Yibin Kang

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    Yibin Kang
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Molecular Cytology Laboratory, Memorial Sloan Kettering Cancer Center, NY 10021, USA
    Proc Natl Acad Sci U S A 102:13909-14. 2005
  2. ncbi EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases
    Ji Zhu
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 282:26656-64. 2007
  3. pmc Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    Nat Cell Biol 14:1212-22. 2012
  4. pmc Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, Washington Road, LTL 255, NJ 08544, USA
    Cell Res 20:1012-22. 2010
  5. pmc A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy
    Benjamin J Tiede
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 4:e8035. 2009
  6. pmc Notch signalling in cancer progression and bone metastasis
    N Sethi
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Br J Cancer 105:1805-10. 2011
  7. pmc Epidermal growth factor signalling and bone metastasis
    X Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Br J Cancer 102:457-61. 2010
  8. pmc Tumor cell dissemination: emerging biological insights from animal models and cancer patients
    Yibin Kang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 23:573-81. 2013
  9. pmc Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis
    Vidya Ganapathy
    Division of Medical Oncology, Department of Internal Medicine, UMDNJRobert Wood Johnson Medical School and The Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Mol Cancer 9:122. 2010
  10. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011

Collaborators

Detail Information

Publications58

  1. pmc Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    Yibin Kang
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Molecular Cytology Laboratory, Memorial Sloan Kettering Cancer Center, NY 10021, USA
    Proc Natl Acad Sci U S A 102:13909-14. 2005
    ..Our findings provide functional evidence for a switch of the Smad pathway, from tumor-suppressor to prometastatic, in the development of breast cancer bone metastasis...
  2. ncbi EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases
    Ji Zhu
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 282:26656-64. 2007
    ..Because a high percentage of human carcinomas express EGF-like ligands, our findings suggest a novel mechanism for osteolytic lesions caused by cancer cells metastasizing to bone...
  3. pmc Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    Nat Cell Biol 14:1212-22. 2012
    ..These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer...
  4. pmc Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, Washington Road, LTL 255, NJ 08544, USA
    Cell Res 20:1012-22. 2010
    ..Our results suggest a potential mechanistic link between ploidy duplication and enhancement of metastatic potentials, as was observed in previous clinical studies of breast cancer...
  5. pmc A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy
    Benjamin J Tiede
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 4:e8035. 2009
    ..These findings validate a powerful system for the analysis of MaSC dynamics in vivo, which will facilitate future characterization of MaSCs during mammary gland development and breast cancer...
  6. pmc Notch signalling in cancer progression and bone metastasis
    N Sethi
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Br J Cancer 105:1805-10. 2011
    ..Of clinical significance, disrupting the Notch pathway and associated molecular mediators of Notch-dependent bone metastasis may provide novel therapeutic strategies to combat aggressive bone metastatic disease...
  7. pmc Epidermal growth factor signalling and bone metastasis
    X Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Br J Cancer 102:457-61. 2010
    ..Therefore, molecular targeting of ERBB receptors may benefit patients with bone metastasis and should be evaluated in clinical trials...
  8. pmc Tumor cell dissemination: emerging biological insights from animal models and cancer patients
    Yibin Kang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 23:573-81. 2013
    ..Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients...
  9. pmc Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis
    Vidya Ganapathy
    Division of Medical Oncology, Department of Internal Medicine, UMDNJRobert Wood Johnson Medical School and The Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Mol Cancer 9:122. 2010
    ....
  10. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011
    ..Accumulating evidence indicates that deregulation of miR is associated with human malignancies including ESCC. The aim of this study was to identify miR that could be specifically expressed and exert distinct biological actions in ESCC...
  11. ncbi New tricks against an old foe: molecular dissection of metastasis tissue tropism in breast cancer
    Yibin Kang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Breast Dis 26:129-38. 2006
    ..Analysis of tissue-specific metastasis not only enriched our understanding about the malignancy of breast cancer, but also provided elegant experimental support for the century-old "seed and soil" hypothesis...
  12. pmc VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
    Xin Lu
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Cancer Cell 20:701-14. 2011
    ..These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone...
  13. pmc MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer
    Guohong Hu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 15:9-20. 2009
    ..These findings establish MTDH as an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk...
  14. pmc Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 106:9385-90. 2009
    ..Our study suggests cell fusion as an efficient means of phenotypic evolution during tumor progression and additionally demonstrates the compatibility of different metastasis organotropisms...
  15. pmc In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cancer Res 70:3905-14. 2010
    ..Our study shows distinct functions of hypoxia in regulating angiogenesis and metastasis in different organ microenvironments and establishes HIF-1alpha as a promising target for controlling organotropic metastasis of breast cancer...
  16. pmc Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions
    Mario Andres Blanco
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 286:19982-92. 2011
    ..Thus, we have uncovered SND1 as a novel MTDH-interacting protein and shown that it is a functionally and clinically significant mediator of metastasis...
  17. pmc Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis
    Brian Ell
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 24:542-56. 2013
    ..These findings establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis...
  18. pmc Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 285:9317-21. 2010
    ..These results suggest possible biomarkers of breast cancer progression as well as opportunities of interrupting tumor progression through the targeting of metabolic pathways...
  19. pmc Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Med 17:1101-8. 2011
    ..Overall, these findings suggest a pleiotropic role of miR-200s in promoting metastatic colonization by influencing E-cadherin-dependent epithelial traits and Sec23a-mediated tumor cell secretome...
  20. ncbi Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, NJ 08554, USA
    Stem Cells 30:1496-508. 2012
    ....
  21. pmc ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 23:1882-94. 2009
    ..This study established MMP1 and ADAMTS1 in tumor cells, as well as EGFR signaling in osteoblasts, as promising therapeutic targets for inhibiting bone metastasis of breast cancer...
  22. doi Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Med 15:960-6. 2009
    ....
  23. pmc Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 284:29087-96. 2009
    ..Therefore, CCL2 and CCR2 are promising therapeutic targets for simultaneously inhibiting lung and bone metastasis of breast cancer...
  24. doi Tumor metastasis: moving new biological insights into the clinic
    Liling Wan
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Med 19:1450-64. 2013
    ..However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression. ..
  25. doi From breast to the brain: unraveling the puzzle of metastasis organotropism
    Guohong Hu
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    J Mol Cell Biol 1:3-5. 2009
    ....
  26. pmc Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    Nilay Sethi
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 19:192-205. 2011
    ..These findings elucidate a stroma-dependent mechanism for Notch signaling in breast cancer and provide rationale for using γ-secretase inhibitors for the treatment of bone metastasis...
  27. pmc Hypoxia and hypoxia-inducible factors: master regulators of metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Clin Cancer Res 16:5928-35. 2010
    ..Multiple approaches to targeting hypoxia and HIFs, including HIF inhibitors, hypoxia-activated bioreductive prodrugs, and gene therapies may become effective treatments to prevent or reduce metastasis...
  28. doi Analysis of cancer stem cell metastasis in xenograft animal models
    Yibin Kang
    Department of Molecular Biology, Princeton University, Princeton, NJ, USA
    Methods Mol Biol 568:7-19. 2009
    ..Similar experimental approach can be applied to analyze the metastatic behavior of CSCs derived from other tumor types...
  29. ncbi Organotropism of breast cancer metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    J Mammary Gland Biol Neoplasia 12:153-62. 2007
    ..A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field...
  30. pmc The metastasis-promoting roles of tumor-associated immune cells
    Heath A Smith
    Department of Molecular Biology, Princeton University, LTL255, Washington Road, Princeton, NJ 08544, USA
    J Mol Med (Berl) 91:411-29. 2013
    ..This review focuses on the interactions between tumor cells and immune cells recruited to the tumor microenvironment and examines the factors allowing these cells to promote each stage of metastasis...
  31. doi A one-two punch of miR-126/126* against metastasis
    Guangwen Ren
    Department of Molecular Biology, LTL255, Washington Road, Princeton University, Princeton, New Jersey 08544, USA
    Nat Cell Biol 15:231-3. 2013
    ....
  32. pmc Global secretome analysis identifies novel mediators of bone metastasis
    Mario Andres Blanco
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell Res 22:1339-55. 2012
    ..Overall, our study has uncovered several new secreted mediators of bone metastasis and therefore demonstrated that secretome analysis is a powerful method for identification of novel biomarkers and candidate therapeutic targets...
  33. pmc Signaling pathways in breast cancer metastasis - novel insights from functional genomics
    Mario Andres Blanco
    Department of Molecular Biology, Washington Road, LTL 255, Princeton University, Princeton, NJ 08544, USA
    Breast Cancer Res 13:206. 2011
    ..Such functional genomics studies hold great promise for understanding the genetic basis of metastasis and improving therapeutics for advanced diseases...
  34. doi Targeting the transforming growth factor-beta signalling pathway in metastatic cancer
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, NJ, United States
    Eur J Cancer 46:1232-40. 2010
    ..Novel mouse models and diagnostic tools are being developed today to circumvent these issues, which may potentially expedite anti-TGF-beta drug development and clinical application...
  35. doi Dysregulation of developmental pathways in bone metastasis
    Nilay Sethi
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Bone 48:16-22. 2011
    ....
  36. pmc The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    RNA Biol 5:115-9. 2008
    ..These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting...
  37. pmc The multifaceted role of MTDH/AEG-1 in cancer progression
    Guohong Hu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Clin Cancer Res 15:5615-20. 2009
    ..These findings suggest that therapeutic targeting of MTDH/AEG-1 may simultaneously suppress tumor growth, block metastasis, and enhance the efficacy of chemotherapeutic treatments...
  38. pmc The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Biol Chem 283:14910-4. 2008
    ..These results suggested that loss of expression of the miR-200 family members may play a critical role in the repression of E-cadherin by ZEB1 and ZEB2 during EMT, thereby enhancing migration and invasion during cancer progression...
  39. pmc Transcriptional control of cancer metastasis
    Brian Ell
    Department of Molecular Biology, Princeton University, Princeton, NJ, USA
    Trends Cell Biol 23:603-11. 2013
    ..We focus here on recent research advances in transcriptional control of metastasis and highlight the therapeutic potential of targeting such transcriptional regulatory networks. ..
  40. doi Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer
    Liling Wan
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Adv Cancer Res 120:113-34. 2013
    ..With increasing mechanistic understanding of AEG-1/MTDH/LYRIC, discovery of agents that can block AEG-1/MTDH/LYRIC and its regulated pathways will be beneficial to cancer patients with aberrant expression of AEG-1/MTDH/LYRIC. ..
  41. doi Cell fusion hypothesis of the cancer stem cell
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA
    Adv Exp Med Biol 714:129-40. 2011
    ..The cell fusion hypothesis of CSCs adds an important functional underpinning to the potential multifaceted roles of cell fusion in the initiation and progression of cancer...
  42. pmc Cell fusion as a hidden force in tumor progression
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cancer Res 69:8536-9. 2009
    ....
  43. pmc From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer
    Benjamin Tiede
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Cell Res 21:245-57. 2011
    ..In particular, we focus on how changes in MaSC populations may explain both the increased risk of developing aggressive ER/PR(-) breast cancer shortly after pregnancy and the long-term decreased risk of developing ER/PR(+) tumors...
  44. pmc Rabconnectin-3 is a functional regulator of mammalian Notch signaling
    Nilay Sethi
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 285:34757-64. 2010
    ..Collectively, these findings define an important role for Rabconnectin-3 and V-ATPase activity in the Notch signaling pathway in mammalian cells...
  45. ncbi Beyond tumorigenesis: cancer stem cells in metastasis
    Feng Li
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Cell Res 17:3-14. 2007
    ..Better understanding of CSCs as a fundamental component of the metastatic cascade will lead to novel therapeutic strategies against metastatic cancer...
  46. pmc Detection of a common chimeric transcript between human chromosomes 7 and 16
    Wenwen Fang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Biol Direct 7:49. 2012
    ..The fusion sequence at the novel exon-exon boundary, and the absence of corresponding DNA rearrangement suggest that this chimeric RNA is likely produced by trans-splicing in human cells...
  47. ncbi Unravelling the complexity of metastasis - molecular understanding and targeted therapies
    Nilay Sethi
    Department of Molecular Biology, Washington Road, LTL 255, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Cancer 11:735-48. 2011
    ..Future research carries with it the potential to translate the wealth of new knowledge and conceptual advances into effective targeted therapies...
  48. pmc Acute infection induces a metastatic niche: a double menace for cancer patients
    Heath A Smith
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Clin Cancer Res 19:4547-9. 2013
    ..New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics...
  49. ncbi Pro-metastasis function of TGFbeta mediated by the Smad pathway
    Yibin Kang
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Cell Biochem 98:1380-90. 2006
    ..Understanding the dual roles of Smad proteins in tumor initiation and progression has important implications for cancer therapeutics...
  50. ncbi Functional genomic analysis of cancer metastasis: biologic insights and clinical implications
    Yibin Kang
    Princeton University Department of Molecular Biology, Princeton, NJ 08544, USA
    Expert Rev Mol Diagn 5:385-95. 2005
    ..This article reviews recent breakthroughs in the functional genomic analysis of metastasis. In addition, its impacts on our understanding of the molecular basis of metastasis and on clinical practice are discussed...
  51. pmc The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells
    Bong Ihn Koh
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    EMBO Rep 13:412-22. 2012
    ..A better understanding of the bipolar nature of these bone marrow-derived cells in physiological and malignant contexts could pave the way for new therapeutics against metastatic disease...
  52. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
    ....
  53. pmc Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
    Andy J Minn
    Cancer Biology and Genetics Program, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 115:44-55. 2005
    ..These results suggest that the bone-specific metastatic phenotypes and gene expression signature identified in a mouse model may be clinically relevant...
  54. ncbi E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
    Chang Rung Chen
    Cell Biology Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 110:19-32. 2002
    ..Smad proteins therefore mediate transcriptional activation or repression depending on their associated partners...
  55. ncbi Epithelial-mesenchymal transitions: twist in development and metastasis
    Yibin Kang
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cell 118:277-9. 2004
    ..A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases...
  56. ncbi A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell 11:915-26. 2003
    ..As a common target of TGFbeta/Smad signals and stress signals via p38 kinase, ATF3 additionally serves to channel synergy between these pathways in the response of epithelial cells to stress and injury...
  57. ncbi Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus
    Lan Xu
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 10:271-82. 2002
    ..Thus, by directly contacting the nuclear pore complex, Smad2 undergoes constant shuttling, providing a dynamic pool that is competitively drawn by cytoplasmic and nuclear signal transduction partners...

Research Grants4

  1. Metadherin in Metastasis and Chemoresistance of Breast Cancer
    Yibin Kang; Fiscal Year: 2009
    ..Furthermore, our research will facilitate the development of anti-metastasis therapeutics based on molecular targeting of Metadherin. ..
  2. The Role of miRNAs in Epithelial-Mesenchymal Transition and Metastasis
    Yibin Kang; Fiscal Year: 2010
    ....
  3. Metadherin in Metastasis and Chemoresistance of Breast Cancer
    Yibin Kang; Fiscal Year: 2010
    ..Furthermore, our research will facilitate the development of anti-metastasis therapeutics based on molecular targeting of Metadherin. ..