Manuel Llinas

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite
    Tracey L Campbell
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 6:e1001165. 2010
  2. doi request reprint Plasmodium gene regulation: far more to factor in
    Manuel Llinas
    Department of Molecular Biology, Princeton University, 246 Carl Icahn Laboratory, Princeton, NJ 08544, USA
    Trends Parasitol 24:551-6. 2008
  3. ncbi request reprint Mining the malaria transcriptome
    Manuel Llinas
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544 1014, USA
    Trends Parasitol 21:350-2. 2005
  4. pmc Specific DNA-binding by apicomplexan AP2 transcription factors
    Erandi K De Silva
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, 246 Carl Icahn Laboratory, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 105:8393-8. 2008
  5. pmc Host-parasite interactions revealed by Plasmodium falciparum metabolomics
    Kellen L Olszewski
    Department of Molecular Biology, 2Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Cell Host Microbe 5:191-9. 2009
  6. pmc Branched tricarboxylic acid metabolism in Plasmodium falciparum
    Kellen L Olszewski
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 466:774-8. 2010

Research Grants

Collaborators

  • Benjamin A Garcia
  • Kellen L Olszewski
  • Erandi K De Silva
  • Tracey L Campbell
  • Akhil B Vaidya
  • Joanne M Morrisey
  • Joshua D Rabinowitz
  • Michael W Mather
  • Olivier Elemento
  • Daniel Wilinski
  • James M Burns
  • Kellen Olszewski
  • Jasdave S Chahal
  • Andrew R Gehrke
  • Ilsa León
  • Martha L Bulyk

Detail Information

Publications6

  1. pmc Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite
    Tracey L Campbell
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 6:e1001165. 2010
    ..Our results offer a detailed view of ApiAP2 DNA binding specificity and take the first step toward inferring comprehensive gene regulatory networks for P. falciparum...
  2. doi request reprint Plasmodium gene regulation: far more to factor in
    Manuel Llinas
    Department of Molecular Biology, Princeton University, 246 Carl Icahn Laboratory, Princeton, NJ 08544, USA
    Trends Parasitol 24:551-6. 2008
    ..These studies have increased our understanding of the role of transcriptional regulation, not only in the control of gene expression for antigenic variation but also in the coordination of stage-specific parasite development...
  3. ncbi request reprint Mining the malaria transcriptome
    Manuel Llinas
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544 1014, USA
    Trends Parasitol 21:350-2. 2005
    ..In this article, we highlight the importance of new computational approaches in mining the malaria transcriptome of the intraerythrocytic developmental cycle of P. falciparum...
  4. pmc Specific DNA-binding by apicomplexan AP2 transcription factors
    Erandi K De Silva
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, 246 Carl Icahn Laboratory, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 105:8393-8. 2008
    ..Because of their origin in the plant lineage, ApiAP2 proteins have no homologues in the human host and may prove to be ideal antimalarial targets...
  5. pmc Host-parasite interactions revealed by Plasmodium falciparum metabolomics
    Kellen L Olszewski
    Department of Molecular Biology, 2Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Cell Host Microbe 5:191-9. 2009
    ..These parasites were viable but did not convert arginine to ornithine. Our results suggest that systemic arginine depletion by the parasite may be a factor in human malarial hypoargininemia associated with cerebral malaria pathogenesis...
  6. pmc Branched tricarboxylic acid metabolism in Plasmodium falciparum
    Kellen L Olszewski
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 466:774-8. 2010
    ..These results significantly clarify our understanding of the Plasmodium metabolic network and highlight the ability of altered variants of central carbon metabolism to arise in response to unique environments...

Research Grants3

  1. Regulation of Plasmodium falciparum transcription
    Manuel Llinas; Fiscal Year: 2010
    ..Our research plan will investigate the mechanisms underlying the regulation of gene expression during parasite development as a potential avenue for new therapeutic interventions. ..