motifs upstream of predicted DAF-16 targets
    Cynthia Kenyon
    Nat Genet 38:397-8; author reply 398. 2006
  12. pmc Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Proc Natl Acad Sci U S A 104:19046-50. 2007
    ..Our findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity among the tissues, and they establish the intestine, which is the animal's entire endoderm, as an important insulin-signaling center...
  13. ncbi request reprint Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
    ....
  14. ncbi request reprint Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    Ao Lin Hsu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Science 300:1142-5. 2003
    ..The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease...
  15. ncbi request reprint Comparing genomic expression patterns across species identifies shared transcriptional profile in aging
    Steven A McCarroll
    Program in Neuroscience, University of California, San Francisco, California 94143, USA
    Nat Genet 36:197-204. 2004
    ..Using this approach to search databases of gene expression data, we found conserved transcriptional signatures in larval development, embryogenesis, gametogenesis and mRNA degradation...

Research Grants2

  1. Molecular Mechanisms Regulating Age-Related Cognitive Decline in C. elegans
    COLEEN MURPHY; Fiscal Year: 2009
    ..Using this test and various molecular tools, we can study the genes and cells responsible for loss of memory with age and in neurodegenerative disease. ..
  2. Molecular Mechanisms Regulating Age-Related Cognitive Decline in C. elegans
    COLEEN TARA MURPHY; Fiscal Year: 2010
    ..Using this test and various molecular tools, we can study the genes and cells responsible for loss of memory with age and in neurodegenerative disease. ..