R Scott McIsaac

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Nucleic Acids Res 41:e57. 2013
  2. pmc Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 22:4447-59. 2011
  3. pmc Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:2993-3007. 2012
  4. pmc Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway
    Allegra A Petti
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:3008-24. 2012
  5. ncbi request reprint Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA, Amyris, Inc, Emeryville, CA 94608, USA, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Nucleic Acids Res 42:e48. 2014
  6. pmc Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast
    Mark J Hickman
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 22:4192-204. 2011

Collaborators

Detail Information

Publications6

  1. pmc Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Nucleic Acids Res 41:e57. 2013
    ..These new tools allow for the elucidation of regulatory network elements dynamically, which we demonstrate with a major metabolic regulator, Gcn4p...
  2. pmc Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 22:4447-59. 2011
    ..These gene induction and protein degradation systems provide important tools for studying the dynamics and functional relationships of genes and their respective regulatory networks...
  3. pmc Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:2993-3007. 2012
    ....
  4. pmc Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway
    Allegra A Petti
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:3008-24. 2012
    ..Finally, CBF1 deletion sometimes has the opposite effect on gene expression from MET31 and MET32 deletion...
  5. ncbi request reprint Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA, Amyris, Inc, Emeryville, CA 94608, USA, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Nucleic Acids Res 42:e48. 2014
    ....
  6. pmc Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast
    Mark J Hickman
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 22:4192-204. 2011
    ..Our results show that rapidly growing cells require significant methylation, likely for the biosynthesis of phospholipids...