- Measuring in vivo signaling kinetics in a mitogen-activated kinase pathway using dynamic input stimulationMegan N McClean
Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
Methods Mol Biol 734:101-19. 2011..These methods are generally useful and can be applied to signaling pathways in S. cerevisiae and other organisms whenever a rapid reporter of pathway activity is available...
- Real-time optogenetic control of intracellular protein concentration in microbial cell culturesJustin Melendez
Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
Integr Biol (Camb) 6:366-72. 2014..We anticipate that this technology will allow for quantitative studies of biological networks as well as external tuning of synthetic gene circuits and bioprocesses. ..
- Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stressesNatalia Petrenko
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Mol Biol Cell 24:2045-57. 2013..This noise imparts diverse behaviors to genetically identical cells, allowing cell populations to "hedge their bets" in responding to an uncertain future, and to balance growth and survival in an unpredictable environment...