Affiliation: Princeton University
- Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasiteTracey L Campbell
Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
PLoS Pathog 6:e1001165. 2010..Our results offer a detailed view of ApiAP2 DNA binding specificity and take the first step toward inferring comprehensive gene regulatory networks for P. falciparum...
- Plasmodium gene regulation: far more to factor inManuel Llinas
Department of Molecular Biology, Princeton University, 246 Carl Icahn Laboratory, Princeton, NJ 08544, USA
Trends Parasitol 24:551-6. 2008..These studies have increased our understanding of the role of transcriptional regulation, not only in the control of gene expression for antigenic variation but also in the coordination of stage-specific parasite development...
- Mining the malaria transcriptomeManuel Llinas
Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544 1014, USA
Trends Parasitol 21:350-2. 2005..In this article, we highlight the importance of new computational approaches in mining the malaria transcriptome of the intraerythrocytic developmental cycle of P. falciparum...
- Specific DNA-binding by apicomplexan AP2 transcription factorsErandi K De Silva
Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, 246 Carl Icahn Laboratory, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 105:8393-8. 2008..Because of their origin in the plant lineage, ApiAP2 proteins have no homologues in the human host and may prove to be ideal antimalarial targets...
- Host-parasite interactions revealed by Plasmodium falciparum metabolomicsKellen L Olszewski
Department of Molecular Biology, 2Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
Cell Host Microbe 5:191-9. 2009..These parasites were viable but did not convert arginine to ornithine. Our results suggest that systemic arginine depletion by the parasite may be a factor in human malarial hypoargininemia associated with cerebral malaria pathogenesis...
- Branched tricarboxylic acid metabolism in Plasmodium falciparumKellen L Olszewski
Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
Nature 466:774-8. 2010..These results significantly clarify our understanding of the Plasmodium metabolic network and highlight the ability of altered variants of central carbon metabolism to arise in response to unique environments...
- Regulation of Plasmodium falciparum transcriptionManuel Llinas; Fiscal Year: 2010..Our research plan will investigate the mechanisms underlying the regulation of gene expression during parasite development as a potential avenue for new therapeutic interventions. ..