Leonid Kruglyak

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi request reprint Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Science 311:1932-6. 2006
  2. pmc Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
    Erik C Andersen
    Lewis Sigler Institute for Integrative Genomics, Princeton University, New Jersey, USA
    Nat Genet 44:285-90. 2012
  3. pmc Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains
    Joseph Schacherer
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 2:e322. 2007
  4. pmc Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast
    Noorossadat Torabi
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 8:e1002546. 2012
  5. pmc Using expression and genotype to predict drug response in yeast
    Douglas M Ruderfer
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 4:e6907. 2009
  6. doi request reprint The road to genome-wide association studies
    Leonid Kruglyak
    Lewis Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Genet 9:314-8. 2008
  7. ncbi request reprint Evolution. An embarrassment of switches
    Leonid Kruglyak
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 317:758-9. 2007
  8. pmc Dissection of genetically complex traits with extremely large pools of yeast segregants
    Ian M Ehrenreich
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 464:1039-42. 2010
  9. pmc Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS
    Zia Khan
    Department of Computer Science, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 8:602. 2012
  10. pmc Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae
    Joseph Schacherer
    Lewis Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology and Howard Hughes Medical Institute, Princeton University, Princeton, New Jersey 08544, USA
    Nature 458:342-5. 2009

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Science 311:1932-6. 2006
    ..We applied this approach to elucidate the genetic basis of phenotypic variants and to identify the small number of single-base pair changes accumulated during experimental evolution of yeast...
  2. pmc Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
    Erik C Andersen
    Lewis Sigler Institute for Integrative Genomics, Princeton University, New Jersey, USA
    Nat Genet 44:285-90. 2012
    ..These sweeps, which we hypothesize to be a result of human activity, have drastically reshaped the global C. elegans population in the recent past...
  3. pmc Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains
    Joseph Schacherer
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 2:e322. 2007
    ..These data and new visualization tools are accessible online in a new resource: the Yeast SNPs Browser (YSB; http://gbrowse.princeton.edu/cgi-bin/gbrowse/yeast_strains_snps) that is available to all researchers...
  4. pmc Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast
    Noorossadat Torabi
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 8:e1002546. 2012
    ..We found that the allelic state of SKY1 interacts with readthrough level and the genetic background to determine growth rate in these two conditions...
  5. pmc Using expression and genotype to predict drug response in yeast
    Douglas M Ruderfer
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 4:e6907. 2009
    ..Marker-based prediction is usually more accurate than transcript-based prediction, likely reflecting the genetic determination of gene expression in this cross...
  6. doi request reprint The road to genome-wide association studies
    Leonid Kruglyak
    Lewis Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Genet 9:314-8. 2008
    ..Here, I look back at how the necessary pieces fell into place, focusing on the less well-chronicled days before the launch of the HapMap project, and speculate about future developments...
  7. ncbi request reprint Evolution. An embarrassment of switches
    Leonid Kruglyak
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 317:758-9. 2007
  8. pmc Dissection of genetically complex traits with extremely large pools of yeast segregants
    Ian M Ehrenreich
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 464:1039-42. 2010
    ..Our method should have broad applications in yeast and can be extended to other organisms...
  9. pmc Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS
    Zia Khan
    Department of Computer Science, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 8:602. 2012
    ..Our results provide the first analysis of the relative contribution of cis-acting and trans-acting regulatory differences to protein expression divergence between yeast species...
  10. pmc Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae
    Joseph Schacherer
    Lewis Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology and Howard Hughes Medical Institute, Princeton University, Princeton, New Jersey 08544, USA
    Nature 458:342-5. 2009
    ..We also examined the population structure of S. cerevisiae, providing support for multiple domestication events as well as insight into the origins of pathogenic strains...
  11. pmc Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays
    Joshua S Bloom
    Lewis Sigler Institute of Integrative Genomics, Princeton University, New Jersey, USA
    BMC Genomics 10:221. 2009
    ..High-throughput cDNA synthesis and sequencing of poly(A)-enriched RNA is rapidly emerging as a technology competing to replace microarrays as a quantitative platform for measuring gene expression...
  12. doi request reprint Genetics of single-cell protein abundance variation in large yeast populations
    Frank W Albert
    1 Department of Human Genetics, University of California, Los Angeles, California 90095, USA 2 Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 506:494-7. 2014
    ..The variants that underlie these hotspots have profound effects on the gene regulatory network and provide insights into genetic variation in cell physiology between yeast strains. ..
  13. pmc Widespread genetic incompatibility in C. elegans maintained by balancing selection
    Hannah S Seidel
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 319:589-94. 2008
    ..Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome...
  14. pmc Genetic architecture of highly complex chemical resistance traits across four yeast strains
    Ian M Ehrenreich
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    PLoS Genet 8:e1002570. 2012
    ..These results improve our understanding of complex traits in yeast and have implications for study design in other organisms...
  15. ncbi request reprint Population genomic analysis of outcrossing and recombination in yeast
    Douglas M Ruderfer
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Genet 38:1077-81. 2006
    ..Our results provide the initial foundation for population studies of association between genotype and phenotype in S. cerevisiae...
  16. pmc Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans
    Rajarshi Ghosh
    Lewis Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology, and Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Science 335:574-8. 2012
    ..These results implicate variation in glutamate-gated chloride channels in avermectin resistance and provide a mechanism by which such resistance can be maintained...
  17. pmc Breeding designs for recombinant inbred advanced intercross lines
    Matthew V Rockman
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genetics 179:1069-78. 2008
    ..We find that the easiest crosses to perform are well suited to the task of generating populations of highly recombinant inbred lines...
  18. pmc Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes
    David Gresham
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 107:1482-7. 2010
    ..Moreover, designing microarray probes with optimized sensitivity to mismatches should increase the accuracy of standard microarray applications such as copy-number variation detection and gene expression analysis...
  19. pmc Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae
    Noorossadat Torabi
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 7:e1002211. 2011
    ..Our results also provide genetic evidence for a new role of Trm10p in translation termination efficiency...
  20. pmc Accurate proteome-wide protein quantification from high-resolution 15N mass spectra
    Zia Khan
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Washington Rd, Princeton, NJ 08544, USA
    Genome Biol 12:R122. 2011
    ..Application of this method to an Escherichia coli growth transition reveals significant improvement in quantification accuracy over previous methods...
  21. pmc A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans
    Hannah S Seidel
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey, United States of America
    PLoS Biol 9:e1001115. 2011
    ..Our results demonstrate that the tight physical linkage between two novel transmembrane proteins has facilitated their co-evolution into an element capable of promoting its own transmission to the detriment of organisms carrying it...
  22. pmc Gene-environment interaction in yeast gene expression
    Erin N Smith
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Biol 6:e83. 2008
    ..These observations will guide the design of studies aimed at understanding the genetic basis of complex traits...
  23. pmc Finding the sources of missing heritability in a yeast cross
    Joshua S Bloom
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 494:234-7. 2013
    ..These results substantially advance our understanding of the missing heritability problem and have important implications for future studies of complex and quantitative traits...
  24. pmc Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans
    Rajarshi Ghosh
    Lewis Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    BMC Biol 10:85. 2012
    ..Here we use the nematode C. elegans to address the neurogenetic basis of responses to thermal stimuli over a broad range of intensities...
  25. pmc Recombinational landscape and population genomics of Caenorhabditis elegans
    Matthew V Rockman
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 5:e1000419. 2009
    ..elegans strains...
  26. doi request reprint Genetics. It's the sequence, stupid!
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 322:380-1. 2008
  27. pmc Protein quantification across hundreds of experimental conditions
    Zia Khan
    Department of Computer Science, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA
    Proc Natl Acad Sci U S A 106:15544-8. 2009
    ..We demonstrate the scalability of these techniques by applying them to a large dataset that comprises a total of 472 experimental conditions and replicates...
  28. pmc Comparative developmental expression profiling of two C. elegans isolates
    Emily J Capra
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    PLoS ONE 3:e4055. 2008
    ....
  29. pmc A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays
    Zia Khan
    Department of Computer Science, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Bioinformatics 25:1609-16. 2009
    ....
  30. pmc A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology
    Erik C Andersen
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 10:e1004156. 2014
    ..These results suggest that variation in npr-1 has broad pleiotropic effects mediated by altered exposure to bacterial food. ..
  31. ncbi request reprint Genetics of global gene expression
    Matthew V Rockman
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Genet 7:862-72. 2006
    ....
  32. pmc Rise of the machines
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 4:e1000134. 2008
  33. pmc Genetic basis of metabolome variation in yeast
    Jeffrey S Breunig
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 10:e1004142. 2014
    ..These results highlight specific examples of genetic variability, including in genes without prior known metabolic regulatory function, that impact yeast metabolism...
  34. pmc Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells
    Marshall Louis Reaves
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Science 337:470-3. 2012
    ..Furthermore, mass spectrometry showed that this DNA contains only trace amounts of free arsenate and no detectable covalently bound arsenate...
  35. pmc Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
    Jun Zhu
    Rosetta Inpharmatics, LLC, Seattle, Washington 98109, USA
    Nat Genet 40:854-61. 2008
    ..We then prospectively validate predictions, providing direct experimental evidence that predictive networks can be constructed by integrating multiple, appropriate data types...
  36. pmc Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast
    Ann Demogines
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000123. 2008
    ..It also provides tools for understanding the effect of genetic background on sensitivity to genotoxic agents...
  37. pmc Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans
    Michael F Palopoli
    Department of Biology, Bowdoin College, 6500 College Station, Brunswick, Maine 04011, USA
    Nature 454:1019-22. 2008
    ..The reduced selection on male?male competition associated with the origin of hermaphroditism may have permitted the global spread of a loss-of-function mutation with restricted pleiotropy...
  38. ncbi request reprint Revealing complex traits with small molecules and naturally recombinant yeast strains
    Ethan O Perlstein
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Chem Biol 13:319-27. 2006
    ..The systematic combination of natural variants of yeast and small molecules that modulate evolutionarily conserved cellular processes can enable a better understanding of the general features of complex traits...
  39. pmc Population history and natural selection shape patterns of genetic variation in 132 genes
    Joshua M Akey
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 2:e286. 2004
    ..More generally, our results have important implications for mapping genes underlying complex human diseases...
  40. ncbi request reprint Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'
    Christopher S Carlson
    Bioinformatics 21:141-3. 2005
  41. pmc Sequence-based linkage analysis
    Itay Furman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109 1024, USA
    Am J Hum Genet 75:647-53. 2004
    ..We validate these results experimentally by implementing the sequence-based linkage approach for chromosome 19 in CEPH pedigrees...
  42. ncbi request reprint Mapping complex disease loci in whole-genome association studies
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, Washington 98195 7730, USA
    Nature 429:446-52. 2004
    ....
  43. ncbi request reprint Genetic structure of the purebred domestic dog
    Heidi G Parker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Post Office Box 19024, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, USA
    Science 304:1160-4. 2004
    ..These results provide a genetic classification of dog breeds and will aid studies of the genetics of phenotypic breed differences...
  44. ncbi request reprint Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
    Gael Yvert
    Howard Hughes Medical Institute and Division of Human Biology, Fred Hutchinson Cancer Research Center, Mailstop D4 100, 1100 Fairview Avenue North, Seattle, Washington 98103 USA
    Nat Genet 35:57-64. 2003
    ..Notably, transcription factors showed no enrichment, and trans-regulatory variation seems to be broadly dispersed across classes of genes with different molecular functions...
  45. pmc A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set
    Tara C Matise
    Department of Genetics, Rutgers University, Piscataway, NJ, 08840, USA
    Am J Hum Genet 73:271-84. 2003
    ..Evaluations indicate that this SNP screening set is more informative than the Marshfield Clinic's commonly used microsatellite-based screening set...
  46. ncbi request reprint Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, Washington 98195 7730, USA
    Nat Genet 33:518-21. 2003
    ....
  47. ncbi request reprint Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population
    Oumou Niare
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Science 298:213-6. 2002
    ..The apparently high natural frequency of resistance alleles suggests that malaria parasites (or a similar pathogen) exert a significant selective pressure on vector populations...
  48. ncbi request reprint Patterns of linkage disequilibrium in the human genome
    Kristin G Ardlie
    Genomics Collaborative, 99 Erie Street, Cambridge, Massachusetts 02139, USA
    Nat Rev Genet 3:299-309. 2002
    ..In this review, we draw on empirical studies in humans and Drosophila, as well as simulation studies, to assess the current state of knowledge about patterns of LD, and consider the implications for the use of LD as a mapping tool...
  49. ncbi request reprint Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
    ..We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function...
  50. pmc Extensive and breed-specific linkage disequilibrium in Canis familiaris
    Nathan B Sutter
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genome Res 14:2388-96. 2004
    ..We also report low haplotype diversity within regions of high LD, with 80% of chromosomes in a breed carrying two to four haplotypes, as well as a high degree of haplotype sharing among breeds...
  51. pmc The landscape of genetic complexity across 5,700 gene expression traits in yeast
    Rachel B Brem
    Division of Human Biology and Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:1572-7. 2005
    ..Sixteen percent of highly heritable transcripts exhibit evidence of interacting loci. Our results will aid design of future QTL mapping studies and may shed light on the evolution of quantitative traits...
  52. ncbi request reprint Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region
    Michelle M Riehle
    Center for Microbial and Plant Genomics and Department of Microbiology, University of Minnesota, St Paul, MN 55108, USA
    Science 312:577-9. 2006
    ....
  53. ncbi request reprint Power tools for human genetics
    Leonid Kruglyak
    Nat Genet 37:1299-300. 2005
  54. pmc Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome
    Michael A Eberle
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 2:e142. 2006
    ..The SNP pairs exhibiting perfect LD showed a significant bias for derived, nonancestral alleles, providing evidence for positive natural selection in the human genome...
  55. pmc Genetic interactions between polymorphisms that affect gene expression in yeast
    Rachel B Brem
    Program in Computational Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B876, Seattle, Washington 98109, USA
    Nature 436:701-3. 2005
    ..Our results indicate that genetic interactions are widespread in the genetics of transcript levels, and that many QTLs will be missed by single-locus tests but can be detected by two-stage tests that allow for interactions...
  56. pmc Multiple locus linkage analysis of genomewide expression in yeast
    John D Storey
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    PLoS Biol 3:e267. 2005
    ..In addition, we show that a two-dimensional scan does not truly allow one to test for simultaneous linkage, and the statistical significance measured from this existing method cannot be interpreted among many traits...
  57. ncbi request reprint Genetic basis of individual differences in the response to small-molecule drugs in yeast
    Ethan O Perlstein
    Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:496-502. 2007
    ..Our results provide a step toward a systematic understanding of small-molecule drug action in genetically distinct individuals...
  58. pmc Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays
    James Ronald
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genome Res 15:284-91. 2005
    ..With this method, we discovered 70 ORFs with evidence for preferential expression of one allele in a diploid hybrid of two S. cerevisiae strains...
  59. pmc Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast
    Tonibelle Gatbonton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Genet 2:e35. 2006
    ..Furthermore, our results laid the foundation for studying genetic determinants of telomere length-variation and their roles in human disease...
  60. ncbi request reprint Genetic basis of proteome variation in yeast
    Eric J Foss
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Genet 39:1369-75. 2007
    ..Loci that influenced protein abundance differed from those that influenced transcript levels, emphasizing the importance of direct analysis of the proteome...
  61. pmc Molecular genetics: DNA analysis of a putative dog clone
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 440:E1-2. 2006
    ..In light of recent concerns regarding the creation of cloned human cell lines from the same institution, we have undertaken an independent test to determine the validity of the claims made by Lee et al....
  62. pmc Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA
    Am J Hum Genet 74:106-20. 2004
    ..We demonstrate that, although common variation tends to be shared between populations, tagSNPs should be selected separately for populations with different ancestries...
  63. pmc Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle 98195 7730, USA
    Am J Hum Genet 74:610-22. 2004
    ....
  64. pmc Local regulatory variation in Saccharomyces cerevisiae
    James Ronald
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    PLoS Genet 1:e25. 2005
    ..These findings point to the importance of cis-acting variation, but also suggest that there is a diverse set of mechanisms through which local variation can affect gene expression levels...
  65. pmc No bias in linkage analysis
    Goncalo Abecasis
    Am J Hum Genet 75:722-3; author reply 723-7. 2004
  66. pmc A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34
    Michael A Eberle
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 70:1044-8. 2002
    ..56 in two-point analysis and 5.36 in three-point analysis) on chromosome 4q32-34, providing evidence for a major locus for pancreatic cancer...