Megan N McClean

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. doi request reprint Measuring in vivo signaling kinetics in a mitogen-activated kinase pathway using dynamic input stimulation
    Megan N McClean
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Methods Mol Biol 734:101-19. 2011
  2. doi request reprint Real-time optogenetic control of intracellular protein concentration in microbial cell cultures
    Justin Melendez
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Integr Biol (Camb) 6:366-72. 2014
  3. doi request reprint Microfluidic platforms for generating dynamic environmental perturbations to study the responses of single yeast cells
    Anjali Bisaria
    Lewis Sigler Institute for Integrative Genomics, Princeton University, 120 Carl Icahn Laboratory, Washington Road, Princeton, NJ, USA
    Methods Mol Biol 1205:111-29. 2014
  4. pmc Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae
    Joseph P Dexter
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    BMC Syst Biol 9:17. 2015
  5. pmc Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses
    Natalia Petrenko
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 24:2045-57. 2013

Collaborators

Detail Information

Publications5

  1. doi request reprint Measuring in vivo signaling kinetics in a mitogen-activated kinase pathway using dynamic input stimulation
    Megan N McClean
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Methods Mol Biol 734:101-19. 2011
    ..These methods are generally useful and can be applied to signaling pathways in S. cerevisiae and other organisms whenever a rapid reporter of pathway activity is available...
  2. doi request reprint Real-time optogenetic control of intracellular protein concentration in microbial cell cultures
    Justin Melendez
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Integr Biol (Camb) 6:366-72. 2014
    ..We anticipate that this technology will allow for quantitative studies of biological networks as well as external tuning of synthetic gene circuits and bioprocesses. ..
  3. doi request reprint Microfluidic platforms for generating dynamic environmental perturbations to study the responses of single yeast cells
    Anjali Bisaria
    Lewis Sigler Institute for Integrative Genomics, Princeton University, 120 Carl Icahn Laboratory, Washington Road, Princeton, NJ, USA
    Methods Mol Biol 1205:111-29. 2014
    ....
  4. pmc Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae
    Joseph P Dexter
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    BMC Syst Biol 9:17. 2015
    ..Nevertheless, the extent to and mechanisms by which inhibition is robust to fluctuations in the concentrations of the phospho-relay components has received little attention...
  5. pmc Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses
    Natalia Petrenko
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 24:2045-57. 2013
    ..This noise imparts diverse behaviors to genetically identical cells, allowing cell populations to "hedge their bets" in responding to an uncertain future, and to balance growth and survival in an unpredictable environment...