Gary LeRoy

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines
    Gary LeRoy
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544 1014, USA
    Nucleic Acids Res 33:6251-7. 2005
  2. pmc One-pot shotgun quantitative mass spectrometry characterization of histones
    Mariana D Plazas-Mayorca
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    J Proteome Res 8:5367-74. 2009
  3. pmc Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications
    Gary LeRoy
    Department Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Mol Cell Proteomics 8:2432-42. 2009
  4. pmc Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a
    Nicolas L Young
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Am Soc Mass Spectrom 21:960-70. 2010
  5. pmc Proteomic interrogation of human chromatin
    Mariana P Torrente
    Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e24747. 2011
  6. pmc The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription
    Gary LeRoy
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 30:51-60. 2008
  7. pmc Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown
    Mariana D Plazas-Mayorca
    Department of Chemistry, Princeton University, Princeton, NJ 08540, USA
    Mol Biosyst 6:1719-29. 2010
  8. pmc Global secretome analysis identifies novel mediators of bone metastasis
    Mario Andres Blanco
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell Res 22:1339-55. 2012
  9. pmc In vivo residue-specific histone methylation dynamics
    Barry M Zee
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 285:3341-50. 2010
  10. pmc Nucleolin is required for RNA polymerase I transcription in vivo
    Brenden Rickards
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell Biol 27:937-48. 2007

Collaborators

Detail Information

Publications12

  1. pmc Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines
    Gary LeRoy
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544 1014, USA
    Nucleic Acids Res 33:6251-7. 2005
    ..A reduction in the level of RecQL1 induced by RNA interference in HeLa cells leads to an increase in sister chromatid exchange. We propose that RecQL1 is involved in the processing of Holliday junctions in human cells...
  2. pmc One-pot shotgun quantitative mass spectrometry characterization of histones
    Mariana D Plazas-Mayorca
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    J Proteome Res 8:5367-74. 2009
    ..Our protocol significantly streamlines the analysis of histone PTMs and will allow for studies of differentially expressed PTMs between multiple samples during biologically relevant processes in a rapid and quantitative fashion...
  3. pmc Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications
    Gary LeRoy
    Department Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Mol Cell Proteomics 8:2432-42. 2009
    ....
  4. pmc Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a
    Nicolas L Young
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Am Soc Mass Spectrom 21:960-70. 2010
    ..This report presents one of the most detailed analyses of HMGA1a to date and illustrates the strength of using a combined MS effort...
  5. pmc Proteomic interrogation of human chromatin
    Mariana P Torrente
    Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e24747. 2011
    ....
  6. pmc The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription
    Gary LeRoy
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 30:51-60. 2008
    ..These data identify proteins that render nucleosomes marked by acetylation permissive to the passage of elongating RNA polymerase II...
  7. pmc Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown
    Mariana D Plazas-Mayorca
    Department of Chemistry, Princeton University, Princeton, NJ 08540, USA
    Mol Biosyst 6:1719-29. 2010
    ..Our results provide new insights into the intra- and inter- histone cross-regulation of histone K9 methylation and its potential downstream gene targets...
  8. pmc Global secretome analysis identifies novel mediators of bone metastasis
    Mario Andres Blanco
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell Res 22:1339-55. 2012
    ..Overall, our study has uncovered several new secreted mediators of bone metastasis and therefore demonstrated that secretome analysis is a powerful method for identification of novel biomarkers and candidate therapeutic targets...
  9. pmc In vivo residue-specific histone methylation dynamics
    Barry M Zee
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 285:3341-50. 2010
    ..Here we show that quantitative proteomic approaches such as this can determine the dynamics of multiple methylated residues, an understudied portion of histone biology...
  10. pmc Nucleolin is required for RNA polymerase I transcription in vivo
    Brenden Rickards
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell Biol 27:937-48. 2007
    ..Knockdown of nucleolin by RNA interference resulted in specific inhibition of RNA polymerase I transcription. We therefore propose that an important function of nucleolin is to permit RNA polymerase I to transcribe nucleolar chromatin...
  11. pmc The adenovirus L4 33-kilodalton protein binds to intragenic sequences of the major late promoter required for late phase-specific stimulation of transcription
    Humayra Ali
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Virol 81:1327-38. 2007
    ..Furthermore, the L4 33-kDa protein binds to the promoter with the specificity characteristic of DEF-A and stimulates transcription from the ML promoter in transient-expression assays...
  12. pmc Functional analysis of the subunits of the chromatin assembly factor RSF
    Alejandra Loyola
    Howard Hughes Medical Institute, University of Medicine and Dentistry of New JerseyRobert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 23:6759-68. 2003
    ..HBXAP actually contains a 252-amino-acid truncation of the amino terminus of Rsf-1. Finally, comparison of HBXAP and Rsf-1 properties shows that they are functionally different...